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Original Research

Lung penetration and patient adherence considerations in the management of asthma: role of extra-fine formulations

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Pages 11-21 | Published online: 09 Jan 2013

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (9)

Adolfo Baloira, Araceli Abad, Antonia Fuster, Juan Luis García Rivero, Patricia García-Sidro, Eduardo Márquez-Martín, Marta Palop, Néstor Soler, J L Velasco & Fernando González-Torralba. (2021) Lung Deposition and Inspiratory Flow Rate in Patients with Chronic Obstructive Pulmonary Disease Using Different Inhalation Devices: A Systematic Literature Review and Expert Opinion. International Journal of Chronic Obstructive Pulmonary Disease 16, pages 1021-1033.
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Pieter Nicolaas Richard Dekhuijzen, Federico Lavorini & Omar S Usmani. (2016) Patients’ perspectives and preferences in the choice of inhalers: the case for Respimat® or HandiHaler®. Patient Preference and Adherence 10, pages 1561-1572.
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Bita Hajian, Jan De Backer, Wim Vos, Jelle Aerts, Johan Cluckers & Wilfried De Backer. (2016) Efficacy of inhaled medications in asthma and COPD related to disease severity. Expert Opinion on Drug Delivery 13:12, pages 1719-1727.
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Ernesto Crisafulli, Andrea Zanini, Giovanna Pisi, Patrizia Pignatti, Gianluigi Poli, Mario Scuri & Alfredo Chetta. (2016) Inhaled beclometasone dipropionate/formoterol fumarate extrafine fixed combination for the treatment of asthma. Expert Review of Respiratory Medicine 10:5, pages 481-490.
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Andrea S. Melani & Davide Paleari. (2016) Maintaining Control of Chronic Obstructive Airway Disease: Adherence to Inhaled Therapy and Risks and Benefits of Switching Devices. COPD: Journal of Chronic Obstructive Pulmonary Disease 13:2, pages 241-250.
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Salvatore Battaglia, Alida Benfante & Nicola Scichilone. (2015) Asthma in the older adult: presentation, considerations and clinical management. Expert Review of Clinical Immunology 11:12, pages 1297-1308.
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Massimo Corradi, Henry Chrystyn, Borja G Cosio, Michal Pirozynski, Stelios Loukides, Renaud Louis, Monica Spinola & Omar S Usmani. (2014) NEXThaler, an innovative dry powder inhaler delivering an extrafine fixed combination of beclometasone and formoterol to treat large and small airways in asthma. Expert Opinion on Drug Delivery 11:9, pages 1497-1506.
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Andrea S Melani. (2014) Flunisolide for the treatment of asthma. Expert Review of Clinical Pharmacology 7:3, pages 251-258.
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Nicola Scichilone, Salvatore Battaglia, Alida Benfante & Vincenzo Bellia. (2013) Safety and efficacy of montelukast as adjunctive therapy for treatment of asthma in elderly patients. Clinical Interventions in Aging 8, pages 1329-1337.
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Articles from other publishers (24)

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Aysu YURDASİPER. (2022) Development of Triamcinolone Acetonide Loaded Poly(lactide-co-glycolic acid) Dry Powder Inhaler Formulations For The Treatment of Asthma. Clinical and Experimental Health Sciences 12:1, pages 249-256.
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Paschalis Steiropoulos, Petros Bakakos, Elpis Hatziagorou, Paraskevi Katsaounou, Stelios Loukides, Andriana Papaioannou, Konstantinos Porpodis, Konstantinos Samaras, Argyrios Tzouvelekis, Konstantinos Kalafatakis & Konstantinos Kostikas. (2021) The present and future of inhalation therapy for the management of obstructive airway diseases: Emphasis on pressurized metered-dose inhalers. Pneumon, pages 1-13.
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Ting Liu, Dan Yang & Chuntao Liu. (2021) Extrafine HFA-beclomethasone-formoterol vs. nonextrafine combination of an inhaled corticosteroid and a long acting β2-agonist in patients with persistent asthma: A systematic review and meta-analysis. PLOS ONE 16:9, pages e0257075.
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Henrik WatzSara BarileDaniele GuastallaEva TopoleDaniela CocconiBenjamin MignotDennis BelmansDildar DumanGianluigi PoliLeonardo M. Fabbri. (2021) Targeting the Small Airways with Inhaled Corticosteroid/Long-Acting Beta Agonist Dry Powder Inhalers: A Functional Respiratory Imaging Study. Journal of Aerosol Medicine and Pulmonary Drug Delivery 34:5, pages 280-292.
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Maria Paula Henao, Jennifer L. Kraschnewski, Matthew D. Bolton, Faoud Ishmael & Timothy Craig. (2020) Effects of Inhaled Corticosteroids and Particle Size on Risk of Obstructive Sleep Apnea: A Large Retrospective Cohort Study. International Journal of Environmental Research and Public Health 17:19, pages 7287.
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Azza A. Mahmoud, Nermeen A. Elkasabgy & Abdelfattah A. Abdelkhalek. (2018) Design and characterization of emulsified spray dried alginate microparticles as a carrier for the dually acting drug roflumilast. European Journal of Pharmaceutical Sciences 122, pages 64-76.
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Huner K. Omer, Nozad R. Hussein, Amina Ferraz, Mohammad Najlah, Waqar Ahmed, Kevin M. G. Taylor & Abdelbary M. A. Elhissi. (2018) Spray-Dried Proliposome Microparticles for High-Performance Aerosol Delivery Using a Monodose Powder Inhaler. AAPS PharmSciTech 19:5, pages 2434-2448.
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Cedric Van Holsbeke, Jan De Backer, Wim Vos & Jonathan Marshall. (2018) Use of functional respiratory imaging to characterize the effect of inhalation profile and particle size on lung deposition of inhaled corticosteroid/long-acting β2-agonists delivered via a pressurized metered-dose inhaler . Therapeutic Advances in Respiratory Disease 12, pages 175346661876094.
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Ayah Shakshuki & Remigius U. Agu. (2017) Improving the Efficiency of Respiratory Drug Delivery: A Review of Current Treatment Trends and Future Strategies for Asthma and Chronic Obstructive Pulmonary Disease. Pulmonary Therapy 3:2, pages 267-281.
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Árpád Farkas, David Lewis, Tanya Church, Alan Tweedie, Francesca Mason, Allen E. Haddrell, Jonathan P. Reid, Alpár Horváth & Imre Balásházy. (2017) Experimental and computational study of the effect of breath-actuated mechanism built in the NEXThaler® dry powder inhaler. International Journal of Pharmaceutics 533:1, pages 225-235.
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Francesca Buttini, James Hannon, Kristi Saavedra, Irene Rossi, Anna Giulia Balducci, Hugh Smyth, Andy Clark & Paolo Colombo. (2016) Accessorized DPI: a Shortcut towards Flexibility and Patient Adaptability in Dry Powder Inhalation. Pharmaceutical Research 33:12, pages 3012-3020.
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Francesca ButtiniGaetano BrambillaDiego CopelliViviana SistiAnna Giulia BalducciRuggero BettiniIrene Pasquali. (2016) Effect of Flow Rate on In Vitro Aerodynamic Performance of NEXThaler ® in Comparison with Diskus ® and Turbohaler ® Dry Powder Inhalers . Journal of Aerosol Medicine and Pulmonary Drug Delivery 29:2, pages 167-178.
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Vicente Plaza Moral & Jordi Giner Donaire. (2016) Terapia inhalada en el asma. Medicina Clínica 146:7, pages 316-323.
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Vicente Plaza Moral & Jordi Giner Donaire. (2016) Inhaled therapy in asthma. Medicina Clínica (English Edition) 146:7, pages 316-323.
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Anna Giulia Balducci, Hartwig Steckel, Francesco Guarneri, Alessandra Rossi, Gaia Colombo, Fabio Sonvico, Eike Cordts, Ruggero Bettini, Paolo Colombo & Francesca Buttini. (2015) High shear mixing of lactose and salmeterol xinafoate dry powder blends: Biopharmaceutic and aerodynamic performances. Journal of Drug Delivery Science and Technology 30, pages 443-449.
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Anne H. de Boer, Doetie Gjaltema, Paul Hagedoorn & Henderik W. Frijlink. (2015) Can ‘extrafine’ dry powder aerosols improve lung deposition?. European Journal of Pharmaceutics and Biopharmaceutics 96, pages 143-151.
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Nicola Scichilone. (2015) Asthma Control: The Right Inhaler for the Right Patient. Advances in Therapy 32:4, pages 285-292.
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Frank Kanniess, Mario Scuri, Stefano Vezzoli, Catherine Francisco & Stefano Petruzzelli. (2015) Extrafine beclomethasone/formoterol combination via a dry powder inhaler (NEXThaler®) or pMDI and beclomethasone monotherapy for maintenance of asthma control in adult patients: A randomised, double-blind trial. Pulmonary Pharmacology & Therapeutics 30, pages 121-127.
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Salvatore Battaglia, Marco Basile, Mario Spatafora & Nicola Scichilone. (2015) Are Asthmatics Enrolled in Randomized Trials Representative of Real-Life Outpatients?. Respiration 89:5, pages 383-389.
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Thomas VoshaarMonica SpinolaPatrick LinnaneAlice CampaniniDaniel LockAnthony LafrattaMario ScuriBarbara RoncaAndrea S. Melani. (2014) Comparing Usability of NEXThaler ® with Other Inhaled Corticosteroid/Long-Acting β 2 -Agonist Fixed Combination Dry Powder Inhalers in Asthma Patients . Journal of Aerosol Medicine and Pulmonary Drug Delivery 27:5, pages 363-370.
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S. Saturni, F. Bellini, F. Braido, P. Paggiaro, A. Sanduzzi, N. Scichilone, P.A. Santus, L. Morandi & A. Papi. (2014) Randomized controlled trials and real life studies. Approaches and methodologies: a clinical point of view.. Pulmonary Pharmacology & Therapeutics 27:2, pages 129-138.
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Omar S Usmani. (2014) Small Airways Dysfunction in Asthma: Evaluation and Management to Improve Asthma Control. Allergy, Asthma & Immunology Research 6:5, pages 376.
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. (2013) Consenso SEPAR-ALAT sobre terapia inhalada. Archivos de Bronconeumología 49, pages 2-14.
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