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International Journal of Nanomedicine Volume 10, 2015 - Issue
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Original Research

Simvastatin enhances Rho/actin/cell rigidity pathway contributing to mesenchymal stem cells’ osteogenic differentiation

I-Chun Tai1 Graduate Institute of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan;2 Department of Physiology, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan;3 Orthopaedic Research Center, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan
,
Yao-Hsien Wang3 Orthopaedic Research Center, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan
,
Chung-Hwan Chen3 Orthopaedic Research Center, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan;4 Department of Orthopedics, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan
,
Shu-Chun Chuang3 Orthopaedic Research Center, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan
,
Je-Ken Chang3 Orthopaedic Research Center, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan;4 Department of Orthopedics, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan;5 Department of Orthopedics, Kaohsiung Municipal Ta-Tung Hospital, Kaohsiung, TaiwanCorrespondence[email protected]
&
Mei-Ling Ho1 Graduate Institute of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan;2 Department of Physiology, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan;3 Orthopaedic Research Center, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan;6 Department of Marine Biotechnology and Resources, National Sun Yat-sen UniVersity, Kaohsiung, TaiwanCorrespondence[email protected]
Pages 5881-5894 | Published online: 21 Sep 2015

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Liu Zi, Wencheng Zhou, Jiake Xu, Junshu Li, Ning Li, Jianguo Xu, Chao You, Chengwei Wang & Meng Tian. (2021) Rosuvastatin Nanomicelles Target Neuroinflammation and Improve Neurological Deficit in a Mouse Model of Intracerebral Hemorrhage. International Journal of Nanomedicine 16, pages 2933-2947.
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Nicola Alessio, Servet Özcan, Kazuki Tatsumi, Ayşegül Murat, Gianfranco Peluso, Mari Dezawa & Umberto Galderisi. (2017) The secretome of MUSE cells contains factors that may play a role in regulation of stemness, apoptosis and immunomodulation. Cell Cycle 16:1, pages 33-44.
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Articles from other publishers (9)

Mariane B. Sordi, Raissa B. Curtarelli, Iara F. Mantovani, Anderson C. Moreira, Celso P. Fernandes, Ariadne C. C. Cruz & Ricardo S. Magini. (2021) Enhanced osteoinductive capacity of poly(lactic-co-glycolic) acid and biphasic ceramic scaffolds by embedding simvastatin. Clinical Oral Investigations 26:3, pages 2693-2701.
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Yiqing Lan, Nannan Huang, Yiru Fu, Kehao Liu, He Zhang, Yuzhou Li & Sheng Yang. (2022) Morphology-Based Deep Learning Approach for Predicting Osteogenic Differentiation. Frontiers in Bioengineering and Biotechnology 9.
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Hui Jin, Youbo Ji, Yutao Cui, Li Xu, He Liu & Jincheng Wang. (2021) Simvastatin-Incorporated Drug Delivery Systems for Bone Regeneration. ACS Biomaterials Science & Engineering 7:6, pages 2177-2191.
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Jun-Sung Oh, Jeong-Sun Park & Eun-Jung Lee. (2021) Enhanced Effect of Polyethyleneimine-Modified Graphene Oxide and Simvastatin on Osteogenic Differentiation of Murine Bone Marrow-Derived Mesenchymal Stem Cells. Biomedicines 9:5, pages 501.
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Chung-Da Yang, Shu-Chun Chuang, Tsung-Lin Cheng, Mon-Juan Lee, Hui-Ting Chen, Sung-Yen Lin, Hsuan-Ti Huang, Cheng-Jung Ho, Yi-Shan Lin, Lin Kang, Mei-Ling Ho, Je-Ken Chang & Chung-Hwan Chen. (2021) An Intermediate Concentration of Calcium with Antioxidant Supplement in Culture Medium Enhances Proliferation and Decreases the Aging of Bone Marrow Mesenchymal Stem Cells. International Journal of Molecular Sciences 22:4, pages 2095.
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Christopher Murphy, Evelyne Deplazes, Charles G. Cranfield & Alvaro Garcia. (2020) The Role of Structure and Biophysical Properties in the Pleiotropic Effects of Statins. International Journal of Molecular Sciences 21:22, pages 8745.
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Yi-Hsiung Lin, Lin Kang, Wen-Han Feng, Tsung-Lin Cheng, Wei-Chung Tsai, Hsuan-Ti Huang, Hsiang-Chun Lee & Chung-Hwan Chen. (2020) Effects of Lipids and Lipoproteins on Mesenchymal Stem Cells Used in Cardiac Tissue Regeneration. International Journal of Molecular Sciences 21:13, pages 4770.
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Carol P. Y. Lau, Cathy S. H. Fung, Kwok Chuen Wong, Yu‐Hsuan Wang, Lin Huang, Stephen K. W. Tsui, Oscar K. Lee & Shekhar M. Kumta. (2019) Simvastatin Possesses Antitumor and Differentiation‐Promoting Properties That Affect Stromal Cells in Giant Cell Tumor of Bone. Journal of Orthopaedic Research 38:2, pages 297-310.
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Mohammad Samiei, Marziyeh Agazadeh, Effat Alizadeh, Naser Aslaminabadi, Soodabeh Davaran, Sajjad Shirazi, Farhad Ashrafi & Roya Salehi. (2016) Osteogenic/Odontogenic Bioengineering with co-Administration of Simvastatin and Hydroxyapatite on Poly Caprolactone Based Nanofibrous Scaffold. Advanced Pharmaceutical Bulletin 6:3, pages 353-365.
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