96
Views
55
CrossRef citations to date
0
Altmetric
Review

Retinoic acid and arsenic trioxide in the treatment of acute promyelocytic leukemia: current perspectives

, &
Pages 1585-1601 | Published online: 14 Mar 2017

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (7)

Meihua Guo, Jin Zhou, Shengjin Fan, Limin Li, Hongzhu Chen, Liwang Lin, Qilei Zhao, Xinyu Wang, Wensheng Liu, Zhiqiang Wu & Xin Hai. (2021) Characteristics and clinical influence factors of arsenic species in plasma and their role of arsenic species as predictors for clinical efficacy in acute promyelocytic leukemia (APL) patients treated with arsenic trioxide. Expert Review of Clinical Pharmacology 14:4, pages 503-512.
Read now
Yaxue Wu, Peng Ke, Haixia Zhou, Depei Wu, Suning Chen, Huiying Qiu, Yue Han, Caixia Li, Xiao Ma, Aining Sun, Xiaowen Tang & Xiaohui Hu. (2021) Safety and efficacy of different doses of anthracyclines combined with arsenic trioxide and all-trans retinoic acid in the treatment of de novo acute promyelocytic leukemia. Hematology 26:1, pages 271-276.
Read now
Lu Nie, Rongjun Ma, Xiaoli Yuan, Li Jiang, Shiwei Yang, Hui Xu, Xiaoyin Liu, Yuanbo Liu, Lin Zhang & Zunmin Zhu. (2020) The prognostic value of CD2, CD4, and HLA-DR expression and FLT3-ITD mutation in adult acute promyelocytic leukemia. Leukemia & Lymphoma 61:10, pages 2482-2487.
Read now
Xiaoling Ni, Guohua Hu & Xun Cai. (2019) The success and the challenge of all-trans retinoic acid in the treatment of cancer. Critical Reviews in Food Science and Nutrition 59:sup1, pages S71-S80.
Read now
Shandong Tao, Chunling Wang, Yue Chen, Yuan Deng, Lixiao Song, Yuyue Shi, Lanlan Ling, Banghe Ding, Zhengmei He & Liang Yu. (2019) Long-term effect of all-trans retinoic acid and arsenic trioxide sequential maintenance in patients with acute promyelocytic leukemia. Leukemia & Lymphoma 60:3, pages 711-719.
Read now
Wei Fang, Zhao Liang Peng, Ya Ji Dai, Dian Lei Wang, Peng Huang & He Ping Huang. (2019) (-)-Epigallocatechin-3-gallate encapsulated realgar nanoparticles exhibit enhanced anticancer therapeutic efficacy against acute promyelocytic leukemia. Drug Delivery 26:1, pages 1058-1067.
Read now
Ying Shi, Tong Cao, Hua Huang, Chaoqun Lian, Ying Yang, Zhiwei Wang, Jia Ma & Jun Xia. (2017) Arsenic trioxide inhibits cell growth and motility via up-regulation of let-7a in breast cancer cells. Cell Cycle 16:24, pages 2396-2403.
Read now

Articles from other publishers (48)

Gabriel Silva Marques Borges, Pierre Sicard, Cristina de Mello Gomides Loures, Fernanda Gontijo Cristina Evangelista, Camila Campos Sales, Adriano de Paula Sabino, Christian Fernandes, Lucas Antônio Miranda Ferreira & Sylvain Richard. (2023) Tocotrienols-enriched Self-nanoemulsifying Drug Delivery System Enhances the Antileukemic Activity of All-trans Retinoic Acid but not Electrocardiogram Alterations Evoked by Its Combination with Arsenic Trioxide. AAPS PharmSciTech 24:3.
Crossref
Tâmara Dauare de Almeida, Fernanda Cristina Gontijo Evangelista & Adriano de Paula Sabino. (2023) Acute Promyelocytic Leukemia (APL): A Review of the Classic and Emerging Target Therapies towards Molecular Heterogeneity. Future Pharmacology 3:1, pages 162-179.
Crossref
Antónia Gonçalves, Fernando Rocha & Berta N. Estevinho. (2023) Pharmaceutical/Clinical Strategies in the Treatment of Acute Promyelocytic Leukemia: All-Trans Retinoic Acid Encapsulation by Spray-Drying Technology as an Innovative Approach–Comprehensive Overview. Pharmaceuticals 16:2, pages 180.
Crossref
Sudjit Luanpitpong, Napachai Rodboon, Parinya Samart, Montira Janan, Phatchanat Klaihmon, Chanchao Lorthongpanich, Yaowalak U-Pratya & Surapol Issaragrisil. (2022) Inhibition of O -GlcNAcase Inhibits Hematopoietic and Leukemic Stem Cell Self-Renewal and Drives Dendritic Cell Differentiation via STAT3/5 Signaling . Stem Cells 40:12, pages 1078-1093.
Crossref
Fabienne Aurora, Anita Arasaretnam & Andrew Hobkirk. (2022) The recognition of oral manifestations of haematological disease saves lives: a case report. Bulletin of the National Research Centre 46:1.
Crossref
Chunxu Wang, Yufeng Wang, Nan Zuo, Shaohong Fang & Jialan Shi. (2022) CD44–fibrinogen binding promotes bleeding in acute promyelocytic leukemia by in situ fibrin(ogen) deposition. Blood Advances 6:15, pages 4617-4633.
Crossref
Shiyi Xu, Xinyu Zhang, Xingyu Zhu, Hui Su & Xueying Yan. (2022) A combined arsenic trioxide/tetrandrine nanoparticle formulation with improved inhibitory effect against promyelocytic leukemia. Journal of Drug Delivery Science and Technology 74, pages 103572.
Crossref
Ewa Marcinkowska. (2022) Vitamin D Derivatives in Acute Myeloid Leukemia: The Matter of Selecting the Right Targets. Nutrients 14:14, pages 2851.
Crossref
Dinh Hoa Hoang, Ralf Buettner, Melissa Valerio, Lucy Ghoda, Bin Zhang, Ya-Huei Kuo, Steven T. Rosen, John Burnett, Guido Marcucci, Vinod Pullarkat & Le Xuan Truong Nguyen. (2022) Arsenic Trioxide and Venetoclax Synergize against AML Progenitors by ROS Induction and Inhibition of Nrf2 Activation. International Journal of Molecular Sciences 23:12, pages 6568.
Crossref
Mette Kalager, Hans‐Olov Adami, Paul W. Dickman, Pernilla Lagergren & Karen Steindorf. (2022) Cancer outcome research – a European challenge Part II: Opportunities and priorities. Molecular Oncology 16:12, pages 2300-2311.
Crossref
Veronika Borutinskaitė, Andrius Žučenka, Aida Vitkevičienė, Mindaugas Stoškus, Algirdas Kaupinis, Mindaugas Valius, Eglė Gineikienė & Rūta Navakauskienė. (2022) Genetic and Epigenetic Signatures in Acute Promyelocytic Leukemia Treatment and Molecular Remission. Frontiers in Genetics 13.
Crossref
Fabrizio Fontana & Patrizia Limonta. (2021) The multifaceted roles of mitochondria at the crossroads of cell life and death in cancer. Free Radical Biology and Medicine 176, pages 203-221.
Crossref
Sara Ribeiro, Anna M. Eiring & Jamshid S. Khorashad. (2021) Genomic Abnormalities as Biomarkers and Therapeutic Targets in Acute Myeloid Leukemia. Cancers 13:20, pages 5055.
Crossref
Jihong Lin, Lei Zhang, Zhiwei Wang, Qi Guan, Kai Bao & Lan Wu. (2021) G 2 /M cell cycle arrest and apoptosis induced by COH‑203 in human promyelocytic leukemia HL‑60 cells . Oncology Letters 22:6.
Crossref
Viswanathan Mariammal Berlin Grace, Devarajan David Wilson, Chandrasekharan Guruvayoorappan, Jesubatham Perinba Danisha & Lucia Bonati. (2021) Liposome nano‐formulation with cationic polar lipid DOTAP and cholesterol as a suitable pH‐responsive carrier for molecular therapeutic drug (all‐ trans retinoic acid) delivery to lung cancer cells . IET Nanobiotechnology 15:4, pages 380-390.
Crossref
Jaeyeun Lee, Jennifer Stone, Prashant Desai, John G. Kosowicz, Jun O. Liu & Richard F. Ambinder. (2021) Arsenicals, the Integrated Stress Response, and Epstein–Barr Virus Lytic Gene Expression. Viruses 13:5, pages 812.
Crossref
Zhi-xiao Zhang, Ai-dong Lu, Jun Wu, Ying-xi Zuo, Yue-ping Jia, Le-ping Zhang & Jiong Qin. (2020) Retrospective analysis of data from 73 patients with childhood acute promyelocytic leukaemia receiving modified chemotherapy: a single-centre study. Journal of Cancer Research and Clinical Oncology 147:4, pages 1189-1201.
Crossref
Andrew J. Robinson, Richard L. Darley & Alex Tonks. 2021. Acute Leukemias. Acute Leukemias.
Yosi Gilad, Gary Gellerman, David M. Lonard & Bert W. O’Malley. (2021) Drug Combination in Cancer Treatment—From Cocktails to Conjugated Combinations. Cancers 13:4, pages 669.
Crossref
Benedikt Emde, Heike Kreher, Nicole Bäumer, Sebastian Bäumer, Dominique Bouwes & Lara Tickenbrock. (2020) Microfluidic-Based Detection of AML-Specific Biomarkers Using the Example of Promyelocyte Leukemia. International Journal of Molecular Sciences 21:23, pages 8942.
Crossref
Hong-Hu Zhu. (2020) The History of the Chemo-Free Model in the Treatment of Acute Promyelocytic Leukemia. Frontiers in Oncology 10.
Crossref
Xiao Yu, Tongfeng Weng, Changgui Gu & Huijie Yang. (2020) Comparison of gene regulatory networks to identify pathogenic genes for lymphoma. Journal of Bioinformatics and Computational Biology 18:05, pages 2050029.
Crossref
Lara Costantini, Romina Molinari, Barbara Farinon, Veronica Lelli, Anna Maria Timperio & Nicolò Merendino. (2020) Docosahexaenoic Acid Reverted the All-trans Retinoic Acid-Induced Cellular Proliferation of T24 Bladder Cancer Cell Line. Journal of Clinical Medicine 9:8, pages 2494.
Crossref
Erin E. Heyer & James Blackburn. (2020) Sequencing Strategies for Fusion Gene Detection. BioEssays 42:7.
Crossref
Issa Hindi, Guomiao Shen, Qian Tan, Paolo Cotzia, Matija Snuderl, Xiaojun Feng & George Jour. (2020) Feasibility and clinical utility of a pan-solid tumor targeted RNA fusion panel: A single center experience. Experimental and Molecular Pathology 114, pages 104403.
Crossref
Yuchen Liu, Fangwei Liu, Weifeng Liang, Lingxiang Zhu, R. Clark Lantz, Jiapeng Zhu & Yin Chen. (2020) Arsenic represses airway epithelial mucin expression by affecting retinoic acid signaling pathway. Toxicology and Applied Pharmacology 394, pages 114959.
Crossref
Si Chen, Xiang Li, Shifan Ma, Xinrui Xing, Xiaobo Wang & Zhenyu Zhu. (2020) Chemogenomics analysis of drug targets for the treatment of acute promyelocytic leukemia. Annals of Hematology 99:4, pages 753-763.
Crossref
G. A. Belitskiy, K. I. Kirsanov, E. A. Lesovaya & M. G. Yakubovskaya. (2020) Drug-Related Carcinogenesis: Risk Factors and Approaches for Its Prevention. Biochemistry (Moscow) 85:S1, pages 79-107.
Crossref
Sven Christian, Claudia Merz, Laura Evans, Stefan Gradl, Henrik Seidel, Anders Friberg, Ashley Eheim, Pascale Lejeune, Krzysztof Brzezinka, Katja Zimmermann, Steven Ferrara, Hanna Meyer, Ralf Lesche, Detlef Stoeckigt, Marcus Bauser, Andrea Haegebarth, David B Sykes, David T Scadden, Julie-Aurore Losman & Andreas Janzer. (2019) The novel dihydroorotate dehydrogenase (DHODH) inhibitor BAY 2402234 triggers differentiation and is effective in the treatment of myeloid malignancies. Leukemia 33:10, pages 2403-2415.
Crossref
Fengqi Chang, Fumin Lin, Kajia Cao, Lea F. Surrey, Richard Aplenc, Rochelle Bagatell, Adam C. Resnick, Mariarita Santi, Phillip B. Storm, Sarah K. Tasian, Angela J. Waanders, Stephen P. Hunger & Marilyn M. Li. (2019) Development and Clinical Validation of a Large Fusion Gene Panel for Pediatric Cancers. The Journal of Molecular Diagnostics 21:5, pages 873-883.
Crossref
Cui Liang, Ming Ding, Xiang-qin Weng, Yan Sheng, Jing Wu & Xun Cai. (2019) The combination of UCN-01 and ATRA triggers differentiation in ATRA resistant acute promyelocytic leukemia cell lines via RAF-1 independent activation of MEK/ERK. Food and Chemical Toxicology 126, pages 303-312.
Crossref
Yang Cao, Li Yao, Yue Liu, Quan Gu, Weimin Dong, Zhilin Wang, Fei Wang, Rongrong Lin, Xiaobao Xie, Jiannong Cen, Suning Chen & Weiying Gu. (2019) An Atypical <b><i>PML-RARA</i></b> Rearrangement Resulting from Submicroscopic Insertion of the <b><i>RARA</i></b> Gene at the <b><i>PML</i></b> Locus with Novel Breakpoints within <b><i>PML</i></b> Exon 7b and <b><i>RARA</i></b> Exon 3. Acta Haematologica 142:2, pages 98-104.
Crossref
Huifang Wu, Jian Liu, Xiaofeng Huang, Lili Pian, Qianqian Cheng, Qingyang Wang, Min Zhao, Zhou Lin, Beifen Shen, Jiyan Zhang, Shulian Li & Jing Wang. (2018) RACK1 deficiency synergizes with all-trans retinoic acid to induce apoptosis in human acute promyelocytic leukemia cells. Molecular and Cellular Biochemistry 451:1-2, pages 155-163.
Crossref
Yasamin Al-Qassab, Silvia Grassilli, Federica Brugnoli, Federica Vezzali, Silvano Capitani & Valeria Bertagnolo. (2018) Protective role of all-trans retinoic acid (ATRA) against hypoxia-induced malignant potential of non-invasive breast tumor derived cells. BMC Cancer 18:1.
Crossref
Alessandra Pannunzio & Mauro Coluccia. (2018) Cyclooxygenase-1 (COX-1) and COX-1 Inhibitors in Cancer: A Review of Oncology and Medicinal Chemistry Literature. Pharmaceuticals 11:4, pages 101.
Crossref
Sook-Kyoung Heo, Eui-Kyu Noh, Jeong Yi Kim, SungHoo Jegal, Yookyung Jeong, Jaekyung Cheon, SuJin Koh, Jin Ho Baek, Young Joo Min, Yunsuk Choi & Jae-Cheol Jo. (2018) Rhein augments ATRA-induced differentiation of acute promyelocytic leukemia cells. Phytomedicine 49, pages 66-74.
Crossref
Ming Ding, Xiang-qin Weng, Yan Sheng, Jing Wu, Cui Liang & Xun Cai. (2018) Dasatinib synergizes with ATRA to trigger granulocytic differentiation in ATRA resistant acute promyelocytic leukemia cell lines via Lyn inhibition-mediated activation of RAF-1/MEK/ERK. Food and Chemical Toxicology 119, pages 464-478.
Crossref
Kazuyuki Sato, Hirotaka Sakai, Yusuke Saiki, Akiko Uchida, Yu Uemura, Satoshi Yokoi, Yuka Tsuruoka, Yuji Nishio, Manabu Matsunawa, Yoshinori Suzuki, Yasushi Isobe, Masayuki Kato, Naoto Tomita, Yasuyuki Inoue & Ikuo Miura. (2018) Cell dynamics during differentiation therapy with all-trans retinoic acid in acute promyelocytic leukemia. International Journal of Hematology 108:3, pages 274-281.
Crossref
Francesco Lo-Coco & Laura Cicconi. (2018) Towards home-based treatment for acute promyelocytic leukaemia, with caution. The Lancet Oncology 19:7, pages 846-847.
Crossref
Yingli Zhao, Xing Fang, Hui Fang, Yubin Feng, Feihu Chen & Quan Xia. (2018) ATPR‐induced G 0 /G 1 phase arrest in gastric cancer cells by regulating the binding of 14‐3‐3ε and filamin A . Cancer Medicine 7:7, pages 3373-3384.
Crossref
Hae Ryung Chang, Anudari Munkhjargal, Myung-Jin Kim, Seon Young Park, Eunyoung Jung, Jae-Ha Ryu, Young Yang, Jong-Seok Lim & Yonghwan Kim. (2018) The functional roles of PML nuclear bodies in genome maintenance. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 809, pages 99-107.
Crossref
Amir Amanzadeh, Vahid Molla-kazemiha, Saeed Samani, Mahdi Habibi-Anbouhi, Kayhan Azadmanesh, Mohsen Abolhassani & Mohammad Ali Shokrgozar. (2018) New synergistic combinations of differentiation-inducing agents in the treatment of acute promyelocytic leukemia cells. Leukemia Research 68, pages 98-104.
Crossref
Martijn Kerkhofs, Mart Bittremieux, Giampaolo Morciano, Carlotta Giorgi, Paolo Pinton, Jan B. Parys & Geert Bultynck. (2018) Emerging molecular mechanisms in chemotherapy: Ca2+ signaling at the mitochondria-associated endoplasmic reticulum membranes. Cell Death & Disease 9:3.
Crossref
Vibeke Andresen & Bjørn T. Gjertsen. (2017) Drug Repurposing for the Treatment of Acute Myeloid Leukemia. Frontiers in Medicine 4.
Crossref
Kai‑Ling Jiang, Liang Zhong, Xiao‑Qun Yang, Peng‑Peng Ma, Hui Wang, Xin‑Yu Zhu & Bei‑Zhong Liu. (2017) NLS‑RARα is a novel transcriptional factor. Oncology Letters.
Crossref
M. Schmalzing, M. Aringer, M. Bornhäuser & J. Atta. (2017) Myelodysplastisches Syndrom, akute Leukämie und StammzelltransplantationMyelodysplastic syndrome, acute leukemia and stem cell transplantation. Zeitschrift für Rheumatologie 76:S2, pages 26-32.
Crossref
Shibing Chen, Juan Yu, Xin Lv & Lijuan Zhang. (2017) HOXA9 is critical in the proliferation, differentiation, and malignancy of leukaemia cells both in vitro and in vivo. Cell Biochemistry and Function 35:7, pages 433-440.
Crossref
伟 江. (2017) Research Progress of Leukemia Induced Differentiation Agents. World Journal of Cancer Research 07:03, pages 75-80.
Crossref