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International Journal of Nanomedicine Volume 7, 2012 - Issue
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Original Research

Formation of methotrexate-PLLA-PEG-PLLA composite microspheres by microencapsulation through a process of suspension-enhanced dispersion by supercritical CO2

Ai-Zheng Chen1 College of Chemical Engineering, Institute of Biomaterials and Tissue Engineering, Huaqiao University, Xiamen 361021, China;2 Institute of Pharmaceutical Engineering, Institute of Biomaterials and Tissue Engineering, Huaqiao University, Xiamen 361021, China
,
Guang-Ya Wang1 College of Chemical Engineering, Institute of Biomaterials and Tissue Engineering, Huaqiao University, Xiamen 361021, China
,
Shi-Bin Wang1 College of Chemical Engineering, Institute of Biomaterials and Tissue Engineering, Huaqiao University, Xiamen 361021, China;2 Institute of Pharmaceutical Engineering, Institute of Biomaterials and Tissue Engineering, Huaqiao University, Xiamen 361021, ChinaCorrespondence[email protected] [email protected]
,
Li Li1 College of Chemical Engineering, Institute of Biomaterials and Tissue Engineering, Huaqiao University, Xiamen 361021, China
,
Yuan-Gang Liu1 College of Chemical Engineering, Institute of Biomaterials and Tissue Engineering, Huaqiao University, Xiamen 361021, China;2 Institute of Pharmaceutical Engineering, Institute of Biomaterials and Tissue Engineering, Huaqiao University, Xiamen 361021, China
&
Chen Zhao1 College of Chemical Engineering, Institute of Biomaterials and Tissue Engineering, Huaqiao University, Xiamen 361021, China
Pages 3013-3022 | Published online: 18 Jun 2012

Citations (24)

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Read on this site (3)

Ranjith Kumar Kankala, Biao-Qi Chen, Chen-Guang Liu, Han-Xiao Tang, Shi-Bin Wang & Ai-Zheng Chen. (2018) Solution-enhanced dispersion by supercritical fluids: an ecofriendly nanonization approach for processing biomaterials and pharmaceutical compounds. International Journal of Nanomedicine 13, pages 4227-4245.
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Nusaiba K. Al-Nemrawi, Juliana Marques, Carlos J. Tavares, Rami J. Oweis & Mohamed G. Al-Fandi. (2018) Synthesis and characterization of photocatalytic polyurethane and poly(methyl methacrylate) microcapsules for the controlled release of methotrexate. Drug Development and Industrial Pharmacy 44:12, pages 2083-2088.
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Ai-Zheng Chen, Lin-Qing Chen, Shi-Bin Wang, Ya-Qiong Wang & Jun-Zhe Zha. (2015) Study of magnetic silk fibroin nanoparticles for massage-like transdermal drug delivery. International Journal of Nanomedicine 10, pages 4639-4651.
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Articles from other publishers (21)

Ranjith Kumar Kankala, Pei-Yao Xu, Biao-Qi Chen, Shi-Bin Wang & Ai-Zheng Chen. (2021) Supercritical fluid (SCF)-assisted fabrication of carrier-free drugs: An eco-friendly welcome to active pharmaceutical ingredients (APIs). Advanced Drug Delivery Reviews 176, pages 113846.
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Jayvadan K. Patel, Deepak Bhatia, Yashwant V. Pathak & Anita Patel. 2021. Emerging Technologies for Nanoparticle Manufacturing. Emerging Technologies for Nanoparticle Manufacturing 109 128 .
Maimoona Qindeel, Dildar Khan, Naveed Ahmed, Salman Khan & Asim.ur.Rehman. (2020) Surfactant-Free, Self-Assembled Nanomicelles-Based Transdermal Hydrogel for Safe and Targeted Delivery of Methotrexate against Rheumatoid Arthritis. ACS Nano 14:4, pages 4662-4681.
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Letícia Bueno Macedo, Daniele Rubert Nogueira-Librelotto, Josiele de Vargas, Laís Engroff Scheeren, María Pilar Vinardell & Clarice Madalena Bueno Rolim. (2019) Poly (ɛ-Caprolactone) Nanoparticles with pH-Responsive Behavior Improved the In Vitro Antitumor Activity of Methotrexate. AAPS PharmSciTech 20:5.
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Aurélie Schoubben, Maurizio Ricci & Stefano Giovagnoli. (2019) Meeting the unmet: from traditional to cutting-edge techniques for poly lactide and poly lactide-co-glycolide microparticle manufacturing. Journal of Pharmaceutical Investigation 49:4, pages 381-404.
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Ravenna L. Matos, Silvio A.B. Vieira de Melo, Elaine C.M. Cabral Albuquerque & Neil R. Foster. (2019) Dense CO2 technology: Overview of recent applications for drug processing/formulation/delivery. Chemical Engineering and Processing - Process Intensification 140, pages 64-77.
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Maobin Xie, Man Xu, Xiaoming Chen & Yi Li. (2019) Recent Progress of Supercritical Carbon Dioxide in Producing Natural Nanomaterials. Mini-Reviews in Medicinal Chemistry 19:6, pages 465-476.
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Luís Padrela, Miguel A. Rodrigues, Andreia Duarte, Ana M.A. Dias, Mara E.M. Braga & Hermínio C. de Sousa. (2018) Supercritical carbon dioxide-based technologies for the production of drug nanoparticles/nanocrystals – A comprehensive review. Advanced Drug Delivery Reviews 131, pages 22-78.
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Kobra Rostamizadeh, Mostafa Manafi, Hamed Nosrati, Hamidreza Kheiri Manjili & Hossein Danafar. (2018) Methotrexate-conjugated mPEG–PCL copolymers: a novel approach for dual triggered drug delivery. New Journal of Chemistry 42:8, pages 5937-5945.
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Mukesh Dhanka, Chaitra Shetty & Rohit Srivastava. (2018) Methotrexate loaded alginate microparticles and effect of Ca2+ post-crosslinking: An in vitro physicochemical and biological evaluation. International Journal of Biological Macromolecules 110, pages 294-307.
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Mukesh Dhanka, Chaitra Shetty & Rohit Srivastava. (2017) Injectable methotrexate loaded polycaprolactone microspheres: Physicochemical characterization, biocompatibility, and hemocompatibility evaluation. Materials Science and Engineering: C 81, pages 542-550.
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Onanong Nuchuchua, M. Reza Nejadnik, Sebastiaan C. Goulooze, Nataša Jovanović Lješković, Hayley A. Every & Wim Jiskoot. (2017) Characterization of drug delivery particles produced by supercritical carbon dioxide technologies. The Journal of Supercritical Fluids 128, pages 244-262.
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Ranjith Kumar Kankala, Yu Shrike Zhang, Shi-Bin Wang, Chia-Hung Lee & Ai-Zheng Chen. (2017) Supercritical Fluid Technology: An Emphasis on Drug Delivery and Related Biomedical Applications. Advanced Healthcare Materials 6:16, pages 1700433.
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Farhad Gharebaghi, Naser Dalali, Ebrahim Ahmadi & Hossein Danafar. (2017) Preparation of wormlike polymeric nanoparticles coated with silica for delivery of methotrexate and evaluation of anticancer activity against MCF7 cells. Journal of Biomaterials Applications 31:9, pages 1305-1316.
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Harmeet Kaur & Jasbir Singh. 2015. Encyclopedia of Biomedical Polymers and Polymeric Biomaterials. Encyclopedia of Biomedical Polymers and Polymeric Biomaterials 5858 5880 .
Ai-Zheng Chen, Na Tang, Shi-Bin Wang, Yong-Qiang Kang & Hu-Fan Song. (2015) Insulin-loaded poly-l-lactide porous microspheres prepared in supercritical CO2 for pulmonary drug delivery. The Journal of Supercritical Fluids 101, pages 117-123.
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Zheng Zhao, Yi Li & Mao-Bin Xie. (2015) Silk Fibroin-Based Nanoparticles for Drug Delivery. International Journal of Molecular Sciences 16:3, pages 4880-4903.
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Ai-Zheng Chen, Yong-Qiang Kang, Shi-Bin Wang, Na Tang & Xiao-Qian Su. (2015) Preparation and antitumor effect evaluation of composite microparticles co-loaded with siRNA and paclitaxel by a supercritical process. Journal of Materials Chemistry B 3:31, pages 6439-6447.
Crossref
Yong Sun, Yihang Huang, Shaoquan Bian, Jie Liang, Yujiang Fan & Xingdong Zhang. (2013) Reduction-degradable PEG-b–PAA-b–PEG triblock copolymer micelles incorporated with MTX for cancer chemotherapy. Colloids and Surfaces B: Biointerfaces 112, pages 197-203.
Crossref
Yong-Qiang Kang, Chen Zhao, Ai-Zheng Chen, Shi-Bin Wang, Yuan-Gang Liu, Wen-Guo Wu & Xiao-Qian Su. (2013) Study of Lysozyme-Loaded Poly-L-Lactide (PLLA) Porous Microparticles in a Compressed CO2 Antisolvent Process. Materials 6:8, pages 3571-3583.
Crossref
Ai-Zheng Chen, Chen Zhao, Shi-Bin Wang, Yuan-Gang Liu & Dong-Liang Lin. (2013) Generation of porous poly-l-lactide microspheres by emulsion-combined precipitation with a compressed CO2 antisolvent process. Journal of Materials Chemistry B 1:23, pages 2967.
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