Tailored nanostructured platforms for boosting transcorneal permeation: Box–Behnken statistical optimization, comprehensive in vitro, ex vivo and in vivo characterization

References

• ErenOTArmağanRTalmaçMANonsteroidal Anti-inflammatory Drugs (NSAIDs) and CorticosteroidsKorkusuzFMusculoskeletal Research and Basic ScienceAmsterdamSpringer2016683693
   Google Scholar
• BrayfieldAMartindale: The Complete Drug ReferenceNYPharmaceutical Press2014
   Google Scholar
• MoffatACClarke’s Analysis of Drugs and PoisonsNYPharmaceutical Press2011
   Google Scholar
• MadniMARazaAAbbasSDetermination of tenoxicam in the plasma by reverse phase HPLC method using single step extraction technique: a reliable and cost effective approachActa Pol Pharm201673511291134
   PubMedGoogle Scholar
• BandyopadhyayREvelethDVan HaarlemTInventorsGoogle Patents, assigneeMethod of using COX-2 inhibitors in the treatment and prevention of ocular COX-2 mediated disordersUS 20020128267 A12002912
   Google Scholar
• CagleGAbshireRLStromanDWInventorsGoogle Patents, assigneeMethods of treating ophthalmic, otic and nasal infections and attendant inflammationUS 6395746 B12002528
   Google Scholar
• Del PuppoMKienleMGRatigliaRIntraocular and plasma kinetics of tenoxicam in rabbitsGraefes Arch Clin Exp Ophthalmol199323121151178444358
   PubMedGoogle Scholar
• GratieriTSanterVKaliaYNBasic principles and current status of transcorneal and transscleral iontophoresisExpert Opin Drug Deliv20171491091110227892757
   PubMed Web of Science ®Google Scholar
• ThassuDChaderGJOcular Drug Delivery Systems: Barriers and Application of Nanoparticulate SystemsFLCRC Press2012
   Google Scholar
• PrausnitzMRNoonanJSPermeability of cornea, sclera, and conjunctiva: a literature analysis for drug delivery to the eyeJ Pharm Sci199887121479148810189253
   PubMed Web of Science ®Google Scholar
• GaudanaRAnanthulaHKParenkyAMitraAKOcular drug deliveryAAPS J201012334836020437123
   PubMed Web of Science ®Google Scholar
• SchoenwaldRDWardRLRelationship between steroid permeability across excised rabbit cornea and octanol-water partition coefficientsJ Pharm Sci1978676786788660456
   PubMed Web of Science ®Google Scholar
• HabibFSFouadEAAbdel-RhamanMSFathallaDLiposomes as an ocular delivery system of fluconazole: in-vitro studiesActa Ophthalmol201088890190419681761
   PubMed Web of Science ®Google Scholar
• LawSLHuangKJChiangCHAcyclovir-containing liposomes for potential ocular delivery: corneal penetration and absorptionJ Control Release2000631–213514010640587
   PubMed Web of Science ®Google Scholar
• El-GazayerlyONHikalAHPreparation and evaluation of acetazolamide liposomes as an ocular delivery systemInt J Pharm19971582121127
   Web of Science ®Google Scholar
• ZhangJLiangXLiXOcular delivery of cyanidin-3-glycoside in liposomes and its prevention of selenite-induced oxidative stressDrug Dev Ind Pharm201642454655326393779
   PubMed Web of Science ®Google Scholar
• ChenHPanHLiPThe potential use of novel chitosan-coated deformable liposomes in an ocular drug delivery systemColloids Surf B Biointerfaces201614345546227037783
   PubMed Web of Science ®Google Scholar
• TakeuchiHMatsuiYYamamotoHKawashimaYMucoadhesive properties of carbopol or chitosan-coated liposomes and their effectiveness in the oral administration of calcitonin to ratsJ Control Release2003862–323524212526820
   PubMed Web of Science ®Google Scholar
• ChiouCJTsengLPDengMCMucoadhesive liposomes for intranasal immunization with an avian influenza virus vaccine in chickensBiomaterials200930295862586819608270
   PubMed Web of Science ®Google Scholar
• VyasSPMysoreNJaitelyVVenkatesanNDiscoidal niosome based controlled ocular delivery of timolol maleatePharmazie19985374664699742041
   PubMed Web of Science ®Google Scholar
• AbdelkaderHIsmailSKamalAAlanyRGDesign and evaluation of controlled-release niosomes and discomes for naltrexone hydrochloride ocular deliveryJ Pharm Sci201110051833184621246556
   PubMed Web of Science ®Google Scholar
• AbdelbaryGAAminMMZakariaMYOcular ketoconazole-loaded proniosomal gels: formulation, ex vivo corneal permeation and in vivo studiesDrug Deliv201724130931928165809
   PubMed Web of Science ®Google Scholar
• ParadkarMUParmarMFormulation development and evaluation of Natamycin niosomal in-situ gel for ophthalmic drug deliveryJ Drug Deliv Sci Technol201739113122
   Web of Science ®Google Scholar
• AbdelbaryAAAbd-ElsalamWHAl-MahallawiAMFabrication of novel ultradeformable bilosomes for enhanced ocular delivery of terconazole: in vitro characterization, ex vivo permeation and in vivo safety assessmentInt J Pharm20165131–268869627717916
   PubMed Web of Science ®Google Scholar
• González-RodríguezMLArroyoCMCózar-BernalMJDeform-ability properties of timololloaded transfersomes based on the extrusion mechanism. Statistical optimization of the processDrug Dev Ind Pharm201642101683169426981839
   PubMed Web of Science ®Google Scholar
• Rodriguez VillanuevaJRodriguez VillanuevaLTurning the screw even further to increase microparticle retention and ocular bioavailability of associated drugs: the bioadhesion goalInt J Pharm2017531116717828822703
   PubMedGoogle Scholar
• GrimaldiNAndradeFSegoviaNLipid-based nanovesicles for nanomedicineChem Soc Rev201645236520654527722570
   PubMed Web of Science ®Google Scholar
• DuxfieldLSultanaRWangROcular delivery systems for topical application of anti-infective agentsDrug Dev Ind Pharm201642111126325119
   PubMed Web of Science ®Google Scholar
• M A FathallaZVangalaALongmanMPoloxamer-based thermoresponsive ketorolac tromethamine in situ gel preparations: design, characterisation, toxicity and transcorneal permeation studiesEur J Pharm Biopharm201711411913428126392
   PubMed Web of Science ®Google Scholar
• PatelNThakkarVMetaliaVBaldaniyaLGandhiTGohelMFormulation and development of ophthalmic in situ gel for the treatment ocular inflammation and infection using application of quality by design conceptDrug Dev Ind Pharm20164291406142326716613
   PubMed Web of Science ®Google Scholar
• Fernández-FerreiroASilva-RodríguezJOtero-EspinarFJIn vivo eye surface residence determination by high-resolution scintigraphy of a novel ion-sensitive hydrogel based on gellan gum and kappa-carrageenanEur J Pharm Biopharm201711431732328189624
   PubMedGoogle Scholar
• MealyJEFedorchakMVLittleSRIn vitro characterization of a controlled-release ocular insert for delivery of brimonidine tartrateActa Biomater2014101879324080317
   PubMedGoogle Scholar
• HornofMWeyenbergWLudwigABernkop-SchnürchAMucoadhesive ocular insert based on thiolated poly (acrylic acid): development and in vivo evaluation in humansJ Control Release200389341942812737844
   PubMed Web of Science ®Google Scholar
• RefaiHTagRDevelopment and characterization of sponge-like acyclovir ocular minitabletsDrug Deliv2011181384520804440
   PubMed Web of Science ®Google Scholar
• SamadASultanaYAqilMLiposomal drug delivery systems: an update reviewCurr Drug Deliv20074429730517979650
   PubMedGoogle Scholar
• DoppalapudiSJainAChopraDKKhanWPsoralen loaded liposomal nanocarriers for improved skin penetration and efficacy of topical PUVA in psoriasisEur J Pharm Sci20179651552927777066
   PubMed Web of Science ®Google Scholar
• ShammaRNElsayedITransfersomal lyophilized gel of buspirone HCl: formulation, evaluation and statistical optimizationJ Liposome Res201323324425423713516
   PubMed Web of Science ®Google Scholar
• FerreiraSLBrunsREFerreiraHSBox-Behnken design: an alternative for the optimization of analytical methodsAnal Chim Acta2007597217918617683728
   PubMed Web of Science ®Google Scholar
• YangRNamKKimSWFactorial design based multivariate modeling and optimization of tunable bioresponsive arginine grafted poly (cystaminebis (acrylamide)-diaminohexane) polymeric matrix based nanocarriersMol Pharm201714125226328043134
   PubMedGoogle Scholar
• SurianarayananRShivakumarHGVegesnaNSKVSrivastavaAEffect of sample concentration on the characterization of liposomes using dynamic light scattering techniquePharm Methods2016717074
   Google Scholar
• ChangRYangJGeSSynthesis and self-assembly of octenyl succinic anhydride modified short glucan chains based amphiphilic biopolymer: micelles, ultrasmall micelles, vesicles, and lutein encapsulation/releaseFood Hydrocoll2017671426
   Web of Science ®Google Scholar
• LiuZLiJNieSLiuHDingPPanWStudy of an alginate/HPMC-based in situ gelling ophthalmic delivery system for gatifloxacinInt J Pharm20063151–2121716616442
   PubMed Web of Science ®Google Scholar
• WeiGXuHDingPTLiSMZhengJMThermosetting gels with modulated gelation temperature for ophthalmic use: the rheological and gamma scintigraphic studiesJ Control Release2002831657412220839
   PubMed Web of Science ®Google Scholar
• ChoiaHGJungbJHRyubJMYoonbSJOhaYKKimaCKDevelopment of in situ-gelling and mucoadhesive acetaminophen liquid suppositoryInt J Pharm199816513344
   Google Scholar
• ElKasabgyNAElsayedIElshafeeyAHDesign of lipotomes as a novel dual functioning nanocarrier for bioavailability enhancement of lacidipine: in-vitro and in-vivo characterizationInt J Pharm20144721–236937924979531
   PubMed Web of Science ®Google Scholar
• LiaoJWeiXRanBPengJQuYQianZPolymer hybrid magnetic nanocapsules encapsulating IR820 and PTX for external magnetic field-guided tumor targeting and multifunctional theranosticsNanoscale2017972479249128150848
   PubMedGoogle Scholar
• FaithDHorsfieldCJNazarovWCharacterization of pore size of trimethylol propane triacrylate (TMPTA) polymer foam by pulsed sputter coating and SEM analysisJ Mater Sci2006411339733977
   Google Scholar
• MorsiNMAbdelbaryGAAhmedMASilver sulfadiazine based cubosome hydrogels for topical treatment of burns: development and in vitro/in vivo characterizationEur J Pharm Biopharm201486217818923688805
   PubMed Web of Science ®Google Scholar
• YeFMiaoMLuKJiangBLiXCuiSWStructure and physicochemical properties for modified starch-based nanoparticle from different maize varietiesFood Hydrocoll2017673744
   Web of Science ®Google Scholar
• RathodLVKapadiaRSawantKKA novel nanoparticles impregnated ocular insert for enhanced bioavailability to posterior segment of eye: In vitro, in vivo and stability studiesMater Sci Eng C Mater Biol Appl20177152954027987741
   PubMed Web of Science ®Google Scholar
• NagarwalRCKumarRPanditJKChitosan coated sodium alginate-chitosan nanoparticles loaded with 5-FU for ocular delivery: in vitro characterization and in vivo study in rabbit eyeEur J Pharm Sci201247467868522922098
   PubMed Web of Science ®Google Scholar
• BalzusBSahleFFHönzkeSFormulation and ex vivo evaluation of polymeric nanoparticles for controlled delivery of corticosteroids to the skin and the corneal epitheliumEur J Pharm Biopharm201711512213028189623
   PubMed Web of Science ®Google Scholar
• Al-mahallawiAMKhowessahOMShoukriRAEnhanced non invasive trans-tympanic delivery of ciprofloxacin through encapsulation into nano-spanlastic vesicles: Fabrication, in-vitro characterization, and comparative ex-vivo permeation studiesInt J Pharm20175221–215716428279741
   PubMed Web of Science ®Google Scholar
• de Oliveira VercikLCVercikAda Silva RigoECKinetics of silver nanoparticle release from chitosan spheresMRS Advances2017219–2010891094
   Google Scholar
• KimTKangEChunIGwakHPharmacokinetics of formulated tenoxicam transdermal delivery systemsJ Pharm Pharmacol200860113513818088513
   PubMedGoogle Scholar
• Sanchez-LopezEEgeaMACanoAPEGylated PLGA nanospheres optimized by design of experiments for ocular administration of dexibuprofen-in vitro, ex vivo and in vivo characterizationColloids Surf B Biointerfaces201614524125027187188
   PubMed Web of Science ®Google Scholar
• SalamaAHShammaRNTri/tetra-block co-polymeric nanocarriers as a potential ocular delivery system of lornoxicam: in-vitro characterization, and in-vivo estimation of corneal permeationInt J Pharm20154921–2283926151106
   PubMed Web of Science ®Google Scholar
• VenkateswarluVManjunathKPreparation, characterization and in vitro release kinetics of clozapine solid lipid nanoparticlesJ Control Release200495362763815023472
   PubMed Web of Science ®Google Scholar
• CaddeoCMancaMLMatosMFunctional response of novel bioprotective poloxamer-structured vesicles on inflamed skinNanomedicine20171331127113628064008
   PubMed Web of Science ®Google Scholar
• DharSMurawalaPShirasAPokharkarVPrasadBLGellan gum capped silver nanoparticle dispersions and hydrogels: cytotoxicity and in vitro diffusion studiesNanoscale20124256356722134682
   PubMed Web of Science ®Google Scholar
• MorsiNIbrahimMRefaiHEl SorogyHNanoemulsion-based electrolyte triggered in situ gel for ocular delivery of acetazolamideEur J Pharm Sci201710430231428433750
   PubMed Web of Science ®Google Scholar
• BaşDBoyacıİHModeling and optimization I: usability of response surface methodologyJ Food Eng2007783836845
   Web of Science ®Google Scholar
• VuchkovINBoyadjievaLQuality Improvement with Design of Experiments: A Response Surface ApproachAmsterdamSpringer2013
   Google Scholar
• LasonESikoraEOgonowskiJInfluence of process parameters on properties of Nanostructured Lipid Carriers (NLC) formulationActa Biochim Pol201360477377724432330
   PubMed Web of Science ®Google Scholar
• AdityaNPMacedoASDoktorovovaSDevelopment and evaluation of lipid nanocarriers for quercetin delivery: A comparative study of solid lipid nanoparticles (SLN), nanostructured lipid carriers (NLC), and lipid nanoemulsions (LNE)Food Sci Technol2014591115121
   Google Scholar
• IzquierdoPFengJEsquenaJThe influence of surfactant mixing ratio on nano-emulsion formation by the pit methodJ Colloid Interface Sci2005285138839415797437
   PubMedGoogle Scholar
• FreitasCMüllerRHEffect of light and temperature on zeta potential and physical stability in solid lipid nanoparticle (SLN™) dispersionsInt J Pharm19981682221229
   Web of Science ®Google Scholar
• ChakrabortyHDeviPGSarkarMNew functions of old drugs aureolic acid group of anticancer antibiotics and non-steroidal anti-inflammatory drugsChoudharyMIPerryGRecent Advances in Medicinal ChemistryAmsterdamElsevier Science2015355
   Google Scholar
• BezerraMASantelliREOliveiraEPVillarLSEscaleiraLAResponse surface methodology (RSM) as a tool for optimization in analytical chemistryTalanta200876596597718761143
   PubMed Web of Science ®Google Scholar
• VialSReisRLOliveiraJMRecent advances using gold nanoparticles as a promising multimodal tool for tissue engineering and regenerative medicineCurr Opin Solid State Mater Sci201721292112
   Web of Science ®Google Scholar
• WhiteBBanerjeeSO’BrienSTurroNJHermanIPZeta-potential measurements of surfactant-wrapped individual single-walled carbon nanotubesJ Phys Chem C2007111371368413690
   Web of Science ®Google Scholar
• YehMKChangLCChiouAHImproving tenoxicam solubility and bioavailability by cosolvent systemAAPS PharmSciTech200910116617119224373
   PubMedGoogle Scholar
• YusufMSharmaVPathakKNanovesicles for transdermal delivery of felodipine: Development, characterization, and pharmacokineticsInt J Pharm Investig201443119130
   PubMedGoogle Scholar
• El MaghrabyGMWilliamsACBarryBWOestradiol skin delivery from ultradeformable liposomes: refinement of surfactant concentrationInt J Pharm20001961637410675708
   PubMed Web of Science ®Google Scholar
• DewanMSarkarGBhowmikMEffect of gellan gum on the thermogelation property and drug release profile of Poloxamer 407 based ophthalmic formulationInt J Biol Macromol201710225826528390828
   PubMed Web of Science ®Google Scholar
• SniegowskiMErlangerMVelez-MontoyaROlsonJLDifference in ocular surface temperature by infrared thermography in phakic and pseudophakic patientsClin Ophthalmol2015946146625834383
   PubMedGoogle Scholar
• SouzaLGSilvaEJMartinsALDevelopment of topotecan loaded lipid nanoparticles for chemical stabilization and prolonged releaseEur J Pharm Biopharm201179118919621352915
   PubMed Web of Science ®Google Scholar
• El-DahmyRMElsayedIElshafeeyAHGawadNAEl-GazayerlyONOptimization of long circulating mixed polymeric micelles containing vinpocetine using simple lattice mixture design, in vitro and in vivo characterizationInt J Pharm20144771–2394625290813
   PubMed Web of Science ®Google Scholar
• SzleiferIGerasimovOVThompsonDHSpontaneous liposome formation induced by grafted poly(ethylene oxide) layers: theoretical prediction and experimental verificationProc Natl Acad Sci U S A1998953103210379448280
   PubMedGoogle Scholar
• KalariaDRSharmaGBeniwalVRavi KumarMNDesign of biodegradable nanoparticles for oral delivery of doxorubicin: in vivo pharmacokinetics and toxicity studies in ratsPharm Res200926349250118998202
   PubMed Web of Science ®Google Scholar
• JainAKSwarnakarNKGoduguCSinghRPJainSThe effect of the oral administration of polymeric nanoparticles on the efficacy and toxicity of tamoxifenBiomaterials201132250351520934747
   PubMed Web of Science ®Google Scholar
• ChaconMMolpeceresJBergesLGuzmánMAberturasMRStability and freeze-drying of cyclosporine loaded poly(D,L lactide-glycolide) carriersEur J Pharm Sci1999829910710210732
   PubMed Web of Science ®Google Scholar
• ChaurasiaSSLimRRLakshminarayananRMohanRRNanomedicine approaches for corneal diseasesJ Funct Biomater20156227729825941990
   PubMedGoogle Scholar
• Ramos YacasiGRCalpena CampmanyACEgea GrasMAEspina GarcíaMGarcía LópezMLFreeze drying optimization of polymeric nanoparticles for ocular flurbiprofen delivery: effect of protectant agents and critical process parameters on long-term stabilityDrug Dev Ind Pharm201743463765128044462
   PubMed Web of Science ®Google Scholar
• ChanJMaghrabyGMCraigJPAlanyRGPhase transition water-in-oil microemulsions as ocular drug delivery systems: in vitro and in vivo evaluationInt J Pharm20073281657117092668
   PubMedGoogle Scholar
• SolimanGMFetihGAbbasAMThermosensitive bioadhesive gels for the vaginal delivery of sildenafil citrate: in vitro characterization and clinical evaluation in women using clomiphene citrate for induction of ovulationDrug Dev Ind Pharm201743339940827783532
   PubMed Web of Science ®Google Scholar
• JenningVSchäfer-KortingMGohlaSVitamin A-loaded solid lipid nanoparticles for topical use: drug release propertiesJ Control Release2000662–311512610742573
   PubMed Web of Science ®Google Scholar
• SiepmannJPeppasNAModeling of drug release from delivery systems based on hydroxypropyl methylcellulose (HPMC)Adv Drug Deliv Rev2001482–313915711369079
   PubMed Web of Science ®Google Scholar
• ChenYLuYZhongYWangQWuWGaoSOcular delivery of cyclosporine A based on glyceryl monooleate/poloxamer 407 liquid crystalline nanoparticles: preparation, characterization, in vitro corneal penetration and ocular irritationJ Drug Target2012201085686323050903
   PubMed Web of Science ®Google Scholar
• Al KhatebKOzhmukhametovaEKMussinMNIn situ gelling systems based on Pluronic F127/Pluronic F68 formulations for ocular drug deliveryInt J Pharm20165021–2707926899977
   PubMed Web of Science ®Google Scholar
• Del AmoEMUrttiACurrent and future ophthalmic drug delivery systems. A shift to the posterior segmentDrug Discov Today2008133–413514318275911
   PubMed Web of Science ®Google Scholar