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International Journal of Nanomedicine Volume 7, 2012 - Issue
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Original Research

Ibuprofen delivered by poly(lactic-co-glycolic acid) (PLGA) nanoparticles to human gastric cancer cells exerts antiproliferative activity at very low concentrations

Patrizia Bonelli1 Laboratory of Molecular Biology and Viral Oncogenesis, National Cancer Institute G Pascale, Naples, ItalyCorrespondence[email protected]
,
Franca M Tuccillo1 Laboratory of Molecular Biology and Viral Oncogenesis, National Cancer Institute G Pascale, Naples, Italy
,
Antonella Federico5 Microtech Laboratory, Naples, Italy
,
Maria Napolitano2 Department of Clinical Immunology, National Cancer Institute G Pascale, Naples, Italy
,
Antonella Borrelli1 Laboratory of Molecular Biology and Viral Oncogenesis, National Cancer Institute G Pascale, Naples, Italy
,
Daniela Melisi6 Pharmaceutical and Toxicological Chemistry Department, School of Pharmacy, University “Federico II”, Naples, Italy
,
Maria G Rimoli6 Pharmaceutical and Toxicological Chemistry Department, School of Pharmacy, University “Federico II”, Naples, Italy
,
Raffaele Palaia3 Department of Gastrointestinal-Hepatobiliary-Pancreatic Cancer Oncology Surgery, National Cancer Institute G Pascale, Naples, Italy
,
Claudio Arra4 Animal Facility, National Cancer Institute G Pascale, Naples, Italy
&
Francesco Carinci7 Department of Maxillofacial Surgery, University of Ferrara, Ferrara, Italy
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Pages 5683-5691 | Published online: 09 Nov 2012

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Gülsel Yurtdaş-Kırımlıoğlu, Şennur Görgülü & Murat Sami Berkman. (2020) Novel approaches to cancer therapy with ibuprofen-loaded Eudragit RS 100 and/or octadecylamine-modified PLGA nanoparticles by assessment of their effects on apoptosis. Drug Development and Industrial Pharmacy 46:7, pages 1133-1149.
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Panagiota Papanagnou, Panagiotis Baltopoulos & Maria Tsironi. (2015) Marketed nonsteroidal anti-inflammatory agents, antihypertensives, and human immunodeficiency virus protease inhibitors: as-yet-unused weapons of the oncologists’ arsenal. Therapeutics and Clinical Risk Management 11, pages 807-819.
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Lanxin Jiang, Xiaomin Gong, Wangdi Liao, Nonghua Lv & Runwei Yan. (2021) Molecular targeted treatment and drug delivery system for gastric cancer. Journal of Cancer Research and Clinical Oncology 147:4, pages 973-986.
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S. Manjunath Kamath, K. Sridhar, D. Jaison, V. Gopinath, B. K. Mohamed Ibrahim, Nilkantha Gupta, A. Sundaram, P. Sivaperumal, S. Padmapriya & S. Shantanu Patil. (2020) Fabrication of tri-layered electrospun polycaprolactone mats with improved sustained drug release profile. Scientific Reports 10:1.
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Leila Pourtalebi Jahromi, Mohammad Ghazali, Hajar Ashrafi & Amir Azadi. (2020) A comparison of models for the analysis of the kinetics of drug release from PLGA-based nanoparticles. Heliyon 6:2, pages e03451.
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Ahmed M. Gouda, Eman A. Beshr, Faisal A. Almalki, Hadeel H. Halawah, Batool Fawzi Taj, Athir Faiz Alnafaei, Rahaf Sulaiman Alharazi, Weam Mahmood Kazi & Malak M. AlMatrafi. (2019) Arylpropionic acid-derived NSAIDs: New insights on derivatization, anticancer activity and potential mechanism of action. Bioorganic Chemistry 92, pages 103224.
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Tori Czech, Reza Lalani & Moses O. Oyewumi. (2019) Delivery Systems as Vital Tools in Drug Repurposing. AAPS PharmSciTech 20:3.
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Awanish Kumar & Ashwini Kumar. 2019. Materials for Biomedical Engineering. Materials for Biomedical Engineering 199 216 .
Edith Estefany Delgado-Rosales, David Quintanar-Guerrero, Elizabeth Piñón-Segundo, Nancy Evelyn Magaña-Vergara, Gerardo Leyva-Gómez, Francisco Javier Martínez-Martínez & Néstor Mendoza-Muñoz. (2018) Novel drug delivery systems based on the encapsulation of superparamagnetic nanoparticles into lipid nanocomposites. Journal of Drug Delivery Science and Technology 46, pages 259-267.
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Hassan Akrami, Behrouz Moradi, Diba Borzabadi Farahani & Kiumars Mehdizadeh. (2018) Ibuprofen reduces cell proliferation through inhibiting Wnt/β catenin signaling pathway in gastric cancer stem cells. Cell Biology International 42:8, pages 949-958.
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Isabel Lozoya-Agullo, Francisca Araújo, Isabel González-Álvarez, Matilde Merino-Sanjuán, Marta González-Álvarez, Marival Bermejo & Bruno Sarmento. (2018) PLGA nanoparticles are effective to control the colonic release and absorption on ibuprofen. European Journal of Pharmaceutical Sciences 115, pages 119-125.
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Nicholas P. Murphy & Kyle J. Lampe. (2018) Fabricating PLGA microparticles with high loads of the small molecule antioxidant N-acetylcysteine that rescue oligodendrocyte progenitor cells from oxidative stress. Biotechnology and Bioengineering 115:1, pages 246-256.
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Corinne N. Riggin, Feini Qu, Dong Hwa Kim, Julianne Huegel, David R. Steinberg, Andrew F. Kuntz, Louis J. Soslowsky, Robert L. Mauck & Joseph Bernstein. (2017) Electrospun PLGA Nanofiber Scaffolds Release Ibuprofen Faster and Degrade Slower After In Vivo Implantation. Annals of Biomedical Engineering 45:10, pages 2348-2359.
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Raj Kumar, Prem Felix Siril & Farideh Javid. (2016) Unusual anti-leukemia activity of nanoformulated naproxen and other non-steroidal anti-inflammatory drugs. Materials Science and Engineering: C 69, pages 1335-1344.
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Koji Kinoshita, Elisa Parra, Abdirazak Hussein, Anders Utoft, Prasad Walke, Robin de Bruijn & David Needham. (2016) From Single Microparticles to Microfluidic Emulsification: Fundamental Properties (Solubility, Density, Phase Separation) from Micropipette Manipulation of Solvent, Drug and Polymer Microspheres. Processes 4:4, pages 49.
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Christine Charrueau & Christelle Zandanel. 2016. Polymer Nanoparticles for Nanomedicines. Polymer Nanoparticles for Nanomedicines 439 503 .
Christelle Zandanel & Christine Charrueau. 2016. Polymer Nanoparticles for Nanomedicines. Polymer Nanoparticles for Nanomedicines 381 437 .
Hassan Akrami, Saman Aminzadeh & Hossein Fallahi. (2014) Inhibitory effect of ibuprofen on tumor survival and angiogenesis in gastric cancer cell. Tumor Biology 36:5, pages 3237-3243.
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ARVIND THAKKAR, SUSHMA CHENREDDY, JEFFREY WANG & SUNIL PRABHU. (2015) Evaluation of ibuprofen loaded solid lipid nanoparticles and its combination regimens for pancreatic cancer chemoprevention. International Journal of Oncology 46:4, pages 1827-1834.
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