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Clinical Ophthalmology Volume 13, 2019 - Issue
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REVIEW

Brolucizumab: evidence to date in the treatment of neovascular age-related macular degeneration

Nicolas A Yannuzzi1 Department of Ophthalmology, Bascom Palmer Eye Institute/University of Miami Miller School of Medicine, Miami, FL, USA
&
K Bailey Freund2 Luesther T. Mertz Retinal Research Center, Manhattan Eye, Ear and Throat Hospital, New York, NY, USA;3 Vitreous Retina Macula Consultants of New York, New York, NY, USA;4 Department of Ophthalmology, New York University School of Medicine, New York, NY, USACorrespondence[email protected]
Pages 1323-1329 | Published online: 24 Jul 2019

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Andrea Servillo, Ilaria Zucchiatti, Riccardo Sacconi, Mariacristina Parravano, Lea Querques, Paula La Rubia, Francesco Prascina, Francesco Bandello & Giuseppe Querques. (2023) The state-of-the-art pharmacotherapeutic management of neovascular age-related macular degeneration. Expert Opinion on Pharmacotherapy 24:2, pages 197-206.
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Manhong Xu, Ruiyan Fan, Xiaoe Fan, Yan Shao & Xiaorong Li. (2022) Progress and Challenges of Anti-VEGF Agents and Their Sustained-Release Strategies for Retinal Angiogenesis. Drug Design, Development and Therapy 16, pages 3241-3262.
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Alessandro Arrigo, Emanuela Aragona & Francesco Bandello. (2022) VEGF-targeting drugs for the treatment of retinal neovascularization in diabetic retinopathy. Annals of Medicine 54:1, pages 1089-1111.
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Jaycob Avaylon, Sol Lee & Ron P Gallemore. (2020) Case Series on Initial Responses to Intravitreal Brolucizumab in Patients with Recalcitrant Chronic Wet Age-Related Macular Degeneration. International Medical Case Reports Journal 13, pages 145-152.
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Mathew W. MacCumber, Charles C. Wykoff, Helene Karcher, Eser Adiguzel, Samriddhi Buxy Sinha, Saloni Vishwakarma, Andrew LaPrise, Franklin Igwe, Rita Freitas, Michael S. Ip & Marco A. Zarbin. (2023) Factors Linked to Injection Interval Extension in Eyes with Wet Age-Related Macular Degeneration Switched to Brolucizumab. Ophthalmology 130:8, pages 795-803.
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Shuqian Zhu, Shilong Fan, Tianxin Tang, Jinliang Huang, Heng Zhou, Chengnan Huang, Youxin Chen & Feng Qian. (2023) Polymorphic nanobody crystals as long‐acting intravitreal therapy for wet age‐related macular degeneration. Bioengineering & Translational Medicine.
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Wataru Kikushima, Yoichi Sakurada, Yoshiko Fukuda, Mio Matsubara, Yumi Kotoda, Atsushi Sugiyama & Kenji Kashiwagi. (2023) A Treat-and-Extend Regimen of Intravitreal Brolucizumab for Exudative Age-Related Macular Degeneration Refractory to Aflibercept: A 12-Month Result. Pharmaceuticals 16:4, pages 562.
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Mathew W. MacCumber, Charles C. Wykoff, Helene Karcher, Eser Adiguzel, Samriddhi Buxy Sinha, Saloni Vishwakarma, Andrew LaPrise, Franklin Igwe, Rita Freitas, Michael S. Ip & Marco A. Zarbin. (2023) One-Year Real-World Brolucizumab Outcomes in Neovascular Age-Related Macular Degeneration from a Large US Cohort in the IRIS® Registry. Ophthalmology.
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Chengnan Huang, Jinliang Huang, Shuqian Zhu, Tianxin Tang, Youxin Chen & Feng Qian. (2023) Multivalent nanobodies with rationally optimized linker and valency for intravitreal VEGF neutralization. Chemical Engineering Science 270, pages 118521.
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Nikhil S. PatilArjan S. DhootMarko M. PopovicPeter J. Kertes & Rajeev H. Muni. (2022) RISK OF INTRAOCULAR INFLAMMATION AFTER INJECTION OF ANTIVASCULAR ENDOTHELIAL GROWTH FACTOR AGENTS. Retina 42:11, pages 2134-2142.
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Samaneh ToutounchianNaser AhmadbeigiVahid Mansouri. (2022) Retinal and Choroidal Neovascularization Antivascular Endothelial Growth Factor Treatments: The Role of Gene Therapy. Journal of Ocular Pharmacology and Therapeutics 38:8, pages 529-548.
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Marie Fabre, Lou Mateo, Diana Lamaa, Stéphanie Baillif, Gilles Pagès, Luc Demange, Cyril Ronco & Rachid Benhida. (2022) Recent Advances in Age-Related Macular Degeneration Therapies. Molecules 27:16, pages 5089.
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Srinath Soundararajan, Cason B. Robbins, Henry L. Feng & Sharon Fekrat. (2021) Management Patterns and Outcomes for Intravitreal Injection–Related Endophthalmitis. Journal of VitreoRetinal Diseases 6:3, pages 188-193.
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Mirataollah Salabati, Anthony Obeid, Raziyeh Mahmoudzadeh, Omesh Gupta, Allen Chiang, Marc Spirn, Michael A. Klufas & Jason Hsu. (2022) Outcomes after switching eyes that were stable on aflibercept to ranibizumab versus continuing aflibercept in neovascular age-related macular degeneration. Graefe's Archive for Clinical and Experimental Ophthalmology.
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Alessandro Arrigo & Francesco Bandello. (2022) Towards the Development of Longer and More Efficacious Therapies for Wet and Dry Age-related Macular Degeneration. US Ophthalmic Review 16:1, pages 30.
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Begoña Pina Marín, Nuria María Gajate Paniagua, Laia Gómez-Baldó & Roberto Gallego-Pinazo. (2021) Burden of disease assessment in patients with neovascular age-related macular degeneration in Spain: Results of the AMD-MANAGE study. European Journal of Ophthalmology 32:1, pages 385-394.
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Ashwin Gupta, Nicholas Nosbisch, Ishan Agarwal, Anjali Patel, Sowmyanarayanan Thuppal, Chaitanya Mamillipalli, Jessi Prentice, Jaycob Avaylon, Ron Gallemore & Ramanath Bhandari. (2022) Intravitreal Brolucizumab in Patients with Aflibercept-Resistant Neovascular Age-Related Macular Degeneration. Re:GEN Open 2:1, pages 4-8.
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Sami El Khatib & Mohamed Salla. (2022) The mosaic puzzle of the therapeutic monoclonal antibodies and antibody fragments - A modular transition from full-length immunoglobulins to antibody mimetics. Leukemia Research Reports 18, pages 100335.
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Dionysis D. Balatsoukas, Konstantinos T. Tsaousis, Konstadinos G. Boboridis, Anastasios G. Konstas & Fotis Topouzis. (2021) Emerging Treatment Modalities for Neovascular Age-Related Macular Degeneration: A Systematic Overview. Advances in Therapy 39:1, pages 5-32.
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Gunnar Houen. 2022. Therapeutic Antibodies. Therapeutic Antibodies 1 25 .
Charles Shin, Sung Soo Kim & Yong Hwa Jo. (2021) Extending traditional antibody therapies: Novel discoveries in immunotherapy and clinical applications. Molecular Therapy - Oncolytics 22, pages 166-179.
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Alessandro Arrigo & Francesco Bandello. (2021) Molecular Features of Classic Retinal Drugs, Retinal Therapeutic Targets and Emerging Treatments. Pharmaceutics 13:7, pages 1102.
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Paulina Jakubiak, Rubén Alvarez-Sánchez, Matthias Fueth, Olaf Broders, Hubert Kettenberger, Kay Stubenrauch & Antonello Caruso. (2021) Ocular Pharmacokinetics of Intravitreally Injected Protein Therapeutics: Comparison among Standard-of-Care Formats. Molecular Pharmaceutics 18:6, pages 2208-2217.
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Vittal Shivva, C. Andrew Boswell, Hanine Rafidi, Robert F. Kelley, Amrita V. Kamath & Susan R. Crowell. (2021) Antibody Format and Serum Disposition Govern Ocular Pharmacokinetics of Intravenously Administered Protein Therapeutics. Frontiers in Pharmacology 12.
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Matias Iglicki, David Pérez González, Anat Loewenstein & Dinah Zur. (2021) Longer-acting treatments for neovascular age-related macular degeneration—present and future. Eye 35:4, pages 1111-1116.
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Ji Woong Kim, Yea Bin Cho & Sukmook Lee. (2021) Cell Surface GRP94 as a Novel Emerging Therapeutic Target for Monoclonal Antibody Cancer Therapy. Cells 10:3, pages 670.
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Jacob T. Cox, Dean Eliott & Lucia Sobrin. (2021) Inflammatory Complications of Intravitreal Anti-VEGF Injections. Journal of Clinical Medicine 10:5, pages 981.
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L. Mautone, C. Skevas & M. S. Spitzer. (2021) Therapie der postoperativen EndophthalmitisTreatment of postoperative endophthalmitis. Der Ophthalmologe 118:3, pages 219-229.
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Ramin Tadayoni, Laura Sararols, Georges Weissgerber, Rohini Verma, Andreas Clemens & Frank G. Holz. (2021) Brolucizumab: A Newly Developed Anti-VEGF Molecule for the Treatment of Neovascular Age-Related Macular Degeneration. Ophthalmologica 244:2, pages 93-101.
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Fan-Li Lin, Peng-Yuan Wang, Yu-Fan Chuang, Jiang-Hui Wang, Vickie H.Y. Wong, Bang V. Bui & Guei-Sheung Liu. (2020) Gene Therapy Intervention in Neovascular Eye Disease: A Recent Update. Molecular Therapy 28:10, pages 2120-2138.
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Zois Papadopoulos. (2020) Recent Developments in the Treatment of Wet Age-related Macular Degeneration. Current Medical Science 40:5, pages 851-857.
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Claudio Campa. (2020) New Anti-VEGF Drugs in Ophthalmology. Current Drug Targets 21:12, pages 1194-1200.
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Ashish Sharma, Nikulaa Parachuri, Nilesh Kumar, Rohini Sharma, Francesco Bandello, Baruch D. Kuppermann & Anat Loewenstein. (2020) Brolucizumab-key learnings from HAWK and HARRIER. Eye 34:8, pages 1318-1320.
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Marib Akanda, Alexander Weiss & Ronni Lieberman. (2020) Update and Advances in Long-Acting Anti–Vascular Endothelial Growth Factor Agents. Advances in Ophthalmology and Optometry 5, pages 141-146.
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Sahar Awwad, Christin Henein, Nkiruka Ibeanu, Peng T. Khaw & Steve Brocchini. (2020) Preclinical challenges for developing long acting intravitreal medicines. European Journal of Pharmaceutics and Biopharmaceutics 153, pages 130-149.
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Małgorzata Seredyka-Burduk, Michał Wiciński, Sławomir Liberski, Daria Marczak, Magdalena Pol, Bartosz Malinowski & Bartlomiej J. Kaluzny. (2020) Elevated Levels of Serum IL-17A Secondary to Repeated Intravitreal Injections of Aflibercept in Treatment-Naive Patients with Neovascular Age-Related Macular Degeneration. Applied Sciences 10:12, pages 4109.
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Konstantin Petrukhin. 2020. Drug Delivery Challenges and Novel Therapeutic Approaches for Retinal Diseases. Drug Delivery Challenges and Novel Therapeutic Approaches for Retinal Diseases 125 160 .

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