Citations (61)
Keep up to date with the latest research on this topic with citation updates for this article.
Read on this site (3)
John T. Lear, Linda M. Morris, Dylan B. Ness & Lionel D. Lewis. (2023) Pharmacokinetics and pharmacodynamics of Hedgehog pathway inhibitors used in the treatment of advanced or treatment-refractory basal cell carcinoma. Expert Review of Clinical Pharmacology 16:12, pages 1211-1220.
Read now
Read now
Yucong Li, Dong Wang, Jingshu Liu, Yunzhe Li, Duke Chen, Lei Zhou, Tingyuan Lang & Qi Zhou. (2020) Baicalin Attenuates YAP Activity to Suppress Ovarian Cancer Stemness. OncoTargets and Therapy 13, pages 7151-7163.
Read now
Read now
Emmanuel Lee Boniao, Richard C. Allen & Gangadhara Sundar. Targeted therapy and immunotherapy for orbital and periorbital tumors: a major review. Orbit 0:0, pages 1-18.
Read now
Read now
Articles from other publishers (58)
Prateek D. Bansal, Soumajit Dutta & Diwakar Shukla. (2023) Activation mechanism of the human Smoothened receptor. Biophysical Journal 122:7, pages 1400-1413.
Crossref
Crossref
Sotai Kimura, Tomoka Morita, Kosuke Hosoba, Hiroshi Itoh, Takashi Yamamoto & Tatsuo Miyamoto. (2023) Cholesterol in the ciliary membrane as a therapeutic target against cancer. Frontiers in Molecular Biosciences 10.
Crossref
Crossref
Ruolan Xia, Maosen Xu, Jing Yang & Xuelei Ma. (2022) The role of Hedgehog and Notch signaling pathway in cancer. Molecular Biomedicine 3:1.
Crossref
Crossref
Tanuja Angre, Adarsh Kumar, Ankit Kumar Singh, Suresh Thareja & Pradeep Kumar. (2022) Role of Collagen Regulators in Cancer Treatment: A Comprehensive Review. Anti-Cancer Agents in Medicinal Chemistry 22:17, pages 2956-2984.
Crossref
Crossref
Rahul Rimal, Prachi Desai, Rasika Daware, Aisa Hosseinnejad, Jai Prakash, Twan Lammers & Smriti Singh. (2022) Cancer-associated fibroblasts: Origin, function, imaging, and therapeutic targeting. Advanced Drug Delivery Reviews 189, pages 114504.
Crossref
Crossref
Meghan W. Dukes & Thomas J. Meade. (2022) Modulation of Hedgehog Signaling for the Treatment of Basal Cell Carcinoma and the Development of Preclinical Models. Biomedicines 10:10, pages 2376.
Crossref
Crossref
Enrico Franceschi, Caterina Giannini, Julia Furtner, Kristian W. Pajtler, Sofia Asioli, Raphael Guzman, Clemens Seidel, Lidia Gatto & Peter Hau. (2022) Adult Medulloblastoma: Updates on Current Management and Future Perspectives. Cancers 14:15, pages 3708.
Crossref
Crossref
Anirudh M. K. Nambiar, Christopher P. Breen, Travis Hart, Timothy Kulesza, Timothy F. Jamison & Klavs F. Jensen. (2022) Bayesian Optimization of Computer-Proposed Multistep Synthetic Routes on an Automated Robotic Flow Platform. ACS Central Science 8:6, pages 825-836.
Crossref
Crossref
Peng Guo, Qiang Chen, Kesong Peng, Jianyuan Xie, Junjia Liu, Wenjing Ren, Zhangwei Tong, Ming Li, Jianming Xu, Yongyou Zhang, Chundong Yu & Pingli Mo. (2022) Nuclear receptor coactivator SRC-1 promotes colorectal cancer progression through enhancing GLI2-mediated Hedgehog signaling. Oncogene 41:20, pages 2846-2859.
Crossref
Crossref
Aleksandra Sochacka-Ćwikła, Marcin Mączyński & Andrzej Regiec. (2022) FDA-Approved Small Molecule Compounds as Drugs for Solid Cancers from Early 2011 to the End of 2021. Molecules 27:7, pages 2259.
Crossref
Crossref
Lidia Gatto, Enrico Franceschi, Alicia Tosoni, Vincenzo Di Nunno, Stefania Bartolini & Alba Ariela Brandes. (2022) Molecular Targeted Therapies: Time for a Paradigm Shift in Medulloblastoma Treatment?. Cancers 14:2, pages 333.
Crossref
Crossref
Trupti N. Patel & Pavan Kumar Dhanyamraju. (2022) Role of aberrant Sonic hedgehog signaling pathway in cancers and developmental anomalies. The Journal of Biomedical Research 36:1, pages 1.
Crossref
Crossref
Zahra Khorsandi, Fariba Keshavarzipour, Rajender S. Varma, Abdol R. Hajipour & Hojjat Sadeghi-Aliabadi. (2022) Sustainable synthesis of potential antitumor new derivatives of Abemaciclib and Fedratinib via C-N cross coupling reactions using Pd/Cu-free Co-catalyst. Molecular Catalysis 517, pages 112011.
Crossref
Crossref
Laura Eibenschutz, Silvia Caputo, Emanuela Camera, Anna Carbone, Vitaliano Silipo, Emilia Migliano, Caterina Aurizi, Carlo Cota, Pasquale Frascione & Barbara Bellei. (2021) Evaluation of Hedgehog Pathway Inhibition on Nevoid Basal Cell Carcinoma Syndrome Fibroblasts and Basal Cell Carcinoma-Associated Fibroblasts: Are Vismodegib and Sonidegib Useful to Target Cancer-Prone Fibroblasts?. Cancers 13:22, pages 5858.
Crossref
Crossref
Silpa Gampala & Jer-Yen Yang. (2021) Hedgehog Pathway Inhibitors against Tumor Microenvironment. Cells 10:11, pages 3135.
Crossref
Crossref
Yuqing Wang, Shanshan Lu, Yifei Chen, Liang Li, Xia Li, Zhongwei Qu, Junbo Huang, Liu FanChao Yuan, Nan Song, Jun Zhang, Wendong XuShenglian Yang & Yizheng Wang. (2021) Smoothened is a therapeutic target for reducing glutamate toxicity in ischemic stroke. Science Translational Medicine 13:610.
Crossref
Crossref
Natalie Kash & Sirunya Silapunt. (2021) A review of emerging and non-US FDA-approved topical agents for the treatment of basal cell carcinoma. Future Oncology 17:23, pages 3111-3132.
Crossref
Crossref
Peter Hau, Didier Frappaz, Elizabeth Hovey, Martin G. McCabe, Kristian W. Pajtler, Benedikt Wiestler, Clemens Seidel, Stephanie E. Combs, Linda Dirven, Martin Klein, Antoinette Anazodo, Elke Hattingen, Silvia Hofer, Stefan M. Pfister, Claus Zimmer, Rolf-Dieter Kortmann, Marie-Pierre Sunyach, Ronan Tanguy, Rachel Effeney, Andreas von Deimling, Felix Sahm, Stefan Rutkowski, Anna S. Berghoff, Enrico Franceschi, Estela Pineda, Dagmar Beier, Ellen Peeters, Thierry Gorlia, Maureen Vanlancker, Jacoline E. C. Bromberg, Julien Gautier, David S. Ziegler, Matthias Preusser, Wolfgang Wick & Michael Weller. (2021) Development of Randomized Trials in Adults with Medulloblastoma—The Example of EORTC 1634-BTG/NOA-23. Cancers 13:14, pages 3451.
Crossref
Crossref
Eiki Koyama, Christina Mundy, Cheri Saunders, Juliet Chung, Sarah E Catheline, Danielle Rux, Masahiro Iwamoto & Maurizio Pacifici. (2021) Premature Growth Plate Closure Caused by a Hedgehog Cancer Drug Is Preventable by Co‐Administration of a Retinoid Antagonist in Mice. Journal of Bone and Mineral Research 36:7, pages 1387-1402.
Crossref
Crossref
Chiyu Sun, Dajun Zhang, Tian Luan, Youbing Wang, Wenhu Zhang, Lin Lin, Meihua Jiang, Ziqian Hao & Ying Wang. (2021) Synthesis of 2-methoxybenzamide derivatives and evaluation of their hedgehog signaling pathway inhibition. RSC Advances 11:37, pages 22820-22825.
Crossref
Crossref
Lei Zhong, Yueshan Li, Liang Xiong, Wenjing Wang, Ming Wu, Ting Yuan, Wei Yang, Chenyu Tian, Zhuang Miao, Tianqi Wang & Shengyong Yang. (2021) Small molecules in targeted cancer therapy: advances, challenges, and future perspectives. Signal Transduction and Targeted Therapy 6:1.
Crossref
Crossref
Jayachandra Rayadurgam, Sravani Sana, M. Sasikumar & Qiong Gu. (2021) Palladium catalyzed C–C and C–N bond forming reactions: an update on the synthesis of pharmaceuticals from 2015–2020. Organic Chemistry Frontiers 8:2, pages 384-414.
Crossref
Crossref
Zeeshan Javed, Muhammad Javed Iqbal, Amna Rasheed, Haleema Sadia, Shahid Raza, Asma Irshad, Wojciech Koch, Wirginia Kukula-Koch, Anna Głowniak-Lipa, William C. Cho & Javad Sharifi-Rad. (2021) Regulation of Hedgehog Signaling by miRNAs and Nanoformulations: A Possible Therapeutic Solution for Colorectal Cancer. Frontiers in Oncology 10.
Crossref
Crossref
Inamul Haque, Hameem I. Kawsar, Hannah Motes, Mukut Sharma, Snigdha Banerjee, Sushanta K. Banerjee, Andrew K. Godwin & Chao H. Huang. (2020) Downregulation of miR-506-3p Facilitates EGFR-TKI Resistance through Induction of Sonic Hedgehog Signaling in Non-Small-Cell Lung Cancer Cell Lines. International Journal of Molecular Sciences 21:23, pages 9307.
Crossref
Crossref
Roberto Carta, Giada Del Baldo, Evelina Miele, Agnese Po, Zein Mersini Besharat, Francesca Nazio, Giovanna Stefania Colafati, Eleonora Piccirilli, Emanuele Agolini, Martina Rinelli, Mariachiara Lodi, Antonella Cacchione, Andrea Carai, Luigi Boccuto, Elisabetta Ferretti, Franco Locatelli & Angela Mastronuzzi. (2020) Cancer Predisposition Syndromes and Medulloblastoma in the Molecular Era. Frontiers in Oncology 10.
Crossref
Crossref
Daniel Doheny, Sherona Sirkisoon, Richard L. Carpenter, Noah Reeve Aguayo, Angelina T. Regua, Marlyn Anguelov, Sara G. Manore, Austin Arrigo, Sara Abu Jalboush, Grace L. Wong, Yang Yu, Calvin J. Wagner, Michael Chan, Jimmy Ruiz, Alexandra Thomas, Roy Strowd, Jiayuh Lin & Hui-Wen Lo. (2020) Combined inhibition of JAK2-STAT3 and SMO-GLI1/tGLI1 pathways suppresses breast cancer stem cells, tumor growth, and metastasis. Oncogene 39:42, pages 6589-6605.
Crossref
Crossref
Alessia Villani, Gabriella Fabbrocini, Claudia Costa & Massimiliano Scalvenzi. (2020) Sonidegib: Safety and Efficacy in Treatment of Advanced Basal Cell Carcinoma. Dermatology and Therapy 10:3, pages 401-412.
Crossref
Crossref
José Antonio Encinar & Javier A. Menendez. (2020) Potential Drugs Targeting Early Innate Immune Evasion of SARS-Coronavirus 2 via 2’-O-Methylation of Viral RNA. Viruses 12:5, pages 525.
Crossref
Crossref
Rebecca King, Lara Zebic & Vinod Patel. (2020) Deciphering novel chemotherapy and its impact on dentistry. British Dental Journal 228:6, pages 415-421.
Crossref
Crossref
Soufiane Boumahdi & Frederic J. de Sauvage. (2019) The great escape: tumour cell plasticity in resistance to targeted therapy. Nature Reviews Drug Discovery 19:1, pages 39-56.
Crossref
Crossref
Bin Yang, Alexander W. Hird, Michael S. Bodnarchuk, Xiaolan Zheng, Les Dakin, Qibin Su, Kevin Daly, Robert Godin, Maureen M. Hattersley, Patrick Brassil, Sean Redmond, Daniel John Russell & James W. Janetka. (2020) Heteroarylamide smoothened inhibitors: Discovery of N-[2,4-dimethyl-5-(1-methylimidazol-4-yl)phenyl]-4-(2-pyridylmethoxy)benzamide (AZD8542) and N-[5-(1H-imidazol-2-yl)-2,4-dimethyl-phenyl]-4-(2- pyridylmethoxy)benzamide (AZD7254). Bioorganic & Medicinal Chemistry 28:2, pages 115227.
Crossref
Crossref
Melvin J. Rivera, Bryan Do, Jeffrey C. Bryan, Terri Lynn Shigle & Rina Patel. 2020. Oncologic Critical Care. Oncologic Critical Care
201
227
.
Sagar Kansara, Christopher M. K. L. Yao & Neil D. Gross. 2020. Basal Cell Carcinoma. Basal Cell Carcinoma
147
160
.
Julia Maier, Salma Elmenofi, Alexander Taschauer, Martina Anton, Haider Sami & Manfred Ogris. (2019) Luminescent and fluorescent triple reporter plasmid constructs for Wnt, Hedgehog and Notch pathway. PLOS ONE 14:12, pages e0226570.
Crossref
Crossref
Yuchen Li, Qingkun Song & Bryan W. Day. (2019) Phase I and phase II sonidegib and vismodegib clinical trials for the treatment of paediatric and adult MB patients: a systemic review and meta-analysis. Acta Neuropathologica Communications 7:1.
Crossref
Crossref
Dany Gaillard, Lauren A. Shechtman, Sarah E. Millar & Linda A. Barlow. (2019) Fractionated head and neck irradiation impacts taste progenitors, differentiated taste cells, and Wnt/β-catenin signaling in adult mice. Scientific Reports 9:1.
Crossref
Crossref
Ramiz N. Hamid & Zeynep M. Akkurt. (2019) Hereditary Tumor Syndromes with Skin Involvement. Dermatologic Clinics 37:4, pages 607-613.
Crossref
Crossref
Alexandra Collins, Jessica Savas & Laura Doerfler. (2019) Nonsurgical Treatments for Nonmelanoma Skin Cancer. Dermatologic Clinics 37:4, pages 435-441.
Crossref
Crossref
Robert Taylor, Jun Long, Joon Won Yoon, Ronnie Childs, Kathrine B. Sylvestersen, Michael L. Nielsen, King-Fu Leong, Stephen Iannaccone, David O. Walterhouse, David J. Robbins & Philip Iannaccone. (2019) Regulation of GLI1 by cis DNA elements and epigenetic marks. DNA Repair 79, pages 10-21.
Crossref
Crossref
Jorge E. Cortes, Ralf Gutzmer, Mark W. Kieran & James A. Solomon. (2019) Hedgehog signaling inhibitors in solid and hematological cancers. Cancer Treatment Reviews 76, pages 41-50.
Crossref
Crossref
Ralf Gutzmer & James A. Solomon. (2019) Hedgehog Pathway Inhibition for the Treatment of Basal Cell Carcinoma. Targeted Oncology 14:3, pages 253-267.
Crossref
Crossref
Jezabel Rodriguez-Blanco, Bin Li, Jun Long, Chen Shen, Fan Yang, Darren Orton, Sara Collins, Noriyuki Kasahara, Nagi G. Ayad, Heather J. McCrea, Martine F. Roussel, William A. Weiss, Anthony J. Capobianco & David J. Robbins. (2019) A CK1α Activator Penetrates the Brain and Shows Efficacy Against Drug-resistant Metastatic Medulloblastoma. Clinical Cancer Research 25:4, pages 1379-1388.
Crossref
Crossref
Richard L. Carpenter & Haimanti Ray. (2019) Safety and Tolerability of Sonic Hedgehog Pathway Inhibitors in Cancer. Drug Safety 42:2, pages 263-279.
Crossref
Crossref
Uwe Fricke, Lutz Hein & Ulrich Schwabe. 2019. Arzneiverordnungs-Report 2019. Arzneiverordnungs-Report 2019
61
175
.
Melvin J. Rivera, Bryan Do, Jeffrey C. Bryan, Terri Lynn Shigle & Rina Patel. 2019. Oncologic Critical Care. Oncologic Critical Care
1
27
.
Matteo Scaramuzzi, Lucy T. Xu, Arun D. Singh & Elias I. Traboulsi. 2019. Clinical Ophthalmic Oncology. Clinical Ophthalmic Oncology
113
129
.
Michael S. Taccone & James T. Rutka. 2019. Oncology of CNS Tumors. Oncology of CNS Tumors
389
424
.
Angelica Jimenez-Rosales & Miriam Veronica Flores-Merino. (2018) A Brief Review of the Pathophysiology of Non-melanoma Skin Cancer and Applications of Interpenetrating and Semi-interpenetrating Polymer Networks in Its Treatment. Regenerative Engineering and Translational Medicine 4:4, pages 187-205.
Crossref
Crossref
Jorge E. Cortes, B. Douglas Smith, Eunice S. Wang, Akil Merchant, Vivian G. Oehler, Martha Arellano, Daniel J. DeAngelo, Daniel A. Pollyea, Mikkael A. Sekeres, Tadeusz Robak, Weidong Wendy Ma, Mirjana Zeremski, M. Naveed Shaik, A. Douglas Laird, Ashleigh O'Connell, Geoffrey Chan & Mark A. Schroeder. (2018) Glasdegib in combination with cytarabine and daunorubicin in patients with AML or high-risk MDS: Phase 2 study results. American Journal of Hematology 93:11, pages 1301-1310.
Crossref
Crossref
Sadegh Fattahi, Maryam Pilehchian Langroudi & Haleh Akhavan‐Niaki. (2018) Hedgehog signaling pathway: Epigenetic regulation and role in disease and cancer development. Journal of Cellular Physiology 233:8, pages 5726-5735.
Crossref
Crossref
Jean Chamcheu, Islam Rady, Roxane-Cherille Chamcheu, Abu Siddique, Melissa Bloch, Sergette Banang Mbeumi, Abiola Babatunde, Mohammad Uddin, Felicite Noubissi, Peter Jurutka, Yong-Yu Liu, Vladimir Spiegelman, G. Whitfield & Khalid El Sayed. (2018) Graviola (Annona muricata) Exerts Anti-Proliferative, Anti-Clonogenic and Pro-Apoptotic Effects in Human Non-Melanoma Skin Cancer UW-BCC1 and A431 Cells In Vitro: Involvement of Hedgehog Signaling. International Journal of Molecular Sciences 19:6, pages 1791.
Crossref
Crossref
Maryam Akbari, Harold Chen, Grace Guo, Zachary Legan & Ghali Ghali. (2018) Basal cell nevus syndrome (Gorlin syndrome): genetic insights, diagnostic challenges, and unmet milestones. Pathophysiology 25:2, pages 77-82.
Crossref
Crossref
Miroslava Didiasova, Liliana Schaefer & Malgorzata Wygrecka. (2018) Targeting GLI Transcription Factors in Cancer. Molecules 23:5, pages 1003.
Crossref
Crossref
Xiao-Yu Li, Li-Fei Zhou, Li-Juan Gao, Yang Wei, Shi-Fang Xu, Feng-Yang Chen, Wen-Jing Huang, Wen-Fu Tan & Yi-Ping Ye. (2018) Cynanbungeigenin C and D, a pair of novel epimers from Cynanchum bungei, suppress hedgehog pathway-dependent medulloblastoma by blocking signaling at the level of Gli. Cancer Letters 420, pages 195-207.
Crossref
Crossref
Ann M John & Robert A Schwartz. 2001. eLS. eLS
1
8
.
Julia Taeubner, Triantafyllia Brozou, Nan Qin, Jasmin Bartl, Sebastian Ginzel, Joerg Schaper, Joerg Felsberg, Simone Fulda, Christian Vokuhl, Arndt Borkhardt & Michaela Kuhlen. (2017) Congenital embryonal rhabdomyosarcoma caused by heterozygous concomitant PTCH1 and PTCH2 germline mutations. European Journal of Human Genetics 26:1, pages 137-142.
Crossref
Crossref
Sarah E. Fenton, Jeffrey A. Sosman & Sunandana Chandra. (2017) Current Therapy for Basal Cell Carcinoma and the Potential Role for Immunotherapy With Checkpoint Inhibitors. Clinical Skin Cancer 2:1-2, pages 59-65.
Crossref
Crossref
Archana KumariAlexandre N. ErmilovMarina GrachtchoukAndrzej A. Dlugosz, Benjamin L. Allen, Robert M. BradleyCharlotte M. Mistretta. (2017) Recovery of taste organs and sensory function after severe loss from Hedgehog/Smoothened inhibition with cancer drug sonidegib. Proceedings of the National Academy of Sciences 114:48.
Crossref
Crossref