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International Journal of Nanomedicine Volume 9, 2014 - Issue sup2
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Original Research

Toxicity of 100 nm zinc oxide nanoparticles: a report of 90-day repeated oral administration in Sprague Dawley rats

Yu-Ri Kim1 Department of Biochemistry and Molecular Biology, Korea University Medical School and College, Seoul, Korea
,
Jong-Il Park2 General Toxicology Team, Korea Testing and Research Institute, Seoul, Korea
,
Eun Jeong Lee1 Department of Biochemistry and Molecular Biology, Korea University Medical School and College, Seoul, Korea
,
Sung Ha Park3 Department of Biochemistry, University of Bath, Bath, UK
,
Nak-won Seong2 General Toxicology Team, Korea Testing and Research Institute, Seoul, Korea
,
Jun-Ho Kim2 General Toxicology Team, Korea Testing and Research Institute, Seoul, Korea
,
Geon-Yong Kim2 General Toxicology Team, Korea Testing and Research Institute, Seoul, Korea
,
Eun-Ho Meang2 General Toxicology Team, Korea Testing and Research Institute, Seoul, Korea
,
Jeong-Sup Hong2 General Toxicology Team, Korea Testing and Research Institute, Seoul, Korea
,
Su-Hyon Kim2 General Toxicology Team, Korea Testing and Research Institute, Seoul, Korea
,
Sang-Bum Koh2 General Toxicology Team, Korea Testing and Research Institute, Seoul, Korea
,
Min-Seok Kim2 General Toxicology Team, Korea Testing and Research Institute, Seoul, Korea
,
Cheol-Su Kim4 Department of Microbiology, Wonju College of Medicine, Yonsei University, Wonju-si, Gangwon, Korea
,
Soo-Ki Kim4 Department of Microbiology, Wonju College of Medicine, Yonsei University, Wonju-si, Gangwon, Korea
,
Sang Wook Son5 Department of Life Science, Institute of Environmental Medicine for Green Chemistry, Dongguk University, Seoul, Korea
,
Young Rok Seo6 Nonclinical Research Institute, Chemon Inc., Yongin, Gyeonggi, Korea
,
Boo Hyon Kang7 Toxicological Research Center, Hoseo University, Ansan, Chungnam, Korea
,
Beom Seok Han8 Department of Bionanotechnology, Gachon University, Seongnam, Gyeonggi, Korea
,
Seong Soo A An9 College of Veterinary Medicine, Chungnam National University, Daejon, Korea
,
Hyo-In Yun9 College of Veterinary Medicine, Chungnam National University, Daejon, KoreaCorrespondence[email protected]
&
Meyoung-Kon Kim1 Department of Biochemistry and Molecular Biology, Korea University Medical School and College, Seoul, KoreaCorrespondence[email protected]
 show all
Pages 109-126 | Published online: 15 Dec 2014

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Asmaa M Shehata, Fatma M S Salem, Eiman M El-Saied, Sahar S Abd El-Rahman, Mohamed Y Mahmoud & Peter A Noshy. (2021) Zinc Nanoparticles Ameliorate the Reproductive Toxicity Induced by Silver Nanoparticles in Male Rats. International Journal of Nanomedicine 16, pages 2555-2568.
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Eun-Jung Park, Soo Nam Kim, Cheolho Yoon, Jae-Woo Cho, Gwang-Hee Lee, Dong-Wan Kim, Junhee Park, Inhee Choi, Seung Hyeun Lee, Jeongah Song, Hyun-Ji Lim, Min-Sung Kang & Hong-Soo Lee. (2021) Repeated intratracheal instillation of zinc oxide nanoparticles induced pulmonary damage and a systemic inflammatory response in cynomolgus monkeys. Nanotoxicology 15:5, pages 621-635.
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Manal A. M. Mahmoud, Doha Yahia, Doaa S. Abdel-Magiud, Madeha H. A. Darwish, Mahmoud Abd-Elkareem & Usama T. Mahmoud. (2021) Broiler welfare is preserved by long-term low-dose oral exposure to zinc oxide nanoparticles: preliminary study. Nanotoxicology 15:5, pages 605-620.
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S. Keerthana & A. Kumar. (2020) Potential risks and benefits of zinc oxide nanoparticles: a systematic review. Critical Reviews in Toxicology 50:1, pages 47-71.
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Cheng Teng Ng, Liang Qing Yong, Manoor Prakash Hande, Choon Nam Ong, Liya E Yu, Boon Huat Bay & Gyeong Hun Baeg. (2017) Zinc oxide nanoparticles exhibit cytotoxicity and genotoxicity through oxidative stress responses in human lung fibroblasts and Drosophila melanogaster. International Journal of Nanomedicine 12, pages 1621-1637.
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Jia Liu, Xiaoli Feng, Limin Wei, Liangjiao Chen, Bin Song & Longquan Shao. (2016) The toxicology of ion-shedding zinc oxide nanoparticles. Critical Reviews in Toxicology 46:4, pages 348-384.
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Andreea Mariana Negrescu, Manuela S. Killian, Swathi N. V. Raghu, Patrik Schmuki, Anca Mazare & Anisoara Cimpean. (2022) Metal Oxide Nanoparticles: Review of Synthesis, Characterization and Biological Effects. Journal of Functional Biomaterials 13:4, pages 274.
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Amjad Ali Khan, Khaled S. Allemailem, Ahmad Almatroudi, Saleh A. Almatroodi, Ali Mahzari, Mohammed A. Alsahli & Arshad Husain Rahmani. (2020) Endoplasmic Reticulum Stress Provocation by Different Nanoparticles: An Innovative Approach to Manage the Cancer and Other Common Diseases. Molecules 25:22, pages 5336.
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Shalabh Pandey & Awanish Mishra. (2019) Rational approaches for toxicological assessments of nanobiomaterials. Journal of Biochemical and Molecular Toxicology 33:7.
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Priyanka R. Sharma, Sunil K. Sharma, Richard Antoine & Benjamin S. Hsiao. (2019) Efficient Removal of Arsenic Using Zinc Oxide Nanocrystal-Decorated Regenerated Microfibrillated Cellulose Scaffolds. ACS Sustainable Chemistry & Engineering 7:6, pages 6140-6151.
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Sara S. EssaEiman M. El-SaiedOsama S. El-TawilInas M. GamalSahar S. Abd El-Rahman. (2019) Nanoparticles of zinc oxide defeat chlorpyrifos-induced immunotoxic effects and histopathological alterations. Veterinary World 12:3, pages 440-448.
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Majid Akhondipour, Ali Faghihi Zarandi, Asghar Amirri, Nasser Gommnami & Reza Vazirinejad. (2018) Studying the toxicity of molybdenum trioxide nanoparticles in male Wister rats. Journal of Occupational Health and Epidemiology 7:4, pages 233-239.
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V. N. Kalpana & V. Devi Rajeswari. (2018) A Review on Green Synthesis, Biomedical Applications, and Toxicity Studies of ZnO NPs. Bioinorganic Chemistry and Applications 2018, pages 1-12.
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Ekta Yadav, Deepika Singh, Pankajkumar Yadav & Amita Verma. (2018) Comparative Evaluation of Prosopis cineraria (L.) Druce and Its ZnO Nanoparticles on Scopolamine Induced Amnesia. Frontiers in Pharmacology 9.
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