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Original Research

Long non-coding RNA CCAT2 is associated with poor prognosis in hepatocellular carcinoma and promotes tumor metastasis by regulating Snail2-mediated epithelial–mesenchymal transition

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Pages 1191-1198 | Published online: 24 Feb 2017

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (4)

Jun Ding, Lin Zhang, Shiwen Chen, Heli Cao, Chen Xu & Xuyang Wang. (2020) lncRNA CCAT2 Enhanced Resistance of Glioma Cells Against Chemodrugs by Disturbing the Normal Function of miR-424. OncoTargets and Therapy 13, pages 1431-1445.
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Xiaoxiao Fan, Shengxi Jin, Yirun Li, Parikshit Asutosh Khadaroo, Yili Dai, Lifeng He, Daizhan Zhou & Hui Lin. (2019) Genetic And Epigenetic Regulation Of E-Cadherin Signaling In Human Hepatocellular Carcinoma. Cancer Management and Research 11, pages 8947-8963.
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Shinichi Umeda, Mitsuro Kanda & Yasuhiro Kodera. (2019) Recent advances in molecular biomarkers for patients with hepatocellular carcinoma. Expert Review of Molecular Diagnostics 19:8, pages 725-738.
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Johannes Foßelteder, George A. Calin & Martin Pichler. (2018) Long non-coding RNA CCAT2 as a therapeutic target in colorectal cancer. Expert Opinion on Therapeutic Targets 22:12, pages 973-976.
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Articles from other publishers (28)

Mehrdad Hashemi, Niloufar Nadafzadeh, Mohammad Hassan Imani, Romina Rajabi, Setayesh Ziaolhagh, Seyedeh Delaram Bayanzadeh, Raheleh Norouzi, Reihaneh Rafiei, Zeinab Khazaei Koohpar, Behnaz Raei, Mohammad Arad Zandieh, Shokooh Salimimoghadam, Maliheh Entezari, Afshin Taheriazam, Athanasios Alexiou, Marios Papadakis & Shing Cheng Tan. (2023) Targeting and regulation of autophagy in hepatocellular carcinoma: revisiting the molecular interactions and mechanisms for new therapy approaches. Cell Communication and Signaling 21:1.
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Shuoshuo Ma, Wenjing WangDengyong Zhang, Guanru Zhao & Zheng Lu. (2022) Long non-coding RNA colon cancer-associated transcript 2: role and function in human cancers. Chinese Medical Journal 135:23, pages 2785-2797.
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Amira M.F. Shehata, Suzy F. Gohar, Nashwa M. Muharram & Samar M. Kamal Eldin. (2022) LncRNA CCAT2 expression at diagnosis predicts imatinib response in chronic phase chronic myeloid leukemia patients. Leukemia Research 116, pages 106838.
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Radu Pirlog, Rares Drula, Andreea Nutu, George Adrian Calin & Ioana Berindan-Neagoe. (2021) The Roles of the Colon Cancer Associated Transcript 2 (CCAT2) Long Non-Coding RNA in Cancer: A Comprehensive Characterization of the Tumorigenic and Molecular Functions. International Journal of Molecular Sciences 22:22, pages 12491.
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Shu Hu, Jiancheng Liu, Shuying Feng, Yue Wang & Hongchao Liu. (2021) LncRNA SUMO1P3 acts as a prognostic biomarker and promotes hepatocellular carcinoma growth and metastasis. Aging 13:9, pages 12479-12492.
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Bang-Hao Xu, Jing-Hang Jiang, Tao Luo, Zhi-Jun Jiang, Xin-Yu Liu & Le-Qun Li. (2021) Signature of prognostic epithelial–mesenchymal transition related long noncoding RNAs (ERLs) in hepatocellular carcinoma. Medicine 100:30, pages e26762.
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Jie Bin, Shaolin Nie, Ziyuan Tang, Anding Kang, Zhongping Fu, Yingbin Hu, Qianjin Liao, Wei Xiong, Yujuan Zhou, Yanyan Tang & Jiarui Jiang. (2020) Long noncoding RNA EPB41L4A‐AS1 functions as an oncogene by regulating the Rho/ROCK pathway in colorectal cancer. Journal of Cellular Physiology 236:1, pages 523-535.
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Jie Liu, Yue Wei, Tao Wang, Zhexiao Zhang, Hairong Huang, Chenfei Wang, Huawen Li, Qing Jia, Hongfu Wu & Tangbin Zou. (2020) The prognostic significance of long non-coding RNAs in hepatocellular carcinoma: An updated meta-analysis. The International Journal of Biological Markers 35:4, pages 3-11.
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Soon Sun Kim, Geum Ok Baek, Hye Ri Ahn, Suna Sung, Chul Won Seo, Hyo Jung Cho, Suk Woo Nam, Jae Youn Cheong & Jung Woo Eun. (2020) Serum small extracellular vesicle‐derived LINC00853 as a novel diagnostic marker for early hepatocellular carcinoma . Molecular Oncology 14:10, pages 2646-2659.
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Chao Niu, Linlin Wang, Weijian Ye, Shikun Guo, Xiaozhou Bao, Yongbiao Wang, Zhaobo Xia, Randong Chen, Chong Liu, Xiaokun Lin & Xiaozhong Huang. (2020) CCAT2 contributes to hepatocellular carcinoma progression via inhibiting miR‐145 maturation to induce MDM2 expression. Journal of Cellular Physiology 235:9, pages 6307-6320.
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Yongbiao Ma, Hongmei Zhang, Gaoxue Li, Jingxia Hu, Xin Liu & Li Lin. (2019) LncRNA ANRIL promotes cell growth, migration and invasion of hepatocellular carcinoma cells via sponging miR-144. Anti-Cancer Drugs 30:10, pages 1013-1021.
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Mohammad Sarfi, Maryam Abbastabar & Ehsan Khalili. (2019) Long noncoding RNAs biomarker‐based cancer assessment. Journal of Cellular Physiology 234:10, pages 16971-16986.
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Soudeh Ghafouri‐Fard & Mohammad Taheri. (2019) Colon Cancer‐Associated Transcripts 1 and 2 : Roles and functions in human cancers . Journal of Cellular Physiology 234:9, pages 14581-14600.
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Edie-Rosmin Wu, Ming-Ju Hsieh, Whei-Ling Chiang, Kuan-Chun Hsueh, Shun-Fa Yang & Shih-Chi Su. (2019) Association of lncRNA CCAT2 and CASC8 Gene Polymorphisms with Hepatocellular Carcinoma. International Journal of Environmental Research and Public Health 16:16, pages 2833.
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Yang Zhang, Min Zhu, Yuanbo Sun, Wenyuan Li, Ying Wang & Weiguang Yu. (2019) Upregulation of lncRNA CASC2 Suppresses Cell Proliferation and Metastasis of Breast Cancer via Inactivation of the TGF-β Signaling Pathway. Oncology Research Featuring Preclinical and Clinical Cancer Therapeutics 27:3, pages 379-387.
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Tingting An, Tianxiu Dong, Haoxin Zhou, Yaodong Chen, Jiuwei Zhang, Yu Zhang, Zizhuo Li & Xiuhua Yang. (2019) The transcription factor Krüppel-like factor 5 promotes cell growth and metastasis via activating PI3K/AKT/Snail signaling in hepatocellular carcinoma. Biochemical and Biophysical Research Communications 508:1, pages 159-168.
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Yanyan Tang, Yi He, Ping Zhang, Jinpeng Wang, Chunmei Fan, Liting Yang, Fang Xiong, Shanshan Zhang, Zhaojian Gong, Shaolin Nie, Qianjin Liao, Xiayu Li, Xiaoling Li, Yong Li, Guiyuan Li, Zhaoyang Zeng, Wei Xiong & Can Guo. (2018) LncRNAs regulate the cytoskeleton and related Rho/ROCK signaling in cancer metastasis. Molecular Cancer 17:1.
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Xiaoge Hu, Jiahong Jiang, Qiuran Xu, Chao Ni, Liu Yang & Dongsheng Huang. (2018) A Systematic Review of Long Noncoding RNAs in Hepatocellular Carcinoma: Molecular Mechanism and Clinical Implications. BioMed Research International 2018, pages 1-13.
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Ben-Gang Wang, Qian Xu, Zhi Lv, Xin-Xin Fang, Han-Xi Ding, Jing Wen & Yuan Yuan. (2018) Association of twelve polymorphisms in three onco-lncRNA genes with hepatocellular cancer risk and prognosis: A case-control study. World Journal of Gastroenterology 24:23, pages 2482-2490.
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Yue Yao, Ping Gao, Lili Chen, Wei Wang, Jinchao Zhang, Qiang Li & Yi Xu. (2018) Upregulated long non-coding RNA SPRY4-IT1 predicts dismal prognosis for pancreatic ductal adenocarcinoma and regulates cell proliferation and apoptosis. Gene 659, pages 52-58.
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Jianwei Ruan, Longlong Zheng, Nan Hu, Guoyi Guan, Jialin Chen, Xiaozhong Zhou & Maoquan Li. (2018) Long noncoding RNA SNHG6 promotes osteosarcoma cell proliferation through regulating p21 and KLF2. Archives of Biochemistry and Biophysics 646, pages 128-136.
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Yi Xu, Yue Yao, Wei Qin, Xiangyu Zhong, Xingming Jiang & Yunfu Cui. (2018) Long non-coding RNA CCAT2 promotes cholangiocarcinoma cells migration and invasion by induction of epithelial-to-mesenchymal transition. Biomedicine & Pharmacotherapy 99, pages 121-127.
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Aya El Khodiry, Menna Afify & Hend M El Tayebi. (2018) Behind the curtain of non-coding RNAs; long non-coding RNAs regulating hepatocarcinogenesis. World Journal of Gastroenterology 24:5, pages 549-572.
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Ji Ma, Tengfei Li, Xinwei Han & Huifeng Yuan. (2017) Knockdown of LncRNA ANRIL suppresses cell proliferation, metastasis, and invasion via regulating miR-122-5p expression in hepatocellular carcinoma. Journal of Cancer Research and Clinical Oncology 144:2, pages 205-214.
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Pengmu Xie, Hongying Cao, Ying Li, Jianhua Wang & Zhumei Cui. (2017) RETRACTED: Knockdown of lncRNA CCAT2 inhibits endometrial cancer cells growth and metastasis via sponging miR-216b. Cancer Biomarkers 21:1, pages 123-133.
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Zhipeng Ma, Senyao Xue, Bi Zeng & Daoxian Qiu. (2017) lncRNA SNHG5 is associated with poor prognosis of bladder cancer and promotes bladder cancer cell proliferation through targeting p27. Oncology Letters.
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Ye-Bin Lu, Qin Jiang, Man-Yi Yang, Ji-Xiang Zhou & Qi Zhang. (2017) Long noncoding RNA NNT-AS1 promotes hepatocellular carcinoma progression and metastasis through miR-363/CDK6 axis. Oncotarget 8:51, pages 88804-88814.
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Guang-Wei Tian, Nan Li & Yan Xin. (2017) Prognostic and Clinicopathological Significance of CCAT2 in Chinese Patients with Various Tumors. The International Journal of Biological Markers 32:3, pages 344-351.
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