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Original Research

Effectiveness and safety of tapentadol prolonged release with tapentadol immediate release on-demand for the management of severe, chronic osteoarthritis-related knee pain: results of an open-label, phase 3b study

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Pages 121-138 | Published online: 15 Jun 2012

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Giuseppe Rinonapoli, Stefano Coaccioli & Lorenzo Panella. (2019) Tapentadol in the treatment of osteoarthritis: pharmacological rationale and clinical evidence. Journal of Pain Research 12, pages 1529-1536.
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Laura E. Gressler, Drayton A. Hammond & Jacob T. Painter. (2017) Serotonin Syndrome in Tapentadol Literature: Systematic Review of Original Research. Journal of Pain & Palliative Care Pharmacotherapy 31:3-4, pages 228-236.
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Anirudh Sharma, Prtha Kudesia, Qian Shi & Rajiv Gandhi. (2016) Anxiety and depression in patients with osteoarthritis: impact and management challenges. Open Access Rheumatology: Research and Reviews 8, pages 103-113.
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Nebojsa Nick Knezevic, Tatiana Tverdohleb, Ivana Knezevic & Kenneth D Candido. (2015) Unique pharmacology of tapentadol for treating acute and chronic pain. Expert Opinion on Drug Metabolism & Toxicology 11:9, pages 1475-1492.
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Howard S. Smith, Robert B. Raffa, Joseph V. Pergolizzi, Robert Taylor & Ronald J. Tallarida. (2014) Combining Opioid and Adrenergic Mechanisms for Chronic Pain. Postgraduate Medicine 126:4, pages 98-114.
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Nalini Vadivelu, Yili Huang, Brian Mirante, Michael Jacoby, Ferne R Braveman, Roberta L Hines & Raymond Sinatra. (2013) Patient considerations in the use of tapentadol for moderate to severe pain. Drug, Healthcare and Patient Safety 5, pages 151-159.
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Articles from other publishers (22)

Diana Fonseca-Rodrigues, André Rodrigues, Teresa Martins, Joana Pinto, Diana Amorim, Armando Almeida & Filipa Pinto-Ribeiro. (2022) Correlation between pain severity and levels of anxiety and depression in osteoarthritis patients: a systematic review and meta-analysis. Rheumatology 61:1, pages 53-75.
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Suganthiya S. Croosu, Jens B. Frøkjær, Asbjørn M. Drewes & Tine M. Hansen. (2021) Tapentadol and oxycodone affect resting‐state functional brain connectivity: A randomized, placebo‐controlled trial. Journal of Neuroimaging 31:5, pages 956-961.
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Andreas Schwittay, Melanie Sohns, Birgit Heckes & Christian Elling. (2020) Tapentadol Prolonged Release for Severe Chronic Osteoarthritis Pain in the Elderly—A Subgroup Analysis of Routine Clinical Practice Data. Pain Research and Management 2020, pages 1-10.
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Kai-Uwe Kern, Melanie Sohns, Birgit Heckes & Christian Elling. (2020) Tapentadol prolonged release for severe chronic osteoarthritis pain in the elderly: improvements in daily functioning and quality of life. Pain Management 10:2, pages 85-95.
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Tine Donk, Monique Velzen, Albert Dahan & Marieke Niesters. (2019) Cornea nerve fibre state determines analgesic response to tapentadol in fibromyalgia patients without effective endogenous pain modulation. European Journal of Pain 23:9, pages 1586-1595.
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Jessie S Channell & Stephan Schug. (2018) Toxicity of tapentadol: a systematic review. Pain Management 8:5, pages 327-339.
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Renata Zajączkowska, Barbara Przewłocka, Magdalena Kocot-Kępska, Joanna Mika, Wojciech Leppert & Jerzy Wordliczek. (2018) Tapentadol – A representative of a new class of MOR-NRI analgesics. Pharmacological Reports 70:4, pages 812-820.
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Joseph V. PergolizziJrJr, Robert TaylorJrJr, Jo Ann LeQuang, Robert B. Raffa & John Bisney. (2018) Tapentadol Extended Release in the Treatment of Severe Chronic Low Back Pain and Osteoarthritis Pain. Pain and Therapy 7:1, pages 37-57.
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L. Arendt‐Nielsen, B. Morlion, S. Perrot, A. Dahan, A. Dickenson, H.G. Kress, C. Wells, D. Bouhassira & A. Mohr Drewes. (2017) Assessment and manifestation of central sensitisation across different chronic pain conditions. European Journal of Pain 22:2, pages 216-241.
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Ralf Baron, Leopold Eberhart, Kai-Uwe Kern, Stefan Regner, Roman Rolke, Christian Simanski & Thomas Tölle. (2017) Tapentadol Prolonged Release for Chronic Pain: A Review of Clinical Trials and 5 Years of Routine Clinical Practice Data. Pain Practice 17:5, pages 678-700.
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Matthew Thakur & Stephen B. McMahon. 2016. An Introduction to Pain and its Relation to Nervous System Disorders. An Introduction to Pain and its Relation to Nervous System Disorders 89 121 .
Chris Martini, Monique van Velzen, Asbjørn Drewes, Leon Aarts, Albert Dahan & Marieke Niesters. (2015) A Randomized Controlled Trial on the Effect of Tapentadol and Morphine on Conditioned Pain Modulation in Healthy Volunteers. PLOS ONE 10:6, pages e0128997.
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Ralf Baron, Emilio Martin‐Mola, Matthias Müller, Cecile Dubois, Dietmar Falke & Ilona Steigerwald. (2014) Effectiveness and Safety of Tapentadol Prolonged Release ( PR ) Versus a Combination of Tapentadol PR and Pregabalin for the Management of Severe, Chronic Low Back Pain With a Neuropathic Component: A Randomized, Double‐blind, Phase 3b Study . Pain Practice 15:5, pages 455-470.
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Boaz G. Samolsky Dekel, Sivia Ghedini, Alberto Gori, Alessio Vasarri, GianFranco Di Nino & Rita M. Melotti. (2015) Lasting Prolonged-Release Tapentadol for Moderate/Severe Non-Cancer Musculoskeletal Chronic Pain. Pain and Therapy 4:1, pages 107-117.
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Barbara Rakel, Carol Vance, M. Bridget Zimmerman, Nicole Petsas-Blodgett, Annunziato Amendola & Kathleen A. Sluka. (2015) Mechanical Hyperalgesia and Reduced Quality of Life Occur in People With Mild Knee Osteoarthritis Pain. The Clinical Journal of Pain 31:4, pages 315-322.
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Manuel J. Sánchez del Águila, Michael Schenk, Kai-Uwe Kern, Tanja Drost & Ilona Steigerwald. (2015) Practical Considerations for the Use of Tapentadol Prolonged Release for the Management of Severe Chronic Pain. Clinical Therapeutics 37:1, pages 94-113.
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M. Niesters, P.L. Proto, L. Aarts, E.Y. Sarton, A.M. Drewes & A. Dahan. (2014) Tapentadol potentiates descending pain inhibition in chronic pain patients with diabetic polyneuropathy. British Journal of Anaesthesia 113:1, pages 148-156.
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Maren Reimer, Stephanie M. Helfert & Ralf Baron. (2014) Phenotyping neuropathic pain patients. Current Opinion in Supportive & Palliative Care 8:2, pages 124-129.
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Rainer Sabatowski, Rüdiger Scharnagel, Anne Gyllensvärd & Ilona Steigerwald. (2014) Driving Ability in Patients with Severe Chronic Low Back or Osteoarthritis Knee Pain on Stable Treatment with Tapentadol Prolonged Release: A Multicenter, Open-label, Phase 3b Trial. Pain and Therapy 3:1, pages 17-29.
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Ilona Steigerwald, Michael Schenk, Uwe Lahne, Peter Gebuhr, Dietmar Falke & Barbara Hoggart. (2013) Effectiveness and Tolerability of Tapentadol Prolonged Release Compared With Prior Opioid Therapy for the Management of Severe, Chronic Osteoarthritis Pain. Clinical Drug Investigation 33:9, pages 607-619.
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he. (2013) Starke Wirksamkeit bei Schmerz. Der Hausarzt 50:10, pages 59-59.
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Robert Taylor, Joseph V. Pergolizzi & Robert B. Raffa. (2013) Tapentadol Extended Release for Chronic Pain Patients. Advances in Therapy 30:1, pages 14-27.
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