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Neuropsychiatric Disease and Treatment Volume 15, 2019 - Issue

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Original Research

Ginaton improves neurological function in ischemic stroke rats via inducing autophagy and maintaining mitochondrial homeostasis

Xiaoqiang Li1 Department of Pharmacy, Lanzhou University Second Hospital, Lanzhou730030, People’s Republic of China

Deli Zhang1 Department of Pharmacy, Lanzhou University Second Hospital, Lanzhou730030, People’s Republic of ChinaCorrespondence[email protected]

Yinliang Bai1 Department of Pharmacy, Lanzhou University Second Hospital, Lanzhou730030, People’s Republic of China

Jiyuan Xiao1 Department of Pharmacy, Lanzhou University Second Hospital, Lanzhou730030, People’s Republic of China

Haisheng Jiao1 Department of Pharmacy, Lanzhou University Second Hospital, Lanzhou730030, People’s Republic of China

Rongxia He2 Department of Gynecology, Lanzhou University Second Hospital, Lanzhou730030, People’s Republic of China

Pages 1813-1822 | Published online: 03 Jul 2019

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Tingting Li, Qianhui Sun, Mingzhen Qin, Xiangyi Zheng, Boyuan Wang, Xuebin Zhang, Xiaolong Xie, Dawei Wei, Xinyi Shi, Hongrui Zhang, Qiuyang Jia, Chi Zhang & Ying Gao. (2023) Comparative efficacy and safety of ginkgo biloba related agents in patients with acute ischemic stroke: A Bayesian network meta-analysis of randomized controlled trials. Pharmacological Research - Modern Chinese Medicine 7, pages 100242.
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Lu Liu, Daohong Chen, Ziyang Zhou, Jing Yuan, Ying Chen, Mingsheng Sun, Mengdi Zhou, Yi Liu, Shiqi Sun, Jiao Chen & Ling Zhao. (2023) Traditional Chinese medicine in treating ischemic stroke by modulating mitochondria: A comprehensive overview of experimental studies. Frontiers in Pharmacology 14.
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Aiqing Deng, Limin Ma, Qiuhong Ji, Jiajun Xing, Jianxin Qin, Xueli Zhou, Xin Wang, Shouyan Wang, Jianjun Wu & Xia Chen. (2023) Activation of the Akt/FoxO3 signaling pathway enhances oxidative stress-induced autophagy and alleviates brain damage in a rat model of ischemic stroke. Canadian Journal of Physiology and Pharmacology 101:1, pages 18-26.
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Yahao Gao, Changshui Wang, Di Jiang, Gang An, Feng Jin, Junchen Zhang, Guangkui Han, Changmeng Cui & Pei Jiang. (2022) New insights into the interplay between autophagy and oxidative and endoplasmic reticulum stress in neuronal cell death and survival. Frontiers in Cell and Developmental Biology 10.
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Yue Hu, Yumin Luo & Yangmin Zheng. (2022) Nrf2 Pathway and Autophagy Crosstalk: New Insights into Therapeutic Strategies for Ischemic Cerebral Vascular Diseases. Antioxidants 11:9, pages 1747.
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Tayebeh Noori, Samira Shirooie, Antoni Sureda, Eduardo Sobarzo-Sanchez, Ahmad Reza Dehpour, Marianela Saldías & Esra Küpeli Akkol. (2022) Regulation of DAPK1 by Natural Products: An Important Target in Treatment of Stroke. Neurochemical Research 47:8, pages 2142-2157.
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Zihuan Shen, Mi Xiang, Chen Chen, Fan Ding, Yuling Wang, Chang Shang, Laiyun Xin, Yang Zhang & Xiangning Cui. (2022) Glutamate excitotoxicity: Potential therapeutic target for ischemic stroke. Biomedicine & Pharmacotherapy 151, pages 113125.
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Sabra Mouhi, Breona Martin & Sharon Owino. (2022) Emerging Roles for the Orphan GPCRs, GPR37 and GPR37 L1, in Stroke Pathophysiology. International Journal of Molecular Sciences 23:7, pages 4028.
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Sandeep Appunni, Deepika Gupta, Muni Rubens, Venkataraghavan Ramamoorthy, Himanshu Narayan Singh & Vishnu Swarup. (2021) Deregulated Protein Kinases: Friend and Foe in Ischemic Stroke. Molecular Neurobiology 58:12, pages 6471-6489.
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Zhenwei Huang, Xian Zhou, Xiaoqin Zhang, Lili Huang, Yibin Sun, Zaixing Cheng, Wen Xu, Chun-Guang Li, Yanfang Zheng & Mingqing Huang. (2021) Pien-Tze-Huang, a Chinese patent formula, attenuates NLRP3 inflammasome-related neuroinflammation by enhancing autophagy via the AMPK/mTOR/ULK1 signaling pathway. Biomedicine & Pharmacotherapy 141, pages 111814.
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Chuanxiang Wang, Zhequan Ma, Zuqiang Wang, Shuping Ming, Yanbing Ding, Sufang Zhou & Hongyu Qian. (2021) Eriodictyol Attenuates MCAO-Induced Brain Injury and Neurological Deficits via Reversing the Autophagy Dysfunction. Frontiers in Systems Neuroscience 15.
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Yuxiang Fei, Bo Zhao, Jianping Zhu, Weirong Fang & Yunman Li. (2021) XQ-1H promotes cerebral angiogenesis via activating PI3K/Akt/GSK3β/β-catenin/VEGF signal in mice exposed to cerebral ischemic injury. Life Sciences 272, pages 119234.
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Qian-yu Zhao, Rong-hua Tang, Guo-xiong Lu, Xu-zheng Cao, Lu-ran Liu, Ji-hua Zhang, Jin-tao Zhang, Bin Xu, Hong-tao Wei, Miao Yang, Ling Wei, Mei Zhang, Wen-zong Zhu, Hong Wang, Hong-lin Li, Li-ping Ma, Chi Zhong, Yan-jie Gao, Na Zhang, Shan Ren, Lu Chen, Yun-hai Liu & Zhi-gang Chen. (2020) Efficacy of Getong Tongluo Capsule (葛酮通络胶囊) for Convalescent-Phase of Ischemic Stroke and Primary Hypertension: A Multicenter, Randomized, Double-Blind, Controlled Trial. Chinese Journal of Integrative Medicine 27:4, pages 252-258.
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Fernanda Majolo, Alexandre Martins, Stephanie Rehfeldt, João Antônio Pegas Henriques, Verônica Contini & Márcia Inês Goettert. 2021. Bioactive Natural Products. Bioactive Natural Products 1 63 .

Wen Dong, Shunying Zhao, Shaohong Wen, Chengya Dong, Qingfang Chen, Ting Gong, Wentao Chen, Wenqian Liu, Liting Mu, Honglin Shan, Xiaoxuan Xie & Xiangrong Liu. (2020) A preclinical randomized controlled study of ischemia treated with Ginkgo biloba extracts: Are complex components beneficial for treating acute stroke?. Current Research in Translational Medicine 68:4, pages 197-203.
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Alessandra Stacchiotti & Giovanni Corsetti. (2020) Natural Compounds and Autophagy: Allies Against Neurodegeneration. Frontiers in Cell and Developmental Biology 8.
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Claudia Espinosa-Garcia, Fahim Atif, Seema Yousuf, Iqbal Sayeed, Gretchen N. Neigh & Donald G. Stein. (2020) Progesterone Attenuates Stress-Induced NLRP3 Inflammasome Activation and Enhances Autophagy Following Ischemic Brain Injury. International Journal of Molecular Sciences 21:11, pages 3740.
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Xin Liu, Qing Wang, Yiran Cui, Muhammad Hussain, Hongjun Yang & Xianyu Li. (2020) Multiple protein and mRNA expression correlations in the rat cerebral cortex after ischemic injury and repair due to buchang naoxintong jiaonang (BNJ) intervention. Biomedicine & Pharmacotherapy 125, pages 109917.
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Yun Mo, Yin-Yi Sun & Kang-Yong Liu. (2020) Autophagy and inflammation in ischemic stroke. Neural Regeneration Research 15:8, pages 1388.
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Ginaton improves neurological function in ischemic stroke rats via inducing autophagy and maintaining mitochondrial homeostasis

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Ginaton improves neurological function in ischemic stroke rats via inducing autophagy and maintaining mitochondrial homeostasis

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