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International Journal of Nanomedicine Volume 7, 2012 - Issue
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Original Research

Targeted delivery of tissue plasminogen activator by binding to silica-coated magnetic nanoparticle

Jyh-Ping Chen1 Department of Chemical and Materials Engineering, Chang Gung University, Kwei-San, Taoyuan, Taiwan, Republic of ChinaCorrespondence[email protected]
,
Pei-Ching Yang1 Department of Chemical and Materials Engineering, Chang Gung University, Kwei-San, Taoyuan, Taiwan, Republic of China
,
Yunn-Hwa Ma2 Department of Physiology and Pharmacology, Chang Gung University, Kwei-San, Taoyuan, Taiwan, Republic of China
,
Su-Ju Tu3 Department of Medical Imaging and Radiological Sciences, Chang Gung University, Kwei-San, Taoyuan, Taiwan, Republic of China
&
Yu-Jen Lu1 Department of Chemical and Materials Engineering, Chang Gung University, Kwei-San, Taoyuan, Taiwan, Republic of China;4 Department of Neurosurgery, Chang Gung Memorial Hospital, Kwei-San, Taoyuan, Taiwan, Republic of China
Pages 5137-5149 | Published online: 27 Sep 2012

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Sebastian P Pernal, Alexander J Willis, Michael E Sabo, Laura M Moore, Steven T Olson, Sean C Morris, Francis M Creighton & Herbert H Engelhard. (2020) An in vitro Model System for Evaluating Remote Magnetic Nanoparticle Movement and Fibrinolysis. International Journal of Nanomedicine 15, pages 1549-1568.
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Masumeh Zamanlu, Mehdi Farhoudi, Morteza Eskandani, Javad Mahmoudi, Jaleh Barar, Mohammad Rafi & Yadollah Omidi. (2018) Recent advances in targeted delivery of tissue plasminogen activator for enhanced thrombolysis in ischaemic stroke. Journal of Drug Targeting 26:2, pages 95-109.
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Shan Liu, Xiaozhou Feng, Rong Jin & Guohong Li. (2018) Tissue plasminogen activator-based nanothrombolysis for ischemic stroke. Expert Opinion on Drug Delivery 15:2, pages 173-184.
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Chao Liu, Haiyan Gao, Peng Lv, Jingyi Liu & Gang Liu. (2017) Extracellular vesicles as an efficient nanoplatform for the delivery of therapeutics. Human Vaccines & Immunotherapeutics 13:11, pages 2678-2687.
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Sandeep Kumar, Asim K. Jana, Isha Dhamija & Mithu Maiti. (2014) Chitosan-assisted immobilization of serratiopeptidase on magnetic nanoparticles, characterization and its target delivery. Journal of Drug Targeting 22:2, pages 123-137.
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Crossref
Chityal Ganesh Kumar, Yedla Poornachandra & Sujitha Pombala. 2017. Nanostructures for Drug Delivery. Nanostructures for Drug Delivery 1 61 .
Ralf P Friedrich, Jan Zaloga, Eveline Schreiber, Ildikó Y Tóth, Etelka Tombácz, Stefan Lyer & Christoph Alexiou. (2016) Tissue Plasminogen Activator Binding to Superparamagnetic Iron Oxide Nanoparticle—Covalent Versus Adsorptive Approach. Nanoscale Research Letters 11:1.
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Crossref
Andrey S. Drozdov, Vasiliy V. Vinogradov, Ivan P. Dudanov & Vladimir V. Vinogradov. (2016) Leach-proof magnetic thrombolytic nanoparticles and coatings of enhanced activity. Scientific Reports 6:1.
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Crossref
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Crossref
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Crossref
P Gurman, OR Miranda, A Nathan, C Washington, Y Rosen & NM Elman. (2015) Recombinant tissue plasminogen activators (rtPA): A review. Clinical Pharmacology & Therapeutics 97:3, pages 274-285.
Crossref
Eszter Voros, Minjung Cho, Maricela Ramirez, Anna Lisa Palange, Enrica De Rosa, Jaehong Key, Zsolt Garami, Alan B. Lumsden & Paolo Decuzzi. (2015) TPA Immobilization on Iron Oxide Nanocubes and Localized Magnetic Hyperthermia Accelerate Blood Clot Lysis. Advanced Functional Materials 25:11, pages 1709-1718.
Crossref
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Crossref
Joan M. Walker & Jeffrey M. Zaleski. (2014) Non-Enzymatic Remodeling of Fibrin Biopolymers via Photothermally Triggered Radical-Generating Nanoparticles. Chemistry of Materials 26:17, pages 5120-5130.
Crossref
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Crossref
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