Hydrogen (H₂) Alleviates Osteoarthritis by Inhibiting Apoptosis and Inflammation via the JNK Signaling Pathway

Hongwei Lu1 Department of Orthopaedics, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, 325000, People’s Republic of China;2 The Second School of Medicine, Wenzhou Medical University, Wenzhou, People’s Republic of China;3 Bone Research Institute, The Key Orthopaedic Laboratory of Zhejiang Province, Wenzhou, People’s Republic of ChinaView further author information

Wei Wang1 Department of Orthopaedics, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, 325000, People’s Republic of China;2 The Second School of Medicine, Wenzhou Medical University, Wenzhou, People’s Republic of China;3 Bone Research Institute, The Key Orthopaedic Laboratory of Zhejiang Province, Wenzhou, People’s Republic of ChinaView further author information

Xiaodiao Kang1 Department of Orthopaedics, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, 325000, People’s Republic of China;2 The Second School of Medicine, Wenzhou Medical University, Wenzhou, People’s Republic of China;3 Bone Research Institute, The Key Orthopaedic Laboratory of Zhejiang Province, Wenzhou, People’s Republic of ChinaView further author information

Zeng Lin1 Department of Orthopaedics, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, 325000, People’s Republic of China;2 The Second School of Medicine, Wenzhou Medical University, Wenzhou, People’s Republic of China;3 Bone Research Institute, The Key Orthopaedic Laboratory of Zhejiang Province, Wenzhou, People’s Republic of ChinaView further author information

Jun Pan1 Department of Orthopaedics, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, 325000, People’s Republic of China;2 The Second School of Medicine, Wenzhou Medical University, Wenzhou, People’s Republic of China;3 Bone Research Institute, The Key Orthopaedic Laboratory of Zhejiang Province, Wenzhou, People’s Republic of ChinaView further author information

Shaowen Cheng4 Trauma Center, First Affiliated Hospital of Hainan Medical University, Haikou, People’s Republic of ChinaCorrespondence[email protected]
View further author information

Jingdong Zhang1 Department of Orthopaedics, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, 325000, People’s Republic of China;2 The Second School of Medicine, Wenzhou Medical University, Wenzhou, People’s Republic of China;3 Bone Research Institute, The Key Orthopaedic Laboratory of Zhejiang Province, Wenzhou, People’s Republic of ChinaCorrespondence[email protected]
View further author information

show all

Citations (7)

Keep up to date with the latest research on this topic with citation updates for this article.

Articles from other publishers (7)

Chai Rongrong, Yu Xueting, Li Lian, Wei Qiang, Jiao Guangjun, Li Ying, Yu Chen, Mu Yanling, Yao Qingqiang, Li Yan & Wang Fuwen. (2023) Study on the mechanism and pharmacokinetics of HB-NC4 based on C5b-9 target in the treatment of osteoarthritis. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 1869:5, pages 166699.
Crossref

Wenjing Zhang, Lingting Zeng, Huan Yu, Ziheng He, Cuishan Huang, Cairong Li, Yangyi Nie, Long Li, Feifei Zhou, Ben Liu, Yuantao Zhang, Zhenyu Yao, Wei Zhang, Ling Qin, Di Chen, Qianjun He & Yuxiao Lai. (2023) Injectable spontaneous hydrogen-releasing hydrogel for long-lasting alleviation of osteoarthritis. Acta Biomaterialia 158, pages 163-177.
Crossref

Ying Jiang, Xiaoshan Chai, Shengnan Chen, Zhaoying Chen, Hao Tian, Min Liu & Xianqing Wu. (2022) Exosomes from the Uterine Cavity Mediate Immune Dysregulation via Inhibiting the JNK Signal Pathway in Endometriosis. Biomedicines 10:12, pages 3110.
Crossref

M. Zhang, W.J. Tu, Q. Zhang, X.L. Wu, X.Y. Zou & S. Jiang. (2022) Osteocalcin reduces fat accumulation and inflammatory reaction by inhibiting ROS-JNK signal pathway in chicken embryonic hepatocytes. Poultry Science 101:11, pages 102026.
Crossref

Haiyan Zhang, Daozhang Cai & Xiaochun Bai. (2022) Response to: Correspondence on ‘Mechanical overloading promotes chondrocyte senescence and osteoarthritis development through downregulating FBXW7’ by Loeser et al . Annals of the Rheumatic Diseases, pages annrheumdis-2022-222710.
Crossref

D. Liu, Z.-J. Cai, Y.-T. Yang, W.-H. Lu, L.-Y. Pan, W.-F. Xiao & Y.-S. Li. (2022) Mitochondrial quality control in cartilage damage and osteoarthritis: new insights and potential therapeutic targets. Osteoarthritis and Cartilage 30:3, pages 395-405.
Crossref

Yi Cheng, Feng Li, Wen-Sheng Zhang, Guo-You Zou & Yi-Xin Shen. (2021) Silencing BLNK protects against interleukin-1β-induced chondrocyte injury through the NF-κB signaling pathway. Cytokine 148, pages 155686.
Crossref

Hydrogen (H₂) Alleviates Osteoarthritis by Inhibiting Apoptosis and Inflammation via the JNK Signaling Pathway

Articles from other publishers (7)

Information for

Open access

Opportunities

Help and information

Your download is now in progress and you may close this window

Login or register to access this feature

Hydrogen (H2) Alleviates Osteoarthritis by Inhibiting Apoptosis and Inflammation via the JNK Signaling Pathway

Citations (7)

Articles from other publishers (7)

Related research

To cite this article:

Download citation

Information for

Open access

Opportunities

Help and information

Keep up to date

Hydrogen (H₂) Alleviates Osteoarthritis by Inhibiting Apoptosis and Inflammation via the JNK Signaling Pathway