Ginaton improves neurological function in ischemic stroke rats via inducing autophagy and maintaining mitochondrial homeostasis

References

• Guzik A, Bushnell C. Stroke epidemiology and risk factor management. Continuum (Minneap Minn). 2017;23(1, Cerebrovascular Disease):15–39. doi:10.1212/CON.000000000000041628157742
   PubMedGoogle Scholar
• Donnan GA, Fisher M, Macleod M, Davis SM. Stroke. Lancet. 2008;371(9624):1612–1623. doi:10.1016/S0140-6736(08)60694-718468545
   PubMed Web of Science ®Google Scholar
• Feigin VL, Lawes CM, Bennett DA, Anderson CS. Stroke epidemiology: a review of population-based studies of incidence, prevalence, and case-fatality in the late 20th century. Lancet Neurol. 2003;2(1):43–53.12849300
   PubMed Web of Science ®Google Scholar
• Broussalis E, Killer M, McCoy M, Harrer A, Trinka E, Kraus J. Current therapies in ischemic stroke. Part A. Recent developments in acute stroke treatment and in stroke prevention. Drug Discov Today. 2012;17(7–8):296–309. doi:10.1016/j.drudis.2011.11.00522134007
   PubMed Web of Science ®Google Scholar
• Fisher M. New approaches to neuroprotective drug development. Stroke. 2011;42(1 Suppl):S24–S27. doi:10.1161/STROKEAHA.110.59239421164111
   PubMed Web of Science ®Google Scholar
• Xing C, Arai K, Lo EH, Hommel M. Pathophysiologic cascades in ischemic stroke. Int J Stroke. 2012;7(5):378–385. doi:10.1111/j.1747-4949.2012.00839.x22712739
   PubMed Web of Science ®Google Scholar
• Moretti A, Ferrari F, Villa RF. Neuroprotection for ischaemic stroke: current status and challenges. Pharmacol Ther. 2015;146:23–34. doi:10.1016/j.pharmthera.2014.09.00325196155
   PubMed Web of Science ®Google Scholar
• Pandya RS, Mao L, Zhou H, et al. Central nervous system agents for ischemic stroke: neuroprotection mechanisms. Cent Nerv Syst Agents Med Chem. 2011;11(2):81–97.21521165
   PubMedGoogle Scholar
• Sims NR, Anderson MF. Mitochondrial contributions to tissue damage in stroke. Neurochem Int. 2002;40(6):511–526. doi:10.1016/S0197-0186(01)00122-X11850108
   PubMed Web of Science ®Google Scholar
• Sims NR, Muyderman H. Mitochondria, oxidative metabolism and cell death in stroke. Biochim Biophys Acta. 2010;1802(1):80–91. doi:10.1016/j.bbadis.2009.09.00319751827
   PubMed Web of Science ®Google Scholar
• Le Bars PL, Katz MM, Berman N, Itil TM, Freedman AM, Schatzberg AF. A placebo-controlled, double-blind, randomized trial of an extract of Ginkgo biloba for dementia. North American EGb Study Group. Jama. 1997;278(16):1327–1332.9343463
   PubMed Web of Science ®Google Scholar
• Ihl R, Tribanek M, Bachinskaya N; GOTADAY Study Group. Efficacy and tolerability of a once daily formulation of Ginkgo biloba extract EGb 761(R) in Alzheimer’s disease and vascular dementia: results from a randomised controlled trial. Pharmacopsychiatry. 2012;45(2):41–46. doi:10.1055/s-0031-129121722086747
   PubMed Web of Science ®Google Scholar
• Yang X, Zheng T, Hong H, et al. Neuroprotective effects of Ginkgo biloba extract and Ginkgolide B against oxygen-glucose deprivation/reoxygenation and glucose injury in a new in vitro multicellular network model. Front Med. 2018;12(3):307–318. doi:10.1007/s11684-017-0547-229058254
   PubMed Web of Science ®Google Scholar
• Zeng X, Liu M, Yang Y, Li Y, Asplund K. Ginkgo biloba for acute ischaemic stroke. Cochrane Database Syst Rev. 2005;4:CD003691.
   PubMedGoogle Scholar
• van Beek TA, Montoro P. Chemical analysis and quality control of Ginkgo biloba leaves, extracts, and phytopharmaceuticals. J Chromatogr A. 2009;1216(11):2002–2032. doi:10.1016/j.chroma.2009.01.01319195661
   PubMed Web of Science ®Google Scholar
• Nakanishi K. Terpene trilactones from Gingko biloba: from ancient times to the 21st century. Bioorg Med Chem. 2005;13(17):4987–5000. doi:10.1016/j.bmc.2005.06.01415990319
   PubMed Web of Science ®Google Scholar
• Zimmermann M, Colciaghi F, Cattabeni F, et al. Ginkgo biloba extract: from molecular mechanisms to the treatment of alzheimer’s disease. Cell Mol Biol. 2002;48:613–623.12396071
   PubMed Web of Science ®Google Scholar
• Biber A, Koch E. Bioavailability of ginkgolides and bilobalide from extracts of ginkgo biloba using GC/MS. Planta Med. 1999;65(2):192–193. doi:10.1055/s-2006-96046710193211
   PubMed Web of Science ®Google Scholar
• Yin B, Xu Y, Wei R, et al. Ginkgo biloba on focal cerebral ischemia: a systematic review and meta-analysis. Am J Chin Med. 2014;42(4):769–783. doi:10.1142/S0192415X1450049925004874
   PubMed Web of Science ®Google Scholar
• Smith JV, Luo Y. Studies on molecular mechanisms of Ginkgo biloba extract. Appl Microbiol Biotechnol. 2004;64(4):465–472. doi:10.1007/s00253-003-1527-914740187
   PubMed Web of Science ®Google Scholar
• Zhang Z, Peng D, Zhu H, Wang X. Experimental evidence of Ginkgo biloba extract EGB as a neuroprotective agent in ischemia stroke rats. Brain Res Bull. 2012;87(2–3):193–198. doi:10.1016/j.brainresbull.2011.11.00222100334
   PubMed Web of Science ®Google Scholar
• Tian J, Liu Y, Chen K. Ginkgo biloba extract in vascular protection: molecular mechanisms and clinical applications. Curr Vasc Pharmacol. 2017;15(6):532–548. doi:10.2174/157016111566617071309554528707602
   PubMed Web of Science ®Google Scholar
• Zeng GR, Zhou SD, Shao YJ, et al. Effect of Ginkgo biloba extract-761 on motor functions in permanent middle cerebral artery occlusion rats. Phytomedicine. 2018;48:94–103. doi:10.1016/j.phymed.2018.05.00330195885
   PubMed Web of Science ®Google Scholar
• Tulsulkar J, Glueck B, Hinds TD Jr, Shah ZA. Ginkgo biloba extract prevents female mice from ischemic brain damage and the mechanism is independent of the HO1/Wnt pathway. Transl Stroke Res. 2016;7(2):120–131. doi:10.1007/s12975-015-0433-726573919
   PubMed Web of Science ®Google Scholar
• Longa EZ, Weinstein PR, Carlson S, Cummins R. Reversible middle cerebral artery occlusion without craniectomy in rats. Stroke. 1989;20(1):84–91.2643202
   PubMed Web of Science ®Google Scholar
• Chen J, Li Y, Wang L, et al. Therapeutic benefit of intravenous administration of bone marrow stromal cells after cerebral ischemia in rats. Stroke. 2001;32(4):1005–1011.11283404
   PubMed Web of Science ®Google Scholar
• Germano AF, Dixon CE, d’Avella D, Hayes RL, Tomasello F. Behavioral deficits following experimental subarachnoid hemorrhage in the rat. J Neurotrauma. 1994;11(3):345–353.7996588
   PubMed Web of Science ®Google Scholar
• Zhang R, Yang N, Ji C, et al. Neuroprotective effects of Aceglutamide on motor function in a rat model of cerebral ischemia and reperfusion. Restor Neurol Neurosci. 2015;33(5):741–759. doi:10.3233/RNN-15050926444640
   PubMed Web of Science ®Google Scholar
• Dang S, Liu X, Fu P, et al. Neuroprotection by local intra-arterial infusion of erythropoietin after focal cerebral ischemia in rats. Neurol Res. 2011;33(5):520–528. doi:10.1179/016164111X1300785608428721669122
   PubMed Web of Science ®Google Scholar
• Swanson RA, Morton MT, Tsao-Wu G, Savalos RA, Davidson C, Sharp FR. A semiautomated method for measuring brain infarct volume. J Cereb Blood Flow Metab. 1990;10(2):290–293. doi:10.1038/jcbfm.1990.471689322
   PubMed Web of Science ®Google Scholar
• Gabryel B, Kost A, Kasprowska D. Neuronal autophagy in cerebral ischemia–a potential target for neuroprotective strategies? Pharmacol Rep. 2012;64(1):1–15.22580515
   PubMed Web of Science ®Google Scholar
• Mizushima N. Autophagy: process and function. Genes Dev. 2007;21(23):2861–2873. doi:10.1101/gad.159920718006683
   PubMed Web of Science ®Google Scholar
• McKnight NC, Zhenyu Y. Beclin 1, an essential component and master regulator of PI3K-III in health and disease. Curr Pathobiol Rep. 2013;1(4):231–238. doi:10.1007/s40139-013-0028-524729948
   PubMedGoogle Scholar
• Cao Y, Klionsky DJ. Physiological functions of Atg6/Beclin1: a unique autophagy-related protein. Cell Res. 2007;17(10):839–849. doi:10.1038/cr.2007.7817893711
   PubMed Web of Science ®Google Scholar
• Tian W, Li W, Chen Y, et al. Phosphorylation of ULK1 by AMPK regulates translocation of ULK1 to mitochondria and mitophagy. FEBS Lett. 2015;589(15):1847–1854. doi:10.1016/j.febslet.2015.05.02025980607
   PubMed Web of Science ®Google Scholar
• Kim J, Kundu M, Viollet B, Guan KL. AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1. Nat Cell Biol. 2011;13(2):132–141. doi:10.1038/ncb215221258367
   PubMed Web of Science ®Google Scholar
• Lee J, Giordano S, Zhang J. Autophagy, mitochondria and oxidative stress: cross-talk and redox signalling. Biochem J. 2012;441(2):523–540. doi:10.1042/BJ2011145122187934
   PubMed Web of Science ®Google Scholar
• Shacka JJ, Roth KA, Zhang J. The autophagy-lysosomal degradation pathway: role in neurodegenerative disease and therapy. Front Biosci. 2008;13:718–736.17981582
   PubMed Web of Science ®Google Scholar
• Springer W, Kahle PJ. Regulation of PINK1-Parkin-mediated mitophagy. Autophagy. 2011;7(3):266–278. doi:10.4161/auto.7.3.1434821187721
   PubMed Web of Science ®Google Scholar
• Hu C, Huang Y, Li L. Drp1-dependent Mitochondrial fission plays critical roles in physiological and pathological progresses in mammals. Int J Mol Sci. 2017;18(1):E144. doi:10.3390/ijms1801014428098754
   PubMed Web of Science ®Google Scholar
• Farmer T, Reinecke JB, Xie S, Bahl K, Naslavsky N, Caplan S. Control of mitochondrial homeostasis by endocytic regulatory proteins. J Cell Sci. 2017;130(14):2359–2370. doi:10.1242/jcs.20453728596240
   PubMed Web of Science ®Google Scholar
• Zhang P, Yang L, He H, Deng Y. Differential variations of autophagy and apoptosis in permanent focal cerebral ischaemia rat model. Brain Inj. 2017;31(8):1151–1158. doi:10.1080/02699052.2017.129800528506087
   PubMed Web of Science ®Google Scholar
• Gao Y, Chen T, Lei X, et al. Neuroprotective effects of polydatin against mitochondrial-dependent apoptosis in the rat cerebral cortex following ischemia/reperfusion injury. Mol Med Rep. 2016;14(6):5481–5488. doi:10.3892/mmr.2016.593627840959
   PubMed Web of Science ®Google Scholar
• Cao C, Han D, Su Y, Ge Y, Chen H, Xu A. Ginkgo biloba exocarp extracts induces autophagy in Lewis lung cancer cells involving AMPK/mTOR/p70S6k signaling pathway. Biomed Pharmacother. 2017;93:1128–1135. doi:10.1016/j.biopha.2017.07.03628738521
   PubMed Web of Science ®Google Scholar
• Rubinsztein DC, DiFiglia M, Heintz N, et al. Autophagy and its possible roles in nervous system diseases, damage and repair. Autophagy. 2005;1(1):11–22. doi:10.4161/auto.1.1.151316874045
   PubMed Web of Science ®Google Scholar
• Thorburn A. Apoptosis and autophagy: regulatory connections between two supposedly different processes. Apoptosis. 2008;13(1):1–9. doi:10.1007/s10495-007-0154-917990121
   PubMed Web of Science ®Google Scholar
• Alers S, Löffler AS, Wesselborg S, Stork B. Role of AMPK-mTOR-Ulk1/2 in the regulation of autophagy: cross talk, shortcuts, and feedbacks. Mol Cell Biol. 2012;32(1):2–11. doi:10.1128/MCB.06159-1122025673
   PubMed Web of Science ®Google Scholar
• Ni HM, Williams JA, Ding WX. Mitochondrial dynamics and mitochondrial quality control. Redox Biol. 2015;4:6–13. doi:10.1016/j.redox.2014.11.00625479550
   PubMed Web of Science ®Google Scholar
• Tamm I, Schriever F, Dörken B. Apoptosis: implications of basic research for clinical oncology. The Lancet Oncology. 2001;2(1):33–42. doi:10.1016/S1470-2045(00)00193-511905616
   PubMed Web of Science ®Google Scholar