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Case Report

Two grams of sarcosine in schizophrenia – is it too much? A potential role of glutamate-serotonin interaction

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Pages 263-266 | Published online: 04 Feb 2014

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Dominik Strzelecki, Justyna Szyburska, Magdalena Kotlicka-Antczak & Olga Kałużyńska. (2015) Hypomania after augmenting venlafaxine and olanzapine with sarcosine in a patient with schizophrenia: a case study. Neuropsychiatric Disease and Treatment 11, pages 533-536.
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Arzugül Tanas, Özlem Özdemir Tozlu, Tuğba Gezmiş, Ahmet Hacimüftüoğlu, A. M. Abd El-Aty, Onur Ceylan, Adil Mardinoğlu & Hasan Türkez. (2022) In Vitro and In Vivo Neuroprotective Effects of Sarcosine. BioMed Research International 2022, pages 1-11.
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Julia Cappelli, Pamela Khacho, Boyang Wang, Alexandra Sokolovski, Wafae Bakkar, Sophie Raymond, Nina Ahlskog, Julian Pitney, Junzheng Wu, Prakash Chudalayandi, Adrian Y.C. Wong & Richard Bergeron. (2022) Glycine-induced NMDA receptor internalization provides neuroprotection and preserves vasculature following ischemic stroke. iScience 25:1, pages 103539.
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Ju-Chun Pei, Da-Zhong Luo, Shiang-Shin Gau, Chia-Yuan Chang & Wen-Sung Lai. (2021) Directly and Indirectly Targeting the Glycine Modulatory Site to Modulate NMDA Receptor Function to Address Unmet Medical Needs of Patients With Schizophrenia. Frontiers in Psychiatry 12.
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Kevin C.F. Fone, David J.G. Watson, Rodolphe I. Billiras, Dorothee I. Sicard, Anne Dekeyne, Jean-Michel Rivet, Alain Gobert & Mark J. Millan. (2020) Comparative Pro-cognitive and Neurochemical Profiles of Glycine Modulatory Site Agonists and Glycine Reuptake Inhibitors in the Rat: Potential Relevance to Cognitive Dysfunction and Its Management. Molecular Neurobiology 57:5, pages 2144-2166.
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Ju-Chun Pei, Wei-Li Hung, Bei-Xuan Lin, Min-Han Shih, Liang-Yin Lu, Da-Zhong Luo, Hwan-Ching Tai, Vincent Studer, Ming-Yuan Min & Wen-Sung Lai. (2019) Therapeutic potential and underlying mechanism of sarcosine (N-methylglycine) in N-methyl-D-aspartate (NMDA) receptor hypofunction models of schizophrenia. Journal of Psychopharmacology 33:10, pages 1288-1302.
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Naista Zhand, David G. Attwood & Philip D. Harvey. (2019) Glutamate modulators for treatment of schizophrenia. Personalized Medicine in Psychiatry 15-16, pages 1-12.
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Mei-Yi Lee, Yi-Ruu Lin, Yi-Shu Tu, Yufeng Jane Tseng, Ming-Huan Chan & Hwei-Hsien Chen. (2017) Effects of sarcosine and N, N-dimethylglycine on NMDA receptor-mediated excitatory field potentials. Journal of Biomedical Science 24:1.
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. 2016. Meyler's Side Effects of Drugs. Meyler's Side Effects of Drugs 310 .
Hanna Fałtynowicz, Marek Daszkiewicz, Rafał Wysokiński, Anna Adach & Maria Cieślak-Golonka. (2015) Ni(II) complex with sarcosine derived from in situ generated ligand: structural, spectroscopic, and DFT studies. Structural Chemistry 26:5-6, pages 1555-1563.
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. (2014) Citalopram/quetiapine/sarcosine interaction. Reactions Weekly 1491:1, pages 15-15.
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