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Original Research

Platelet Membrane-Coated Nanoparticles Target Sclerotic Aortic Valves in ApoE^−/− Mice by Multiple Binding Mechanisms Under Pathological Shear Stress

Hongbo Yang1 Department of Cardiology, Zhongshan Hospital, Fudan University, Shanghai Institute of Cardiovascular Diseases, Shanghai 200032, People’s Republic of China

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Yanan Song1 Department of Cardiology, Zhongshan Hospital, Fudan University, Shanghai Institute of Cardiovascular Diseases, Shanghai 200032, People’s Republic of China

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Jing Chen1 Department of Cardiology, Zhongshan Hospital, Fudan University, Shanghai Institute of Cardiovascular Diseases, Shanghai 200032, People’s Republic of China

https://orcid.org/0000-0001-7603-3085

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Zhiqing Pang2 School of Pharmacy, Key Laboratory of Smart Drug Delivery, Ministry of Education, Fudan University, Shanghai 201203, People’s Republic of China

https://orcid.org/0000-0003-0228-904X

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Ning Zhang1 Department of Cardiology, Zhongshan Hospital, Fudan University, Shanghai Institute of Cardiovascular Diseases, Shanghai 200032, People’s Republic of China

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Jiatian Cao1 Department of Cardiology, Zhongshan Hospital, Fudan University, Shanghai Institute of Cardiovascular Diseases, Shanghai 200032, People’s Republic of China

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Qiaozi Wang1 Department of Cardiology, Zhongshan Hospital, Fudan University, Shanghai Institute of Cardiovascular Diseases, Shanghai 200032, People’s Republic of China

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Qiyu Li1 Department of Cardiology, Zhongshan Hospital, Fudan University, Shanghai Institute of Cardiovascular Diseases, Shanghai 200032, People’s Republic of China

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Feng Zhang1 Department of Cardiology, Zhongshan Hospital, Fudan University, Shanghai Institute of Cardiovascular Diseases, Shanghai 200032, People’s Republic of China

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Yuxiang Dai1 Department of Cardiology, Zhongshan Hospital, Fudan University, Shanghai Institute of Cardiovascular Diseases, Shanghai 200032, People’s Republic of China

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Chenguang Li1 Department of Cardiology, Zhongshan Hospital, Fudan University, Shanghai Institute of Cardiovascular Diseases, Shanghai 200032, People’s Republic of China

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Zheyong Huang1 Department of Cardiology, Zhongshan Hospital, Fudan University, Shanghai Institute of Cardiovascular Diseases, Shanghai 200032, People’s Republic of China

https://orcid.org/0000-0002-6462-8222

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Juying Qian1 Department of Cardiology, Zhongshan Hospital, Fudan University, Shanghai Institute of Cardiovascular Diseases, Shanghai 200032, People’s Republic of ChinaCorrespondence[email protected] [email protected]

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Junbo Ge1 Department of Cardiology, Zhongshan Hospital, Fudan University, Shanghai Institute of Cardiovascular Diseases, Shanghai 200032, People’s Republic of China