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Original Research

Clinical Significance of the HHLA2 Protein in Hepatocellular Carcinoma and the Tumor Microenvironment

Min Luo1 Department of Oncology, Guangxi Medical University Cancer Hospital, Nanning, Guangxi, 530021, People’s Republic of China

Yan Lin1 Department of Oncology, Guangxi Medical University Cancer Hospital, Nanning, Guangxi, 530021, People’s Republic of China

Rong Liang1 Department of Oncology, Guangxi Medical University Cancer Hospital, Nanning, Guangxi, 530021, People’s Republic of China

Yongqiang Li1 Department of Oncology, Guangxi Medical University Cancer Hospital, Nanning, Guangxi, 530021, People’s Republic of ChinaCorrespondence[email protected]

Lianying Ge2 Department of Endoscopy, Guangxi Medical University Cancer Hospital, Nanning, Guangxi, 530021, People’s Republic of ChinaCorrespondence[email protected]

Pages 4217-4228 | Published online: 28 Aug 2021

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Yuanyuan Fu, Panpan Zheng, Xiao Zheng, Lujun Chen, Caixia Kong, Wenzhi Liu, Shuping Li & Jingting Jiang. (2023) Downregulation of HHLA2 inhibits ovarian cancer progression via the NF-κB signaling pathway and suppresses the expression of CA9. Cellular Immunology 388-389, pages 104730.
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Yang Li, Chao Lv, Yang Yu, Baokang Wu, Yizhou Zhang, Qi Lang, Zhiyun Liang, Chongli Zhong, Yu Shi, Shukun Han, Feng Xu & Yu Tian. (2023) KIR3DL3-HHLA2 and TMIGD2-HHLA2 pathways: The dual role of HHLA2 in immune responses and its potential therapeutic approach for cancer immunotherapy. Journal of Advanced Research 47, pages 137-150.
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Marc C. Pulanco, Anne T. Madsen, Ankit Tanwar, Devin T. Corrigan & Xingxing Zang. (2023) Recent advancements in the B7/CD28 immune checkpoint families: new biology and clinical therapeutic strategies. Cellular & Molecular Immunology 20:7, pages 694-713.
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Renyi Su, Huizhong Zhang, Lincheng Zhang, Abdul Rehman Khan, Xuanyu Zhang, Rui Wang, Chuxiao Shao, Xuyong Wei & Xiao Xu. (2022) Systemic analysis identifying PVT1 / DUSP13 axis for microvascular invasion in hepatocellular carcinoma . Cancer Medicine 12:7, pages 8937-8955.
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Weili Jia, Qianyun Yao, Yanfang Wang, Zhenzhen Mao, Tianchen Zhang, Jianhui Li, Ye Nie, Xinjun Lei, Wen Shi & Wenjie Song. (2022) Protective effect of tertiary lymphoid structures against hepatocellular carcinoma: New findings from a genetic perspective. Frontiers in Immunology 13.
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Yizhou Zhang, Hanrong Li, Chao Lv, Baokang Wu, Yang Yu, Chongli Zhong, Qi Lang, Zhiyun Liang, Yang Li, Yu Shi, Jian Jian, Feng Xu & Yu Tian. (2022) HHLA2 promotes tumor progression by long non‑coding RNA H19 in human gallbladder cancer. International Journal of Oncology 61:3.
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Hui Guo, Cheng Zhang, Xiaotong Tang, Tiantian Zhang, Yang Liu, Hanbing Yu, Yumei Li & Rui Wang. (2022) HHLA2 Activates the JAK/STAT Signaling Pathway by Binding to TMIGD2 in Hepatocellular Carcinoma Cells. Inflammation 45:4, pages 1585-1599.
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Weili Jia, Tianchen Zhang, Qianyun Yao, Jianhui Li, Ye Nie, Xinjun Lei, Zhenzhen Mao, Yanfang Wang, Wen Shi & Wenjie Song. (2022) Tertiary Lymphatic Structures in Primary Hepatic Carcinoma: Controversy Cannot Overshadow Hope. Frontiers in Immunology 13.
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Honggang Ying, Jian Xu, Xiaozhen Zhang, Tingbo Liang & Xueli Bai. (2022) Human endogenous retrovirus-H long terminal repeat-associating 2: The next immune checkpoint for antitumour therapy. eBioMedicine 79, pages 103987.
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Long Long, Li Zhang, Yuhan Yang, Yunfeng Zhou & Honglei Chen. (2022) Different clinical significance of novel B7 family checkpoints VISTA and HHLA2 in human lung adenocarcinoma. Immunotherapy 14:6, pages 419-431.
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Zeng Yang, Diao Xu, Xiao Ye, Xuehua Lin, Min Zhang, Yan Su, Qun Xie & Wenjun Ni. (2022) HHLA2 Used as a Potential Prognostic and Immunological Biomarker and Correlated with Tumor Microenvironment in Pan-Cancer. BioMed Research International 2022, pages 1-21.
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Clinical Significance of the HHLA2 Protein in Hepatocellular Carcinoma and the Tumor Microenvironment

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Clinical Significance of the HHLA2 Protein in Hepatocellular Carcinoma and the Tumor Microenvironment

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