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Neuropsychiatric Disease and Treatment Volume 8, 2012 - Issue
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Review

Sumatriptan transdermal iontophoretic patch (NP101-Zelrix™): review of pharmacology, clinical efficacy, and safety in the acute treatment of migraine

Michail Vikelis1 Glyfada Headache Center, Glyfada, GreeceCorrespondence[email protected]
,
Dimos D Mitsikostas2 Neurology Department, Athens Naval Hospital, Athens, Greece
&
Alan M Rapoport3 The David Geffen School of Medicine at UCLA, Los Angeles, CA, USA
Pages 429-434 | Published online: 26 Sep 2012

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Amanda E. Macone & Michael D. Perloff. (2017) Triptans and migraine: advances in use, administration, formulation, and development. Expert Opinion on Pharmacotherapy 18:4, pages 387-397.
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Piero Barbanti, C. Aurilia, G. Egeo, L. Fofi & R. Palmirotta. (2017) Serotonin receptor targeted therapy for migraine treatment: an overview of drugs in phase I and II clinical development. Expert Opinion on Investigational Drugs 26:3, pages 269-277.
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Ki-Taek Kim, Joon Lee, Min-Hwan Kim, Ju-Hwan Park, Jae-Young Lee, Joo-Hyun Song, Minwoong Jung, Myoung-Hoon Jang, Hyun-Jong Cho, In-Soo Yoon & Dae-Duk Kim. (2017) Novel reverse electrodialysis-driven iontophoretic system for topical and transdermal delivery of poorly permeable therapeutic agents. Drug Delivery 24:1, pages 1204-1215.
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Joon Lee, Kilsung Kwon, Minyoung Kim, Joonhong Min, Nathaniel S. Hwang & Won-serk Kim. (2017) Transdermal iontophoresis patch with reverse electrodialysis. Drug Delivery 24:1, pages 701-706.
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János Tajti, Zsófia Majláth, Délia Szok, Anett Csáti & László Vécsei. (2015) Drug safety in acute migraine treatment. Expert Opinion on Drug Safety 14:6, pages 891-909.
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Miguel JA Láinez, Ana García-Casado & Francisco Gascón. (2013) Optimal management of severe nausea and vomiting in migraine: improving patient outcomes. Patient Related Outcome Measures 4, pages 61-73.
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Articles from other publishers (14)

Sara Assadpour, Mohammad Reza Shiran, Peyman Asadi, Javad Akhtari & Amirhossein Sahebkar. (2022) Harnessing Intranasal Delivery Systems of Sumatriptan for the Treatment of Migraine. BioMed Research International 2022, pages 1-9.
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Shotaro Yoshida, Hiroya Abe, Yuina Abe, Shinya Kusama, Kenichi Tsukada, Ryo Komatsubara & Matsuhiko Nishizawa. (2020) Totally organic electrical skin patch powered by flexible biobattery. Journal of Physics: Energy 2:4, pages 044004.
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P. Bakshi, D. Vora, K. Hemmady & A.K. Banga. (2020) Iontophoretic skin delivery systems: Success and failures. International Journal of Pharmaceutics 586, pages 119584.
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Shotaro Yoshida, Takaya Mizuno, Shinya Kusama, Kaito Sato, Bibek Raut & Matsuhiko Nishizawa. (2019) Series-Connected Flexible Biobatteries for Higher Voltage Electrical Skin Patches. ACS Applied Electronic Materials 2:1, pages 170-176.
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Hiroyuki Kai, Wataru Suda, Shotaro Yoshida & Matsuhiko Nishizawa. (2019) Organic electrochromic timer for enzymatic skin patches. Biosensors and Bioelectronics 123, pages 108-113.
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P. Ronnander, L. Simon, H. Spilgies, A. Koch & S. Scherr. (2018) Dissolving polyvinylpyrrolidone-based microneedle systems for in-vitro delivery of sumatriptan succinate. European Journal of Pharmaceutical Sciences 114, pages 84-92.
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Nathaniel M. Schuster & Alan M. Rapoport. (2016) New strategies for the treatment and prevention of primary headache disorders. Nature Reviews Neurology 12:11, pages 635-650.
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Dikla Gutman, Edward Hellriegel, Ernesto Aycardi, Marcelo E. Bigal, Jeevan Kunta, Rohini Chitra, Sujay Kansagra, Orna Srur Kidron, Helena Knebel, Steven Linder, Yuju Ma, Mark Pierce, Paul K. Winner & Ofer Spiegelstein. (2016) A Phase I, Open-Label, Single-Dose Safety, Pharmacokinetic, and Tolerability Study of the Sumatriptan Iontophoretic Transdermal System in Adolescent Migraine Patients. Headache: The Journal of Head and Face Pain 56:8, pages 1300-1309.
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Michail Vikelis, Konstantinos C. Spingos & Alan M. Rapoport. (2015) The iontophoretic transdermal system formulation of sumatriptan as a new option in the acute treatment of migraine: a perspective. Therapeutic Advances in Neurological Disorders 8:4, pages 160-165.
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Richard B. Lipton & Stephen D. Silberstein. (2015) Episodic and Chronic Migraine Headache: Breaking Down Barriers to Optimal Treatment and Prevention. Headache: The Journal of Head and Face Pain 55, pages 103-122.
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Sarah Vollbracht & Alan M. Rapoport. (2014) New treatments for headache. Neurological Sciences 35:S1, pages 89-97.
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Michail Vikelis, Dimos D Mitsikostas & Alan M Rapoport. (2014) Sumatriptan iontophoretic transdermal system for the acute treatment of migraine. Pain Management 4:2, pages 123-128.
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D. Wu, Y. Tanaka, Y. Jin, K. Yoneto, T. Alama, Y. Quan, F. Kamiyama, K. Kusamori, H. Katsumi, T. Sakane & A. Yamamoto. (2014) Development of a novel transdermal patch containing sumatriptan succinate for the treatment of migraine: in vitro and in vivo characterization. Journal of Drug Delivery Science and Technology 24:6, pages 695-701.
Crossref
Sarah Vollbracht & Alan M. Rapoport. (2013) The Pipeline in Headache Therapy. CNS Drugs 27:9, pages 717-729.
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