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International Journal of Nanomedicine Volume 15, 2020 - Issue
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Original Research

Zein/Phospholipid Composite Nanoparticles for Successful Delivery of Gallic Acid into aHSCs: Influence of Size, Surface Charge, and Vitamin A Coupling

Shaimaa Ali Ali Radwan1 Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Cairo University, Cairo, EgyptORCID Iconhttps://orcid.org/0000-0002-6242-9545
ORCID Icon,
Walaa H El-Maadawy2 Department of Pharmacology, Theodor Bilharz Research Institute, Giza 12411, EgyptORCID Iconhttps://orcid.org/0000-0003-4632-3510
ORCID Icon,
Carol Yousry1 Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Cairo University, Cairo, EgyptORCID Iconhttps://orcid.org/0000-0002-7593-6001
ORCID Icon,
Aliaa Nabil ElMeshad1 Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Cairo University, Cairo, EgyptCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0002-9454-7458
ORCID Icon &
Raguia Aly Shoukri1 Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Cairo University, Cairo, Egypt
Pages 7995-8018 | Published online: 16 Oct 2020

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Rehab Abdelmonem, Inas Essam Ibrahim Al-Samadi, Rasha M. El Nashar, Bhaskara R. Jasti & Mohamed A. El-Nabarawi. (2022) Fabrication of nanostructured lipid carriers ocugel for enhancing Loratadine used in treatment of COVID-19 related symptoms: statistical optimization, in-vitro, ex-vivo, and in-vivo studies evaluation. Drug Delivery 29:1, pages 2868-2882.
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Mahmoud H. Teaima, Moaz A. Eltabeeb, Mohamed A. El-Nabarawi & Menna M. Abdellatif. (2022) Utilization of propranolol hydrochloride mucoadhesive invasomes as a locally acting contraceptive: in-vitro, ex-vivo, and in-vivo evaluation. Drug Delivery 29:1, pages 2549-2560.
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Dina B. E. Farag, Carol Yousry, Abdulaziz Mohsen Al-Mahallawi, Hesham I. El-Askary, Meselhy R. Meselhy & Nermeen AbuBakr. (2022) The efficacy of Origanum majorana nanocubosomal systems in ameliorating submandibular salivary gland alterations in streptozotocin-induced diabetic rats. Drug Delivery 29:1, pages 62-74.
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Doaa Hegazy, Randa Tag & Basant Ahmed Habib. (2022) Statistical Sequential Experimentation: Preliminary Mixed Factorial Design, I-Optimal Mixture Design Then Finally Novel Design Space Expansion for Optimization of Tazarotene Cubosomes. International Journal of Nanomedicine 17, pages 1069-1086.
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Mohamed Ahmed Naseef Soliman, Howida Kamal Ibrahim & Samia Abd El-Kader Nour. (2021) Diacerein solid dispersion loaded tablets for minimization of drug adverse effects: statistical design, formulation, in vitro, and in vivo evaluation. Pharmaceutical Development and Technology 26:3, pages 302-315.
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Rofida Albash, Carol Yousry, Abdulaziz Mohsen Al-Mahallawi & Ahmed Adel Alaa-Eldin. (2021) Utilization of PEGylated cerosomes for effective topical delivery of fenticonazole nitrate: in-vitro characterization, statistical optimization, and in-vivo assessment. Drug Delivery 28:1, pages 1-9.
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Articles from other publishers (16)

Chuye Ji, Muhammad Aslam Khan, Kaiwen Chen & Li Liang. (2023) Coating of DNA and DNA complexes on zein particles for the encapsulation and protection of kaempferol and α-tocopherol. Journal of Food Engineering 352, pages 111520.
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Nicola Ambrosio, Agnese Gagliardi, Silvia Voci, Maria Cristina Salvatici, Massimo Fresta & Donato Cosco. (2023) Strategies of stabilization of zein nanoparticles containing doxorubicin hydrochloride. International Journal of Biological Macromolecules 243, pages 125222.
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Hemil S Patel, Anju Kunjadiya, Abbas Rahdar & Rakesh K Sharma. (2023) Pluronic-phosphatidylcholine mixed polymeric nanomicellar formulation for curcumin drug bioavailability: Design, fabrication, characterization and in vitro bioinvestigations. Journal of Bioactive and Compatible Polymers 38:3, pages 191-208.
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Heba A. Fathi, Carol Yousry, Mahmoud Elsabahy, Mahmoud El-Badry & Omaima N. El Gazayerly. (2023) Effective loading of incompatible drugs into nanosized vesicles: a strategy to allow concurrent administration of furosemide and midazolam in simulated clinical settings. International Journal of Pharmaceutics 636, pages 122852.
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Hai-Bo Huang, Wei Gong, Yi-Yang Hou, Wan-Ying He, Ran Wang, Xin-Chuang Wang & Jiang-Ning Hu. (2023) Mucoadhesive Hydrogel with Anti-gastric Acid and Sustained-Release Functions for Amelioration of DSS-Induced Ulcerative Colitis. Journal of Agricultural and Food Chemistry 71:9, pages 4016-4028.
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Jing Li, Yingxiu Zhang, Wenfang Jin, Yue Wang, Li Yang, Zhifeng Zhang & Zhigang Yan. (2023) Preparation and characterization of zein–lecithin–total flavonoids from Smilax glabra complex nanoparticles and the study of their antioxidant activity on HepG2 cells. Food Chemistry: X 17, pages 100579.
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Carol Yousry, Nourihan S. Farrag & Abeer M. Amin. (2023) Radiolabeling of statistically optimized nanosized atorvastatin suspension for liver targeting and extensive imaging of hepatocellular carcinoma. Journal of Drug Delivery Science and Technology 80, pages 104171.
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Shipra Shukla, Baljinder Singh, Arti Singh & Charan Singh. (2022) Emerging and advanced drug delivery systems for improved biopharmaceutical attributes of gallic acid: A review. Phytomedicine Plus 2:4, pages 100369.
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Yiyang Hou, Haibo Huang, Wei Gong, Ran Wang, Wanying He, Xinchuang Wang & Jiangning Hu. (2022) Co-assembling of natural drug-food homologous molecule into composite hydrogel for accelerating diabetic wound healing. Biomaterials Advances 140, pages 213034.
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V. Sandhiya & U. Ubaidulla. (2022) Enhancing cellular uptake and membrane permeability of gallic acid for breast cancer therapy via folate-tagged PEGylated iron oxide nanoparticles has theronastic agent. Bulletin of the National Research Centre 46:1.
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Haibo Huang, Wei Gong, Xinchuang Wang, Wanying He, Yiyang Hou & Jiangning Hu. (2022) Self‐Assembly of Naturally Small Molecules into Supramolecular Fibrillar Networks for Wound Healing. Advanced Healthcare Materials 11:12, pages 2102476.
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Iolanda De Marco. (2022) Zein Microparticles and Nanoparticles as Drug Delivery Systems. Polymers 14:11, pages 2172.
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Devaraj Ezhilararasan, Thangavelu Lakshmi & Biond Raut. (2021) Novel Nano-Based Drug Delivery Systems Targeting Hepatic Stellate Cells in the Fibrotic Liver. Journal of Nanomaterials 2021, pages 1-9.
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Agnese Gagliardi, Silvia Voci, Elena Giuliano, Maria Cristina Salvatici, Marilena Celano, Massimo Fresta & Donato Cosco. (2021) Phospholipid/zein hybrid nanoparticles as promising carriers for the protection and delivery of all-trans retinoic acid. Materials Science and Engineering: C 128, pages 112331.
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Xinghang Dai, Yujun Zeng, Hu Zhang, Zhongwei Gu, Qiyong Gong & Kui Luo. (2021) Advances on Nanomedicines for Diagnosis and Theranostics of Hepatic Fibrosis. Advanced NanoBiomed Research 1:7.
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Abdurrahman Muhammad Fahmy, Mariam Hassan, Doaa Ahmed El-Setouhy, Saadia Ahmed Tayel & Abdulaziz Mohsen Al-mahallawi. (2021) Voriconazole Ternary Micellar Systems for the Treatment of Ocular Mycosis: Statistical Optimization and In Vivo Evaluation. Journal of Pharmaceutical Sciences 110:5, pages 2130-2138.
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