172
Views
87
CrossRef citations to date
0
Altmetric
Original Research

Spectral domain optical coherence tomography as an effective screening test for hydroxychloroquine retinopathy (the “flying saucer” sign)

, , , , , & show all
Pages 1151-1158 | Published online: 06 Oct 2010

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (9)

Renata Tavares de Souza Cabral, Evandro Mendes Klumb & Sueli Carneiro. (2020) Patients opinion and adherence to antimalarials in lupus erythematosus and rheumatoid arthritis treatment. Journal of Dermatological Treatment 31:3, pages 264-269.
Read now
Heather G. Mack, Tanya Kowalski, Alexis Lucattini, Rc Andrew Symons, Ian Wicks & Anthony Jh Hall. (2020) Genetic susceptibility to hydroxychloroquine retinal toxicity. Ophthalmic Genetics 41:2, pages 159-170.
Read now
Puneet Agarwal, Yuk Hei Wong, Esha Dasgupta, Renu Agarwal, Bethel Indira Livingstone, Srinivasan Ramamurthy & Gun Suk Chyn. (2015) Early effect of hydroxychloroquine therapy: relationship between cumulative dose and retinal thickness. Cutaneous and Ocular Toxicology 34:3, pages 179-184.
Read now
David J Browning, Chong Lee & David Rotberg. (2014) The impact of different algorithms for ideal body weight on screening for hydroxychloroquine retinopathy in women. Clinical Ophthalmology 8, pages 1401-1407.
Read now
Won June Lee, Myung-Kyoo Ko & Byung Ro Lee. (2012) Hydroxychloroquine retinopathy combined with retinal pigment epithelium detachment. Cutaneous and Ocular Toxicology 31:2, pages 144-147.
Read now

Articles from other publishers (78)

Kai Xiong Cheong, Charles Jit Teng Ong, Priya R Chandrasekaran, Jinzhi Zhao, Kelvin Yi Chong Teo & Ranjana Mathur. (2023) Review of Retinal Imaging Modalities for Hydroxychloroquine Retinopathy. Diagnostics 13:10, pages 1752.
Crossref
Pushpinder Kanda, Stuart Coupland, Chloe Gottlieb, Lynca Kantungane & Rustum Karanjia. (2022) Screening for Plaquenil. Advances in Ophthalmology and Optometry 7:1, pages 263-278.
Crossref
Faisal Habib, Huaxiong Huang, Arvind Gupta & Tom Wright. (2022) MERCI: a machine learning approach to identifying hydroxychloroquine retinopathy using mfERG. Documenta Ophthalmologica 145:1, pages 53-63.
Crossref
Sevda Aydın Kurna, Hatice Selen Kanar, Murat Garlı & Necati Çakır. (2022) Evaluation of the role of spectral-domain optical coherence tomography in the early detection of macular and ganglion cell complex thickness changes in patients with rheumatologic diseases taking hydroxychloroquine. Photodiagnosis and Photodynamic Therapy 38, pages 102741.
Crossref
Anahita Bajka, Mario Toro, Christoph Kniestedt & Sandrine Zweifel. (2022) Decrease in Visual Acuity in a 77-Year-old Woman with Age-Related Macular Degeneration after a SARS-CoV-2 Infection Treated with Hydroxychloroquine. Klinische Monatsblätter für Augenheilkunde 239:04, pages 527-530.
Crossref
Gopal Jayakar, Tharindu De Silva & Catherine A. Cukras. (2022) Visual Field Sensitivity Prediction Using Optical Coherence Tomography Analysis in Hydroxychloroquine Toxicity. Investigative Opthalmology & Visual Science 63:1, pages 15.
Crossref
Armaan M Nazir, Bhavya Koganti, Kunal Gupta, Marrium S Memon, Muhammad Bin Aslam Zahid, Vignarth Shantha Kumar, Mamatha Tappiti & Jihan A Mostafa. (2021) Evaluating the Use of Hydroxychloroquine in Treating Patients With Rheumatoid Arthritis. Cureus.
Crossref
Logandran Vijaya Kumar, Kursiah Mohd Razali & Wan Hazabbah Wan Hitam. (2021) Hydroxychloroquine retinal toxicity- Can we do better with SD-OCT?. Indian Journal of Clinical and Experimental Ophthalmology 7:3, pages 457-465.
Crossref
Kyle D. Kovacs, Anton Orlin, Dolan Sondhi, Stephen M. Kaminsky, Donald J. D'Amico, Ronald G. Crystal & Szilárd Kiss. (2021) Automated Retinal Layer Segmentation in CLN2 -Associated Disease: Commercially Available Software Characterizing a Progressive Maculopathy . Translational Vision Science & Technology 10:8, pages 23.
Crossref
Hani Hasan, Andrew Lotery, Elizabeth J. Price & Guy T. Smith. (2020) An objective method of diagnosing hydroxychloroquine maculopathy. Eye 35:7, pages 1922-1929.
Crossref
Ratnesh Ranjan, George J Manayath, Romit Salian & Venkatapathy Narendran. (2020) Methoxsalen-induced advanced bull’s eye maculopathy. European Journal of Ophthalmology 31:3, pages NP70-NP73.
Crossref
Manesh Manoj, Rasmi Ranjan Sahoo, Ankita Singh, Kasturi Hazarika, Prashant Bafna, Apjit Kaur & Anupam Wakhlu. (2021) Prevalence of hydroxychloroquine retinopathy with long-term use in a cohort of Indian patients with rheumatic diseases. Rheumatology International 41:5, pages 929-937.
Crossref
V. V. Neroev, T. N. Kiseleva & E. K. Eliseeva. (2021) Ophthalmological aspects of coronavirus infections. Russian Ophthalmological Journal 14:1, pages 7-14.
Crossref
Dimitrios Kourkoutas, George Triantafyllopoulos, Aristotelis Karamaounas & Nikolaos Karamaounas. (2021) Hydroxychloroquine and SARS-CoV-2 (COVID-19): An Old Problem and New Considerations in Ophthalmology. The Open Ophthalmology Journal 14:1, pages 78-81.
Crossref
Moataz A. Sallam, Arwa S. Beltagi, Mai A. Abdellatif & Magdy A. Awadalla. (2021) Visual Impact of Early Hydroxychloroquine-Related Retinal Structural Changes in Patients with Systemic Lupus Erythematosus. Ophthalmologica 244:4, pages 301-308.
Crossref
Shikha Pandey, Poninder Kumar, P.S. Moulick & Sumedha Vats. (2020) Spectral domain optical coherence tomography–based prevalence of hydroxychloroquine maculopathy in Indian patients on hydroxychloroquine therapy: A utopia of underdiagnosis. Medical Journal Armed Forces India 76:4, pages 395-401.
Crossref
A. Rickmann, S. Al-Nawaiseh, L. Ramirez, S. Röhrig, M. Ladewig, P. Szurman & G. Szurman. (2019) Progressive Makulopathie trotz Absetzen der Chloroquin-Therapie – Multimodale Bildgebung und Review der LiteraturProgressive maculopathy despite discontinuation of chloroquine treatment—multimodal imaging and review of the literature. Der Ophthalmologe 117:9, pages 917-925.
Crossref
Federica Bertoli, Maja Šuštar, Martina Jarc Vidmar, Darko Perovšek, Jelka Brecelj, Špela Markelj, Polona Jaki Mekjavić, Daša Šuput, Matija Tomšič, Miriam Isola, Claudio Battistella, Paolo Lanzetta & Marko Hawlina. (2020) Electrophysiological and SD-OCT findings in patients receiving chloroquine therapy in relation to cumulative dosage and duration of treatment. Documenta Ophthalmologica 141:1, pages 1-14.
Crossref
Weilin SongJustin C. MusteTyler E. GreenleeRishi P. Singh. (2020) Chloroquine and Hydroxychloroquine Toxicity. American Journal of Ophthalmic Clinical Trials 2, pages 8.
Crossref
KAYLENE L. CARTER & DIANA V. DO. (2020) Hydroxychloroquine-induced Retinal Toxicity. The Journal of Rheumatology 47:4, pages 632-632.
Crossref
Neil Sheth, Tara Schaab & Rukhsana G. Mirza. (2019) Advanced Pericentral Hydroxychloroquine Retinopathy in an Asian Woman. Journal of VitreoRetinal Diseases 4:2, pages 148-151.
Crossref
Aviel Hadad, Omar Helmy, Samuel Leeman & Shlomit Schaal. (2020) A Novel Multimethod Image Analysis to Quantify Pentosan Polysulfate Sodium Retinal Toxicity. Ophthalmology 127:3, pages 429-431.
Crossref
Beatrice Adamptey, Christopher J. Rudnisky & Ian M. MacDonald. (2020) Effect of stopping hydroxychloroquine therapy on the multifocal electroretinogram in patients with rheumatic disorders. Canadian Journal of Ophthalmology 55:1, pages 38-44.
Crossref
M.V. Budzinskaya & M.H. Durzhinskaya. (2020) Differential diagnosis of hydroxychloroquine-induced retinal damage. Vestnik oftal'mologii 136:4, pages 265.
Crossref
Mohammad Dahrouj & Lucy Young. (2020) Hydroxychloroquine Retinopathy in the Era of Advanced Imaging Modalities. International Ophthalmology Clinics 60:1, pages 73-83.
Crossref
Giulia Corradetti, Sara Violanti, Adrian Au & David Sarraf. (2019) Wide field retinal imaging and the detection of drug associated retinal toxicity. International Journal of Retina and Vitreous 5:S1.
Crossref
Sean T Garrity, Joo Yeon Jung, Olivia Zambrowski, Francesco Pichi, Daniel Su, Malvika Arya, Nadia K Waheed, Jay S Duker, Yaïr Chetrit, Elisabetta Miserocchi, Chiara Giuffrè, Talia R Kaden, Giuseppe Querques, Eric H Souied, K Bailey Freund & David Sarraf. (2019) Early hydroxychloroquine retinopathy: optical coherence tomography abnormalities preceding Humphrey visual field defects. British Journal of Ophthalmology 103:11, pages 1600-1604.
Crossref
Francisco Javier Lara-Medina, Olivia Esteban, Isabel Bartolomé, C. Ispa, Javier Mateo & Francisco Javier Ascaso. 2019. A Practical Guide to Clinical Application of OCT in Ophthalmology. A Practical Guide to Clinical Application of OCT in Ophthalmology.
Akshay Jain, Itamar Livnat, Michael S. Tsipursky, Alexandra Y. Almasov, Kathleen Campbell Garwood & Leanne T. Labriola. (2019) Automated Segmentation Measurements of the Outer Nuclear Layer in Determining Cases of Hydroxychloroquine Toxicity: A Retrospective Study. Journal of VitreoRetinal Diseases 3:3, pages 135-144.
Crossref
I. Zone Abid, I. Kaibi, R. Turki, S. Gargouri & J. Feki. (2019) Signe de soucoupe volante dans la rétinopathie toxique à l’hydroxychloroquine. Journal Français d'Ophtalmologie 42:5, pages 542-543.
Crossref
Chandoshi Mukherjee, Qusay Al-Fahad & Samer Elsherbiny. (2019) The role of optical coherence tomography in therapeutics and conditions, which primarily have systemic manifestations: a narrative review. Therapeutic Advances in Ophthalmology 11, pages 251584141983115.
Crossref
Madhura A. Tamhankar. 2019. Liu, Volpe, and Galetta's Neuro-Ophthalmology. Liu, Volpe, and Galetta's Neuro-Ophthalmology 53 99 .
Winston Lee, Jana Zernant, Takayuki Nagasaki, Stephen H. Tsang & Rando Allikmets. (2018) Deep Scleral Exposure: A Degenerative Outcome of End-Stage Stargardt Disease. American Journal of Ophthalmology 195, pages 16-25.
Crossref
S. Trad, C. Bonnet & D. Monnet. (2018) Uvéite médicamenteuse et effets indésirables des médicaments en ophtalmologie. La Revue de Médecine Interne 39:9, pages 699-710.
Crossref
Heather G. Mack, R.C. Andrew Symons & Gerard de Jong. (2018) Bull's eye maculopathy and subfoveal deposition in two mucopolysaccharidosis type I patients on long-term enzyme replacement therapy. American Journal of Ophthalmology Case Reports 9, pages 1-6.
Crossref
Remya Mareen Paulose, Jay Chhablani & William F. Mieler. 2018. Retinal and Choroidal Imaging in Systemic Diseases. Retinal and Choroidal Imaging in Systemic Diseases 29 50 .
Hande Husniye Telek, Nilufer Yesilirmak, Gulten Sungur, Yaprak Ozdemir, Nesibe Karahan Yesil & Firdevs Ornek. (2017) Retinal toxicity related to hydroxychloroquine in patients with systemic lupus erythematosus and rheumatoid arthritis. Documenta Ophthalmologica 135:3, pages 187-194.
Crossref
Ji-Won Kim, Yoon Young Kim, Hwajeong Lee, Sung-Hoon Park, Seong-Kyu Kim & Jung-Yoon Choe. (2017) Risk of Retinal Toxicity in Longterm Users of Hydroxychloroquine. The Journal of Rheumatology 44:11, pages 1674-1679.
Crossref
A. Couturier, A. Giocanti-Aurégan, B. Dupas, J.-F. Girmens, Y. Le Mer, N. Massamba, E. Barreau & I. Audo. (2017) Mise à jour des recommandations sur la toxicité rétinienne des antipaludéens de synthèse. Journal Français d'Ophtalmologie 40:9, pages 793-800.
Crossref
M Latasiewicz, H Gourier, I H Yusuf, R Luqmani, S M Sharma & S M Downes. (2017) Hydroxychloroquine retinopathy: an emerging problem. Eye 31:6, pages 972-976.
Crossref
M. Zayani, W. Ammari, S. Najjar, R. Bannour, B. Karsou, N. Lahmar, R. Messaoud & M. Khairallah. (2017) Apport de l’OCT spectral domain dans le diagnostic précoce de la maculopathie aux antipaludéens de synthèse : à propos d’un cas. Journal Français d'Ophtalmologie 40:3, pages e105-e107.
Crossref
Nikunjkumar Dadhaniya, Isha Sood, Abhishek Patil, Himanshu Aggarwal, Sundeep Kumar Upadhyaya, Rohini Handa & Sirinder Jit Gupta. (2017) Screening for hydroxychloroquine retinal toxicity: Current recommendations. Apollo Medicine 14:1, pages 27-30.
Crossref
M. Ferrell Ramos, M. Attar, M.E. Stern, J.A. Brassard, A.S. Kim, S. Matsumoto & C. Vangyi. 2017. A Comprehensive Guide to Toxicology in Nonclinical Drug Development. A Comprehensive Guide to Toxicology in Nonclinical Drug Development 757 811 .
David R. Lally, Jeffrey S. Heier, Caroline Baumal, Andre J. Witkin, Steven Maler, Chirag P. Shah, Elias Reichel, Nadia K. Waheed, Igor Bussel, Adam Rogers & Jay S. Duker. (2016) Expanded spectral domain-OCT findings in the early detection of hydroxychloroquine retinopathy and changes following drug cessation. International Journal of Retina and Vitreous 2:1.
Crossref
Andrew J. McClellan, Jonathan S. Chang & William E. Smiddy. (2016) AIMING FOR THE BULL'S EYE. Retina 36:10, pages 1958-1963.
Crossref
Yasha S. Modi, Adrian Au, Vishal S. Parikh, Justis P. Ehlers, Andrew P. Schachat & Rishi P. Singh. (2016) VOLUMETRIC SINGLE-LAYER INNER RETINAL ANALYSIS IN PATIENTS WITH HYDROXYCHLOROQUINE TOXICITY. Retina 36:10, pages 1941-1950.
Crossref
J. Campos-Pavón, J. Sambricio & I. Redondo-García. (2016) Signs of hydroxychloroquine toxicity in a patient with rhegmatogenous retinal detachment. Archivos de la Sociedad Española de Oftalmología (English Edition) 91:9, pages 450-452.
Crossref
J. Campos-Pavón, J. Sambricio & I. Redondo-García. (2016) Signos de toxicidad por hidroxicloroquina en un paciente con desprendimiento de retina regmatógeno. Archivos de la Sociedad Española de Oftalmología 91:9, pages 450-452.
Crossref
Manuel Garza-Leon, Diana Elsa Flores-Alvarado & Juan Manuel Muñoz-Bravo. (2016) Toxicidad retiniana asociada al uso de medicamentos antipalúdicos: revisión de la literatura y presentación de un caso. Medwave 16:05, pages e6471-e6471.
Crossref
Hui Jen Ding, Alastair K. Denniston, Vijay K. Rao & Caroline Gordon. (2016) Hydroxychloroquine-related retinal toxicity. Rheumatology 55:6, pages 957-967.
Crossref
Kalev Nõupuu, Winston Lee, Jana Zernant, Vivienne C. Greenstein, Stephen Tsang & Rando Allikmets. (2015) Recessive Stargardt disease phenocopying hydroxychloroquine retinopathy. Graefe's Archive for Clinical and Experimental Ophthalmology 254:5, pages 865-872.
Crossref
R.K. Murthy, Shamim Haji, Kumar Sambhav, Sandeep Grover & K.V. Chalam. (2016) Clinical applications of spectral domain optical coherence tomography in retinal diseases. Biomedical Journal 39:2, pages 107-120.
Crossref
Paradee Kunavisarut, Pimploy Chavengsaksongkram, Aniki Rothova & Kessara Pathanapitoon. (2016) Screening for chloroquine maculopathy in populations with uncertain reliability in outcomes of automatic visual field testing. Indian Journal of Ophthalmology 64:10, pages 710.
Crossref
Hasim Uslu, Bulent Gurler, Aydin Yildirim, Mehmet Gurkan Tatar, Feride Aylin Kantarcı, Hasan Goker, Hatice Seval Pehlevan & Hatice Nur Colak. (2016) Effect of Hydroxychloroquine on the Retinal Layers: A Quantitative Evaluation with Spectral-Domain Optical Coherence Tomography. Journal of Ophthalmology 2016, pages 1-8.
Crossref
Priya Sharma & Robert C. Sergott. 2016. Optical Coherence Tomography. Optical Coherence Tomography 1 10 .
G Y Liu, T O Utset & J T Bernard. (2015) Retinal nerve fiber layer and macular thinning in systemic lupus erythematosus: an optical coherence tomography study comparing SLE and neuropsychiatric SLE. Lupus 24:11, pages 1169-1176.
Crossref
Adrian Au, Vishal Parikh, Yasha S. Modi, Justis P. Ehlers, Andrew P. Schachat & Rishi P. Singh. (2015) Hydroxychloroquine Screening Practice Patterns Within a Large Multispecialty Ophthalmic Practice. American Journal of Ophthalmology 160:3, pages 561-568.e2.
Crossref
V.M. Asensio-Sánchez. (2015) SD-OCT as screening test for hydroxychloroquine retinopathy: The “flying saucer” sign. Archivos de la Sociedad Española de Oftalmología (English Edition) 90:7, pages 338-340.
Crossref
V.M. Asensio-Sánchez. (2015) SD-OCT como prueba de detección en retinopatía por hidroxicloroquina: el «signo del platillo volante». Archivos de la Sociedad Española de Oftalmología 90:7, pages 338-340.
Crossref
Dong Hoon Lee, Ronald B. Melles, Soo Geun Joe, Joo Yong Lee, June-Gone Kim, Chang-Keun Lee, Bin Yoo, Bon San Koo, Jee Taek Kim, Michael F. Marmor & Young Hee Yoon. (2015) Pericentral Hydroxychloroquine Retinopathy in Korean Patients. Ophthalmology 122:6, pages 1252-1256.
Crossref
S. Jaumouillé, D. Espargillière, F. Mouriaux & B. Mortemousque. (2015) Évaluation en pratique clinique des nouvelles stratégies de dépistage des maculopathies toxiques au plaquénil, selon les nouvelles recommandations de l’American Academy of Ophthalmology. Étude prospective monocentrique à propos de 184 patients. Journal Français d'Ophtalmologie 38:5, pages 377-387.
Crossref
Catherine Cukras, Nancy Huynh, Susan Vitale, Wai T. Wong, Fredrick L. FerrisIIIIII & Paul A. Sieving. (2015) Subjective and Objective Screening Tests for Hydroxychloroquine Toxicity. Ophthalmology 122:2, pages 356-366.
Crossref
Vivienne C. Greenstein, Luz Amaro-Quireza, Evelyn S. Abraham, Rithambara Ramachandran, Stephen H. Tsang & Donald C. Hood. (2014) A comparison of structural and functional changes in patients screened for hydroxychloroquine retinopathy. Documenta Ophthalmologica 130:1, pages 13-23.
Crossref
HemangK Pandya, Mark Robinson, Nawajes Mandal & VinayA Shah. (2015) Hydroxychloroquine retinopathy: A review of imaging. Indian Journal of Ophthalmology 63:7, pages 570.
Crossref
Riham S. H. M. Allam, Mai N. Abd-Elmohsen, Mohamed M. Khafagy, Karim A. Raafat & Sherif M. Sheta. (2015) Spectral-Domain Optical Coherence Tomography of Preclinical Chloroquine Maculopathy in Egyptian Rheumatoid Arthritis Patients. Journal of Ophthalmology 2015, pages 1-7.
Crossref
Gabrielle S. Graves, Murtaza K. Adam, Kimberly E. Stepien & Dennis P. Han. (2014) Validation of the colour difference plot scoring system analysis of the 103 hexagon multifocal electroretinogram in the evaluation of hydroxychloroquine retinal toxicity. Acta Ophthalmologica 92:5, pages e377-e381.
Crossref
David J. BrowningDavid J. Browning. 2014. Hydroxychloroquine and Chloroquine Retinopathy. Hydroxychloroquine and Chloroquine Retinopathy 227 245 .
David J. BrowningDavid J. Browning. 2014. Hydroxychloroquine and Chloroquine Retinopathy. Hydroxychloroquine and Chloroquine Retinopathy 155 226 .
David J. BrowningDavid J. Browning. 2014. Hydroxychloroquine and Chloroquine Retinopathy. Hydroxychloroquine and Chloroquine Retinopathy 133 154 .
David J. BrowningDavid J. Browning. 2014. Hydroxychloroquine and Chloroquine Retinopathy. Hydroxychloroquine and Chloroquine Retinopathy 107 131 .
David J. BrowningDavid J. Browning. 2014. Hydroxychloroquine and Chloroquine Retinopathy. Hydroxychloroquine and Chloroquine Retinopathy 85 94 .
David J. BrowningDavid J. Browning. 2014. Hydroxychloroquine and Chloroquine Retinopathy. Hydroxychloroquine and Chloroquine Retinopathy 1 34 .
Lucía Martínez-Costa, María Victoria Ibañez, Cinta Murcia-Bello, Irene Epifanio, Cristina Verdejo-Gimeno, Emma Beltrán-Catalán & Pilar Marco-Ventura. (2013) Use of microperimetry to evaluate hydroxychloroquine and chloroquine retinal toxicity. Canadian Journal of Ophthalmology 48:5, pages 400-405.
Crossref
R V Jivrajka, M A Genead, J J McAnany, C C Chow & W F Mieler. (2013) Microperimetric sensitivity in patients on hydroxychloroquine (Plaquenil) therapy. Eye 27:9, pages 1044-1052.
Crossref
David J. Browning. (2013) Impact of the Revised American Academy of Ophthalmology Guidelines Regarding Hydroxychloroquine Screening on Actual Practice. American Journal of Ophthalmology 155:3, pages 418-428.e1.
Crossref
Naoual Tarfaoui, Elisabeth Autret-Leca, Samuel Mazjoub, Hawaré Cissoko & Annie-Pierre Jonville-Béra. (2013) Toxicité rétinienne de l’hydroxychloroquine chez le nouveau-né exposé in utero. Therapies 68:1, pages 43-47.
Crossref
Rajen Tailor, Ibrahim Elaraoud, Peter Good, Monique Hope-Ross & Robert A. H. Scott. (2012) A Case of Severe Hydroxychloroquine-Induced Retinal Toxicity in a Patient with Recent Onset of Renal Impairment: A Review of the Literature on the Use of Hydroxychloroquine in Renal Impairment. Case Reports in Ophthalmological Medicine 2012, pages 1-3.
Crossref
Randy H. Kardon. (2011) Role of the Macular Optical Coherence Tomography Scan in Neuro-Ophthalmology. Journal of Neuro-Ophthalmology 31:4, pages 353-361.
Crossref