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Original Research

A novel intravitreal fluocinolone acetonide implant (Iluvien®) in the treatment of patients with chronic diabetic macular edema that is insufficiently responsive to other medical treatment options: a case series

Pages 801-811 | Published online: 04 May 2015

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (9)

Yusuf Mushtaq, Maryam M Mushtaq, Zisis Gatzioufas, Matteo Ripa, Lorenzo Motta & Georgios D Panos. (2023) Intravitreal Fluocinolone Acetonide Implant (ILUVIEN®) for the Treatment of Retinal Conditions. A Review of Clinical Studies. Drug Design, Development and Therapy 17, pages 961-975.
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Sarah E. Holden, Maged Habib & Craig J. Currie. (2020) Retinal thickness fluctuations in patients receiving fluocinolone acetonide implant for diabetic macular edema. Current Medical Research and Opinion 36:6, pages 959-965.
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Jessica D McCluskey, Paul L Kaufman, Kathy Wynne & Gregory Lewis. (2019) Early adoption of the fluocinolone acetonide (FAc) intravitreal implant in patients with persistent or recurrent diabetic macular edema (DME). International Medical Case Reports Journal 12, pages 93-102.
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Sarah E. Holden, Craig J. Currie & David R. Owens. (2017) Evaluation of the clinical effectiveness in routine practice of fluocinolone acetonide 190 µg intravitreal implant in people with diabetic macular edema. Current Medical Research and Opinion 33:sup2, pages 5-17.
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Daniele Veritti, Valentina Sarao, Laura Diplotti, Francesco Samassa & Paolo Lanzetta. (2017) Fluocinolone acetonide for the treatment of diabetic macular edema. Expert Opinion on Pharmacotherapy 18:14, pages 1507-1516.
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Christos Haritoglou, Wolfgang Mayer & Armin Wolf. (2016) Fluocinolone acetonide for the treatment of diabetic macular edema. Expert Review of Clinical Pharmacology 9:3, pages 367-374.
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Articles from other publishers (35)

Osama A. Sorour, Emily S. Levine, Caroline R. Baumal, Ayman G. Elnahry, Phillip Braun, Jessica Girgis & Nadia K. Waheed. (2023) Persistent diabetic macular edema: Definition, incidence, biomarkers, and treatment methods. Survey of Ophthalmology 68:2, pages 147-174.
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Noura Al Qassimi, Igor Kozak, Maysoon Al Karam, Piergiorgio Neri, Patricio M. Aduriz-Lorenzo, Alaa Attawan, Mohamed Awadalla, Ahmed El Khashab, Mohamed Abdul-Nabi, Ammar Safar, Hanan Al Shamsi, Prasan Rao, Madhav Rao, Amr Farid & Avinash Gurbaxani. (2022) Management of Diabetic Macular Edema: Guidelines from the Emirates Society of Ophthalmology. Ophthalmology and Therapy 11:5, pages 1937-1950.
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Elizaveta R. Orlova, Aleksandr V. Gorobets, Dmitry A. Dorofeev, Elena V. Kirilik & Irina V. Kozlova. (2022) Intravitreal Systems For Targeted Drug Delivery To The Posterior Eye Segment: A Systematic Review. Russian Open Medical Journal 11:2.
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Fernanda Pacella, Elena Pacella, Edoardo Trovato Battagliola, Mariaelena Malvasi, Sergio Zaccaria Scalinci, Paolo Turchetti, Mauro Salducci, Luca Lucchino & Loredana Arrico. (2021) Efficacy and safety of intravitreal Fluocinolone Acetonide microimplant (ILUVIEN ® ) in patients with chronic diabetic macular edema: 1 year follow-up . European Journal of Ophthalmology 32:2, pages 1109-1113.
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Megan M. Allyn, Richard H. Luo, Elle B. Hellwarth & Katelyn E. Swindle-Reilly. (2022) Considerations for Polymers Used in Ocular Drug Delivery. Frontiers in Medicine 8.
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Ayah Mohammad Burhan, Butsabarat Klahan, Wayne Cummins, Vanessa Andrés-Guerrero, Mark E. Byrne, Niall J. O’Reilly, Anuj Chauhan, Laurence Fitzhenry & Helen Hughes. (2021) Posterior Segment Ophthalmic Drug Delivery: Role of Muco-Adhesion with a Special Focus on Chitosan. Pharmaceutics 13:10, pages 1685.
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Sherif A. Gaballa, Uday B. Kompella, Omar Elgarhy, Ali M. Alqahtani, Barbara Pierscionek, Raid G. Alany & Hamdy Abdelkader. (2020) Corticosteroids in ophthalmology: drug delivery innovations, pharmacology, clinical applications, and future perspectives. Drug Delivery and Translational Research 11:3, pages 866-893.
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Sunil Kumar Dubey, Rajesh Pradhan, Siddhanth Hejmady, Gautam Singhvi, Hira Choudhury, Bapi Gorain & Prashant Kesharwani. (2021) Emerging innovations in nano-enabled therapy against age-related macular degeneration: A paradigm shift. International Journal of Pharmaceutics 600, pages 120499.
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Josh O. Wallsh & Ron P. Gallemore. (2021) Anti-VEGF-Resistant Retinal Diseases: A Review of the Latest Treatment Options. Cells 10:5, pages 1049.
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Aditya Sudhalkar, Alper Bilgic, Shail Vasavada, Laurent Kodjikian, Thibaud Mathis, FransescMarch de Ribot, Thanos Papakostas, Viraj Vasavada, Vaishali Vasavada, Samaresh Srivastava, Deepak Bhojwani, Pooja Ghia & Anand Sudhalkar. (2021) Current intravitreal therapy and ocular hypertension: A review. Indian Journal of Ophthalmology 69:2, pages 236.
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Kritika Nayak, Manisha Vinayak Choudhari, Swati Bagul, Tejas Avinash Chavan & Manju Misra. 2021. Drug Delivery Devices and Therapeutic Systems. Drug Delivery Devices and Therapeutic Systems 515 566 .
Nahla Jemni-Damer, Atocha Guedan-Duran, María Fuentes-Andion, Nora Serrano-Bengoechea, Nuria Alfageme-Lopez, Felix Armada-Maresca, Gustavo V. Guinea, José Pérez-Rigueiro, Francisco Rojo, Daniel Gonzalez-Nieto, David L. Kaplan & Fivos Panetsos. (2020) Biotechnology and Biomaterial-Based Therapeutic Strategies for Age-Related Macular Degeneration. Part I: Biomaterials-Based Drug Delivery Devices. Frontiers in Bioengineering and Biotechnology 8.
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Matus Rehak, Catharina Busch, Jan-Darius Unterlauft, Claudia Jochmann & Peter Wiedemann. (2019) Outcomes in diabetic macular edema switched directly or after a dexamethasone implant to a fluocinolone acetonide intravitreal implant following anti-VEGF treatment. Acta Diabetologica 57:4, pages 469-478.
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Albert J Augustin, Silvia Bopp, Martin Fechner, Frank Holz, Dirk Sandner, Andrea-M Winkgen, Ramin Khoramnia, Thomas Neuhann, Marcus Warscher, Martin Spitzer, Walter Sekundo, Berthold Seitz, Tobias Duncker, Christian Ksinsik, Helmuth Höh & Daniela Gentsch. (2019) Three-year results from the Retro-IDEAL study: Real-world data from diabetic macular edema (DME) patients treated with ILUVIEN ® (0.19 mg fluocinolone acetonide implant) . European Journal of Ophthalmology 30:2, pages 382-391.
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Raquel Estebainha, Raquel Goldhardt & Manuel Falcão. (2020) A New Approach for Diabetic Macular Edema Treatment: Review of Clinical Practice Results with 0.19 mg Fluocinolone Acetonide Intravitreal Implant Including Vitrectomized Eyes. Current Ophthalmology Reports 8:1, pages 1-10.
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Sara Vaz-Pereira, João Paulo Castro-de-Sousa, David Martins, Joaquim Prates Canelas, Pedro Reis, António Sampaio, Helena Urbano, Paulo Kaku, João Nascimento & Carlos Marques-Neves. (2020) The Outcomes of Switching from Short- to Long-Term Intravitreal Corticosteroid Implant Therapy in Patients with Diabetic Macular Edema. Ophthalmic Research 63:2, pages 114-121.
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Usha Chakravarthy, Simon R Taylor, Frank H Johannes Koch, João Paulo Castro de Sousa & Clare Bailey. (2019) Changes in intraocular pressure after intravitreal fluocinolone acetonide (ILUVIEN): real-world experience in three European countries. British Journal of Ophthalmology 103:8, pages 1072-1077.
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Rajini Nagaraj, Divya Rani Bijukumar, Benjamin Mathew, Evan A. Scott & Mathew T. Mathew. (2019) A review on recent advancements in ophthalmology devices: Currently in market and under clinical trials. Journal of Drug Delivery Science and Technology 52, pages 334-345.
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Fernando J. Cabrera, Daniel C. Wang, Kartik Reddy, Ghanashyam Acharya & Crystal S. Shin. (2019) Challenges and opportunities for drug delivery to the posterior of the eye. Drug Discovery Today 24:8, pages 1679-1684.
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Fernanda P. Pons-Faudoa, Andrea Ballerini, Jason Sakamoto & Alessandro Grattoni. (2019) Advanced implantable drug delivery technologies: transforming the clinical landscape of therapeutics for chronic diseases. Biomedical Microdevices 21:2.
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Horace Massa, Anindyt M. NagarAthanasios Vergados, Panagiotis Dadoukis, Sudeshna Patra & Georgios D. Panos. (2018) Intravitreal fluocinolone acetonide implant (ILUVIEN®) for diabetic macular oedema: a literature review. Journal of International Medical Research 47:1, pages 31-43.
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Kritika Nayak & Manju Misra. (2018) A review on recent drug delivery systems for posterior segment of eye. Biomedicine & Pharmacotherapy 107, pages 1564-1582.
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Rita Santos Gonçalves, Carla Teixeira & Pedro Coelho. (2018) Rezidivierendes diabetisches Makulaödem: Was tun?. Kompass Ophthalmologie 4:3, pages 161-166.
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C Bailey, U Chakravarthy, A Lotery, G Menon & J Talks. (2017) Real-world experience with 0.2 μg/day fluocinolone acetonide intravitreal implant (ILUVIEN) in the United Kingdom. Eye 31:12, pages 1707-1715.
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Rita Santos Gonçalves, Carla Teixeira & Pedro Coelho. (2017) Recurrent Diabetic Macular Edema: What to Do. Case Reports in Ophthalmology 8:3, pages 465-474.
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Christian Schneider, Robert Langer, Donald Loveday & Dirk Hair. (2017) Applications of ethylene vinyl acetate copolymers (EVA) in drug delivery systems. Journal of Controlled Release 262, pages 284-295.
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João Rafael de Oliveira Dias, Renata Portella Nunes & Raquel Goldhardt. (2017) New Drugs and New Posterior Delivery Methods in CME. Current Ophthalmology Reports 5:2, pages 160-168.
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Ibraheem El-Ghrably, David H.W. Steel, Maged Habib, Daniela Vaideanu-Collins, Sridhar Manvikar & Roxane J. Hillier. (2017) Diabetic Macular Edema Outcomes in Eyes Treated with Fluocinolone Acetonide 0.2 µg/d Intravitreal Implant: Real-World UK Experience. European Journal of Ophthalmology 27:3, pages 357-362.
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Yahiya Y. Syed. (2017) Fluocinolone Acetonide Intravitreal Implant 0.19 mg (ILUVIEN®): A Review in Diabetic Macular Edema. Drugs 77:5, pages 575-583.
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. (2017) Intravitreal Aflibercept for Patients With Diabetic Macular Edema Refractory to Bevacizumab or Ranibizumab: Analysis of Response to Aflibercept. Asia-Pacific Journal of Ophthalmology.
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Michael W. StewartMichael W. Stewart. 2017. Diabetic Retinopathy. Diabetic Retinopathy 141 162 .
Alaa H. Salama, Azza A. Mahmoud & Rabab Kamel. (2015) A Novel Method for Preparing Surface-Modified Fluocinolone Acetonide Loaded PLGA Nanoparticles for Ocular Use: In Vitro and In Vivo Evaluations. AAPS PharmSciTech 17:5, pages 1159-1172.
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. (2016) Fluocinolone acetonide. Reactions Weekly 1621:1, pages 118-118.
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Peter Coombs & R. V. Paul Chan. (2016) Intravitreal Steroid Therapy in the Management of Diabetic Macular Edema. Current Ophthalmology Reports 4:2, pages 56-60.
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Sarah A. Logan, Christina Y. Weng & Petros E. Carvounis. (2016) Intravitreal Steroid Implants in the Management of Retinal Disease and Uveitis. International Ophthalmology Clinics 56:4, pages 127-149.
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