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Journal of Inflammation Research Volume 14, 2021 - Issue
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Original Research

Microglial Activation Mediates Noradrenergic Locus Coeruleus Neurodegeneration via Complement Receptor 3 in a Rotenone-Induced Parkinson’s Disease Mouse Model

Lu Jing1 Institute of Toxicology, School of Public Health, Dalian Medical University, Dalian, 116044, People’s Republic of China;2 Department of Neurology, The First Affiliated Hospital of Dalian Medical University, Dalian, 116011, People’s Republic of ChinaView further author information
,
Liyan Hou1 Institute of Toxicology, School of Public Health, Dalian Medical University, Dalian, 116044, People’s Republic of ChinaView further author information
,
Dongdong Zhang1 Institute of Toxicology, School of Public Health, Dalian Medical University, Dalian, 116044, People’s Republic of ChinaView further author information
,
Sheng Li3 National-Local Joint Engineering Research Center for Drug-Research and Development (R & D) of Neurodegenerative Diseases, Dalian Medical University, Dalian, 116044, People’s Republic of ChinaView further author information
,
Zhengzheng Ruan1 Institute of Toxicology, School of Public Health, Dalian Medical University, Dalian, 116044, People’s Republic of ChinaView further author information
,
Xiaomeng Zhang3 National-Local Joint Engineering Research Center for Drug-Research and Development (R & D) of Neurodegenerative Diseases, Dalian Medical University, Dalian, 116044, People’s Republic of ChinaView further author information
,
Jau-Shyong Hong4 Neurobiology Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC, USAView further author information
&
Qingshan Wang1 Institute of Toxicology, School of Public Health, Dalian Medical University, Dalian, 116044, People’s Republic of China;3 National-Local Joint Engineering Research Center for Drug-Research and Development (R & D) of Neurodegenerative Diseases, Dalian Medical University, Dalian, 116044, People’s Republic of ChinaCorrespondence[email protected]
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Pages 1341-1356 | Published online: 09 Apr 2021

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Qianxue Mou, Ke Yao, Meng Ye, Bowen Zhao, Yuanyuan Hu, Xiaotong Lou, Huixia Li, Hong Zhang & Yin Zhao. (2021) Modulation of Sirt1-mTORC1 Pathway in Microglia Attenuates Retinal Ganglion Cell Loss After Optic Nerve Injury. Journal of Inflammation Research 14, pages 6857-6869.
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Articles from other publishers (11)

Tarun N. Bhatia, Anuj S. Jamenis, Muslim Abbas, Rachel N. Clark, Kristin M. Miner, Manisha N. Chandwani, Roxanne E. Kim, William Hilinski, Lauren A. O'Donnell, Kelvin C. Luk, Yejie Shi, Xiaoming Hu, Jun Chen, Jeffrey L. Brodsky & Rehana K. Leak. (2023) A 14-day pulse of PLX5622 modifies α-synucleinopathy in preformed fibril-infused aged mice of both sexes. Neurobiology of Disease 184, pages 106196.
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Yulia Aleksandrova, Kirill Chaprov, Alexandra Podturkina, Oleg Ardashov, Ekaterina Yandulova, Konstantin Volcho, Nariman Salakhutdinov & Margarita Neganova. (2023) Monoterpenoid Epoxidiol Ameliorates the Pathological Phenotypes of the Rotenone-Induced Parkinson’s Disease Model by Alleviating Mitochondrial Dysfunction. International Journal of Molecular Sciences 24:6, pages 5842.
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Zijian Zheng, Shushan Zhang, Hanwen Zhang, Zhongzheng Gao, Xiangrong Wang, Xinjie Liu, Cheng Xue, Longping Yao & Guohui Lu. (2022) Mechanisms of Autoimmune Cell in DA Neuron Apoptosis of Parkinson’s Disease: Recent Advancement. Oxidative Medicine and Cellular Longevity 2022, pages 1-20.
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Sarah Thomas Broome & Alessandro Castorina. (2022) Systemic Rotenone Administration Causes Extra-Nigral Alterations in C57BL/6 Mice. Biomedicines 10:12, pages 3174.
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Nima Javanmehr, Kiarash Saleki, Parsa Alijanizadeh & Nima Rezaei. (2022) Microglia dynamics in aging-related neurobehavioral and neuroinflammatory diseases. Journal of Neuroinflammation 19:1.
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Sarah Thomas Broome, Giuseppe Musumeci & Alessandro Castorina. (2022) PACAP and VIP Mitigate Rotenone-Induced Inflammation in BV-2 Microglial Cells. Journal of Molecular Neuroscience 72:11, pages 2163-2175.
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Yonghe Zheng, Linfeng Fan, Siqi Xia, Qiguo Yang, Zhihua Zhang, Huaijun Chen, Hanhai Zeng, Xiongjie Fu, Yucong Peng, Chaoran Xu, Kaibo Yu, Fuyi Liu & Shenglong Cao. (2022) Role of complement C1q/C3-CR3 signaling in brain injury after experimental intracerebral hemorrhage and the effect of minocycline treatment. Frontiers in Immunology 13.
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Xiaomeng Zhang, Dezhen Tu, Sheng Li, Na Li, Donglai Li, Yun Gao, Lu Tian, Jianing Liu, Xuan Zhang, Jau-Shyong Hong, Liyan Hou, Jie Zhao & Qingshan Wang. (2022) A novel synthetic peptide SVHRSP attenuates dopaminergic neurodegeneration by inhibiting NADPH oxidase-mediated neuroinflammation in experimental models of Parkinson's disease. Free Radical Biology and Medicine 188, pages 363-374.
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Zhengzheng Ruan, Dongdong Zhang, Ruixue Huang, Wei Sun, Liyan Hou, Jie Zhao & Qingshan Wang. (2022) Microglial Activation Damages Dopaminergic Neurons through MMP-2/-9-Mediated Increase of Blood-Brain Barrier Permeability in a Parkinson’s Disease Mouse Model. International Journal of Molecular Sciences 23:5, pages 2793.
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Ziyang Guo, Zhengzheng Ruan, Dongdong Zhang, Xiaohui Liu, Liyan Hou & Qingshan Wang. (2022) Rotenone impairs learning and memory in mice through microglia-mediated blood brain barrier disruption and neuronal apoptosis. Chemosphere 291, pages 132982.
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Qing Li, Chenye Shen, Zhaolin Liu, Yuanyuan Ma, Jinghui Wang, Hongtian Dong, Xiaoshuang Zhang, Zishan Wang, Mei Yu, Lei Ci, Ruilin Sun, Ruling Shen, Jian Fei & Fang Huang. (2021) Partial depletion and repopulation of microglia have different effects in the acute MPTP mouse model of Parkinson’s disease. Cell Proliferation 54:8.
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