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International Journal of Nanomedicine Volume 6, 2011 - Issue
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Original Research

Pharmacokinetics of ligustrazine ethosome patch in rats and anti-myocardial ischemia and anti-ischemic reperfusion injury effect

Xingyan Liu1 China-America Cancer Research Institute, Guangdong Medical College, Dongguan, Guangdong
,
Hong Liu1 China-America Cancer Research Institute, Guangdong Medical College, Dongguan, Guangdong
,
Zhaowu Zeng2 Guangdong Key Laboratory for Research and Development of Natural Drugs, Guangdong Medical College, Dongguan, GuangdongCorrespondence[email protected] [email protected]
,
Weihua Zhou3 Yichun University, Yichun, Jiangxi, People’s Republic of China
,
Jianqiang Liu2 Guangdong Key Laboratory for Research and Development of Natural Drugs, Guangdong Medical College, Dongguan, Guangdong
&
Zhiwei He1 China-America Cancer Research Institute, Guangdong Medical College, Dongguan, Guangdong
Pages 1391-1398 | Published online: 04 Jul 2011

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Atoosa Jafari, Saeid Daneshamouz, Parisa Ghasemiyeh & Soliman Mohammadi-Samani. (2023) Ethosomes as dermal/transdermal drug delivery systems: applications, preparation and characterization. Journal of Liposome Research 33:1, pages 34-52.
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Nidhi Nainwal, Sunil Jawla, Ranjit Singh & Vikas Anand Saharan. (2019) Transdermal applications of ethosomes – a detailed review. Journal of Liposome Research 29:2, pages 103-113.
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Xiao Zheng, Fei Wu, Xiao Lin, Lan Shen & Yi Feng. (2018) Developments in drug delivery of bioactive alkaloids derived from traditional Chinese medicine. Drug Delivery 25:1, pages 398-416.
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Ibrahim M Abdulbaqi, Yusrida Darwis, Nurzalina Abdul Karim Khan, Reem Abou Assi & Arshad A Khan. (2016) Ethosomal nanocarriers: the impact of constituents and formulation techniques on ethosomal properties, in vivo studies, and clinical trials. International Journal of Nanomedicine 11, pages 2279-2304.
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Lili Feng, Wenchao Mao, Jian Zhang, Xiaoting Liu, Yibo Jiao, Xin Zhao, Xiuping Wang, Dongxing Zhang, Dayong Cai & Yueqi Wang. (2014) Pharmacokinetic variations of tetramethylpyrazine phosphate after oral administration in hepatic precancerous mice and its hepatoprotective effects. Drug Development and Industrial Pharmacy 40:1, pages 1-8.
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Teng Shen, Huinan Xu, Weiyu Weng & Jianfeng Zhang. (2013) Development of a reservoir-type transdermal delivery system containing eucalyptus oil for tetramethylpyrazine. Drug Delivery 20:1, pages 19-24.
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Articles from other publishers (18)

Huinan Wang, Zhicheng Wang, Mingrui Jiang, Zhuzhu Yue, Jingqiu Zhang, Mengyu Chen, Menglin Wang, Xiaotong Wei, Shuanghui Shi & Yingzi Wang. (2022) Pharmacokinetics and tissue distribution of five bioactive components in the Corydalis yanhusuo total alkaloids transdermal patch following Shenque acupoint application in rats assessed by ultra‐performance liquid chromatography–tandem mass spectrometry . Biomedical Chromatography 37:1.
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In Sook Kang & Kihwan Kwon. (2022) Potential application of biomimetic exosomes in cardiovascular disease: focused on ischemic heart disease. BMB Reports 55:1, pages 30-38.
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Xiao Zheng, Teng Guo, Fei Wu, Lan Shen & Xiao Lin. 2021. Novel Drug Delivery Systems for Chinese Medicines. Novel Drug Delivery Systems for Chinese Medicines 49 76 .
Sruti Bheri, Jessica R Hoffman, Hyun-Ji Park & Michael E Davis. (2020) Biomimetic nanovesicle design for cardiac tissue repair. Nanomedicine 15:19, pages 1873-1896.
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Yuqin Chen, Wenjun He, Haiping Ouyang, Chunli Liu, Cheng Hong, Tao Wang, Kai Yang, Wenju Lu & Jian Wang. (2019) Efficacy and safety of tetramethylpyrazine phosphate on pulmonary hypertension: study protocol for a randomized controlled study. Trials 20:1.
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V Sankar, V. Wilson, K. Siram, A. Karuppaiah, S Hariharan & A. Justin. (2019) TOPICAL DELIVERY OF DRUGS USING ETHOSOMES: A REVIEW. INDIAN DRUGS 56:08, pages 7-20.
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Tianle Gao, Tiansheng Shi, Zsuzsanna Wiesenfeld-Hallin, Tao Li, Jian-Dong Jiang & Xiao-Jun Xu. (2019) Sinomenine facilitates the efficacy of gabapentin or ligustrazine hydrochloride in animal models of neuropathic pain. European Journal of Pharmacology 854, pages 101-108.
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Min Fang, Xiaolong Mei, Hui Yao, Tao Zhang, Tao Zhang, Na Lu, Yanshi Liu, Wenyue Xu & Chunyou Wan. (2018) β-elemene enhances anticancer and anti-metastatic effects of osteosarcoma of ligustrazine in�vitro and in�vivo. Oncology Letters.
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Shan Lin, Jianfeng Chu, Ling Zhang, Daxin Chen, Fei Xiao, Hongwei Chen, Jiumao Lin, Youqin Chen, Yuling Zhu & Jun Peng. (2017) Protective effects of Shexiang Tongxin Dropping Pill on pituitrin-induced acute myocardial ischemia in rats. Molecular Medicine Reports 16:3, pages 3125-3132.
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Yun Luan, Junli Liu, Xiaoli Liu, Xia Xue, Feng Kong, Chao Sun, Jue Wang, Ling Liu & Hongying Jia. (2016) Tetramethypyrazine inhibits renal cell carcinoma cells through inhibition of NKG2D signaling pathways. International Journal of Oncology 49:4, pages 1704-1712.
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Heather A. E. Benson. 2016. Percutaneous Penetration Enhancers Chemical Methods in Penetration Enhancement. Percutaneous Penetration Enhancers Chemical Methods in Penetration Enhancement 297 307 .
Lin Zheng, Zipeng Gong, Yuan Lu, Yumin Xie, Yong Huang, Yue Liu, Yanyu Lan, Aimin Wang & Yonglin Wang. (2015) A UPLC–MS/MS method for simultaneous determination of danshensu, protocatechuic aldehyde, rosmarinic acid, and ligustrazine in rat plasma, and its application to pharmacokinetic studies of Shenxiong glucose injection in rats. Journal of Chromatography B 997, pages 210-217.
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Yu Li, Ping Song, Qing Zhu, Qiu-yi Yin, Jia-wen Ji, Wei Li & Hui-min Bian. (2014) Liguzinediol improved the heart function and inhibited myocardial cell apoptosis in rats with heart failure. Acta Pharmacologica Sinica 35:10, pages 1257-1264.
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Lei Xu, Chang-Yuan Wang, Li Lv, Ke-Xin Liu, Hui-Jun Sun & Guo-Zhu Han. (2014) Pharmacokinetics of phosphocreatine and its active metabolite creatine in the mouse plasma and myocardium. Pharmacological Reports 66:5, pages 908-914.
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Mingfei Zeng, Jing Zhang, Yifang Yang, Yan Jin, Wei Xiao, Zhenzhong Wang, Gang Ding & Renjie Yan. (2014) An automated dual-gradient liquid chromatography–MS/MS method for the simultaneous determination of ferulic acid, ligustrazine and ligustilide in rat plasma and its application to a pharmacokinetic study. Journal of Pharmaceutical and Biomedical Analysis 88, pages 354-363.
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BO YI, DAN LIU, MING HE, QIYUN LI, TIANDE LIU & JIANGHUA SHAO. (2013) Role of the ROS/AMPK signaling pathway in tetramethylpyrazine-induced apoptosis in gastric cancer cells. Oncology Letters 6:2, pages 583-589.
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Gergö Hofgart & László Csiba. (2012) Commentaries. International Journal of Therapy and Rehabilitation 19:11, pages 611a-611a.
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Keat Wei Loo & Siew Hua Gan. (2012) Commentaries. International Journal of Therapy and Rehabilitation 19:11, pages 611-611.
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