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Original Research

Niclosamide inhibition of STAT3 synergizes with erlotinib in human colon cancer

, , , , , , , , & show all
Pages 1767-1776 | Published online: 23 Mar 2017

References

  • SiegelRLMillerKDJemalACancer statistics, 2016CA Cancer J Clin201666173026742998
  • ZahidAYoungCJHow to decide on stent insertion or surgery in colorectal obstruction?World J Gastrointest Surg201681848926843916
  • YoungJIMongoue-TchokoteSWieghardNTreatment and survival of small-bowel adenocarcinoma in the United States: a comparison with colon cancerDis Colon Rectum201659430631526953989
  • de Castro-CarpeñoJBelda-IniestaCCasado SáenzEHernández AgudoEFeliu BatlleJGonzález BarónMEGFR and colon cancer: a clinical viewClin Transl Oncol200810161318208787
  • KuwaiTNakamuraTSasakiTPhosphorylated epidermal growth factor receptor on tumor-associated endothelial cells is a primary target for therapy with tyrosine kinase inhibitorsNeoplasia200810548950018472966
  • LiRYouSHuZInhibition of STAT3 by niclosamide synergizes with erlotinib against head and neck cancerPLoS One201389e7467024019973
  • KangYHuWBaiECurcumin sensitizes human gastric cancer cells to 5-fluorouracil through inhibition of the NFkB survival-signaling pathwayOnco Targets Ther201697373738427980427
  • YuHPardollDJoveRSTATs in cancer inflammation and immunity: a leading role for STAT3Nat Rev Cancer200991179880919851315
  • ShodeindeALBartonBEPotential use of STAT3 inhibitors in targeted prostate cancer therapy: future prospectsOnco Targets Ther2012511912522815644
  • LeeHDengJKujawskiMSTAT3-induced S1PR1 expression is crucial for persistent STAT3 activation in tumorsNat Med201016121421142821102457
  • LesinaMKurkowskiMULudesKStat3/Socs3 activation by IL-6 transsignaling promotes progression of pancreatic intraepithelial neoplasia and development of pancreatic cancerCancer Cell201119445646921481788
  • GaoSPMarkKGLeslieKMutations in the EGFR kinase domain mediate STAT3 activation via IL-6 production in human lung adenocarcinomasJ Clin Invest2007117123846385618060032
  • HauraEBZhengZSongLCantorABeplerGActivated epidermal growth factor receptor-Stat-3 signaling promotes tumor survival in vivo in non-small cell lung cancerClin Cancer Res200511238288829416322287
  • CrescenzoRAbateFLasorsaEEuropean T-Cell Lymphoma Study Group, T-Cell Project: Prospective Collection of Data in Patients with Peripheral T-Cell Lymphoma and the AIRC 5xMille Consortium “Genetics-Driven Targeted Management of Lymphoid Malignancies”Convergent mutations and kinase fusions lead to oncogenic STAT3 activation in anaplastic large cell lymphomaCancer Cell201527451653225873174
  • WakeMSWatsonCJSTAT3 the oncogene – still eluding therapy?FEBS J2015282142600261125825152
  • PanJXDingKWangCYNiclosamide, an old antihelminthic agent, demonstrates antitumor activity by blocking multiple signaling pathways of cancer stem cellsChin J Cancer201231417818422237038
  • ChongCRSullivanDJJrNew uses for old drugsNature2007448715464564617687303
  • JinYLuZDingKAntineoplastic mechanisms of niclosamide in acute myelogenous leukemia stem cells: inactivation of the NF-kappaB pathway and generation of reactive oxygen speciesCancer Res20107062516252720215516
  • WangAMKuHHLiangYCChenYCHwuYMYehTSThe autonomous notch signal pathway is activated by baicalin and baicalein but is suppressed by niclosamide in K562 cellsJ Cell Biochem2009106468269219160421
  • OsadaTChenMYangXYAntihelminth compound niclosamide downregulates Wnt signaling and elicits antitumor responses in tumors with activating APC mutationsCancer Res201171124172418221531761
  • BalgiADFonsecaBDDonohueEScreen for chemical modulators of autophagy reveals novel therapeutic inhibitors of mTORC1 signalingPLoS One200949e712419771169
  • ZouMZhangXXuCIL6-induced metastasis modulators p-STAT3, MMP-2 and MMP-9 are targets of 3,3′-diindolylmethane in ovarian cancer cellsCell Oncol (Dordr)2016391475726510945
  • EiringAMPageBDKraftILCombined STAT3 and BCR-ABL1 inhibition induces synthetic lethality in therapy-resistant chronic myeloid leukemiaLeukemia201529358659725134459
  • LiuJChenXWardTPegramMShenKCombined niclosamide with cisplatin inhibits epithelial-mesenchymal transition and tumor growth in cisplatin-resistant triple-negative breast cancerTumour Biol20163779825983526810188
  • JinBWangCLiJDuXDingKPanJAnthelmintic Niclosamide Disrupts the Interplay of p65 and FOXM1/β-catenin and Eradicates Leukemia Stem Cells in Chronic Myelogenous LeukemiaClin Cancer Res201723378980327492973
  • ZhuYYeTYuXNifuroxazide exerts potent anti-tumor and anti-metastasis activity in melanomaSci Rep201662025326830149
  • YeTXiongYYanYThe anthelmintic drug niclosamide induces apoptosis, impairs metastasis and reduces immunosuppressive cells in breast cancer modelPLoS One201491e8588724416452
  • ZhuZZhaoYLiJCryptotanshinone, a novel tumor angiogenesis inhibitor, destabilizes tumor necrosis factor-α mRNA via decreasing nuclear-cytoplasmic translocation of RNA-binding protein HuRMol Carcinog201655101399141026310813
  • KhanMYiFRasulAAlantolactone induces apoptosis in glioblastoma cells via GSH depletion, ROS generation, and mitochondrial dysfunctionIUBMB Life201264978379422837216
  • MorrisGMHueyRLindstromWAutoDock4 and AutoDockTools4: automated docking with selective receptor flexibilityJ Comput Chem200930162785279119399780
  • BeckerSGronerBMüllerCWThree-dimensional structure of the Stat3-beta homodimer bound to DNANature199839466891451519671298
  • AlexanderNWoetzelNMeilerJBcl::Cluster: a method for clustering biological molecules coupled with visualization in the Pymol Molecular Graphics SystemIEEE Int Conf Comput Adv Bio Med Sci201120111318
  • YangFHuMLeiQNifuroxazide induces apoptosis and impairs pulmonary metastasis in breast cancer modelCell Death Dis20156e170125811798
  • YuHJParkCKimSJChoNPChoSDSignal transducer and activators of transcription 3 regulates cryptotanshinone-induced apoptosis in human mucoepidermoid carcinoma cellsPharmacogn Mag201410Suppl 3S622S62925298683
  • ChunJLiRJChengMSKimYSAlantolactone selectively suppresses STAT3 activation and exhibits potent anticancer activity in MDA-MB-231 cellsCancer Lett2015357139340325434800
  • ZhaoCXiaoHWuXRational combination of MEK inhibitor and the STAT3 pathway modulator for the therapy in K-Ras mutated pancreatic and colon cancer cellsOncotarget2015616144721448725961376
  • ZhaoCLiHLinHJYangSLinJLiangGFeedback activation of STAT3 as a cancer drug-resistance mechanismTrends Pharmacol Sci2016371476126576830
  • van KesselKEZuiverloonTCAlbertsARBoormansJLZwarthoffECTargeted therapies in bladder cancer: an overview of in vivo researchNat Rev Urol2015121268169426390971
  • ChorostMIDattaRSantiagoRCColon cancer screening: where have we come from and where do we go?J Surg Oncol200485171314696082
  • Azcárate-PerilMASikesMBruno-BárcenaJMThe intestinal microbiota, gastrointestinal environment and colorectal cancer: a putative role for probiotics in prevention of colorectal cancer?Am J Physiol Gastrointest Liver Physiol20113013G401G42421700901
  • PohlMStrickerISchoeneckAAntitumor activity of the HER2 dimerization inhibitor pertuzumab on human colon cancer cells in vitro and in vivoJ Cancer Res Clin Oncol2009135101377138619340455
  • WenWWuJLiuLSynergistic anti-tumor effect of combined inhibition of EGFR and JAK/STAT3 pathways in human ovarian cancerMol Cancer20151410025928246
  • SackUWaltherWScudieroDNovel effect of antihelminthic Niclosamide on S100A4-mediated metastatic progression in colon cancerJ Natl Cancer Inst2011103131018103621685359
  • WangXGoldsteinDCrowePJOvercoming resistance of targeted EGFR monotherapy by inhibition of STAT3 escape pathway in soft tissue sarcomaOncotarget2016716214962150926909593
  • KraljevicSStambrookPJPavelicKAccelerating drug discoveryEMBO Rep20045983784215470377
  • SakamotoKMGrantSSaleiroDTargeting novel signaling pathways for resistant acute myeloid leukemiaMol Genet Metab2015114339740225533111