Advanced search
Publication Cover
International Journal of Nanomedicine Volume 10, 2015 - Issue
Submit an article Journal homepage
161
Views
43
CrossRef citations to date
0
Altmetric
Original Research

Caenorhabditis elegans as an alternative in vivo model to determine oral uptake, nanotoxicity, and efficacy of melatonin-loaded lipid-core nanocapsules on paraquat damage

Mariele Feiffer Charão1 Post-Graduate Programme in Pharmaceutical Sciences, Federal University of Rio Grande do Sul, Porto Alegre, RS, Brazil;2 Laboratory of Toxicology (LATOX), Department of Analysis, Pharmacy Faculty, Federal University of Rio Grande do Sul, Porto Alegre, RS, Brazil
,
Caroline Souto2 Laboratory of Toxicology (LATOX), Department of Analysis, Pharmacy Faculty, Federal University of Rio Grande do Sul, Porto Alegre, RS, Brazil
,
Natália Brucker1 Post-Graduate Programme in Pharmaceutical Sciences, Federal University of Rio Grande do Sul, Porto Alegre, RS, Brazil;2 Laboratory of Toxicology (LATOX), Department of Analysis, Pharmacy Faculty, Federal University of Rio Grande do Sul, Porto Alegre, RS, Brazil
,
Anelise Barth1 Post-Graduate Programme in Pharmaceutical Sciences, Federal University of Rio Grande do Sul, Porto Alegre, RS, Brazil;2 Laboratory of Toxicology (LATOX), Department of Analysis, Pharmacy Faculty, Federal University of Rio Grande do Sul, Porto Alegre, RS, Brazil
,
Denise S Jornada1 Post-Graduate Programme in Pharmaceutical Sciences, Federal University of Rio Grande do Sul, Porto Alegre, RS, Brazil;3 Department of Production and Control of Drugs, Pharmacy Faculty, Federal University of Rio Grande do Sul, Porto Alegre, RS, Brazil
,
Daiandra Fagundez4 Research Group in Biochemistry and Toxicology in Caenorhabditis elegans (GBToxCE), Federal University of Pampa – UNIPAMPA, Uruguaiana, RS, Brazil
,
Daiana Silva Ávila4 Research Group in Biochemistry and Toxicology in Caenorhabditis elegans (GBToxCE), Federal University of Pampa – UNIPAMPA, Uruguaiana, RS, Brazil
,
Vera L Eifler-Lima1 Post-Graduate Programme in Pharmaceutical Sciences, Federal University of Rio Grande do Sul, Porto Alegre, RS, Brazil;5 Laboratory of Medical Synthesis Organic (LaSOM), Pharmacy Faculty, Federal University of Rio Grande do Sul, Porto Alegre, RS, Brazil
,
Silvia S Guterres1 Post-Graduate Programme in Pharmaceutical Sciences, Federal University of Rio Grande do Sul, Porto Alegre, RS, Brazil;3 Department of Production and Control of Drugs, Pharmacy Faculty, Federal University of Rio Grande do Sul, Porto Alegre, RS, Brazil
,
Adriana R Pohlmann1 Post-Graduate Programme in Pharmaceutical Sciences, Federal University of Rio Grande do Sul, Porto Alegre, RS, Brazil;6 Department of Organic Chemistry, Chemistry Institute, Federal University of Rio Grande do Sul, Porto Alegre, RS, Brazil
&
Solange Cristina Garcia1 Post-Graduate Programme in Pharmaceutical Sciences, Federal University of Rio Grande do Sul, Porto Alegre, RS, Brazil;2 Laboratory of Toxicology (LATOX), Department of Analysis, Pharmacy Faculty, Federal University of Rio Grande do Sul, Porto Alegre, RS, BrazilCorrespondence[email protected]
 show all
Pages 5093-5106 | Published online: 10 Aug 2015

Citations (43)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (4)

Luana Schmidt, Natália de Vargas Heck, Ingrid Ferreira, Gabriela Göethel, Sabrina Somacal, Tatiana Emanuelli, Eliseu Rodrigues, Solange Cristina Garcia, Juliane Elisa Welke & Paula Rossini Augusti. (2020) Ochratoxin A presence in Cabernet Sauvignon wine changes antioxidant activity in vitro and oxidative stress markers in vivo. Food Additives & Contaminants: Part A 37:10, pages 1755-1764.
Read now
Ying-Fei Yang, Yi-Jun Lin & Chung-Min Liao. (2017) Toxicity-based toxicokinetic/toxicodynamic assessment of bioaccumulation and nanotoxicity of zerovalent iron nanoparticles in Caenorhabditis elegans. International Journal of Nanomedicine 12, pages 4607-4621.
Read now
Mohammad Hossein Asghari, Milad Moloudizargari, Haji Bahadar & Mohammad Abdollahi. (2017) A review of the protective effect of melatonin in pesticide-induced toxicity. Expert Opinion on Drug Metabolism & Toxicology 13:5, pages 545-554.
Read now
Irina Mirela Apetrei & Constantin Apetrei. (2016) Voltammetric determination of melatonin using a graphene-based sensor in pharmaceutical products. International Journal of Nanomedicine 11, pages 1859-1866.
Read now

Articles from other publishers (39)

Yiyuan Yin & Haitao Shen. (2023) Melatonin ameliorates acute lung injury caused by paraquat poisoning by promoting PINK1 and BNIP3 expression. Toxicology 490, pages 153506.
Crossref
Juliana Damasceno Oliveira, Gustavo Henrique Rodrigues da Silva, Ludmila David de Moura, Gabriela Göethel, Juliana Z.B. Papini, Bruna Renata Casadei, Ligia Nunes de Morais Ribeiro, Luis Fernando Cabeça, Solange Cristina Garcia, Elizabeth Ferreira Martinez, Giovana Radomille Tofoli & Eneida de Paula. (2023) DoE development of ionic gradient liposomes: A successful approach to improve encapsulation, prolong anesthesia and decrease the toxicity of etidocaine. International Journal of Pharmaceutics 634, pages 122672.
Crossref
Danielle Araujo Agarrayua, Ana Claudia Funguetto-Ribeiro, Paula Trevisan, Sandra Elisa Haas & Daiana Silva Ávila. (2023) Safety assessment of different unloaded polymeric nanocapsules in Caenorhabditis elegans. Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology 263, pages 109477.
Crossref
Chunyan Ling, Liangcheng Shang, Xin Xie, Sudan Ye, Ningjing Wang & Chun Chen. (2022) AdoR-1 (Adenosine Receptor) Contributes to Protection against Paraquat-Induced Oxidative Stress in Caenorhabditis elegans. Oxidative Medicine and Cellular Longevity 2022, pages 1-13.
Crossref
Marina Griebeler Moreira, Gabriela Zimmermann Prado Rodrigues, Ana Leticia Hilario Garcia, Diulliane de Jesus Borba, Maria Gabriela Bloedow Scheffer, Laura Cé da Silva, Giovana Piva Peteffi, Rafael Linden, Mariele Feiffer Charão, Günther Gehlen, Magda Susana Perassolo & Ana Luiza Ziulkoski. (2022) Association of different biomarkers in vivo and in vitro to assess water quality in Ilha River, Southern Brazil. Ecohydrology & Hydrobiology 22:4, pages 578-588.
Crossref
Jing Li, Di Liu, Danqing Li, Yujie Guo, Hongzhi Du & Yan Cao. (2022) Phytochemical Composition and Anti‐Aging Activity of Butanol Extract of Hedyotis diffusa in Caenorhabditis elegans . Chemistry & Biodiversity 19:2.
Crossref
Rafaela P. Gazzi, Caroline Portela Peruzzi, Ingrid Mullich Flesch, Giovana Onzi, Luiza Abrahão Frank & Solange Cristina Garcia. 2022. The ADME Encyclopedia. The ADME Encyclopedia 840 853 .
Anny Leudjo Taka, Charlotte Mungho Tata, Michael John Klink, Xavier Yangkou Mbianda, Fanyana Moses Mtunzi & Eliazer Bobby Naidoo. (2021) A Review on Conventional and Advanced Methods for Nanotoxicology Evaluation of Engineered Nanomaterials. Molecules 26:21, pages 6536.
Crossref
Roberto Davila‐Trujillo, Sibele Santos Fernandes, Cristiana Lima Dora, José Maria Monserrat, Carlos Prentice & Myriam de las Mercedes Salas‐Mellado. (2021) Physical, chemical, and biological evaluation of nanoparticles containing phenolic compounds from wine production residues. Journal of Food Processing and Preservation 45:7.
Crossref
Luiz Gustavo de Almeida Chuffa, Fábio Rodrigues Ferreira Seiva, Adriana Alonso Novais, Vinícius Augusto Simão, Virna Margarita Martín Giménez, Walter Manucha, Debora Aparecida Pires de Campos Zuccari & Russel J. Reiter. (2021) Melatonin-Loaded Nanocarriers: New Horizons for Therapeutic Applications. Molecules 26:12, pages 3562.
Crossref
Felícia Pereira de Albuquerque, Jhones Luiz de Oliveira, Leila dos Santos Machado, Vinicius Sobrinho Richardi, Mario Antônio Navarro da Silva, Marcelo Luiz Martins Pompêo, Leonardo Fernandes Fraceto & Viviane Moschini Carlos. (2021) Use of nontarget organism Chironomus sancticaroli to study the toxic effects of nanoatrazine. Ecotoxicology 30:4, pages 733-750.
Crossref
Aline Keller Couto Soares, Antônio Domingos de Sousa Júnior, Mariane Fioroti Lorençoni, Júlia Araujo de Castro, Flávia Vitorino de Araujo Porto, Iana Soares Pessoa, Marcos Vinicius Toledo e Silva, Ana Claudia Hertel Pereira, Flavia de Souza Andrade Moraes, Tadeu Uggere de Andrade, Denise Coutinho Endringer, Rodrigo Scherer, Thiago Barth & Marcio Fronza. (2021) In vitro and in vivo anti-inflammatory activity and chemical composition of Renealmia petasites Gagnep. Inflammopharmacology 29:2, pages 451-465.
Crossref
Ming Chang, Jinyue Yang, Xin Guo, Tao Zhang, Ruijie Liu, Qingzhe Jin & Xingguo Wang. (2021) Medium / long-chain structured triglycerides are superior to physical mixtures triglycerides in Caenorhabditis elegans lifespan through an AMPK modified pathway. Food Bioscience 39, pages 100815.
Crossref
Rafaela P. Gazzi, Caroline Portela Peruzzi, Ingrid Mullich Flesch, Giovana Onzi, Luiza Abrahão Frank & Solange Cristina Garcia. 2021. The ADME Encyclopedia. The ADME Encyclopedia 1 13 .
Fernanda Camboim Rockett, Helena de Oliveira Schmidt, Luana Schmidt, Eliseu Rodrigues, Bruna Tischer, Viviani Ruffo de Oliveira, Vanuska Lima da Silva, Paula Rossini Augusti, Simone Hickmann Flôres & Alessandro Rios. (2020) Phenolic compounds and antioxidant activity in vitro and in vivo of Butia and Opuntia fruits. Food Research International 137, pages 109740.
Crossref
Sudeep Lama, Olivier Merlin-Zhang & Chunhua Yang. (2020) In Vitro and In Vivo Models for Evaluating the Oral Toxicity of Nanomedicines. Nanomaterials 10:11, pages 2177.
Crossref
Cassiana Bigolin, Talitha Stella Sant’Anna Oliveira, Laura Cé da Silva, Tainara Ayres, Júlia Machado Menezes, Ivan Da Rocha Pitta, Mariele Feiffer Charão & Andresa Heemann Betti. (2020) Evaluation of the potential toxicity of haloperidol, clozapine and a new putative antipsychotic molecule, PT-31, in an alternative toxicity model, C. elegans. International Journal for Innovation Education and Research 8:6, pages 502-512.
Crossref
Miao Zhang, Zhihui Li, Dawen Gao, Wenjing Gong, Yan Gao & Chenggang Zhang. (2020) Hydrogen extends Caenorhabditis elegans longevity by reducing reactive oxygen species. PLOS ONE 15:4, pages e0231972.
Crossref
Juliana Ferreira Boelter, Adriano Brandelli, Stela Maris Meister Meira, Gabriela Göethel & Solange Cristina Garcia. (2020) Toxicology study of nanoclays adsorbed with the antimicrobial peptide nisin on Caenorhabditis elegans. Applied Clay Science 188, pages 105490.
Crossref
Ana De la Parra-Guerra & Jesus Olivero-Verbel. (2020) Toxicity of nonylphenol and nonylphenol ethoxylate on Caenorhabditis elegans. Ecotoxicology and Environmental Safety 187, pages 109709.
Crossref
A. Suriya Prabha, R. Dorothy, S. Jancirani, Susai Rajendran, Gurmeet Singh & S. Senthil Kumaran. 2020. Nanotoxicity. Nanotoxicity 143 165 .
Sandeep Kumar & Kitlangki Suchiang. 2020. Model Organisms to Study Biological Activities and Toxicity of Nanoparticles. Model Organisms to Study Biological Activities and Toxicity of Nanoparticles 333 369 .
Mariele F. Charão, Gabriela Goethel, Natália Brucker, Karina Paese, Vera L. Eifler-Lima, Adriana R. Pohlmann, Silvia S. Guterres & Solange C. Garcia. (2019) Melatonin-loaded lipid-core nanocapsules protect against lipid peroxidation caused by paraquat through increased SOD expression in Caenorhabditis elegans. BMC Pharmacology and Toxicology 20:S1.
Crossref
Gaurav Pandey, Mohana Marimuthu, Pandiayaraj Kanagavalli, Velayutham Ravichandiran, Krishnaswamy Balamurugan & Murugan Veerapandian. (2019) Chitosanylated MoO 3 –Ruthenium(II) Nanocomposite as Biocompatible Probe for Bioimaging and Herbaceutical Detection . ACS Biomaterials Science & Engineering 5:7, pages 3606-3617.
Crossref
Tianshu Wu, Hongsheng Xu, Xue Liang & Meng Tang. (2019) Caenorhabditis elegans as a complete model organism for biosafety assessments of nanoparticles. Chemosphere 221, pages 708-726.
Crossref
Kelle Velasques, Tamara Ramos Maciel, Ana Helena de Castro Dal Forno, Flávia Elizabete Guerra Teixeira, Amanda Luisa da Fonseca, Fernando de Pilla Varotti, André Ricardo Fajardo, Daiana Silva de Ávila & Sandra Elisa Haas. (2018) Co-nanoencapsulation of antimalarial drugs increases their in vitro efficacy against Plasmodium falciparum and decreases their toxicity to Caenorhabditis elegans. European Journal of Pharmaceutical Sciences 118, pages 1-12.
Crossref
Daiana Silva Ávila, Juliana Fredo Roncato & Maurício Tavares Jacques. (2018) Nanotoxicology assessment in complementary/alternative models. Energy, Ecology and Environment 3:2, pages 72-80.
Crossref
Lígia Nunes de Morais Ribeiro, Verônica Muniz Couto, Leonardo Fernandes Fraceto & Eneida de Paula. (2018) Use of nanoparticle concentration as a tool to understand the structural properties of colloids. Scientific Reports 8:1.
Crossref
Hemant K.S. Yadav, Manar Dibi & Alyazya Mohammed. 2018. Nanoscale Fabrication, Optimization, Scale-Up and Biological Aspects of Pharmaceutical Nanotechnology. Nanoscale Fabrication, Optimization, Scale-Up and Biological Aspects of Pharmaceutical Nanotechnology 219 252 .
Dayong WangDayong Wang. 2018. Nanotoxicology in Caenorhabditis elegans. Nanotoxicology in Caenorhabditis elegans 1 10 .
Adriano Brandelli. 2018. Nanomaterials: Ecotoxicity, Safety, and Public Perception. Nanomaterials: Ecotoxicity, Safety, and Public Perception 57 76 .
Michelli Antonow, Camila Franco, Willian Prado, Aline Beckenkamp, Gustavo Silveira, Andréia Buffon, Sílvia Guterres & Adriana Pohlmann. (2017) Arginylglycylaspartic Acid-Surface-Functionalized Doxorubicin-Loaded Lipid-Core Nanocapsules as a Strategy to Target Alpha(V) Beta(3) Integrin Expressed on Tumor Cells. Nanomaterials 8:1, pages 2.
Crossref
Paula Rossini Augusti, Allana Von Sulzback Brasil, Caroline Souto, Gabriela Göethel, Alessandro de Oliveira Rios, Tatiana Emanuelli, Marilise Escobar Bürger & Solange Cristina Garcia. (2017) Microcystin-LR exposure induces oxidative damage in Caenorhabditis elegans : Protective effect of lutein extracted from marigold flowers. Food and Chemical Toxicology 109, pages 60-67.
Crossref
Monique C. P. Mendonça, Cintia Rizoli, Daiana S. Ávila, Mónica J. B. Amorim & Marcelo B. de Jesus. (2017) Nanomaterials in the Environment: Perspectives on in Vivo Terrestrial Toxicity Testing. Frontiers in Environmental Science 5.
Crossref
Michelli B. Antonow, Ana Carolina C. Asbahr, Paula Raddatz, Aline Beckenkamp, Andréia Buffon, Sílvia S. Guterres & Adriana R. Pohlmann. (2017) Liquid formulation containing doxorubicin-loaded lipid-core nanocapsules: Cytotoxicity in human breast cancer cell line and in vitro uptake mechanism. Materials Science and Engineering: C 76, pages 374-382.
Crossref
Mauricio T. Jacques, Jhones L. Oliveira, Estefânia V.R. Campos, Leonardo F. Fraceto & Daiana Silva Ávila. (2017) Safety assessment of nanopesticides using the roundworm Caenorhabditis elegans. Ecotoxicology and Environmental Safety 139, pages 245-253.
Crossref
F. Benyettou, H. Fahs, R. Elkharrag, R. A. Bilbeisi, B. Asma, R. Rezgui, L. Motte, M. Magzoub, J. Brandel, J.-C. Olsen, F. Piano, K. C. Gunsalus, C. Platas-Iglesias & A. Trabolsi. (2017) Selective growth inhibition of cancer cells with doxorubicin-loaded CB[7]-modified iron-oxide nanoparticles. RSC Advances 7:38, pages 23827-23834.
Crossref
Marília Baierle, Gabriela Göethel, Sabrina N. Nascimento, Mariele F. Charão, Angela M. Moro, Natália Brucker, Elisa Sauer, Bruna Gauer, Caroline Souto, Juliano Durgante, Marcelo Dutra Arbo & Solange Cristina Garcia. (2017) DNA damage in the elderly is associated with 5-MTHF levels: a pro-oxidant activity. Toxicology Research 6:3, pages 333-341.
Crossref
Silvia Gabriella Ciappellano, Erik Tedesco, Marco Venturini & Federico Benetti. (2016) In vitro toxicity assessment of oral nanocarriers. Advanced Drug Delivery Reviews 106, pages 381-401.
Crossref

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.