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Journal of Inflammation Research Volume 8, 2015 - Issue
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Original Research

Exploring the translational disconnect between the murine and human inflammatory response: analysis of LPS dose–response relationship in murine versus human cell lines and implications for translation into murine models of sepsis

Eamon P McCarron1 Department of Clinical and Molecular Pharmacology, Centre for Drug Safety Science, Institute of Translational Medicine, University of Liverpool, Liverpool, UKCorrespondence[email protected]
,
Dominic P Williams1 Department of Clinical and Molecular Pharmacology, Centre for Drug Safety Science, Institute of Translational Medicine, University of Liverpool, Liverpool, UK
,
Daniel J Antoine1 Department of Clinical and Molecular Pharmacology, Centre for Drug Safety Science, Institute of Translational Medicine, University of Liverpool, Liverpool, UK
,
Anja Kipar2 Department of Veterinary Pathology, University of Liverpool, Liverpool, UK
,
Jana Lemm3 Department of Anaesthesiology and Intensive Care Medicine, Jena University Hospital, Jena, Germany
,
Sebastian Stehr3 Department of Anaesthesiology and Intensive Care Medicine, Jena University Hospital, Jena, Germany
&
Ingeborg D Welters4 Department of Obesity and Endocrinology, Institute of Ageing and Chronic Disease, University of Liverpool, Liverpool, UK
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Pages 201-209 | Published online: 16 Oct 2015

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