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Journal of Inflammation Research Volume 14, 2021 - Issue
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Original Research

Dexmedetomidine Attenuates Ischemia/Reperfusion-Induced Myocardial Inflammation and Apoptosis Through Inhibiting Endoplasmic Reticulum Stress Signaling

Yu-fan Yang1 Department of Anesthesiology, First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, People’s Republic of China
,
Hui Wang1 Department of Anesthesiology, First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, People’s Republic of China;2 Department of Anesthesiology, Wuxi People’s Hospital Affiliated to Nanjing Medical University, Wuxi, Jiangsu, People’s Republic of ChinaORCID Iconhttps://orcid.org/0000-0003-2699-8086
ORCID Icon,
Nan Song1 Department of Anesthesiology, First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, People’s Republic of China
,
Ya-hui Jiang1 Department of Anesthesiology, First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, People’s Republic of China
,
Jun Zhang1 Department of Anesthesiology, First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, People’s Republic of China
,
Xiao-wen Meng1 Department of Anesthesiology, First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, People’s Republic of ChinaORCID Iconhttps://orcid.org/0000-0001-6961-8683
ORCID Icon,
Xiao-mei Feng3 Department of Anesthesiology, University of Utah Health, Salt Lake City, UT, USA;4 Transitional Residency Program, Intermountain Medical Center, Murray, UT, USA
,
Hong Liu5 Department of Anesthesiology and Pain Medicine, University of California Davis Health, Sacramento, CA, USAORCID Iconhttps://orcid.org/0000-0003-3611-7131
ORCID Icon,
Ke Peng1 Department of Anesthesiology, First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, People’s Republic of ChinaCorrespondence[email protected] [email protected]
ORCID Iconhttps://orcid.org/0000-0003-2879-1759
ORCID Icon &
Fu-hai Ji1 Department of Anesthesiology, First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, People’s Republic of ChinaORCID Iconhttps://orcid.org/0000-0001-6649-665X
ORCID Icon show all
Pages 1217-1233 | Published online: 31 Mar 2021

Citations (16)

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Feng Wang & Lili Han. (2022) Upregulation of serum and glucocorticoid-regulated kinase 1 (SGK1) ameliorates doxorubicin-induced cardiotoxic injury, apoptosis, inflammation and oxidative stress by suppressing glucose regulated protein 78 (GRP78)-mediated endoplasmic reticulum stress. Bioengineered 13:1, pages 844-855.
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Xiaotian Liu, Yueqin Li, Li Kang & Qian Wang. (2021) Recent Advances in the Clinical Value and Potential of Dexmedetomidine. Journal of Inflammation Research 14, pages 7507-7527.
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Articles from other publishers (14)

Jiayue Qing, Hongmei Zhou, Li Hu & Zhipeng Zhu. (2023) The key mediators involved in myocardial endoplasmic reticulum stress induced by ischaemia reperfusion injury in rats. European Journal of Inflammation 21, pages 1721727X2311731.
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Zhao-Rong Chen, Yu HongShi-Hong Wen, Ya-Qing Zhan & Wen-Qi Huang. (2023) Dexmedetomidine Pretreatment Protects Against Myocardial Ischemia/Reperfusion Injury by Activating STAT3 Signaling. Anesthesia & Analgesia 137:2, pages 426-439.
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Zhao Chen & Shi-Liang Zhang. (2023) Endoplasmic Reticulum Stress: A Key Regulator of Cardiovascular Disease. DNA and Cell Biology 42:6, pages 322-335.
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Maryam Mohammad Sadeghipour, Seyedeh Atekeh Torabizadeh & Mojgan Noroozi Karimabad. (2023) The Glucose-Regulated Protein78 (GRP78) in the Unfolded Protein Response (UPR) Pathway: A Potential Therapeutic Target for Breast Cancer. Anti-Cancer Agents in Medicinal Chemistry 23:5, pages 505-524.
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Peng Guo, Han Yi, Mingming Han, Xinxin Liu, Kemin Chen, Jie Qing & Fengrui Yang. (2023) Dexmedetomidine alleviates myocardial ischemia–reperfusion injury by down-regulating miR-34b-3p to activate the Jagged1/Notch signaling pathway. International Immunopharmacology 116, pages 109766.
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Basheer Abdullah Marzoog & Tatyana Ivanovna Vlasova. (2022) Myocardiocyte autophagy in the context of myocardiocytes regeneration: a potential novel therapeutic strategy. Egyptian Journal of Medical Human Genetics 23:1.
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Reino Pöyhiä, Teija Nieminen, Ville W. T. Tuompo & Hannu Parikka. (2022) Effects of Dexmedetomidine on Basic Cardiac Electrophysiology in Adults; a Descriptive Review and a Prospective Case Study. Pharmaceuticals 15:11, pages 1372.
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Xiao-Wen Meng, Mian Zhang, Jun-Kai Hu, Xin-Yu Chen, Yu-Qin Long, Hong Liu, Xiao-Mei Feng, Fu-Hai Ji & Ke Peng. (2022) Activation of CCL21-GPR174/CCR7 on cardiac fibroblasts underlies myocardial ischemia/reperfusion injury. Frontiers in Genetics 13.
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Wen-hui Tao, Xi-sheng Shan, Jia-xin Zhang, Hua-yue Liu, Bi-ying Wang, Xiang Wei, Mian Zhang, Ke Peng, Jun Ding, Shang-xian Xu, Lin-gui Li, Jun-kai Hu, Xiao-wen Meng & Fu-hai Ji. (2022) Dexmedetomidine Attenuates Ferroptosis-Mediated Renal Ischemia/Reperfusion Injury and Inflammation by Inhibiting ACSL4 via α2-AR. Frontiers in Pharmacology 13.
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Ramón Rodrigo, Catalina Retamal, Denisse Schupper, Diego Vergara-Hernández, Sarmistha Saha, Elisabetta Profumo, Brigitta Buttari & Luciano Saso. (2022) Antioxidant Cardioprotection against Reperfusion Injury: Potential Therapeutic Roles of Resveratrol and Quercetin. Molecules 27:8, pages 2564.
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Konstantin G. Gurevich, Aleksandr L. Urakov, Eugeniy L. Fisher, Timer A. Abzalilov, Kseniya A. Khairzamanova, Timur A. Yagudin & Aleksandr V. Samorodov. (2021) Possibilities of pharmacological correction of reperfusion injury of ischemic myocardium (review). Reviews on Clinical Pharmacology and Drug Therapy 19:3, pages 259-267.
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Shima Shabani, Mehdi Forouzandeh Moghadam & Seyed Latif Mousavi Gargari. (2021) Isolation and characterization of a novel GRP78-specific single-chain variable fragment (scFv) using ribosome display method. Medical Oncology 38:9.
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Xiaoyan Feng, Weiwei Ma, Jie Zhu, Wei Jiao & Yuhai Wang. (2021) Dexmedetomidine alleviates early brain injury following traumatic brain injury by inhibiting autophagy and neuroinflammation through the ROS/Nrf2 signaling pathway. Molecular Medicine Reports 24:3.
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Yi Cen, Hong-liu Jin, Sen-Ling Feng, Wen-Ting Zhu, Dong-Dong Jing, Zhongwen Yuan & Pen-Ke Yan. (2021) Hplc-Ms/Ms Analysis of Key Components of the Amino Acid Metabolism in the Serum of Acute Myocardial Infarction Patients. SSRN Electronic Journal.
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