Platelet Membrane-Coated Nanoparticles Target Sclerotic Aortic Valves in ApoE^−/− Mice by Multiple Binding Mechanisms Under Pathological Shear Stress

Hongbo Yang1 Department of Cardiology, Zhongshan Hospital, Fudan University, Shanghai Institute of Cardiovascular Diseases, Shanghai 200032, People’s Republic of China

Yanan Song1 Department of Cardiology, Zhongshan Hospital, Fudan University, Shanghai Institute of Cardiovascular Diseases, Shanghai 200032, People’s Republic of China

Jing Chen1 Department of Cardiology, Zhongshan Hospital, Fudan University, Shanghai Institute of Cardiovascular Diseases, Shanghai 200032, People’s Republic of China

https://orcid.org/0000-0001-7603-3085

Zhiqing Pang2 School of Pharmacy, Key Laboratory of Smart Drug Delivery, Ministry of Education, Fudan University, Shanghai 201203, People’s Republic of China

https://orcid.org/0000-0003-0228-904X

Ning Zhang1 Department of Cardiology, Zhongshan Hospital, Fudan University, Shanghai Institute of Cardiovascular Diseases, Shanghai 200032, People’s Republic of China

Jiatian Cao1 Department of Cardiology, Zhongshan Hospital, Fudan University, Shanghai Institute of Cardiovascular Diseases, Shanghai 200032, People’s Republic of China

Qiaozi Wang1 Department of Cardiology, Zhongshan Hospital, Fudan University, Shanghai Institute of Cardiovascular Diseases, Shanghai 200032, People’s Republic of China

Qiyu Li1 Department of Cardiology, Zhongshan Hospital, Fudan University, Shanghai Institute of Cardiovascular Diseases, Shanghai 200032, People’s Republic of China

Feng Zhang1 Department of Cardiology, Zhongshan Hospital, Fudan University, Shanghai Institute of Cardiovascular Diseases, Shanghai 200032, People’s Republic of China

Yuxiang Dai1 Department of Cardiology, Zhongshan Hospital, Fudan University, Shanghai Institute of Cardiovascular Diseases, Shanghai 200032, People’s Republic of China

Chenguang Li1 Department of Cardiology, Zhongshan Hospital, Fudan University, Shanghai Institute of Cardiovascular Diseases, Shanghai 200032, People’s Republic of China

Zheyong Huang1 Department of Cardiology, Zhongshan Hospital, Fudan University, Shanghai Institute of Cardiovascular Diseases, Shanghai 200032, People’s Republic of China

https://orcid.org/0000-0002-6462-8222

Juying Qian1 Department of Cardiology, Zhongshan Hospital, Fudan University, Shanghai Institute of Cardiovascular Diseases, Shanghai 200032, People’s Republic of ChinaCorrespondence[email protected] [email protected]

Junbo Ge1 Department of Cardiology, Zhongshan Hospital, Fudan University, Shanghai Institute of Cardiovascular Diseases, Shanghai 200032, People’s Republic of China

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Platelet Membrane-Coated Nanoparticles Target Sclerotic Aortic Valves in ApoE^−/− Mice by Multiple Binding Mechanisms Under Pathological Shear Stress

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Platelet Membrane-Coated Nanoparticles Target Sclerotic Aortic Valves in ApoE−/− Mice by Multiple Binding Mechanisms Under Pathological Shear Stress

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Platelet Membrane-Coated Nanoparticles Target Sclerotic Aortic Valves in ApoE^−/− Mice by Multiple Binding Mechanisms Under Pathological Shear Stress