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Journal of Inflammation Research Volume 8, 2015 - Issue
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Original Research

Exploring the translational disconnect between the murine and human inflammatory response: analysis of LPS dose–response relationship in murine versus human cell lines and implications for translation into murine models of sepsis

Eamon P McCarron1 Department of Clinical and Molecular Pharmacology, Centre for Drug Safety Science, Institute of Translational Medicine, University of Liverpool, Liverpool, UKCorrespondence[email protected]
,
Dominic P Williams1 Department of Clinical and Molecular Pharmacology, Centre for Drug Safety Science, Institute of Translational Medicine, University of Liverpool, Liverpool, UK
,
Daniel J Antoine1 Department of Clinical and Molecular Pharmacology, Centre for Drug Safety Science, Institute of Translational Medicine, University of Liverpool, Liverpool, UK
,
Anja Kipar2 Department of Veterinary Pathology, University of Liverpool, Liverpool, UK
,
Jana Lemm3 Department of Anaesthesiology and Intensive Care Medicine, Jena University Hospital, Jena, Germany
,
Sebastian Stehr3 Department of Anaesthesiology and Intensive Care Medicine, Jena University Hospital, Jena, Germany
&
Ingeborg D Welters4 Department of Obesity and Endocrinology, Institute of Ageing and Chronic Disease, University of Liverpool, Liverpool, UK
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Pages 201-209 | Published online: 16 Oct 2015

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Naqi Lian, Mengxi Shen, Kai Zhang, Jiacheng Pan, Yi Jiang, Yang Yu & Yonghao Yu. (2021) Drinking Hydrogen-Rich Water Alleviates Chemotherapy-Induced Neuropathic Pain Through the Regulation of Gut Microbiota. Journal of Pain Research 14, pages 681-691.
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Felix Lauffer & Johannes Ring. (2016) Target-oriented therapy: Emerging drugs for atopic dermatitis. Expert Opinion on Emerging Drugs 21:1, pages 81-89.
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Leonardo Cecotto, Kok van Kessel, Margreet A. Wolfert, Charles Vogely, Bart van der Wal, Harrie Weinans, Jos van Strijp & Saber Amin Yavari. (2022) Antibacterial and anti-inflammatory properties of host defense peptides against Staphylococcus aureus. iScience 25:10, pages 105211.
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Yi Jiang, Kai Zhang, Yang Yu, Yaoqi Wang, Naqi Lian, Keliang Xie & Yonghao Yu. (2020) Molecular hydrogen alleviates brain injury and cognitive impairment in a chronic sequelae model of murine polymicrobial sepsis. Experimental Brain Research 238:12, pages 2897-2908.
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Jamie Golden, Laura Illingworth, Patil Kavarian, Oswaldo Escobar, Patrick Delaplain, Mubina Isani, Jin Wang, Joanna Lim, Jordan Bowling, Brandon Bell, Christopher P. Gayer, Anatoly Grishin & Henri R. Ford. (2020) EP2 Receptor Blockade Attenuates COX-2 Upregulation During Intestinal Inflammation. Shock 54:3, pages 394-401.
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Manasi Nandi, Simon K. JacksonDuncan MacraeManu Shankar-HariJordi L. TremoledaElliot Lilley. (2020) Rethinking animal models of sepsis – working towards improved clinical translation whilst integrating the 3Rs. Clinical Science 134:13, pages 1715-1734.
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Nicolas Tardif, Franck Polia, Inga Tjäder, Thomas Gustafsson & Olav Rooyackers. (2019) Autophagy flux in critical illness, a translational approach. Scientific Reports 9:1.
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Julie Cagliero, Sharon Y. A. M. Villanueva & Mariko Matsui. (2018) Leptospirosis Pathophysiology: Into the Storm of Cytokines. Frontiers in Cellular and Infection Microbiology 8.
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G. Forn-Cuní, M. Varela, P. Pereiro, B. Novoa & A. Figueras. (2017) Conserved gene regulation during acute inflammation between zebrafish and mammals. Scientific Reports 7:1.
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Leonardo Cecotto, Kok van Kessel, Margreet A. Wolfert, Charles Vogely, Bart van der Wal, Harrie Weinans, Jos van Strijp & Saber Amin Yavari. (2022) Antibacterial and Anti-Inflammatory Properties of Host Defense Peptides Against <i>Staphylococcus Aureus</i>. SSRN Electronic Journal.
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