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OncoTargets and Therapy Volume 10, 2017 - Issue
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Original Research

Niclosamide inhibition of STAT3 synergizes with erlotinib in human colon cancer

Lingyi Shi1 Chemical Biology Research Center, School of Pharmaceutical Sciences
,
Hailun Zheng1 Chemical Biology Research Center, School of Pharmaceutical Sciences
,
Wanle Hu2 Department of Coloproctology, The Second Affiliated Hospital and Yuying Children’s Hospital
,
Bin Zhou2 Department of Coloproctology, The Second Affiliated Hospital and Yuying Children’s Hospital
,
Xuanxuan Dai3 Department of Oncological Surgery, The First Affiliated Hospital, Wenzhou Medical University, Wenzhou, People’s Republic of China
,
Yi Zhang3 Department of Oncological Surgery, The First Affiliated Hospital, Wenzhou Medical University, Wenzhou, People’s Republic of China
,
Zhiguo Liu1 Chemical Biology Research Center, School of Pharmaceutical Sciences
,
Xiaoping Wu1 Chemical Biology Research Center, School of Pharmaceutical SciencesCorrespondence[email protected] [email protected]
,
Chengguang Zhao1 Chemical Biology Research Center, School of Pharmaceutical SciencesCorrespondence[email protected] [email protected]
&
Guang Liang1 Chemical Biology Research Center, School of Pharmaceutical Sciences
 show all
Pages 1767-1776 | Published online: 23 Mar 2017

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Amruta Prabhakar Padakanti, Sachin Dattaram Pawar, Pramod Kumar & Naveen Chella. (2023) Development and validation of HPLC method for simultaneous estimation of erlotinib and niclosamide from liposomes optimized by screening design. Journal of Liposome Research 33:3, pages 268-282.
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Yan Zhuang, Ying Bai, Yan Hu, Yueqin Guo, Lingyuan Xu, Wanle Hu, Lehe Yang, Chengguang Zhao, Xiaokun Li & Haiyang Zhao. (2019) Rhein sensitizes human colorectal cancer cells to EGFR inhibitors by inhibiting STAT3 pathway. OncoTargets and Therapy 12, pages 5281-5291.
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Zhaohong Wang, Hui Chen, Jingjing Chen, Zhong Hong, Yi Liao, Qiyu Zhang & Hongfei Tong. (2019) Emodin sensitizes human pancreatic cancer cells to EGFR inhibitor through suppressing Stat3 signaling pathway. Cancer Management and Research 11, pages 8463-8473.
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Hannah M. Neuendorf, Jacinta L. Simmons & Glen M. Boyle. (2023) Therapeutic targeting of anoikis resistance in cutaneous melanoma metastasis. Frontiers in Cell and Developmental Biology 11.
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Haowen Jiang, Albert M. Li & Jiangbin Ye. (2022) The magic bullet: Niclosamide. Frontiers in Oncology 12.
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Junyi Ren, Bo Wang, Qifeng Wu & Guiling Wang. (2022) Combination of niclosamide and current therapies to overcome resistance for cancer: New frontiers for an old drug. Biomedicine & Pharmacotherapy 155, pages 113789.
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Jyoti Kaushal, Rakesh Bhatia, Ranjana Kanchan, Pratima Raut, Surya Mallapragada, Quan Ly, Surinder Batra & Satyanarayana Rachagani. (2021) Repurposing Niclosamide for Targeting Pancreatic Cancer by Inhibiting Hh/Gli Non-Canonical Axis of Gsk3β. Cancers 13:13, pages 3105.
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Po-Chang Shih & Kuo-Ching Mei. (2021) Role of STAT3 signaling transduction pathways in cancer stem cell-associated chemoresistance. Drug Discovery Today 26:6, pages 1450-1458.
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Mia M. Wu, Z. Zhang, Christy W.S. Tong, ViVi W. Yan, William C.S. Cho & Kenneth K.W. To. (2020) Repurposing of niclosamide as a STAT3 inhibitor to enhance the anticancer effect of chemotherapeutic drugs in treating colorectal cancer. Life Sciences 262, pages 118522.
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Shalini Dimri, Renu Malhotra, Tanuja Shet, Smruti Mokal, Sudeep Gupta & Abhijit De. (2020) Noncanonical pS727 post translational modification dictates major STAT3 activation and downstream functions in breast cancer. Experimental Cell Research 396:2, pages 112313.
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Ellen Weisberg, Alexander Parent, Priscilla L. Yang, Martin Sattler, Qingsong Liu, Qingwang Liu, Jinhua Wang, Chengcheng Meng, Sara J. Buhrlage, Nathanael Gray & James D. Griffin. (2020) Repurposing of Kinase Inhibitors for Treatment of COVID-19. Pharmaceutical Research 37:9.
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Arianna Gelain, Matteo Mori, Fiorella Meneghetti & Stefania Villa. (2019) Signal Transducer and Activator of Transcription Protein 3 (STAT3): An Update on its Direct Inhibitors as Promising Anticancer Agents. Current Medicinal Chemistry 26:27, pages 5165-5206.
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Shun Yang, Xiaoqian Tang, Xiuzhen Sheng, Jing Xing & Wenbin Zhan. (2019) Analysis of the role of IL-10 in the phagocytosis of mIgM+ B lymphocytes in flounder (Paralichthys olivaceus). Fish & Shellfish Immunology 92, pages 813-820.
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Winnie Fong & Kenneth K. W. To. (2019) Drug repurposing to overcome resistance to various therapies for colorectal cancer. Cellular and Molecular Life Sciences 76:17, pages 3383-3406.
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Eduardo José Barbosa, Raimar Löbenberg, Gabriel Lima Barros de Araujo & Nádia Araci Bou-Chacra. (2019) Niclosamide repositioning for treating cancer: Challenges and nano-based drug delivery opportunities. European Journal of Pharmaceutics and Biopharmaceutics 141, pages 58-69.
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Hachemi Kadri, Olivia A. Lambourne & Youcef Mehellou. (2018) Niclosamide, a Drug with Many (Re)purposes. ChemMedChem 13:11, pages 1088-1091.
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Bin Zhou, Zhong Hong, Hailun Zheng, Min Chen, Lingyi Shi, Chengguang Zhao & Haixin Qian. (2017) Pectolinarigenin Suppresses Pancreatic Cancer Cell Growth by Inhibiting STAT3 Signaling. Natural Product Communications 12:12, pages 1934578X1701201.
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Xiong Jin, Xun Jin & Hyunggee Kim. (2017) Cancer stem cells and differentiation therapy. Tumor Biology 39:10, pages 101042831772993.
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