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Original Research

New Insights into the Mechanism of Action of Viloxazine: Serotonin and Norepinephrine Modulating Properties

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Pages 285-300 | Published online: 25 Aug 2020

Keep up to date with the latest research on this topic with citation updates for this article.

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Erika Ryst & Ann Childress. (2023) An updated safety review of the current drugs for managing ADHD in children. Expert Opinion on Drug Safety 22:11, pages 1025-1040.
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Ann Childress, Robert Sottile & Sherine Khanbijian. (2023) Viloxazine extended-release capsules for the treatment of attention-deficit/ hyperactivity disorder in adult patients. Expert Review of Neurotherapeutics 23:11, pages 945-953.
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Ann Childress & Shelby Burton. (2022) Evaluating the pharmacokinetics of extended release viloxazine in the treatment of children with attention-deficit/hyperactivity disorder. Expert Opinion on Drug Metabolism & Toxicology 18:6, pages 357-366.
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Haley Raible & Manoranjan S. D’Souza. (2023) Extended-Release Viloxazine for the Treatment of Attention-Deficit Hyperactivity Disorder in School-Age Children and Adolescents. Annals of Pharmacotherapy, pages 106002802311632.
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Edmund J.S. Sonuga‐Barke, Stephen P. Becker, Sven Bölte, Francisco Xavier Castellanos, Barbara Franke, Jeffrey H. Newcorn, Joel T. Nigg, Luis Augusto Rohde & Emily Simonoff. (2022) Annual Research Review: Perspectives on progress in ADHD science – from characterization to cause . Journal of Child Psychology and Psychiatry 64:4, pages 506-532.
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Kelsey K. Wiggs, Tanya E. Froehlich & Stephen P. Becker. (2023) Pharmacologic Management of Cognitive Disengagement Syndrome (CDS) and Implications for Attention-Deficit/Hyperactivity Disorder (ADHD) Treatment: Emerging Treatments and Recommendations for Future Research. CNS Drugs 37:4, pages 293-304.
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Stephen V. Faraone, Roberto Gomeni, Joseph T. Hull, Gregory D. Busse, Brendan Lujan, Jonathan Rubin & Azmi Nasser. (2023) Response of peer relations and social activities to treatment with viloxazine extended‐release capsules (Qelbree ® ): A post hoc analysis of four randomized clinical trials of children and adolescents with attention‐deficit/hyperactivity disorder . Brain and Behavior 13:4.
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Hueng-Chuen Fan, Kuo-Liang Chiang, Kuang-Hsi Chang, Chuan-Mu Chen & Jeng-Dau Tsai. (2023) Epilepsy and Attention Deficit Hyperactivity Disorder: Connection, Chance, and Challenges. International Journal of Molecular Sciences 24:6, pages 5270.
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Stephen V. Faraone, Roberto Gomeni, Joseph T. Hull, Gregory D. Busse, Zare Melyan, Jonathan Rubin & Azmi Nasser. (2021) A post hoc analysis of the effect of viloxazine extended-release capsules on learning and school problems in children and adolescents with attention-deficit/hyperactivity disorder. European Child & Adolescent Psychiatry 32:3, pages 491-499.
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Alessio Bellato, John Perna, Preethi S. Ganapathy, Marco Solmi, Andrea Zampieri, Samuele Cortese & Stephen V. Faraone. (2022) Association between ADHD and vision problems. A systematic review and meta-analysis. Molecular Psychiatry 28:1, pages 410-422.
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Victoria A. Nazarova, Aleksandr V. Sokolov, Vladimir N. Chubarev, Vadim V. Tarasov & Helgi B. Schiöth. (2022) Treatment of ADHD: Drugs, psychological therapies, devices, complementary and alternative methods as well as the trends in clinical trials. Frontiers in Pharmacology 13.
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Azmi Nasser, Roberto Gomeni, Zhao Wang, Joseph T. Hull, Gregory D. Busse, Zare Melyan, Maurizio Fava, Welton O'Neal & Jonathan Rubin. (2022) The role of placebo response in the efficacy outcome assessment in viloxazine extended‐release pivotal trials in paediatric subjects with attention‐deficit/hyperactivity disorder. British Journal of Clinical Pharmacology 88:11, pages 4828-4838.
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Christopher L Robinson, Katelyn Parker, Saurabh Kataria, Evan Downs, Rajesh Supra, Alan D. Kaye, Omar Viswanath & Ivan Urits. (2022) Viloxazine for the Treatment of Attention Deficit Hyperactivity Disorder. Health Psychology Research 10:3.
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Xin-Peng Xu, Wei Wang, Song Wan & Chun-Feng Xiao. (2022) Convergence mechanism of mindfulness intervention in treating attention deficit hyperactivity disorder: Clues from current evidence. World Journal of Clinical Cases 10:26, pages 9219-9227.
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AK Chigome, JC Meyer & N Schellack. (2022) The management of attention-deficit hyperactivity disorder in children: updated 2022. South African General Practitioner 3:4, pages 121-131.
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Mohamed Adil Shah Khoodoruth, Sami Ouanes & Yasser Saeed Khan. (2022) A systematic review of the use of atomoxetine for management of comorbid anxiety disorders in children and adolescents with attention-deficit hyperactivity disorder. Research in Developmental Disabilities 128, pages 104275.
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Azmi Nasser, Joseph T. Hull, Soumya A. Chaturvedi, Tesfaye Liranso, Oyinkansola Odebo, Alisa R. Kosheleff, Nicholas Fry, Andrew J. Cutler, Jonathan Rubin, Stefan Schwabe & Ann Childress. (2022) A Phase III, Randomized, Double-Blind, Placebo-Controlled Trial Assessing the Efficacy and Safety of Viloxazine Extended-Release Capsules in Adults with Attention-Deficit/Hyperactivity Disorder. CNS Drugs 36:8, pages 897-915.
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Hannah W Haddad, Paul B. Hankey, Jimin Ko, Zahaan Eswani, Pravjit Bhatti, Amber N. Edinoff, Adam M. Kaye & Alan D. Kaye. (2022) Viloxazine, a Non-stimulant Norepinephrine Reuptake Inhibitor, for the Treatment of Attention Deficit Hyperactivity Disorder: A 3 Year Update. Health Psychology Research 10:2.
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Brayden Kameg. (2022) Viloxazine ER (Qelbree ® ): A New Non-Stimulant Option in the Treatment of Pediatric Attention-Deficit/Hyperactivity Disorder . Journal of Psychosocial Nursing and Mental Health Services 60:7, pages 7-9.
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Keith Mather & Michelle Condren. (2022) Extended-Release Viloxazine for Children and Adolescents With Attention Deficit Hyperactivity Disorder. The Journal of Pediatric Pharmacology and Therapeutics 27:5, pages 409-414.
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Andrew J. Cutler, Gregory W. Mattingly, Rakesh Jain & Welton O’Neal. (2020) Current and future nonstimulants in the treatment of pediatric ADHD: monoamine reuptake inhibitors, receptor modulators, and multimodal agents. CNS Spectrums 27:2, pages 199-207.
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Mahesh Kumar Balasundaram & Alok Singh. (2022) Viloxazine for attention-deficit hyperactivity disorder: a new formulation for a new indication. Drugs & Therapy Perspectives 38:2, pages 77-83.
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Alok Singh, Mahesh Kumar Balasundaram & Abhishek Singh. (2022) Viloxazine for Attention-Deficit Hyperactivity Disorder: A Systematic Review and Meta-analysis of Randomized Clinical Trials. Journal of Central Nervous System Disease 14, pages 117957352210925.
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Sabahat Hafeez, Javeria Saquib & Nazuk Eraj Qureshi. (2022) Viloxazine: A new miracle drug for attention deficit hyperactivity disorder (ADHD) or just another non-stimulant?. Asian Journal of Psychiatry 67, pages 102948.
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