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International Journal of Nanomedicine Volume 15, 2020 - Issue
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Original Research

Methotrexate-Loaded Nanostructured Lipid Carrier Gel Alleviates Imiquimod-Induced Psoriasis by Moderating Inflammation: Formulation, Optimization, Characterization, In-Vitro and In-Vivo Studies

Yogeeta O Agrawal1 Department of Pharmaceutics and Quality Assurance, R. C. Patel Institute of Pharmaceutical Education and Research, Shirpur, Maharashtra 425405, IndiaCorrespondence[email protected]
,
Umesh B Mahajan2 Department of Pharmacology, R. C. Patel Institute of Pharmaceutical Education and Research, Shirpur, Maharashtra 425405, IndiaORCID Iconhttps://orcid.org/0000-0002-2336-6764
ORCID Icon,
Hitendra S Mahajan1 Department of Pharmaceutics and Quality Assurance, R. C. Patel Institute of Pharmaceutical Education and Research, Shirpur, Maharashtra 425405, India
&
Shreesh Ojha3 Department of Pharmacology and Therapeutics, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain, Abu Dhabi, United Arab Emirates
Pages 4763-4778 | Published online: 07 Jul 2020

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Chayada Chaiyabutr, Primana Punnakitikashem, Narumol Silpa-archa, Chanisada Wongpraprarut & Leena Chularojanamontri. (2022) The Anti-Psoriatic Efficacy and Safety Profile of Topical and Intralesional Methotrexate: A Literature Review. Clinical, Cosmetic and Investigational Dermatology 15, pages 2253-2274.
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Rodayna Atef Shalaby, Omaima El-Gazayerly & Mohammed Abdallah. (2022) Cubosomal Betamethasone-Salicylic Acid Nano Drug Delivery System for Enhanced Management of Scalp Psoriasis. International Journal of Nanomedicine 17, pages 1659-1677.
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Oly Katari & Sanyog Jain. (2021) Solid lipid nanoparticles and nanostructured lipid carrier-based nanotherapeutics for the treatment of psoriasis. Expert Opinion on Drug Delivery 18:12, pages 1857-1872.
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Articles from other publishers (24)

Sushmita Negi, Nikunj Tandel, Prakriti Sharma, Rajinder Kumar & Rajeev K. Tyagi. (2023) Aceclofenac and methotrexate combination therapy could influence Th1/Th17 axis to modulate rheumatoid-arthritis-induced inflammation. Drug Discovery Today 28:8, pages 103671.
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Mahwash Mukhtar, Amanda-Lee Ezra Manicum, Masoumeh Shojaei Barjouei, Rahime Eshaghi Malekshah, Razieh Behzadmehr, Abbas Rahdar, Suresh Ghotekar & Francesco Baino. (2023) Nanocarriers for methotrexate delivery/codelivery in the frame of cancer diagnostics and treatment: a review. Frontiers in Biomaterials Science 2.
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Debarati Maiti, Mohammed Naseeruddin Inamdar, Mansour Almuqbil, Sarasija Suresh, Syed Mohammed Basheeruddin Asdaq, Sultan Alshehri, Saad Ali Al Arfaj, Ali Musharraf Alamri, Meshal Meshary Aldohyan, Misfir Theeb Alqahtani, Turki Mohammed Alosaimi, Sami Haran Alenazi, Moneer E. Almadani, Jameel Ahmed S. Mulla & Syed Imam Rabbani. (2023) Evaluation of solid-lipid nanoparticles formulation of methotrexate for anti-psoriatic activity. Saudi Pharmaceutical Journal 31:6, pages 834-844.
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Siddharth Singh & Rajendra Awasthi. (2023) Breakthroughs and bottlenecks of psoriasis therapy: Emerging trends and advances in lipid based nano-drug delivery platforms for dermal and transdermal drug delivery. Journal of Drug Delivery Science and Technology 84, pages 104548.
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Meraj Alam, Md. Rizwanullah, Showkat Rasool Mir & Saima Amin. (2023) Promising prospects of lipid-based topical nanocarriers for the treatment of psoriasis. OpenNano 10, pages 100123.
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Tulshidas S. Patil, Nayan A. Gujarathi, Abhijeet A. Aher, Hemal E. Pachpande, Charu Sharma, Shreesh Ojha, Sameer N. Goyal & Yogeeta O. Agrawal. (2023) Recent Advancements in Topical Anti-Psoriatic Nanostructured Lipid Carrier-Based Drug Delivery. International Journal of Molecular Sciences 24:3, pages 2978.
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Yashika Tomar, Srividya Gorantla & Gautam Singhvi. (2023) Insight into the pivotal role of signaling pathways in psoriasis pathogenesis, potential therapeutic molecules and drug delivery approaches. Drug Discovery Today 28:2, pages 103465.
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Graziela S. Gomes, Luiza A. Frank, Renata V. Contri, Maria S. Longhi, Adriana R. Pohlmann & Silvia S. Guterres. (2023) Nanotechnology-based alternatives for the topical delivery of immunosuppressive agents in psoriasis. International Journal of Pharmaceutics 631, pages 122535.
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Gurpreet Kaur, Snimmer Kaur, Ashif KTK & Jaspreet Kaur. 2023. Green Sustainable Process for Chemical and Environmental Engineering and Science. Green Sustainable Process for Chemical and Environmental Engineering and Science 213 260 .
Chetna Modi & Praful Bharadia. (2022) Pareto chart‐enabled screening of influential factors in designing transfersomes. SEPARATION SCIENCE PLUS 6:1.
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Bo Yu, Xiangtao Wang, Lijuan Ding, Meihua Han & Yifei Guo. (2022) Hydrophilic Natural Polylysine as Drug Nanocarrier for Preparation of Helical Delivery System. Pharmaceutics 14:11, pages 2512.
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Yogeeta O. Agrawal, Kiran D. Patil, Kamini R. More, Mohd Usman Mohd Siddique, Saad Alkahtani, Nada H. Aljarba & Md Saquib Hasnain. (2022) Amelioration of bioavailability through formulating and optimizing Azilsartan Entrapped nanostructured lipid carriers and its pharmacokinetic assessment. Journal of Drug Delivery Science and Technology 77, pages 103894.
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Chee Chin Chu, Chin Ping Tan, Zafarizal Aldrin Azizul Hasan & Kar Lin Nyam. (2022) Preparation and evaluation of photoprotective kenaf seed oil nanocarriers-based cream of tocotrienol-rich fraction. Industrial Crops and Products 185, pages 115164.
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Yogeeta.O. Agrawal, Muzammil Husain, Kiran D. Patil, Vishal Sodgir, Tulshidas S. Patil, Vinit V. Agnihotri, Hitendra S. Mahajan, Charu Sharma, Shreesh Ojha & Sameer N. Goyal. (2022) Verapamil hydrochloride loaded solid lipid nanoparticles: Preparation, optimization, characterisation, and assessment of cardioprotective effect in experimental model of myocardial infarcted rats. Biomedicine & Pharmacotherapy 154, pages 113429.
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Sepideh Yoosefi, Mehdi Esfandyari-Manesh, Fatemeh Ghorbani-Bidkorpeh, Mahnaz Ahmadi, Fatemeh Moraffah & Rassoul Dinarvand. (2022) Novel biodegradable molecularly imprinted polymer nanoparticles for drug delivery of methotrexate anti-cancer; synthesis, characterization and cellular studies. DARU Journal of Pharmaceutical Sciences 30:2, pages 289-302.
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G.-P. Lang & Y.-Y. Han. (2022) Rutin Ameliorates H2O2-Induced Oxidative Stress Injury in HaCaT Cells via the Nrf2-Regulated Pathway. Journal of Evolutionary Biochemistry and Physiology 58:5, pages 1389-1400.
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Cintia Oliveira Alves, Rômulo Dias Novaes, Maria Tereza Carneiro Paschoal Bernardes, Reggiani Vilela Gonçalves, Laíla Pereira da Silva, Sandra Barbosa Neder Agostini, Gislaine Ribeiro Pereira & Flávia Chiva Carvalho. (2022) Evaluation of methotrexate-loaded surfactants, ceramides and cholesterol-based lamellar phases as a topical treatment for psoriasis. Journal of Pharmacy and Pharmacology 74:9, pages 1342-1352.
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Arya Kadukkattil Ramanunny, Sheetu Wadhwa, Sachin Kumar Singh, Bimlesh Kumar, Monica Gulati, Ankit Kumar, Saud Almawash, Ahmed Al Saqr, Kuppusamy Gowthamarajan, Kamal Dua, Harpreet Singh, Sukriti Vishwas, Rubiya Khursheed, Shaik Rahana Parveen, Aravindhanathan Venkatesan, Keshav Raj Paudel, Philip M Hansbro & Dinesh Kumar Chellappan. (2022) Topical non-aqueous nanoemulsion of Alpinia galanga extract for effective treatment in psoriasis: In vitro and in vivo evaluation. International Journal of Pharmaceutics 624, pages 121882.
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Komal Saini, Snigdha Verma & Vandita Kakkar. (2022) Anti-psoriatic effects of tetrahydrocurcumin lipidic nanoparticles in IMQ induced psoriatic plaque: A research report. Journal of Drug Delivery Science and Technology 71, pages 103301.
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Shaheen Parveen, Musheer Ahmed, Sanjula Baboota & Javed Ali. (2022) An Innovative Approach in Nanotechnology-based Delivery System for the Effective Management of Psoriasis. Current Pharmaceutical Design 28:13, pages 1082-1102.
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Ning Li, Yeping Qin, Dan Dai, Pengyu Wang, Mingfei Shi, Junwei Gao, Jinsheng Yang, Wei Xiao, Ping Song & Ruodan Xu. (2022) Transdermal Delivery of Therapeutic Compounds With Nanotechnological Approaches in Psoriasis. Frontiers in Bioengineering and Biotechnology 9.
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Ummu Umaimah Mohd Nordin, Noraini Ahmad, Norazlinaliza Salim & Nor Saadah Mohd Yusof. (2021) Lipid-based nanoparticles for psoriasis treatment: a review on conventional treatments, recent works, and future prospects. RSC Advances 11:46, pages 29080-29101.
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Prativa Biswasroy, Deepak Pradhan, Biswakanth Kar, Goutam Ghosh & Goutam Rath. (2021) Recent Advancement in Topical Nanocarriers for the Treatment of Psoriasis. AAPS PharmSciTech 22:5.
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Yogeeta O. Agrawal, Umesh B. Mahajan, Vinit V. Agnihotri, Mayur S. Nilange, Hitendra S. Mahajan, Charu Sharma, Shreesh Ojha, Chandragouda R. Patil & Sameer N. Goyal. (2021) Ezetimibe-Loaded Nanostructured Lipid Carrier Based Formulation Ameliorates Hyperlipidaemia in an Experimental Model of High Fat Diet. Molecules 26:5, pages 1485.
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