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Original Research

Dual drug delivery system for targeting H. pylori in the stomach: preparation and in vitro characterization of amoxicillin-loaded Carbopol® nanospheres

Pages 4787-4796 | Published online: 04 Sep 2012

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (7)

Nagaraja SreeHarsha, Katharigatta N Venugopala, Anroop B Nair, Teeka S Roopashree, Mahesh Attimarad, Jagadeesh G Hiremath, Bandar E Al-Dhubiab, Chandramouli Ramnarayanan, Pottathil Shinu, Mukund Handral, Micheline Haroun & Christophe Tratrat. (2019) An Efficient, Lung-Targeted, Drug-Delivery System To Treat Asthma Via Microparticles. Drug Design, Development and Therapy 13, pages 4389-4403.
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Sibghatullah Sangi, Nagaraja SreeHarsha, Abdulhakim Bawadekji & Mouhanad Al Ali. (2018) Chemotherapeutic drug targeting to lungs by way of microspheres after intravenous administration. Drug Design, Development and Therapy 12, pages 3051-3060.
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Sree N Harsha, Bander E Aldhubiab, Anroop B Nair, Ibrahim Abdulrahman Alhaider, Mahesh Attimarad, Katharigatta N Venugopala, Saminathan Srinivasan, Nagesh Gangadhar & Afzal Haq Asif. (2015) Nanoparticle formulation by Büchi B-90 Nano Spray Dryer for oral mucoadhesion. Drug Design, Development and Therapy 9, pages 273-282.
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Sree Harsha, Bandar E. Al-Dhubiab, Anroop B. Nair, Mohammed Al-Khars, Mohammed Al-Hassan, Raja Rajan, Mahesh Attimarad, Katharigatta N. Venugopala & Afzal Haq Asif. (2015) Novel Drying Technology of Microsphere and Its Evaluation for Targeted Drug Delivery for Lungs. Drying Technology 33:4, pages 502-512.
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Dustin L Cooper, Christopher M Conder & Sam Harirforoosh. (2014) Nanoparticles in drug delivery: mechanism of action, formulation and clinical application towards reduction in drug-associated nephrotoxicity. Expert Opinion on Drug Delivery 11:10, pages 1661-1680.
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Articles from other publishers (19)

Taher A. Salaheldin, Kavitha Godugu, Dhruba J. Bharali, Kazutoshi Fujioka, Nabil Elshourbagy & Shaker A. Mousa. (2022) Novel oral nano-hepatic targeted anti-PCSK9 in hypercholesterolemia. Nanomedicine: Nanotechnology, Biology and Medicine 40, pages 102480.
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Yuan Qin, Yeh-Hsing Lao, Haixia Wang, Jiabin Zhang, Ke Yi, Zhuanggui Chen, Jing Han, Wantong Song, Yu Tao & Mingqiang Li. (2021) Combatting Helicobacter pylori with oral nanomedicines . Journal of Materials Chemistry B 9:48, pages 9826-9838.
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A. Alper Öztürk & Cordin Arpagaus. (2021) Nano Spray-Dried Drugs for Oral Administration: A Review. ASSAY and Drug Development Technologies 19:7, pages 412-441.
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Vivek Verma, Kevin M. Ryan & Luis Padrela. (2021) Production and isolation of pharmaceutical drug nanoparticles. International Journal of Pharmaceutics 603, pages 120708.
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Isabel Villegas, María Ángeles Rosillo, Catalina Alarcón-de-la-Lastra, Victoria Vázquez-Román, Maria Llorente, Susana Sánchez, Ana Gloria Gil, Pilar Alcalde, Esther González, Elisabet Rosell, Carles Nieto & Francisco Fernandez-Campos. (2021) Amoxicillin and Clarithromycin Mucoadhesive Delivery System for Helicobacter pylori Infection in a Mouse Model: Characterization, Pharmacokinetics, and Efficacy. Pharmaceutics 13:2, pages 153.
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Mohamed A. Mohamed. (2019) Myco-engineered gold nanoparticles from Jahnula aquatica coated with ampicillin/amoxicillin and their antibacterial and anticancer activity against cancer cells. Biotechnology Letters 42:1, pages 151-170.
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Anroop B. Nair, Nagaraja Sreeharsha, Bandar E. Al-Dhubiab, Jagadeesh G. Hiremath, Pottathil Shinu, Mahesh Attimarad, Katharigatta N. Venugopala & Mohamed Mutahar. (2019) HPMC- and PLGA-Based Nanoparticles for the Mucoadhesive Delivery of Sitagliptin: Optimization and In Vivo Evaluation in Rats. Materials 12:24, pages 4239.
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Mohammed S. Algahtani, Abdul Aleem Mohammed & Javed Ahmad. (2019) Extrusion-Based 3D Printing for Pharmaceuticals: Contemporary Research and Applications. Current Pharmaceutical Design 24:42, pages 4991-5008.
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Cordin Arpagaus, Andreas Collenberg, David Rütti, Elham Assadpour & Seid Mahdi Jafari. (2018) Nano spray drying for encapsulation of pharmaceuticals. International Journal of Pharmaceutics 546:1-2, pages 194-214.
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Tessa Horemans, Gaëlle Boulet, Marian van Kerckhoven, Johannes Bogers, Sofie Thys, Chris Vervaet, Anouck Vervaeck, Peter Delputte, Louis Maes & Paul Cos. (2017) In-vivo evaluation of apocynin for prevention of Helicobacter pylori-induced gastric carcinogenesis. European Journal of Cancer Prevention 26:1, pages 10-16.
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Burcu Devrim & Asuman Bozkır. 2017. Nanostructures for Antimicrobial Therapy. Nanostructures for Antimicrobial Therapy 169 202 .
Sunil K. Jain, Tanweer Haider, Amrish Kumar & Akhlesh Jain. (2015) Lectin-Conjugated Clarithromycin and Acetohydroxamic Acid-Loaded PLGA Nanoparticles: a Novel Approach for Effective Treatment of H. pylori. AAPS PharmSciTech 17:5, pages 1131-1140.
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Wen Li, Han Zhang, Yehuda G. Assaraf, Kun Zhao, Xiaojun Xu, Jinbing Xie, Dong-Hua Yang & Zhe-Sheng Chen. (2016) Overcoming ABC transporter-mediated multidrug resistance: Molecular mechanisms and novel therapeutic drug strategies. Drug Resistance Updates 27, pages 14-29.
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Hinojal Zazo, Clara I. Colino & José M. Lanao. (2016) Current applications of nanoparticles in infectious diseases. Journal of Controlled Release 224, pages 86-102.
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Bing Gu, Brian Linehan & Yin-Chao Tseng. (2015) Optimization of the Büchi B-90 spray drying process using central composite design for preparation of solid dispersions. International Journal of Pharmaceutics 491:1-2, pages 208-217.
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Adeola O Adebisi & Barbara R Conway. (2015) Modification of drug delivery to improve antibiotic targeting to the stomach. Therapeutic Delivery 6:6, pages 741-762.
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Daniela Lopes, Cláudia Nunes, M. Cristina L. Martins, Bruno Sarmento & Salette Reis. (2014) Eradication of Helicobacter pylori: Past, present and future. Journal of Controlled Release 189, pages 169-186.
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Sree Harsha, Mohammed Al-Khars, Mohammed Al-Hassan, N. Prem Kumar, Anroop B. Nair, Mahesh Attimarad & Bandar E. Al-Dhubiab. (2013) Pharmacokinetics and tissue distribution of spray-dried carboplatin microspheres: lung targeting via intravenous route. Archives of Pharmacal Research 37:3, pages 352-360.
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Sree Harsha, Bandar E. Al-Dhubiab, Mahesh Attimarad, Ibrahim Abdulrahman Alhaider & Anroop Nair. (2013) SPECT-CT to study the biodistribtion of orally administered 99mTc-labbeled spraydried gelatin nanospheres. SPECT-CT to study the biodistribtion of orally administered 99mTc-labbeled spraydried gelatin nanospheres.