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Review

XEN glaucoma treatment system in the management of refractory glaucomas: a short review on trial data and potential role in clinical practice

A De Gregorio1 Ophthalmic Unit, San Bassiano Hospital, Bassano del Grappa, ItalyCorrespondence[email protected]
,
E Pedrotti2 Eye Clinic, Department of Neuroscience, Biomedicine and Movement Sciences, University of Verona, Verona, Italy
,
G Stevan1 Ophthalmic Unit, San Bassiano Hospital, Bassano del Grappa, Italy
,
A Bertoncello1 Ophthalmic Unit, San Bassiano Hospital, Bassano del Grappa, Italy
&
S Morselli1 Ophthalmic Unit, San Bassiano Hospital, Bassano del Grappa, Italy
Pages 773-782 | Published online: 30 Apr 2018

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Hanna Faber, Vanessa Guggenberger & Bogomil Voykov. (2022) XEN45 Gelstent Implantation in the Treatment of Glaucoma Secondary to Fuchs Uveitis Syndrome. Ocular Immunology and Inflammation 30:7-8, pages 1678-1685.
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Articles from other publishers (50)

Yasmine Serrar, Amina Rezkallah, Laurent Kodjikian, Muriel Poli, Thibaud Mathis & Philippe Denis. (2022) XEN ® 63 gel stent to treat a refractory uveitic glaucoma: A case report . European Journal of Ophthalmology 33:4, pages NP32-NP36.
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Bjorn Kaijun Betzler, Sheng Yang Lim, Boon Ang Lim, Vivien Cherng Hui Yip & Bryan Chin Hou Ang. (2022) Complications and post-operative interventions in XEN45 gel stent implantation in the treatment of open angle glaucoma—a systematic review and meta-analysis. Eye 37:6, pages 1047-1060.
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Paola Cassottana, Chiara Toma, Cristina Maltese, Viviana Villa, Roberta Ricciarelli, Carlo Enrico Traverso & Michele Iester. (2023) A Case of Bilateral Choroidal Effusion after XEN Gel Stent Implantation. Gels 9:4, pages 276.
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Lillian K. To, Rupak K. Dhoot, Alice Z. Chuang, Sam Karimaghaei, Francisco Guevara-Abadia, Ruchi D. Shah & Robert M. Feldman. (2022) Defining the role of ab externo Xen gel stent in glaucomatous eyes with prior failed surgical intervention. Graefe's Archive for Clinical and Experimental Ophthalmology 261:3, pages 779-789.
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C. About, J. Maalouf, C. Jacob, C. Jolly, Y.-E. Nisse & B. Demore. (2023) Gelatin implant in the treatment of open-angle glaucoma: Safety and efficacy in real-life conditions. Journal Français d'Ophtalmologie 46:2, pages 123-128.
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Michael C Yang, Sahar A Amoozadeh & Ken Y Lin. (2023) A Case of Refractory Open-angle Glaucoma with Failed Baerveldt Glaucoma Implant and Trabeculectomy Treated with Ab Externo XEN Gel Stent Placement. Journal of Current Glaucoma Practice 16:3, pages 192-194.
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Hyung Nam Jin, Jeong Woo Nam, Haowei Zhang, Mi Sun Sung & Sang Woo Park. (2022) Posture-induced changes in intraocular pressure after ab externo XEN45 gel-stent implantation in patients with primary open-angle glaucoma. BMC Ophthalmology 22:1.
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Xiang Yang, Yang Zhao, Yu Zhong & Xuanchu Duan. (2022) The efficacy of XEN gel stent implantation in glaucoma: a systematic review and meta-analysis. BMC Ophthalmology 22:1.
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Chang Kyu Lee, Je Hyun Seo & Su-Ho Lim. (2022) Management of XEN Gel Stent Exposure with Conjunctival Erosion via Rotational Conjunctival Flap and Amniotic Membrane Transplantation—A Case Report. Medicina 58:11, pages 1581.
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Alessandra De Gregorio, Margherita Montali, Giulia Stevan, Emilio Pedrotti & Simonetta Morselli. (2022) Theoretic scientific rationale of double XEN 45 Gel Stent implant in severe glaucomatous ocular hypertension. International Ophthalmology 43:5, pages 1629-1638.
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María Teresa Marcos-Parra, Angi Lizbeth Mendoza-Moreira, Lucía Moreno-Castro, Carlos Mateos-Marcos, Javier Alejandro Salinas-López, María Belén Figuerola-García, Ángela González-Alonso & Juan José Pérez-Santonja. (2022) 3-Year Outcomes of XEN Implant Compared With Trabeculectomy, With or Without Phacoemulsification for Open Angle Glaucoma. Journal of Glaucoma 31:10, pages 826-833.
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Lily Kai Man Xu & Toby Yiu Bong Chan. (2022) Ab Interno XEN Gel Stent Implantation in Eyes with Previous Tube Shunt Surgery. Clinical Ophthalmology Volume 16, pages 3205-3212.
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Andreas Schlatter, Teresa Rauchegger, Eduard Schmid & Barbara Teuchner. (2021) Effects of glaucoma surgery on visual field progression in open‐angle glaucoma considering the floor effect. Acta Ophthalmologica 100:5.
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Sheng Yang Lim, Bjorn Kaijun Betzler, Leonard Wei Leon Yip, Syril Dorairaj & Bryan Chin Hou Ang. (2022) Standalone XEN45 Gel Stent implantation in the treatment of open-angle glaucoma: A systematic review and meta-analysis. Survey of Ophthalmology 67:4, pages 1048-1061.
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Liat Mendel, Ron Eremenko, Lilly Zborowski- Naveh & Maya Kalev -Landoy. (2022) First XEN implantation in Axenfeld- Rieger syndrome: A case report and literature review. American Journal of Ophthalmology Case Reports 26, pages 101486.
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Martina Menchini, Francesco Sartini, Filippo Tatti, Enrico Peiretti & Michele Figus. (2021) Endothelial cell density change in fully dislocated XEN Gel IMPLANT after trabeculectomy: A case report. European Journal of Ophthalmology 32:3, pages NP14-NP18.
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Andrei-Alexandru Szigiato, Samir Touma, Samir Jabbour, Frederic Lord, Younes Agoumi & Harmanjit Singh. (2022) Efficacy of ab-interno gelatin microstent implantation in primary and refractory glaucoma. Canadian Journal of Ophthalmology.
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Vincenzo Ramovecchi, Fabrizio Franco & Giuseppe Ruben Barbera. (2022) XEN Gel Staining with Trypan Blue: A Simple and Effective Technique to Improve Device Visualization during Implantation. Journal of Current Glaucoma Practice 15:3, pages 161-163.
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Raquel Burggraaf-Sánchez de las Matas, Laura Such-Irusta, Enrique A Alfonso-Muñoz, Héctor Mascarós-Mena, Aitor Lanzagorta-Aresti, Jorge Mataix-Boronat & Carolina Font-Julià. (2022) Late-onset Endophthalmitis after XEN45® Implantation: A Retrospective Case Series and Literature Review. Journal of Current Glaucoma Practice 15:3, pages 153-160.
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Myrta Lippera, Stefano Lippera, Piero Ferroni, Giuseppe Pallotta, Sabrina Morodei, Alessia Iannone & Carlo Cagini. (2020) Xen Gel Stent as a minimally invasive option for intraocular pressure control after DSAEK: A case study. European Journal of Ophthalmology 32:1, pages NP194-NP198.
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Vikram Ponnusamy, Van Nguyen & Jella A. An. (2021) Comparative outcome analysis of bleb needling of fibrotic blebs in the clinic versus the operating room: a retrospective case series. BMC Ophthalmology 21:1.
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Brandon W. Kao, Elana Meer, Thomas A. Barbolt, Richard A. Lewis, Iqbal Ike Ahmed, Vivian Lee, Samuel M. Nicaise, Georgia Griggs & Eydie G. Miller-Ellis. (2021) Biocompatibility and feasibility of VisiPlate, a novel ultrathin, multichannel glaucoma drainage device. Journal of Materials Science: Materials in Medicine 32:12.
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Markus Gernhart, Bettina Hohberger & Robert Laemmer. (2021) Two-Year Follow-Up: Therapeutic Success with Respect to Axial Length of Stand-Alone Xen45 Gel Stent Implantation and Combined Procedures. Klinische Monatsblätter für Augenheilkunde 238:11, pages 1240-1247.
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Sheng Yang Lim, Bjorn Kaijun Betzler, Leonard Wei Leon Yip, Syril Dorairaj & Bryan Chin Hou Ang. (2021) Standalone XEN45 Gel Stent implantation versus combined XEN45-phacoemulsification in the treatment of open angle glaucoma—a systematic review and meta-analysis. Graefe's Archive for Clinical and Experimental Ophthalmology 259:11, pages 3209-3219.
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Jill Felicity Durey. (2021) Vivisection through the eyes of Wilkie Collins, HG Wells and John Galsworthy. Medical Humanities 47:3, pages 333-343.
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Cosme Lavin-Dapena, Rosa Cordero-Ros, Oriana D’Anna & Isabel Mogollón. (2020) XEN 63 gel stent device in glaucoma surgery: A 5-years follow-up prospective study. European Journal of Ophthalmology 31:4, pages 1829-1835.
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Carlo Alberto Cutolo, Letizia Negri, Sara Olivari, Francesca Cappelli, Carlo Enrico Traverso & Michele Iester. (2021) Choroidal Detachment after XEN Gel Stent Implantation. Journal of Ophthalmology 2021, pages 1-5.
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Chih-Hung Kuo. (2020) Lamellar sclerectomy augmented XEN gel stent glaucoma surgery. European Journal of Ophthalmology 31:2, pages 782-785.
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Aritz Urcola & Gonzaga Garay-Aramburu. (2021) Safety and efficacy of bilateral simultaneous XEN implant surgery: a pilot study. International Ophthalmology 41:3, pages 859-866.
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Je Hyun Seo & Su-Ho Lim. (2021) Recanalization of XEN-45 gel stent occlusion with cortical material after phaco-XEN surgery using Nd: YAG laser treatment. Medicine 100:34, pages e27010.
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Seungsoo Rho & Su-Ho Lim. (2021) Combined argon laser peripheral iridoplasty and Nd: YAG laser shock wave therapy for recurrent XEN gel stent obstruction due to iris incarceration. Medicine 100:29, pages e26652.
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Jill Felicity DureyJill Felicity Durey. 2021. John Galsworthy’s Compassion. John Galsworthy’s Compassion 209 238 .
Stefano Baiocchi, Cosimo Mazzotta, Arianna Sgheri, Alessandro Di Maggio, Simone Alex Bagaglia, Matteo Posarelli, Leonardo Ciompi, Alessandro Meduri & Gian Marco Tosi. (2020) In vivo confocal microscopy: qualitative investigation of the conjunctival and corneal surface in open angle glaucomatous patients undergoing the XEN-Gel implant, trabeculectomy or medical therapy. Eye and Vision 7:1.
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Karen Hong, John Lind & Arsham Sheybani. (2020) Safety and efficacy outcomes of the Xen45 Gel Stent use for refractory glaucoma: a surgery series from surgeon trainees at a tertiary teaching hospital. Eye and Vision 7:1.
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James M. Harris & David Solá-Del Valle. (2020) Effective treatment of a normal-tension glaucoma patient with bilateral ab externo XEN Gel Stent implantation. American Journal of Ophthalmology Case Reports 20, pages 100947.
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Filipa Jorge Teixeira, David Cordeiro Sousa, Nuno Martins Machado, Filipa Caiado, Rafael Barão, Paula Sens & Luís Abegão Pinto. (2020) XEN‐augmented Baerveldt surgical success rate and comparison with the Ahmed Valve. Acta Ophthalmologica 98:7.
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Ana Ibáñez-Muñoz, Víctor Santiago Soto-Biforcos, Leticia Rodríguez-Vicente, Irune Ortega-Renedo, María Chacón-González, Oscar Rúa-Galisteo, Alexandra Arrieta-Los Santos, María Ester Lizuain-Abadía & José Luis Del Río Mayor. (2019) XEN implant in primary and secondary open-angle glaucoma: A 12-month retrospective study. European Journal of Ophthalmology 30:5, pages 1034-1041.
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Yasmin Islam, Mark Sherwood & Charles Richard Blake. (2020) The Indications for Minimally Invasive Glaucoma Surgery, Trabeculectomy, Tube Shunts, and Cyclophotocoagulation in Glaucoma Surgery. Advances in Ophthalmology and Optometry 5, pages 147-170.
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Antonio M. Fea, Alain M. Bron, Mario A. Economou, Gianluca Laffi, Enrico Martini, Michele Figus & Francesco Oddone. (2020) European study of the efficacy of a cross-linked gel stent for the treatment of glaucoma. Journal of Cataract and Refractive Surgery 46:3, pages 441-450.
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Emma Linton & Leon Au. (2020) Technique of Xen Implant Revision Surgery and the Surgical Outcomes: A Retrospective Interventional Case Series. Ophthalmology and Therapy 9:1, pages 149-157.
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Bryan C. H. Ang, Sheng Yang Lim & Syril Dorairaj. (2019) Intra-operative optical coherence tomography in glaucoma surgery—a systematic review. Eye 34:1, pages 168-177.
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Vikas Shankar, Zaria C Ali, Dawnn I Khoo & Francessco Stringa. (2019) Migration of XEN45 Implant: Findings, Mechanism, and Management. Journal of Current Glaucoma Practice 13:2, pages 79-81.
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María Teresa Marcos Parra, Javier Alejandro Salinas López, Noelia Soledad López Grau, Ana María Ceausescu & Juan José Pérez Santonja. (2019) XEN implant device versus trabeculectomy, either alone or in combination with phacoemulsification, in open-angle glaucoma patients. Graefe's Archive for Clinical and Experimental Ophthalmology 257:8, pages 1741-1750.
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Francesco Stringa, Zaria Ali, Savvas Christou, Sumita Karandikar & Vikas Shankar. (2019) Managing Delayed Suprachoroidal Hemorrhage After Insertion of XEN45 Glaucoma Device. Journal of Glaucoma 28:5, pages e72-e74.
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J.P. Figueroa-Vercellino, M. Pazos, J. Peraza-Nieves & E. Milla. (2019) Relationship between the location of the XEN® stent glaucoma implant (with respect to the Tenon capsule) and the intraocular pressure. Journal Français d'Ophtalmologie 42:4, pages 421-422.
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J. Buffault, C. Baudouin & A. Labbé. (2019) L’implant XEN® pour la prise en charge du glaucome chronique à angle ouvert : une revue de la littérature. Journal Français d'Ophtalmologie 42:4, pages 391-403.
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Tanner J. Ferguson, Mitch Ibach, Justin Schweitzer, Kayla Karpuk, David J. Stephens, Ramu Sudhagoni & John P. Berdahl. (2019) Trabecular microbypass stent implantation in pseudophakic eyes with open-angle glaucoma: Long-term results. Journal of Cataract and Refractive Surgery 45:4, pages 414-420.
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H. Burkhard Dick, Tim Schultz & Ronald D. Gerste. (2019) Miniaturization in Glaucoma Monitoring and Treatment: A Review of New Technologies That Require a Minimal Surgical Approach. Ophthalmology and Therapy 8:1, pages 19-30.
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J. Buffault, C. Baudouin & A. Labbé. (2019) XEN® Gel Stent for management of chronic open angle glaucoma: A review of the literature. Journal Français d'Ophtalmologie 42:2, pages e37-e46.
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S. Yu. Petrov & A. V. Volzhanin. (2018) XEN-45 Gel Stent implant in glaucoma treatment. Vestnik oftal'mologii 134:5, pages 244.
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