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International Journal of Nanomedicine Volume 10, 2015 - Issue
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Original Research

Investigation of enzyme-sensitive lipid nanoparticles for delivery of siRNA to blood–brain barrier and glioma cells

Jonas Bruun1 Department of Micro- and Nanotechnology, Center for Nanomedicine and Theranostics, Technical University of Denmark, DTU Nanotech, Lyngby, Denmark
,
Trine B Larsen1 Department of Micro- and Nanotechnology, Center for Nanomedicine and Theranostics, Technical University of Denmark, DTU Nanotech, Lyngby, Denmark
,
Rasmus I Jølck1 Department of Micro- and Nanotechnology, Center for Nanomedicine and Theranostics, Technical University of Denmark, DTU Nanotech, Lyngby, Denmark
,
Rasmus Eliasen1 Department of Micro- and Nanotechnology, Center for Nanomedicine and Theranostics, Technical University of Denmark, DTU Nanotech, Lyngby, Denmark
,
René Holm2 H Lundbeck A/S, Biologics and Pharmaceutical Science, Valby, Denmark
,
Torben Gjetting1 Department of Micro- and Nanotechnology, Center for Nanomedicine and Theranostics, Technical University of Denmark, DTU Nanotech, Lyngby, Denmark
&
Thomas L Andresen1 Department of Micro- and Nanotechnology, Center for Nanomedicine and Theranostics, Technical University of Denmark, DTU Nanotech, Lyngby, DenmarkCorrespondence[email protected]
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Pages 5995-6008 | Published online: 24 Sep 2015

Citations (18)

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Chang Hyun Kim, Cheol-Ki Sa, Min Su Goh, Eun Seok Lee, Tae Hoon Kang, Ho Yub Yoon, Gantumur Battogtokh, Young Tag Ko & Young Wook Choi. (2018) pH-sensitive PEGylation of RIPL peptide-conjugated nanostructured lipid carriers: design and in vitro evaluation. International Journal of Nanomedicine 13, pages 6661-6675.
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Haitao Pan, Jiayu Liu, Wentong Deng, Jieyu Xing, Qing Li & Zhong Wang. (2018) Site-specific PEGylation of an anti-CEA/CD3 bispecific antibody improves its antitumor efficacy. International Journal of Nanomedicine 13, pages 3189-3201.
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Tanveer A Tabish, Md Zahidul I Pranjol, Ilayda Karadag, David W Horsell, Jacqueline L Whatmore & Shaowei Zhang. (2018) Influence of luminescent graphene quantum dots on trypsin activity. International Journal of Nanomedicine 13, pages 1525-1538.
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Articles from other publishers (15)

Xin Guo, Hengxing Jiao, Lele Cao & Facai Meng. (2022) Biological implications and clinical potential of invasion and migration related miRNAs in glioma. Frontiers in Integrative Neuroscience 16.
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Maria Tsakiri, Cristina Zivko, Costas Demetzos & Vasiliki Mahairaki. (2022) Lipid-based nanoparticles and RNA as innovative neuro-therapeutics. Frontiers in Pharmacology 13.
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Zhe Ren, Tao Liao, Cao Li & Ying Kuang. (2022) Drug Delivery Systems with a “Tumor-Triggered” Targeting or Intracellular Drug Release Property Based on DePEGylation. Materials 15:15, pages 5290.
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Parisa Shamshiripour, Fahimeh Hajiahmadi, Shahla Lotfi, Niloofar Robab Esmaeili, Amir Zare, Mahzad Akbarpour & Davoud Ahmadvand. (2022) Next-Generation Anti-Angiogenic Therapies as a Future Prospect for Glioma Immunotherapy; From Bench to Bedside. Frontiers in Immunology 13.
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Apoorva Sarode, Yuchen Fan, Amy E. Byrnes, Michal Hammel, Greg L. Hura, Yige Fu, Ponien Kou, Chloe Hu, Flora I. Hinz, Jasmine Roberts, Stefan G. Koenig, Karthik Nagapudi, Casper C. Hoogenraad, Tao Chen, Dennis Leung & Chun-Wan Yen. (2022) Predictive high-throughput screening of PEGylated lipids in oligonucleotide-loaded lipid nanoparticles for neuronal gene silencing. Nanoscale Advances 4:9, pages 2107-2123.
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Claire Gazaille, Marion Sicot, Patrick Saulnier, Joël Eyer & Guillaume Bastiat. (2021) Local Delivery and Glioblastoma: Why Not Combining Sustained Release and Targeting?. Frontiers in Medical Technology 3.
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H. Dommisch, KN. Stolte, J. Jager, K. Vogel, R. Müller, S. Hedtrich, M. Unbehauen, R. Haag & K. Danker. (2021) Characterization of an ester-based core-multishell (CMS) nanocarrier for the topical application at the oral mucosa. Clinical Oral Investigations 25:10, pages 5795-5805.
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Tong Li, Liye Zhu, Longjiao Zhu, Pengjie Wang, Wentao Xu & Jiaqiang Huang. (2021) Recent Developments in Delivery of MicroRNAs Utilizing Nanosystems for Metabolic Syndrome Therapy. International Journal of Molecular Sciences 22:15, pages 7855.
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Muhammad Abdur Rahim, Nasrullah Jan, Safiullah Khan, Hassan Shah, Asadullah Madni, Arshad Khan, Abdul Jabar, Shahzeb Khan, Abdelbary Elhissi, Zahid Hussain, Heather C Aziz, Muhammad Sohail, Mirazam Khan & Hnin Ei Thu. (2021) Recent Advancements in Stimuli Responsive Drug Delivery Platforms for Active and Passive Cancer Targeting. Cancers 13:4, pages 670.
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Ricardo Gaspar, Filipe Coelho & Bruno F. B. Silva. (2020) Lipid-Nucleic Acid Complexes: Physicochemical Aspects and Prospects for Cancer Treatment. Molecules 25:21, pages 5006.
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Raneem Jnaidi, António José Almeida & Lídia M. Gonçalves. (2020) Solid Lipid Nanoparticles and Nanostructured Lipid Carriers as Smart Drug Delivery Systems in the Treatment of Glioblastoma Multiforme. Pharmaceutics 12:9, pages 860.
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Bibhash Chandra Mohanta, Subas Chandra Dinda, Narahari Narayan Palei & Jyotirmoy Deb. 2020. Role of Novel Drug Delivery Vehicles in Nanobiomedicine. Role of Novel Drug Delivery Vehicles in Nanobiomedicine.
Anne Z. Eriksen, Rasmus Eliasen, Julia Oswald, Paul J. Kempen, Fredrik Melander, Thomas L. Andresen, Michael Young, Petr Baranov & Andrew J. Urquhart. (2018) Multifarious Biologic Loaded Liposomes that Stimulate the Mammalian Target of Rapamycin Signaling Pathway Show Retina Neuroprotection after Retina Damage. ACS Nano 12:8, pages 7497-7508.
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Tayebeh Anajafi, Junru Yu, Abbas Sedigh, Manas K. Haldar, Wallace W. Muhonen, Seth Oberlander, Heather Wasness, Jamie Froberg, MD Shahjahan Molla, Kalpana S. Katti, Yongki Choi, John B. Shabb, D. K. Srivastava & Sanku Mallik. (2017) Nuclear Localizing Peptide-Conjugated, Redox-Sensitive Polymersomes for Delivering Curcumin and Doxorubicin to Pancreatic Cancer Microtumors. Molecular Pharmaceutics 14:6, pages 1916-1928.
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Yifei Lu & Chen Jiang. (2017) Brain-Targeted Polymers for Gene Delivery in the Treatment of Brain Diseases. Topics in Current Chemistry 375:2.
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