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International Journal of Nanomedicine Volume 9, 2014 - Issue
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Original Research

An optimized nanoparticle delivery system based on chitosan and chondroitin sulfate molecules reduces the toxicity of amphotericin B and is effective in treating tegumentary leishmaniasis

Tatiana G Ribeiro1 Programa de Pós-Graduação em Ciências Farmacêuticas, Faculdade de Farmácia, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil
,
Juçara R Franca1 Programa de Pós-Graduação em Ciências Farmacêuticas, Faculdade de Farmácia, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil
,
Leonardo L Fuscaldi1 Programa de Pós-Graduação em Ciências Farmacêuticas, Faculdade de Farmácia, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil
,
Mara L Santos2 Departamento de Morfologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil
,
Mariana C Duarte3 Programa de Pós-Graduação em Ciências da Saúde: Infectologia e Medicina Tropical, Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil
,
Paula S Lage3 Programa de Pós-Graduação em Ciências da Saúde: Infectologia e Medicina Tropical, Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil
,
Vivian T Martins4 Departamento de Bioquímica e Imunologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil
,
Lourena E Costa3 Programa de Pós-Graduação em Ciências da Saúde: Infectologia e Medicina Tropical, Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil
,
Simone OA Fernandes1 Programa de Pós-Graduação em Ciências Farmacêuticas, Faculdade de Farmácia, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil;5 Departamento de Análises Clínicas e Toxicológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil
,
Valbert N Cardoso1 Programa de Pós-Graduação em Ciências Farmacêuticas, Faculdade de Farmácia, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil;5 Departamento de Análises Clínicas e Toxicológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil
,
Rachel O Castilho1 Programa de Pós-Graduação em Ciências Farmacêuticas, Faculdade de Farmácia, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil;6 Departamento de Produtos Farmacêuticos, Faculdade de Farmácia, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil
,
Manuel Soto7 Centro de Biología Molecular Severo Ochoa (CSIC-UAM), Departamento de Biología Molecular, Universidad Autónoma de Madrid, Madrid, Spain
,
Carlos AP Tavares4 Departamento de Bioquímica e Imunologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil
,
André AG Faraco1 Programa de Pós-Graduação em Ciências Farmacêuticas, Faculdade de Farmácia, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil;6 Departamento de Produtos Farmacêuticos, Faculdade de Farmácia, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil
,
Eduardo AF Coelho3 Programa de Pós-Graduação em Ciências da Saúde: Infectologia e Medicina Tropical, Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil;8 Departamento de Patologia Clínica, COLTEC, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, BrazilCorrespondence[email protected] [email protected]
&
Miguel A Chávez-Fumagalli3 Programa de Pós-Graduação em Ciências da Saúde: Infectologia e Medicina Tropical, Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, BrazilCorrespondence[email protected] [email protected]
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Pages 5341-5353 | Published online: 19 Nov 2014

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Tahereh Zadeh Mehrizi, Ali Khamesipour, Mehdi Shafiee Ardestani, Hasan Ebrahimi Shahmabadi, Mostafa Haji Molla Hoseini, Nariman Mosaffa & Amitis Ramezani. (2019) Comparative analysis between four model nanoformulations of amphotericin B-chitosan, amphotericin B-dendrimer, betulinic acid-chitosan and betulinic acid-dendrimer for treatment of Leishmania major: real-time PCR assay plus. International Journal of Nanomedicine 14, pages 7593-7607.
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Juliane S. Lanza, Sébastien Pomel, Philippe M. Loiseau & Frédéric Frézard. (2019) Recent advances in amphotericin B delivery strategies for the treatment of leishmaniases. Expert Opinion on Drug Delivery 16:10, pages 1063-1079.
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Lais Farias Azevedo, Priscilla da Fonseca Silva, Marianna Porfírio Brandão, Louisianny Guerra da Rocha, Cícero Flávio Soares Aragão, Sâmia Andrícia Souza da Silva, Isabel Cristina Celerino Moraes Porto, Irinaldo Diniz Basílio-Júnior, Eduardo Jorge da Silva Fonseca, Maria Aline Barros Fidelis de Moura & Ticiano Gomes do Nascimento. (2018) Polymeric nanoparticle systems loaded with red propolis extract: a comparative study of the encapsulating systems, PCL-Pluronic versus Eudragit®E100-Pluronic. Journal of Apicultural Research 57:2, pages 255-270.
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Li Qun Jiang, Ting Yu Wang, Thomas J Webster, Hua-Jian Duan, Jing Ying Qiu, Zi Ming Zhao, Xiao Xing Yin & Chun Li Zheng. (2017) Intracellular disposition of chitosan nanoparticles in macrophages: intracellular uptake, exocytosis, and intercellular transport. International Journal of Nanomedicine 12, pages 6383-6398.
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Lívia Maria Coelho de Carvalho Moreira, Ana Beatriz Almeida de Sousa Silva, Kaline de Araújo Medeiros, João Augusto Oshiro Júnior, Dayanne Tomaz Casimiro da Silva & Bolívar Ponciano Goulart de Lima Damasceno. (2024) Effectiveness In Vivo and In Vitro of Polymeric Nanoparticles as a Drug Release System in the Treatment of Leishmaniasis. Current Medicinal Chemistry 31:3, pages 286-307.
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Charmante Registre, Rodrigo D. O. A. Soares, Karina T. S. Rubio, Orlando D. H. Santos & Simone P. Carneiro. (2023) A Systematic Review of Drug-Carrying Nanosystems Used in the Treatment of Leishmaniasis. ACS Infectious Diseases 9:3, pages 423-449.
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Prakash Kumar, Pawan Kumar, Nidhi Singh, Salil Khajuria, Rahul Patel, Vinod Kumar Rajana, Debabrata Mandal & Ravichandiran Velayutham. (2022) Limitations of current chemotherapy and future of nanoformulation-based AmB delivery for visceral leishmaniasis—An updated review. Frontiers in Bioengineering and Biotechnology 10.
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Ellen Wasan, Tavonga Mandava, Pablo Crespo-Moran, Adrienne Nagy & Kishor M. Wasan. (2022) Review of Novel Oral Amphotericin B Formulations for the Treatment of Parasitic Infections. Pharmaceutics 14:11, pages 2316.
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Susana P. Mejía, Daniela López, Luz Elena Cano, Tonny W. Naranjo & Jahir Orozco. (2022) Antifungal Encapsulated into Ligand-Functionalized Nanoparticles with High Specificity for Macrophages. Pharmaceutics 14:9, pages 1932.
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Nowsheen Goonoo, Marie Andrea Laetitia Huët, Itisha Chummun, Nancy Karuri, Kingsley Badu, Fanny Gimié, Jonas Bergrath, Margit Schulze, Mareike Müller & Archana Bhaw-Luximon. (2022) Nanomedicine-based strategies to improve treatment of cutaneous leishmaniasis. Royal Society Open Science 9:6.
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Manal Aly Shalaby, Mohammed Moustapha Anwar & Hesham Saeed. (2022) Nanomaterials for application in wound Healing: current state-of-the-art and future perspectives. Journal of Polymer Research 29:3.
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Douglas O. Escrivani, Gabriela C. Mattos, Bartira Rossi-Bergmann & Ariane J. Sousa-Batista. 2022. Antiprotozoal Drug Development and Delivery. Antiprotozoal Drug Development and Delivery 181 217 .
Sevda Şenel & Selin Yüksel. (2020) Chitosan-based particulate systems for drug and vaccine delivery in the treatment and prevention of neglected tropical diseases. Drug Delivery and Translational Research 10:6, pages 1644-1674.
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Derya Özel & Fatma Yurt. (2020) Investigation of radiolabelled chitosan nanoparticles bearing Cefpodoxime Proxetil, and in vitro antibacterial effect on Gram-positive Staphylococcus aureus and Gram-negative Escherichia coli. Journal of Radioanalytical and Nuclear Chemistry 326:3, pages 1551-1558.
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Michel Muálem de Moraes Alves, Daniel Dias Rufino Arcanjo, Kayo Alves Figueiredo, Jéssica Sara de Sousa Macêdo Oliveira, Felipe José Costa Viana, Elvilene de Sousa Coelho, Glaucia Lais Nunes Lopes, Juan Carlos Ramos Gonçalves, André Luís Menezes Carvalho, Márcia dos Santos Rizzo, Mariana Helena Chaves, Ivete Lopes de Mendonça & Fernando Aécio de Amorim Carvalho. (2020) Gallic and Ellagic Acids Are Promising Adjuvants to Conventional Amphotericin B for the Treatment of Cutaneous Leishmaniasis. Antimicrobial Agents and Chemotherapy 64:12.
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Philippe M. Loiseau, Sébastien Pomel & Simon L. Croft. (2020) Chitosan Contribution to Therapeutic and Vaccinal Approaches for the Control of Leishmaniasis. Molecules 25:18, pages 4123.
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Alaa Riezk, Katrien Van Bocxlaer, Vanessa Yardley, Sudaxshina Murdan & Simon L. Croft. (2020) Activity of Amphotericin B-Loaded Chitosan Nanoparticles against Experimental Cutaneous Leishmaniasis. Molecules 25:17, pages 4002.
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Johannes Almer, Bernd Gesslbauer & Andreas J. Kungl. (2018) Therapeutic strategies to target microbial protein–glycosaminoglycan interactions. Biochemical Society Transactions 46:6, pages 1505-1515.
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Ariane Sousa-Batista & Bartira Rossi-Bergmann. 2018. Leishmaniases as Re-emerging Diseases. Leishmaniases as Re-emerging Diseases.
Tahereh Zadeh Mehrizi, Nariman Mosaffa, Mostafa Haji Molla Hoseini‎Mehdi Shafiee Ardestani, Ali Khamesipour & Amitis Ramezani. (2018) In Vivo Therapeutic Effects of Four Synthesized Antileishmanial Nanodrugs in the Treatment of Leishmaniasis. Archives of Clinical Infectious Diseases In Press:In Press.
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Aline de Souza, Débora Soares Souza Marins, Samir Leite Mathias, Lis Marie Monteiro, Megumi Nishitani Yukuyama, Cauê Benito Scarim, Raimar Löbenberg & Nádia Araci Bou-Chacra. (2018) Promising nanotherapy in treating leishmaniasis. International Journal of Pharmaceutics 547:1-2, pages 421-431.
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