Methotrexate-Loaded Nanostructured Lipid Carrier Gel Alleviates Imiquimod-Induced Psoriasis by Moderating Inflammation: Formulation, Optimization, Characterization, In-Vitro and In-Vivo Studies

References

• Christophers E. Psoriasis− epidemiology and clinical spectrum. Clin Exp Dermatol. 2001;26:314–320. doi:10.1046/j.1365-2230.2001.00832.x11422182
   PubMed Web of Science ®Google Scholar
• Pradhan M, Alexander A, Singh MR, Singh D, Saraf S, Saraf S. Understanding the prospective of nano-formulations towards the treatment of psoriasis. Biomed Pharmacotherap. 2018;107:447–463. doi:10.1016/j.biopha.2018.07.156
   PubMed Web of Science ®Google Scholar
• Gisondi P, Del Giglio M, Girolomoni G. Treatment approaches to moderate to severe psoriasis. Int J Mole Sci. 2017;18:2427.
   PubMed Web of Science ®Google Scholar
• Gungor S, Rezigue M. Nanocarriers mediated topical drug delivery for psoriasis treatment. Curr Drug Metab. 2017;18:454–468. doi:10.2174/138920021866617022214524028228078
   PubMed Web of Science ®Google Scholar
• Tapeinos C, Battaglini M, Ciofani G. Advances in the design of solid lipid nanoparticles and nanostructured lipid carriers for targeting brain diseases. J Control Rel. 2017;264:306–332. doi:10.1016/j.jconrel.2017.08.033
   PubMed Web of Science ®Google Scholar
• Jenning V, Gysler A, Schäfer-Korting M, Gohla SH. Vitamin A loaded solid lipid nanoparticles for topical use: occlusive properties and drug targeting to the upper skin. Eur J Pharm Biopharm. 2000;49:211–218. doi:10.1016/S0939-6411(99)00075-210799811
   PubMed Web of Science ®Google Scholar
• Kamel AE, Fadel M, Louis D. Curcumin-loaded nanostructured lipid carriers prepared using Peceol™ and olive oil in photodynamic therapy: development and application in breast cancer cell line. Int J Nanomed. 2019;14:5073. doi:10.2147/IJN.S210484
   PubMed Web of Science ®Google Scholar
• Jenning V, Gohla SH. Encapsulation of retinoids in solid lipid nanoparticles (SLN). J Microencapsul. 2001;18(2):149–158. doi:10.1080/0265204001000036111253932
   PubMed Web of Science ®Google Scholar
• Souto E, Wissing S, Barbosa C, Müller R. Development of a controlled release formulation based on SLN and NLC for topical clotrimazole delivery. Int J Pharm. 2004;278:71–77. doi:10.1016/j.ijpharm.2004.02.03215158950
   PubMed Web of Science ®Google Scholar
• Küchler S, Herrmann W, Panek-Minkin G, et al. SLN for topical application in skin diseases—Characterization of drug–carrier and carrier–target interactions. Int J Pharm. 2010;390:225–233. doi:10.1016/j.ijpharm.2010.02.00420153414
   PubMed Web of Science ®Google Scholar
• Tung N-T, Vu V-D, Nguyen P-L. DoE-based development, physicochemical characterization, and pharmacological evaluation of a topical hydrogel containing betamethasone dipropionate microemulsion. Colloids Surf B. 2019;181:480–488. doi:10.1016/j.colsurfb.2019.06.002
   PubMed Web of Science ®Google Scholar
• Borgia SL, Regehly M, Sivaramakrishnan R, et al. Lipid nanoparticles for skin penetration enhancement—correlation to drug localization within the particle matrix as determined by fluorescence and parelectric spectroscopy. J Control Rel. 2005;110:151–163. doi:10.1016/j.jconrel.2005.09.045
   PubMed Web of Science ®Google Scholar
• Li Q, Cai T, Huang Y, Xia X, Cole S, Cai Y. A review of the structure, preparation, and application of NLCs, PNPs, and PLNs. Nanomaterial. 2017;7:122. doi:10.3390/nano7060122
   Web of Science ®Google Scholar
• Kaul S, Gulati N, Verma D, Mukherjee S, Nagaich U. Role of nanotechnology in cosmeceuticals: a review of recent advances. J Pharm. 2018;2018.
   Google Scholar
• Souto EB, Muller R. Lipid nanoparticles (solid lipid nanoparticles and nanostructured lipid carriers) for cosmetic, dermal, and transdermal applications. Drugs Pharmaceut Sci. 2007;166:213.
   Google Scholar
• Hollywood A, O’Keeffe C, Boggs J, Feighery C, Collins S. The utility of subcutaneous methotrexate for chronic plaque psoriasis in a real‐world setting. Brit J Dermatol. 2019.
   Web of Science ®Google Scholar
• Costa P, Lobo JMS. Modeling and comparison of dissolution profiles. Eur J Pharm Sci. 2001;13:123–133. doi:10.1016/S0928-0987(01)00095-111297896
   PubMed Web of Science ®Google Scholar
• Harrison C, Jenski L, Voychehovski T, Bernstein D. Modification of immunological responses and clinical disease during topical R-837 treatment of genital HSV-2 infection. Antiviral Res. 1988;10:209–223. doi:10.1016/0166-3542(88)90032-02465735
   PubMed Web of Science ®Google Scholar
• Hejri A, Khosravi A, Gharanjig K, Hejazi M. Optimisation of the formulation of β-carotene loaded nanostructured lipid carriers prepared by solvent diffusion method. Food Chem. 2013;141(1):117–123. doi:10.1016/j.foodchem.2013.02.08023768336
   PubMed Web of Science ®Google Scholar
• Mehta AK, Yadav KS, Sawant KK. Nimodipine loaded PLGA nanoparticles: formulation optimization using factorial design, characterization and in vitro evaluation. Curr Drug Del. 2007;4:185–193. doi:10.2174/156720107781023929
   PubMedGoogle Scholar
• Singka GSL, Samah NA, Zulfakar MH, Yurdasiper A, Heard CM. Enhanced topical delivery and anti-inflammatory activity of methotrexate from an activated nanogel. Eur J Pharm Biopharm. 2010;76:275–281. doi:10.1016/j.ejpb.2010.06.01420600884
   PubMed Web of Science ®Google Scholar
• Tofani R, Sumirtapura Y, Darijanto S. Formulation, characterisation, and in vitro skin diffusion of nanostructured lipid carriers for deoxyarbutin compared to a nanoemulsion and conventional cream. Scientia Pharma. 2016;84:634–645. doi:10.3390/scipharm84040634
   PubMed Web of Science ®Google Scholar
• Han F, Yin R, Che X, et al. Nanostructured lipid carriers (NLC) based topical gel of flurbiprofen: design, characterization and in vivo evaluation. Int J Pharm. 2012;439:349–357. doi:10.1016/j.ijpharm.2012.08.04022989987
   PubMed Web of Science ®Google Scholar
• Parmar SJ, Easwaran S. Metronidazole-loaded nanostructured lipid carriers to improve skin deposition and retention in the treatment of rosacea. 2019.
   Google Scholar
• van der Fits L, Mourits S, Voerman JS, et al. Imiquimod-induced psoriasis-like skin inflammation in mice is mediated via the IL-23/IL-17 axis. J Immunol. 2009;182(9):5836–5845. doi:10.4049/jimmunol.080299919380832
   PubMed Web of Science ®Google Scholar
• Sun Y, Zhang J, Huo R, et al. Paeoniflorin inhibits skin lesions in imiquimod-induced psoriasis-like mice by downregulating inflammation. Int Immunopharmacol. 2015;24:392–399. doi:10.1016/j.intimp.2014.12.03225576402
   PubMed Web of Science ®Google Scholar
• Schaper K, Dickhaut J, Japtok L, et al. Sphingosine-1-phosphate exhibits anti-proliferative and anti-inflammatory effects in mouse models of psoriasis. J Dermatol Sci. 2013;71(1):29–36. doi:10.1016/j.jdermsci.2013.03.00623643308
   PubMed Web of Science ®Google Scholar
• Arora N, Shah K, Pandey-Rai S. Inhibition of imiquimod-induced psoriasis-like dermatitis in mice by herbal extracts from some Indian medicinal plants. Protoplasma. 2016;253:503–515. doi:10.1007/s00709-015-0829-y26016607
   PubMed Web of Science ®Google Scholar
• Molls RR, Savransky V, Liu M, et al. Keratinocyte-derived chemokine is an early biomarker of ischemic acute kidney injury. Am J Physiol-Renal Physiol. 2006;290(5):F1187–F1193. doi:10.1152/ajprenal.00342.200516368740
   PubMed Web of Science ®Google Scholar
• Gore PR, Prajapati CP, Mahajan UB, et al. Protective effect of thymoquinone against cyclophosphamide-induced hemorrhagic cystitis through inhibiting DNA damage and upregulation of Nrf2 expression. Int J Biol Sci. 2016;12:944. doi:10.7150/ijbs.1578127489498
   PubMed Web of Science ®Google Scholar
• Han JH, Lee J, Jeon SJ, et al. In vitro and in vivo growth inhibition of prostate cancer by the small molecule imiquimod. Int J Oncol. 2013;42:2087–2093. doi:10.3892/ijo.2013.189823588478
   PubMed Web of Science ®Google Scholar
• Mayur K, Padhi B, Chougule M, Mishra A. Methotrexate loaded solid lipid nanoparticles for topical treatment of psoriasis: formulation and clinical implication. 2002.
   Google Scholar
• Yang G, Wu F, Chen M, Jin J, Wang R, Yuan Y. Formulation design, characterization, and in vitro and in vivo evaluation of nanostructured lipid carriers containing a bile salt for oral delivery of gypenosides. Int J Nanomed. 2019;14:2267. doi:10.2147/IJN.S194934
   PubMed Web of Science ®Google Scholar
• Gokhale JP, Mahajan HS, Surana SS. Quercetin loaded nanoemulsion-based gel for rheumatoid arthritis: in vivo and in vitro studies. Biomed Pharmacother. 2019;112:108622. doi:10.1016/j.biopha.2019.10862230797146
   PubMed Web of Science ®Google Scholar
• Jenning V, Thünemann AF, Gohla SH. Characterisation of a novel solid lipid nanoparticle carrier system based on binary mixtures of liquid and solid lipids. Int J Pharm. 2000;199:167–177. doi:10.1016/S0378-5173(00)00378-110802410
   PubMed Web of Science ®Google Scholar
• Elmowafy M, Shalaby K, Ali HM, et al. Impact of nanostructured lipid carriers on dapsone delivery to the skin: in vitro and in vivo studies. Int J Pharm. 2019;572:118781. doi:10.1016/j.ijpharm.2019.11878131715347
   PubMed Web of Science ®Google Scholar
• Chen Y, Zhou L, Yuan L, et al. Formulation, characterization, and evaluation of in vitro skin permeation and in vivo pharmacodynamics of surface-charged tripterine-loaded nanostructured lipid carriers. Int J Nanomed. 2012;7:3023.
   PubMed Web of Science ®Google Scholar
• Agrawal Y, Petkar KC, Sawant KK. Development, evaluation and clinical studies of Acitretin loaded nanostructured lipid carriers for topical treatment of psoriasis. Int J Pharm. 2010;401(1–2):93–102. doi:10.1016/j.ijpharm.2010.09.00720858539
   PubMed Web of Science ®Google Scholar
• Lee SY, Nam S, Kim S, et al. Therapeutic efficacies of Artemisia capillaris extract cream formulation in imiquimod-induced psoriasis models. Evid-Based Complement Alternat Med. 2018;2018.
   Web of Science ®Google Scholar
• Na Takuathung M, Wongnoppavich A, Panthong A, et al. Antipsoriatic effects of wannachawee recipe on imiquimod-induced psoriasis-like dermatitis in BALB/c mice. Evid-Based Complement Alternat Med. 2018;2018.
   Web of Science ®Google Scholar
• Dalle–Donne I, Milzani A, Gagliano N, Colombo R, Giustarini D, Rossi R. Molecular mechanisms and potential clinical significance of S-glutathionylation. Antioxidant Redox Signal. 2008;10:445–474. doi:10.1089/ars.2007.1716
   PubMed Web of Science ®Google Scholar
• Allen R, Tresini M. Oxidative stress and gene regulation. Free Radical Biol Med. 2000;28:463–499. doi:10.1016/S0891-5849(99)00242-710699758
   PubMed Web of Science ®Google Scholar
• Zhang S, Liu X, Mei L, Wang H, Fang F. Epigallocatechin-3-gallate (EGCG) inhibits imiquimod-induced psoriasis-like inflammation of BALB/c mice. BMC Complement Alternative Med. 2016;16:334. doi:10.1186/s12906-016-1325-4
   PubMed Web of Science ®Google Scholar