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Original Research

Increased BTLA and HVEM in gastric cancer are associated with progression and poor prognosis

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Pages 919-926 | Published online: 16 Feb 2017

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Xiangmin Li, Zhaoguo Xu, Guoyuan Cui, Li Yu & Xiaoye Zhang. (2020) BTLA Expression in Stage I–III Non–Small-Cell Lung Cancer and Its Correlation with PD-1/PD-L1 and Clinical Outcomes. OncoTargets and Therapy 13, pages 215-224.
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Kazuhiro Mochizuki, Satoshi Kawana, Shoki Yamada, Moe Muramatsu, Hideki Sano, Shogo Kobayashi, Yoshihiro Ohara, Nobuhisa Takahashi, Michiyuki Hakozaki, Hitoshi Yamada, Yuko Hashimoto & Atsushi Kikuta. (2019) Various checkpoint molecules, and tumor-infiltrating lymphocytes in common pediatric solid tumors: Possibilities for novel immunotherapy. Pediatric Hematology and Oncology 36:1, pages 17-27.
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Matthew J. Cascio, Elizabeth M. Whitley, Bikash Sahay, Galaxia Cortes-Hinojosa, Lung-Ji Chang, Jonathan Cowart, Marc Salute, Elias Sayour, Michael Dark, Zachary Sandoval, Duane A. Mitchell & Rowan J. Milner. (2021) Canine osteosarcoma checkpoint expression correlates with metastasis and T-cell infiltrate. Veterinary Immunology and Immunopathology 232, pages 110169.
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Saeid Taghiloo & Hossein Asgarian-Omran. (2021) Immune evasion mechanisms in acute myeloid leukemia: A focus on immune checkpoint pathways. Critical Reviews in Oncology/Hematology 157, pages 103164.
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Christian Sordo-Bahamonde, Seila Lorenzo-Herrero, A.P. González-Rodríguez & Segundo González. 2021. Successes and Challenges of NK Immunotherapy. Successes and Challenges of NK Immunotherapy 267 304 .
R. R. Maniyar, S. Chakraborty, T. Jarboe, R. Suriano, M. Wallack, J. Geliebter & R. K. Tiwari. 2021. Tumor Microenvironment: Cellular, Metabolic and Immunologic Interactions. Tumor Microenvironment: Cellular, Metabolic and Immunologic Interactions 123 143 .
Katarzyna Kuncewicz, Claire Battin, Adam Sieradzan, Agnieszka Karczyńska, Marta Orlikowska, Anna Wardowska, Michał Pikuła, Peter Steinberger, Sylwia Rodziewicz-Motowidło & Marta Spodzieja. (2020) Fragments of gD Protein as Inhibitors of BTLA/HVEM Complex Formation - Design, Synthesis, and Cellular Studies. International Journal of Molecular Sciences 21:22, pages 8876.
Crossref
Salman M. Toor, Varun Sasidharan Nair, Julie Decock & Eyad Elkord. (2020) Immune checkpoints in the tumor microenvironment. Seminars in Cancer Biology 65, pages 1-12.
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Crossref
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Crossref
Marta Spodzieja, Katarzyna Kuncewicz, Adam Sieradzan, Agnieszka Karczyńska, Justyna Iwaszkiewicz, Valérie Cesson, Katarzyna Węgrzyn, Igor Zhukov, Martyna Maszota-Zieleniak, Olivier Michielin, Daniel E. Speiser, Vincent Zoete, Laurent Derré & Sylwia Rodziewicz-Motowidło. (2020) Disulfide-Linked Peptides for Blocking BTLA/HVEM Binding. International Journal of Molecular Sciences 21:2, pages 636.
Crossref
Weifeng Tang, Shuchen Chen, Mingqiang Kang, Jun Liu & Chao Liu. (2019) Investigation of BTLA tagging variants with risk of esophagogastric junction adenocarcinoma . Bioscience Reports 39:12.
Crossref
Yu-Chen S.H. Yang, Zi-Lin Li, Ya-Jung Shih, James A. Bennett, Jaqueline Whang-Peng, Hung-Yun Lin, Paul J. Davis & Kuan Wang. (2019) Herbal Medicines Attenuate PD-L1 Expression to Induce Anti-Proliferation in Obesity-Related Cancers. Nutrients 11:12, pages 2979.
Crossref
Qinchuan Wang, Jinhua Zhang, Huakang Tu, Dong Liang, David. W. Chang, Yuanqing Ye & Xifeng Wu. (2019) Soluble immune checkpoint-related proteins as predictors of tumor recurrence, survival, and T cell phenotypes in clear cell renal cell carcinoma patients. Journal for ImmunoTherapy of Cancer 7:1.
Crossref
Chia-Cheng Lin, Yu-Tang Chin, Ya-Jung Shih, Yi-Ru Chen, Yao-Yu Chung, Chi-Yu Lin, Chao-Nan Hsiung, Jacqueline Whang-Peng, Sheng-Yang Lee, Hung-Yun Lin, Paul J. Davis & Kuan Wang. (2019) Resveratrol antagonizes thyroid hormone-induced expression of checkpoint and proliferative genes in oral cancer cells. Journal of Dental Sciences 14:3, pages 255-262.
Crossref
Ming-Zhi Han, Shuai Wang, Wen-Bo Zhao, Shi-Lei Ni, Ning Yang, Yang Kong, Bin Huang, An-Jing Chen, Xin-Gang Li, Jian Wang & Dong-Hai Wang. (2019) Immune checkpoint molecule herpes virus entry mediator is overexpressed and associated with poor prognosis in human glioblastoma. EBioMedicine 43, pages 159-170.
Crossref
David J. Zahavi & Louis M. Weiner. 2019. Cancer Immunotherapy. Cancer Immunotherapy 61 100 .
Qianyu Guo, Fan Huang, Christophe Goncalves, Sonia V. del Rincón & Wilson H. MillerJrJr. 2019. Immunotherapy of Cancer. Immunotherapy of Cancer 1 62 .
John R. Šedý & Parham Ramezani-Rad. 2019. 145 186 .
Julian A. Marin-Acevedo, Bhagirathbhai Dholaria, Aixa E. Soyano, Keith L. Knutson, Saranya Chumsri & Yanyan Lou. (2018) Next generation of immune checkpoint therapy in cancer: new developments and challenges. Journal of Hematology & Oncology 11:1.
Crossref
Joaquim Carreras, Yara Yukie Kikuti, Masashi Miyaoka, Shinichiro Hiraiwa, Sakura Tomita, Haruka Ikoma, Yusuke Kondo, Sawako Shiraiwa, Kiyoshi Ando, Shinji Sato, Yasuo Suzuki, Ikuo Miura, Giovanna Roncador & Naoya Nakamura. (2018) Genomic Profile and Pathologic Features of Diffuse Large B-Cell Lymphoma Subtype of Methotrexate-associated Lymphoproliferative Disorder in Rheumatoid Arthritis Patients. American Journal of Surgical Pathology 42:7, pages 936-950.
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