397
Views
119
CrossRef citations to date
0
Altmetric
Review

Role of Wnt/β-catenin signaling in hepatocellular carcinoma, pathogenesis, and clinical significance

, , , , , , & show all
Pages 61-73 | Published online: 27 Jun 2018

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (12)

Giulia Francesca Manfredi, Ciro Celsa, Chloe John, Charlotte Jones, Nicole Acuti, Bernhard Scheiner, Claudia Angela Maria Fulgenzi, James Korolewicz, Matthias Pinter, Alessandra Gennari, Francesco A Mauri, Mario Pirisi, Rosalba Minisini, Federica Vincenzi, Michela Burlone, Cristina Rigamonti, Matteo Donadon, Giuseppe Cabibbo, Antonio D’Alessio & David James Pinato. (2023) Mechanisms of Resistance to Immunotherapy in Hepatocellular Carcinoma. Journal of Hepatocellular Carcinoma 10, pages 1955-1971.
Read now
Andressa Megumi Niwa, Simone Cristine Semprebon, Glaucia Fernanda Rocha D’Epiro, Lilian Areal Marques, Thalita Alves Zanetti & Mário Sérgio Mantovani. (2022) Salinomycin induces cell cycle arrest and apoptosis and modulates hepatic cytochrome P450 mRNA expression in HepG2/C3a cells. Toxicology Mechanisms and Methods 32:5, pages 341-351.
Read now
Xiaojiao Zhou, Liling Long, Zhiqing Mo & Yajuan Li. (2021) OATP1B3 Expression in Hepatocellular Carcinoma Correlates with Intralesional Gd-EOB-DTPA Uptake and Signal Intensity on Gd-EOB-DTPA-Enhanced MRI. Cancer Management and Research 13, pages 1169-1177.
Read now
Wei Fan, Lei Chen, Xiaojuan Wu & Tong Zhang. (2021) Circ_0031242 Silencing Mitigates the Progression and Drug Resistance in DDP-Resistant Hepatoma Cells by the miR-924/POU3F2 Axis. Cancer Management and Research 13, pages 743-755.
Read now
Kah Min Yap, Mahendran Sekar, Lay Jing Seow, Siew Hua Gan, Srinivasa Reddy Bonam, Nur Najihah Izzati Mat Rani, Pei Teng Lum, Vetriselvan Subramaniyan, Yuan Seng Wu, Neeraj Kumar Fuloria & Shivkanya Fuloria. (2021) Mangifera indica (Mango): A Promising Medicinal Plant for Breast Cancer Therapy and Understanding Its Potential Mechanisms of Action. Breast Cancer: Targets and Therapy 13, pages 471-503.
Read now
Hara Afaloniati, Katerina Angelopoulou, Alexander Giakoustidis, Alexandros Hardas, Athanasios Pseftogas, Kali Makedou, Athanasios Gargavanis, Thomas Goulopoulos, Stavros Iliadis, Vasileios Papadopoulos, Apostolos Papalois, George Mosialos, Theofilos Poutahidis & Dimitrios Giakoustidis. (2020) HDAC1/2 Inhibitor Romidepsin Suppresses DEN-Induced Hepatocellular Carcinogenesis in Mice. OncoTargets and Therapy 13, pages 5575-5588.
Read now
Tong Liu, Sainan Li, Liwei Wu, Qiang Yu, Jingjing Li, Jiao Feng, Jie Zhang, Jiaojiao Chen, Yuting Zhou, Jie Ji, Kan Chen, Yuqing Mao, Fan Wang, Weiqi Dai, Xiaoming Fan, Jianye Wu & Chuanyong Guo. (2020) Experimental Study of Hepatocellular Carcinoma Treatment by Shikonin Through Regulating PKM2. Journal of Hepatocellular Carcinoma 7, pages 19-31.
Read now
Xiaolan Wen, Yanling Wu, Annoor Awadasseid, Yoshimasa Tanaka & Wen Zhang. (2020) New Advances in Canonical Wnt/β-Catenin Signaling in Cancer. Cancer Management and Research 12, pages 6987-6998.
Read now
Andrea Casadei-Gardini, Orsi Giulia, Caputo Francesco & Ercolani Giorgio. (2020) Developments in predictive biomarkers for hepatocellular carcinoma therapy. Expert Review of Anticancer Therapy 20:1, pages 63-74.
Read now
Malwina Sosnowska, Marta Kutwin, Sławomir Jaworski, Barbara Strojny, Mateusz Wierzbicki, Jarosław Szczepaniak, Maciej Łojkowski, Wojciech Święszkowski, Jaśmina Bałaban, André Chwalibog & Ewa Sawosz. (2019) Mechano-signalling, induced by fullerene C60 nanofilms, arrests the cell cycle in the G2/M phase and decreases proliferation of liver cancer cells. International Journal of Nanomedicine 14, pages 6197-6215.
Read now

Articles from other publishers (107)

Bing Liu, Chenggang Li, Jun Han, Yongliang Chen, Zhiming Zhao & Hongwei Lu. (2023) Biosynthesized gold nanoparticles using leaf extract of Citrus medica inhibit hepatocellular carcinoma through regulation of the Wnt/β-catenin signaling pathway. Arabian Journal of Chemistry 16:8, pages 104800.
Crossref
Min Yao, Jian-Jun Wang, Xi-Yu Chen, Wen-Li Sai, Jie Yang, De-Feng Wang, Li Wang & Deng-Fu Yao. (2023) Oncogenic Wnt3a is a promising sensitive biomarker for monitoring hepatocarcinogenesis. Hepatobiliary & Pancreatic Diseases International 22:3, pages 263-269.
Crossref
Teppei Sakoda, Yoshikane Kikushige, Toshihiro Miyamoto, Hidetoshi Irifune, Takuya Harada, Kiwamu Hatakeyama, Yuya Kunisaki, Koji Kato & Koichi Akashi. (2023) TIM-3 signaling hijacks the canonical Wnt/β-catenin pathway to maintain cancer stemness in acute myeloid leukemia. Blood Advances 7:10, pages 2053-2065.
Crossref
Aqsa Nazir, Muhammad Aqib & Muhammad Usman. 2023. Liver Cancer - Genesis, Progression and Metastasis. Liver Cancer - Genesis, Progression and Metastasis.
Mohammad Jaber MasodKhooy, Massoumeh Farasat, Mohamadreza Salehi Salmi & Hamed Mirzaei. (2023) Combinatorial treatment with Silybum marianum essential oil enhances the therapeutic efficacy of a 5‐fluorouracil base therapy for hepatocellular carcinoma . Phytotherapy Research 37:5, pages 1968-1985.
Crossref
Nives Pećina-Šlaus, Sara Aničić, Anja Bukovac & Anja Kafka. (2023) Wnt Signaling Inhibitors and Their Promising Role in Tumor Treatment. International Journal of Molecular Sciences 24:7, pages 6733.
Crossref
Nourhan Badwei. (2023) Hepatocellular Carcinoma Gene Expression: The New Era, Where It goes?. iLIVER 2:1, pages 36-40.
Crossref
Sergio Salgüero, Óscar Brochado-Kith, Ana Virseda Verdices, Juan Berenguer, Juan González-García, Isidoro Martínez, Cristina Díez, Víctor Hontañón, Leire Pérez-Latorre, Amanda Fernández-Rodríguez, María Ángeles Jiménez-Sousa & Salvador Resino. (2023) PBMCs gene expression signature of advanced cirrhosis with high risk for clinically significant portal hypertension in HIV/HCV coinfected patients: A cross-control study. Biomedicine & Pharmacotherapy 159, pages 114220.
Crossref
Anum Syyam, Hira Raheem Akbar, Zuzana Macek Jilkova & Samia Afzal. (2023) Role of Genetic and Epigenetic Modifications in the Progression of Hepatocellular Carcinoma in Chronic HCV Patients. Livers 3:1, pages 82-92.
Crossref
Jihane N. Benhammou, Jim Sinnett-Smith, Joseph R. Pisegna & Enrique J. Rozengurt. (2023) Interplay Between Fatty Acids, Stearoyl-Co-A Desaturase, Mechanistic Target of Rapamycin, and Yes-Associated Protein/Transcriptional Coactivator With PDZ-Binding Motif in Promoting Hepatocellular Carcinoma. Gastro Hep Advances 2:2, pages 232-241.
Crossref
Deniz Tümen, Philipp Heumann, Karsten Gülow, Cagla-Nur Demirci, Lidia-Sabina Cosma, Martina Müller & Arne Kandulski. (2022) Pathogenesis and Current Treatment Strategies of Hepatocellular Carcinoma. Biomedicines 10:12, pages 3202.
Crossref
Emma Hymel, Kurt W. Fisher & Paraskevi A. Farazi. (2022) Differential methylation patterns in lean and obese non-alcoholic steatohepatitis-associated hepatocellular carcinoma. BMC Cancer 22:1.
Crossref
Thanh Hai Phan, Van Thien Chi Nguyen, Thu Thuy Thi Pham, Van-Chu Nguyen, Tan Dat Ho, Thi Mong Quynh Pham, Thanh-Huong Tran, Thanh Dat Nguyen, Nguyen Duy Khang Le, Trong-Hieu Nguyen, Minh-Long Duong, Hoai-Phuong Thi Bach, Van-Vu Kim, The-Anh Pham, Bao Toan Nguyen, Thanh Nhan Vo Nguyen, Thanh Dang Nguyen, Dung Thai Bieu Phu, Boi Hoan Huu Phan, Duy-Sinh Nguyen, Dinh-Kiet Truong, Thanh-Thuy Thi Do, Hoa Giang, Hoai-Nghia Nguyen, Minh-Duy Phan & Le Son Tran. (2022) Circulating DNA methylation profile improves the accuracy of serum biomarkers for the detection of nonmetastatic hepatocellular carcinoma. Future Oncology 18:39, pages 4399-4413.
Crossref
Marwa A. Abdel-Wahed, Eman Mohamed Abdel Rahman Amer, Ramy Mohamed Mahmoud, Iman Fawzy Montasser, Yassmin M. Massoud, Perihan Hamdy & Safeya Hamdy Zakaria Hassan. (2022) CTNNB1 polymorphism (rs121913407) in circulating tumor DNA (ctDNA) in Egyptian hepatocellular carcinoma patients. Egyptian Liver Journal 12:1.
Crossref
Naela Adel Mohammed Saleh, Rowan Bahaa El-din Abd El-bary, Eric Zadok Mpingirika, Hanaa L. Essa, Mayyada M. H. El-Sayed, Mirna Sarkis Sherbetjian, Hanin Fadel Elfandi, Muhammad Adel Abdel Wahed, Rami Arafeh & Asma Amleh. (2022) Evaluating the Potential Anticancer Properties of Salvia triloba in Human-Osteosarcoma U2OS Cell Line and Ovarian Adenocarcinoma SKOV3 Cell Line. Applied Sciences 12:22, pages 11545.
Crossref
Rainbow Wing Hei Leung & Terence Kin Wah Lee. (2022) Wnt/β-Catenin Signaling as a Driver of Stemness and Metabolic Reprogramming in Hepatocellular Carcinoma. Cancers 14:21, pages 5468.
Crossref
Srinivas Reddy Pallerla, Nghiem Xuan Hoan, Sivaramakrishna Rachakonda, Christian G. Meyer, Hoang Van Tong, Nguyen Linh Toan, Le Thi Kieu Linh, Dao Phuong Giang, Peter G. Kremsner, Mai Hong Bang, Le Huu Song & Thirumalaisamy P. Velavan. (2022) Custom gene expression panel for evaluation of potential molecular markers in hepatocellular carcinoma. BMC Medical Genomics 15:1.
Crossref
Priyadarshini Mohapatra & Natarajan Chandrasekaran. (2022) Wnt/β-catenin targeting in liver carcinoma through nanotechnology-based drug repurposing: A review. Biomedicine & Pharmacotherapy 155, pages 113713.
Crossref
Ishfaq Hassan Mir, K. C. Jyothi & Chinnasamy Thirunavukkarasu. (2021) The prominence of potential biomarkers in the diagnosis and management of hepatocellular carcinoma: Current scenario and future anticipation. Journal of Cellular Biochemistry 123:10, pages 1607-1623.
Crossref
Ki-Fong Man & Stephanie Ma. (2022) Mechanisms of resistance to tyrosine kinase inhibitors in liver cancer stem cells and potential therapeutic approaches. Essays in Biochemistry 66:4, pages 371-386.
Crossref
Fuzhen Dai, Wenlong Chen, Huirong Li, Rubing Deng, Yong Wang & Jie Yang. (2022) Research on mechanism of curcumin carried with PLGA-DSPE-PEG hybridized nanoparticles on regulating the nuclear receptor coactivator5 presentation, oxidative stress and presentation of alfa-fetoprotein in rats with liver cancer. Materials Express 12:9, pages 1203-1210.
Crossref
Monica A. Kamal, Yasmine M. Mandour, Mostafa K. Abd El-Aziz, Ulrike Stein & Hend M. El Tayebi. (2022) Small Molecule Inhibitors for Hepatocellular Carcinoma: Advances and Challenges. Molecules 27:17, pages 5537.
Crossref
Filip Ambrozkiewicz, Andriy Trailin, Lenka Červenková, Radka Vaclavikova, Vojtech Hanicinec, Mohammad Al Obeed Allah, Richard Palek, Vladislav Třeška, Ondrej Daum, Zbyněk Tonar, Václav Liška & Kari Hemminki. (2022) CTNNB1 mutations, TERT polymorphism and CD8+ cell densities in resected hepatocellular carcinoma are associated with longer time to recurrence. BMC Cancer 22:1.
Crossref
Xingzhong Yuan, Li Zhu, Yue Wang, Tian Zhang, Ying Jin, Yangsong Li, Mengting Zeng & Guodong Yu. (2022) Liposome Nanoparticles Carrying miR-22 Suppress Proliferation, Invasion and Epithelial–Mesenchymal Transition (EMT) of Laryngeal Squamous Cell Carcinoma by Targeting Wingless-Related Integration Site (WNT) Pathway. Journal of Biomedical Nanotechnology 18:8, pages 1913-1921.
Crossref
Shaikh Maryam Ghufran, Sachin Sharma, Sampa Ghose & Subhrajit Biswas. (2022) Context dependent role of p53 during the interaction of hepatocellular carcinoma and endothelial cells. Microvascular Research 142, pages 104374.
Crossref
Kwang-Hoon Chun. (2022) Molecular Targets and Signaling Pathways of microRNA-122 in Hepatocellular Carcinoma. Pharmaceutics 14:7, pages 1380.
Crossref
Meritxell Perramón & Wladimiro Jiménez. (2022) Pituitary Tumor-Transforming Gene 1/Delta like Non-Canonical Notch Ligand 1 Signaling in Chronic Liver Diseases. International Journal of Molecular Sciences 23:13, pages 6897.
Crossref
Ting Li, Lei Guan, Guangbo Tang, Bing He, Lili Huang, Juan Wang, Mingyue Li, Yanxia Bai, Xinyuan Li & Huqin Zhang. (2021) Downregulation of TMEM220 promotes tumor progression in Hepatocellular Carcinoma. Cancer Gene Therapy 29:6, pages 835-844.
Crossref
Kurt Sartorius, Samuel O. Antwi, Anil Chuturgoon, Lewis R. Roberts & Anna Kramvis. (2022) RNA Therapeutic Options to Manage Aberrant Signaling Pathways in Hepatocellular Carcinoma: Dream or Reality?. Frontiers in Oncology 12.
Crossref
Reem Mebed, Yasser BM Ali, Nahla Shehata, Nahla Gamal, Nadia El-Guendy, Abdel-Rahman Zekri & Salwa Sabet. (2022) Combining Bevacizumab with Knocked-Down β-Catenin Reduces VEGF-A and Slug mRNA in HepG2 but not in Caco-2 Cell Lines. Current Molecular Medicine 22:4, pages 374-383.
Crossref
Eman M.M. Shehata, Mennatallah A. Gowayed, Samar O. El-Ganainy, Eman Sheta, Yosra S.R. Elnaggar & Ossama Y. Abdallah. (2022) Pectin coated nanostructured lipid carriers for targeted piperine delivery to hepatocellular carcinoma. International Journal of Pharmaceutics 619, pages 121712.
Crossref
Umaira Zakir, Nadir Naveed Siddiqui, Faizan-ul-Hassan Naqvi & Rizma Khan. (2022) Aberrant STAT1 methylation as a non-invasive biomarker in blood of HCV induced hepatocellular carcinoma. Cancer Biomarkers 34:1, pages 95-103.
Crossref
Hyunjung Park, Hyerin Park, Jiyeon Baek, Hyuk Moon & Simon Weonsang Ro. (2022) Target Therapy for Hepatocellular Carcinoma: Beyond Receptor Tyrosine Kinase Inhibitors and Immune Checkpoint Inhibitors. Biology 11:4, pages 585.
Crossref
Al Shaima G. Abd El Salam, Yara A. Samra & Mamdouh M. El-Shishtawy. (2022) Cinnamaldehyde Relieves Induced Hepatocellular Carcinoma in Rat Model via Targeting Wnt/β-Catenin Pathway. Scientia Pharmaceutica 90:2, pages 22.
Crossref
Yating Xu, Xiao Yu, Zongzong Sun, Yuting He & Wenzhi Guo. (2022) Roles of lncRNAs Mediating Wnt/β-Catenin Signaling in HCC. Frontiers in Oncology 12.
Crossref
Prarambh S.R. Dwivedi, Vishal S. Patil, Pukar Khanal, Vishwambhar V. Bhandare, Shailendra Gurav, Darasaguppe R. Harish, B.M. Patil & Subarna Roy. (2022) System biology-based investigation of Silymarin to trace hepatoprotective effect. Computers in Biology and Medicine 142, pages 105223.
Crossref
Chuanrui Xu, Zhong Xu, Yi Zhang, Matthias Evert, Diego F. Calvisi & Xin Chen. (2022) β-Catenin signaling in hepatocellular carcinoma. Journal of Clinical Investigation 132:4.
Crossref
Liang Peng, Rong Ye, Xiansen Zhu, Yuankang Xie, Baiyin Zhong, Yao Liu, Heping Li & Binhui Xie. (2022) LINC02273 Promotes Hepatocellular Carcinoma Progression via Retaining β-Catenin in the Nucleus to Augment Wnt Signaling. BioMed Research International 2022, pages 1-9.
Crossref
Marie Dupuy, Sarah Iltache, Benjamin Rivière, Alexandre Prieur, George Philippe Pageaux, José Ursic Bedoya, Stéphanie Faure, Heloïse Guillaumée & Eric Assenat. (2022) Plasma hPG80 (Circulating Progastrin) as a Novel Prognostic Biomarker for Hepatocellular Carcinoma. Cancers 14:2, pages 402.
Crossref
Nuno Jorge Lamas, Arnaud Martel, Sacha Nahon-Estève, Samantha Goffinet, Adam Macocco, Corine Bertolotto, Sandra Lassalle & Paul Hofman. (2021) Prognostic Biomarkers in Uveal Melanoma: The Status Quo, Recent Advances and Future Directions. Cancers 14:1, pages 96.
Crossref
Rongcai Yue, Haiping Liu, Yaxin Huang, Jing Wang, Dongmei Shi, Yanping Su, Yufei Luo, Ping Cai, Guilin Jin & Changxi Yu. (2021) Sempervirine Inhibits Proliferation and Promotes Apoptosis by Regulating Wnt/β-Catenin Pathway in Human Hepatocellular Carcinoma. Frontiers in Pharmacology 12.
Crossref
Xin Qing, Wenjing Xu, Jingjing Zong, Xuanlong Du, Hao Peng & Yewei Zhang. (2021) Emerging treatment modalities for systemic therapy in hepatocellular carcinoma. Biomarker Research 9:1.
Crossref
Oğuzhan Karaosmanoğlu. (2021) Axin1 translocates into the nucleus in hepatocyte growth factor induced epithelial-mesenchymal transition. Gene Reports 25, pages 101307.
Crossref
Mohammed M.H. Al-Gayyar, Abdullah Alattar, Reem Alshaman & Ahmed M. Hamdan. (2021) QNZ alleviated hepatocellular carcinoma by targeting inflammatory pathways in a rat model. Cytokine 148, pages 155710.
Crossref
Jeong-Su Park, Hwan Ma & Yoon-Seok Roh. (2021) Ubiquitin pathways regulate the pathogenesis of chronic liver disease. Biochemical Pharmacology 193, pages 114764.
Crossref
Sara Muhammad El-Hanboshy, Maged Wasfy Helmy & Mohammad Mahmoud Abd-Alhaseeb. (2021) Catalpol synergistically potentiates the anti-tumour effects of regorafenib against hepatocellular carcinoma via dual inhibition of PI3K/Akt/mTOR/NF-κB and VEGF/VEGFR2 signaling pathways. Molecular Biology Reports 48:11, pages 7233-7242.
Crossref
Pratibha Pandey, Fahad Khan, Huda A. Qari & Mohammad Oves. (2021) Rutin (Bioflavonoid) as Cell Signaling Pathway Modulator: Prospects in Treatment and Chemoprevention. Pharmaceuticals 14:11, pages 1069.
Crossref
Nur Rahadiani, Ignasia Andhini Retnowulan, Marini Stephanie, Diah Rini Handjari & Ening Krisnuhoni. (2021) β-Catenin Expression and Its Association with Prognostic Factors in Hepatocellular Carcinoma: A Study on Alpha-fetoprotein, Histologic Grade, and Microvascular Invasion. Open Access Macedonian Journal of Medical Sciences 9:A, pages 887-893.
Crossref
Ivana Samaržija. (2021) Wnt Signaling Pathway Is among the Drivers of Liver Metastasis. Livers 1:4, pages 180-200.
Crossref
Ayman S. Bannaga, Rocio Alvarez, Lisa Zhou, Michael Petchey, Angela Noufaily, Megan P. Hitchins & Ramesh P. Arasaradnam. (2021) Role of methylated septin 9 as an adjunct diagnostic and prognostic biomarker in hepatocellular carcinoma. HPB 23:10, pages 1595-1606.
Crossref
Shi Wei, Miaomiao Dai, Chi Zhang, Kai Teng, Fengwei Wang, Hongbo Li, Weipeng Sun, Zihao Feng, Tiebang Kang, Xinyuan Guan, Ruihua Xu, Muyan Cai & Dan Xie. (2020) KIF2C: a novel link between Wnt/β-catenin and mTORC1 signaling in the pathogenesis of hepatocellular carcinoma. Protein & Cell 12:10, pages 788-809.
Crossref
Minzhen Qin, Yiliang Meng, Chunying Luo, Shougao He, Fengxue Qin, Yixia Yin, Junling Huang, Hailiang Zhao, Jing Hu, Zhihua Deng, Yiying Qiu, Gaoyu Hu, Hanhe Pan, Zongshuai Qin, Zansong Huang & Tingzhuang Yi. (2021) lncRNA PRR34-AS1 promotes HCC development via modulating Wnt/β-catenin pathway by absorbing miR-296-5p and upregulating E2F2 and SOX12. Molecular Therapy - Nucleic Acids 25, pages 37-52.
Crossref
Srishti Kotiyal & Kimberley Jane Evason. (2021) Exploring the Interplay of Telomerase Reverse Transcriptase and β-Catenin in Hepatocellular Carcinoma. Cancers 13:16, pages 4202.
Crossref
Jie Zhang, Sujie Zhang, Xiaoyan Li, Fan Zhang & Lei Zhao. (2021) HOXB5 promotes the progression of breast cancer through wnt/beta-catenin pathway. Pathology - Research and Practice 224, pages 153117.
Crossref
Alexandru Blidisel, Iasmina Marcovici, Dorina Coricovac, Florin Hut, Cristina Adriana Dehelean & Octavian Marius Cretu. (2021) Experimental Models of Hepatocellular Carcinoma—A Preclinical Perspective. Cancers 13:15, pages 3651.
Crossref
Gulsum Ozlem Elpek. (2021) Molecular pathways in viral hepatitis-associated liver carcinogenesis: An update. World Journal of Clinical Cases 9:19, pages 4890-4917.
Crossref
Yang Zhou, Xun Liu, Yahan Gao, Rulan Tan, Zhiyuan Wu, Qixin Zhong & Feng Zeng. (2021) Paeoniflorin Affects Hepatocellular Carcinoma Progression by Inhibiting Wnt/β-Catenin Pathway through Downregulation of 5-HT1D. Current Pharmaceutical Biotechnology 22:9, pages 1246-1253.
Crossref
Wenrui Ye, Stefan Siwko & Robert Y. L. Tsai. (2021) Sex and Race-Related DNA Methylation Changes in Hepatocellular Carcinoma. International Journal of Molecular Sciences 22:8, pages 3820.
Crossref
Magdelyn Mei-Theng Wong, Hui-Yin Chan, Norazlin Abdul Aziz, Thamil Selvee Ramasamy, Jan-Jin Bong, Ewe Seng Ch’ng, Subasri Armon, Suat-Cheng Peh & Sin-Yeang Teow. (2021) Interplay of autophagy and cancer stem cells in hepatocellular carcinoma. Molecular Biology Reports 48:4, pages 3695-3717.
Crossref
Chrystelle L Vilfranc, Li-Xiao Che, Krushna C Patra, Liang Niu, Olugbenga Olowokure, Jiang Wang, Shimul A Shah & Chun-Ying Du. (2021) Baculovirus repeat-containing ubiquitin conjugating enzyme regulation of β-catenin signaling in the progression of drug-induced hepatic fibrosis and carcinogenesis. World Journal of Hepatology 13:3, pages 343-361.
Crossref
Gabriela Perdomo CORAL, Fernanda BRANCO, Rosalva MEURER, Patrícia dos Santos MARCON, Paulo Roberto Ott FONTES & Angelo Alves de MATTOS. (2021) RESULTS OF IMMUNOHISTOCHEMISTRY IN THE DIFFERENTIAL DIAGNOSIS OF EARLY HEPATOCELLULAR CARCINOMA AND NODULES WITH HIGH-GRADE DYSPLASIA IN PATIENTS WITH CIRRHOSIS. Arquivos de Gastroenterologia 58:1, pages 82-86.
Crossref
Hanan M. Hassan, Sherif M H El-Kannishy, Abdullah Alattar, Reem Alshaman, Ahmed M Hamdan & Mohammed M H Al-Gayyar. (2021) Therapeutic effects of blocking β-catenin against hepatocellular carcinoma-induced activation of inflammation, fibrosis and tumor invasion. Biomedicine & Pharmacotherapy 135, pages 111216.
Crossref
Marina Galicia-Moreno, Jorge A Silva-Gomez, Silvia Lucano-Landeros, Arturo Santos, Hugo C Monroy-Ramirez & Juan Armendariz-Borunda. (2021) Liver Cancer: Therapeutic Challenges and the Importance of Experimental Models. Canadian Journal of Gastroenterology and Hepatology 2021, pages 1-10.
Crossref
Michal Caspi, Amnon Wittenstein, Michal Kazelnik, Yarden Shor-Nareznoy & Rina Rosin-Arbesfeld. (2021) Therapeutic targeting of the oncogenic Wnt signaling pathway for treating colorectal cancer and other colonic disorders. Advanced Drug Delivery Reviews 169, pages 118-136.
Crossref
Yagmur Azbazdar, Mustafa Karabicici, Esra Erdal & Gunes Ozhan. (2021) Regulation of Wnt Signaling Pathways at the Plasma Membrane and Their Misregulation in Cancer. Frontiers in Cell and Developmental Biology 9.
Crossref
Asmaa G. Abdou, Nanis S. Holah, Dina S. Elazab, Walaa G. El-Gendy, Mohammed T. Badr & Dalia R. Al-Sharaky. (2021) Hepatocellular Carcinoma Score and Subclassification Into Aggressive Subtypes Using Immunohistochemical Expression of p53, β-Catenin, CD133, and Ki-67. Applied Immunohistochemistry & Molecular Morphology 29:1, pages 20-33.
Crossref
Moon Jong Kim, Yuanjian Huang & Jae-Il Park. (2020) Targeting Wnt Signaling for Gastrointestinal Cancer Therapy: Present and Evolving Views. Cancers 12:12, pages 3638.
Crossref
Davod Javanmard, Mohammad Najafi, Mohammad Reza Babaei, Mohammad Hadi Karbalaie Niya, Maryam Esghaei, Mahshid Panahi, Fahimeh Safarnezhad Tameshkel, Ahmad Tavakoli, Seyed Mohammad Jazayeri, Hadi Ghaffari, Angila Ataei-Pirkooh, Seyed Hamidreaz Monavari & Farah Bokharaei-Salim. (2020) Investigation of CTNNB1 gene mutations and expression in hepatocellular carcinoma and cirrhosis in association with hepatitis B virus infection. Infectious Agents and Cancer 15:1.
Crossref
Shuai He & Shilei Tang. (2020) WNT/β-catenin signaling in the development of liver cancers. Biomedicine & Pharmacotherapy 132, pages 110851.
Crossref
Nia Adeniji & Renumathy Dhanasekaran. (2020) Genomic Landscape of HCC. Current Hepatology Reports 19:4, pages 448-461.
Crossref
Xiaoguang Chen, Xuemin Zhu, Zhiguo Wei & Qiongxia Lv. (2021) Identification and Differential Expression of microRNA in Response to Elevated Phospholipase Cγ Expression in Liver RH 35 Carcinoma Cells. Cytology and Genetics 54:6, pages 555-565.
Crossref
Menna S. Zeyada, Noha Abdel-Rahman, Amro El-Karef, Sarah Yahia, Ibrahim M. El-Sherbiny & Laila A. Eissa. (2020) Niclosamide-loaded polymeric micelles ameliorate hepatocellular carcinoma in vivo through targeting Wnt and Notch pathways. Life Sciences 261, pages 118458.
Crossref
Abdul Q Khan, Khalid Rashid, Abdulhadi A AlAmodi, Syed Shadab Raza & Shahab Uddin. (2020) Recent developments in unraveling signaling mechanisms underlying drug resistance due to cancer stem-like cells. Current Opinion in Pharmacology 54, pages 130-141.
Crossref
Hamzeh Karimkhanloo, Samira Mohammadi-Yeganeh, Razie Hadavi, Ameneh Koochaki & Mahdi Paryan. (2020) Potential role of miR-214 in β-catenin gene expression within hepatocellular carcinoma. Molecular Biology Reports 47:10, pages 7429-7437.
Crossref
Leonard Kaps & Detlef Schuppan. (2020) Targeting Cancer Associated Fibroblasts in Liver Fibrosis and Liver Cancer Using Nanocarriers. Cells 9:9, pages 2027.
Crossref
Jakob Nikolas Kather, Lara R. Heij, Heike I. Grabsch, Chiara Loeffler, Amelie Echle, Hannah Sophie Muti, Jeremias Krause, Jan M. Niehues, Kai A. J. Sommer, Peter Bankhead, Loes F. S. Kooreman, Jefree J. Schulte, Nicole A. Cipriani, Roman D. Buelow, Peter Boor, Nadina Ortiz-Brüchle, Andrew M. Hanby, Valerie Speirs, Sara Kochanny, Akash Patnaik, Andrew Srisuwananukorn, Hermann Brenner, Michael Hoffmeister, Piet A. van den Brandt, Dirk Jäger, Christian Trautwein, Alexander T. Pearson & Tom Luedde. (2020) Pan-cancer image-based detection of clinically actionable genetic alterations. Nature Cancer 1:8, pages 789-799.
Crossref
Tapas Patra, Keith Meyer, Ratna B. Ray & Ranjit Ray. (2020) A combination of AZD5363 and FH5363 induces lethal autophagy in transformed hepatocytes. Cell Death & Disease 11:7.
Crossref
Anna Gajos-Michniewicz & Malgorzata Czyz. (2020) WNT Signaling in Melanoma. International Journal of Molecular Sciences 21:14, pages 4852.
Crossref
So Mee Kwon, Young-Kyoung Lee, Seongki Min, Hyun Goo Woo, Hee Jung Wang & Gyesoon Yoon. (2020) Mitoribosome Defect in Hepatocellular Carcinoma Promotes an Aggressive Phenotype with Suppressed Immune Reaction. iScience 23:6, pages 101247.
Crossref
Junki Maehara, Yohei Masugi, Tokiya Abe, Hanako Tsujikawa, Yutaka Kurebayashi, Akihisa Ueno, Hidenori Ojima, Shigeo Okuda, Masahiro Jinzaki, Masahiro Shinoda, Yuko Kitagawa, Yoshinao Oda, Hiroshi Honda & Michiie Sakamoto. (2020) Quantification of intratumoral collagen and elastin fibers within hepatocellular carcinoma tissues finds correlations with clinico‐patho‐radiological features. Hepatology Research 50:5, pages 607-619.
Crossref
Nicole Huge, Maria Sandbothe, Anna K. Schröder, Amelie Stalke, Marlies Eilers, Vera Schäffer, Brigitte Schlegelberger, Thomas Illig, Beate Vajen & Britta Skawran. (2019) Wnt status-dependent oncogenic role of BCL9 and BCL9L in hepatocellular carcinoma. Hepatology International 14:3, pages 373-384.
Crossref
Kaku Goto, Armando Andres Roca Suarez, Florian Wrensch, Thomas F. Baumert & Joachim Lupberger. (2020) Hepatitis C Virus and Hepatocellular Carcinoma: When the Host Loses Its Grip. International Journal of Molecular Sciences 21:9, pages 3057.
Crossref
Norihiko YamamotoAkiko EguchiYoshifumi HirokawaSuguru OguraKazushi SugimotoMotoh IwasaMasatoshi WatanabeYoshiyuki Takei. (2020) Expression Pattern of Plexin Domain Containing 2 in Human Hepatocellular Carcinoma. Monoclonal Antibodies in Immunodiagnosis and Immunotherapy 39:2, pages 57-60.
Crossref
Linsong Tang, Ronggao Chen & Xiao Xu. (2020) Synthetic lethality: A promising therapeutic strategy for hepatocellular carcinoma. Cancer Letters 476, pages 120-128.
Crossref
Bo Hu, Jian‐Zhen Lin, Xiao‐Bo Yang & Xin‐Ting Sang. (2020) Aberrant lipid metabolism in hepatocellular carcinoma cells as well as immune microenvironment: A review. Cell Proliferation 53:3.
Crossref
Jihye Choi, Sae Bom Won & Young Hye Kwon. (2020) Maternal Consumption of a Low-Isoflavone Soy Protein Isolate Diet Accelerates Chemically Induced Hepatic Carcinogenesis in Male Rat Offspring. Nutrients 12:2, pages 571.
Crossref
Guang-Cong Zhang, Xiang-Nan Yu, Jia-Lei Sun, Ju Xiong, Yi-Jun Yang, Xue-Mei Jiang & Ji-Min Zhu. (2020) UBE2M promotes cell proliferation via the β-catenin/cyclin D1 signaling in hepatocellular carcinoma. Aging 12:3, pages 2373-2392.
Crossref
Sara Sergio, Addolorata Maria Luce Coluccia, Enrico Domenico Lemma, Barbara Spagnolo, Daniele Vergara, Michele Maffia, Massimo De Vittorio & Ferruccio Pisanello. (2020) 3D-microenvironments initiate TCF4 expression rescuing nuclear β-catenin activity in MCF-7 breast cancer cells. Acta Biomaterialia 103, pages 153-164.
Crossref
Yen-Lin Chen, I-Chuan Yen, Kuen-Tze Lin, Feng-Yi Lai & Shih-Yu Lee. (2020) 4-Acetylantrocamol LT3, a New Ubiquinone from Antrodia cinnamomea , Inhibits Hepatocellular Carcinoma HepG2 Cell Growth by Targeting YAP/TAZ, mTOR, and WNT/β-Catenin Signaling . The American Journal of Chinese Medicine 48:05, pages 1243-1261.
Crossref
Alessia Virzì, Armando Andres Roca Suarez, Thomas F. Baumert & Joachim Lupberger. (2020) Rewiring Host Signaling: Hepatitis C Virus in Liver Pathogenesis. Cold Spring Harbor Perspectives in Medicine 10:1, pages a037366.
Crossref
Jing-Yuan Li, Kang-Kang Ren, Wen-Jie Zhang, Ling Xiao, Han-You Wu, Qian-Yu Liu, Ting Ding, Xiang-Cheng Zhang, Wen-Jia Nie, Yu Ke, Ke-Yu Deng, Quan-Wen Liu & Hong-Bo Xin. (2019) Human amniotic mesenchymal stem cells and their paracrine factors promote wound healing by inhibiting heat stress-induced skin cell apoptosis and enhancing their proliferation through activating PI3K/AKT signaling pathway. Stem Cell Research & Therapy 10:1.
Crossref
Kai Teng, Shi Wei, Chi Zhang, Jiewei Chen, Jinbin Chen, Kanghua Xiao, Jun Liu, Miaomiao Dai, Xinyuan Guan, Jingping Yun & Dan Xie. (2019) KIFC1 is activated by TCF-4 and promotes hepatocellular carcinoma pathogenesis by regulating HMGA1 transcriptional activity. Journal of Experimental & Clinical Cancer Research 38:1.
Crossref
Yu Qiao, Jingxiao Wang, Eylul Karagoz, Binyong Liang, Xinhua Song, Runze Shang, Katja Evert, Meng Xu, Li Che, Matthias Evert, Diego F. Calvisi, Junyan Tao, Bruce Wang, Satdarshan P. Monga & Xin Chen. (2019) Axis inhibition protein 1 (Axin1) Deletion–Induced Hepatocarcinogenesis Requires Intact β‐Catenin but Not Notch Cascade in Mice. Hepatology 70:6, pages 2003-2017.
Crossref
Baharan Fekry, Aleix Ribas-Latre, Corrine Baumgartner, Alaa M.T. Mohamed, Mikhail G. Kolonin, Frances M. Sladek, Mamoun Younes & Kristin L. Eckel-Mahan. (2019) HNF4α-Deficient Fatty Liver Provides a Permissive Environment for Sex-Independent Hepatocellular Carcinoma. Cancer Research 79:22, pages 5860-5873.
Crossref
Chun Chen, Zhe Yang & Zan-Song Huang. (2019) Progress in research on association between cell signal transduction pathways and hepatocellular carcinoma. World Chinese Journal of Digestology 27:21, pages 1330-1338.
Crossref
Weiqi Zhang, Jennifer Meyfeldt, Huabo Wang, Sucheta Kulkarni, Jie Lu, Jordan A. Mandel, Brady Marburger, Ying Liu, Joanna E. Gorka, Sarangarajan Ranganathan & Edward V. Prochownik. (2019) β-Catenin mutations as determinants of hepatoblastoma phenotypes in mice. Journal of Biological Chemistry 294:46, pages 17524-17542.
Crossref
Rodrigo Carlessi, Julia Köhn-Gaone, John K. Olynyk & Janina E. E. Tirnitz-Parker. 2019. Hepatocellular Carcinoma. Hepatocellular Carcinoma 69 94 .
Maha Fezza, Mayssam Moussa, Rita Aoun, Rita Haber & George Hilal. (2019) DKK1 promotes hepatocellular carcinoma inflammation, migration and invasion: Implication of TGF-β1. PLOS ONE 14:9, pages e0223252.
Crossref
Zhong-Liang Su, Chien-Wei Su, Yi-Luen Huang, Wan-Yu Yang, Bonifasius Putera Sampurna, Toru Ouchi, Kuan-Lin Lee, Chen-Sheng Wu, Horng-Dar Wang & Chiou-Hwa Yuh. (2019) A Novel AURKA Mutant-Induced Early-Onset Severe Hepatocarcinogenesis Greater than Wild-Type via Activating Different Pathways in Zebrafish. Cancers 11:7, pages 927.
Crossref
Xiaoxia Tan, Lihua Jiang, Xia Wu, Wen Feng & Qingfang Lin. (2019) MicroRNA-625 inhibits the progression of non‑small cell lung cancer by directly targeting HOXB5 and deactivating the Wnt/β-catenin pathway. International Journal of Molecular Medicine.
Crossref
Diego Almanza, Mehrnaz Gharaee-Kermani, Alisa Zhilin-Roth, Jose A. Rodriguez-Nieves, Cory Colaneri, Todd Riley & Jill A. Macoska. (2018) Nonalcoholic Fatty Liver Disease Demonstrates a Pre-fibrotic and Premalignant Molecular Signature. Digestive Diseases and Sciences 64:5, pages 1257-1269.
Crossref
LILIANA PASLARU, PETRUTA ALEXANDRU, SANDA M. CRETOIU, SIMONA O. DIMA & IRINEL POPESCU. (2019) CRISPR/Cas9 gene editing in Huh7 and Hepa RG cell lines. Romanian Biotechnological Letters 24:2, pages 216-228.
Crossref
Xiaoming Yang, Xingchen Du, Lei Sun, Xunxia Zhao, Jinyuan Zhu, Guizhong Li, Jue Tian, Xiaobo Li & Zhengyang Wang. (2019) SULT2B1b promotes epithelial-mesenchymal transition through activation of the β-catenin/MMP7 pathway in hepatocytes. Biochemical and Biophysical Research Communications 510:4, pages 495-500.
Crossref
Elisa Pedone & Lucia Marucci. (2019) Role of β-Catenin Activation Levels and Fluctuations in Controlling Cell Fate. Genes 10:2, pages 176.
Crossref
Daniela Campion, Alessandra Tucci, Paola Ponzo & Gian Paolo Caviglia. (2019) Non-invasive biomarkers for the detection of hepatocellular carcinoma. Minerva Biotecnologica 31:1.
Crossref
Sharanya M. Kalasekar, Srishti Kotiyal, Christopher Conley, Cindy Phan, Annika Young & Kimberley J. Evason. (2019) Heterogeneous beta-catenin activation is sufficient to cause hepatocellular carcinoma in zebrafish. Biology Open.
Crossref
Pedro Molina-Sánchez & Amaia Lujambio. 2019. Hepatocellular Carcinoma. Hepatocellular Carcinoma 333 358 .