106
Views
49
CrossRef citations to date
0
Altmetric
Review

The RANK/RANKL/OPG system in tumorigenesis and metastasis of cancer stem cell: potential targets for anticancer therapy

, &
Pages 3801-3810 | Published online: 27 Jul 2017

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (1)

Anna Maria Lena, Erica Foffi, Massimiliano Agostini, Mara Mancini, Margherita Annicchiarico-Petruzzelli, Daniel Aberdam, Tania Velletri, Yufang Shi, Gerry Melino, Ying Wang & Eleonora Candi. (2021) TAp63 regulates bone remodeling by modulating the expression of TNFRSF11B/Osteoprotegerin. Cell Cycle 20:22, pages 2428-2441.
Read now

Articles from other publishers (48)

Chengyan Xu, Zixia He & Zhipeng Shen. (2022) Euxanthone Suppresses the Proliferation, Migration and Invasion of Human Medulloblastoma Cells by Inhibiting the RANK/RANKL Pathway. Pharmacognosy Magazine 19:1, pages 23-30.
Crossref
Hélios Bertin, Sophie Peries, Jérôme Amiaud, Nathalie Van Acker, Bastien Perrot, Corinne Bouvier, Sébastien Aubert, Béatrice Marie, Frédérique Larousserie, Gonzague De Pinieux, Vincent Crenn, Françoise Rédini & Anne Gomez-Brouchet. (2023) Characterization of the Tumor Microenvironment in Jaw Osteosarcomas, towards Prognostic Markers and New Therapeutic Targets. Cancers 15:4, pages 1004.
Crossref
Tommaso Greco, Antonio Mascio, Chiara Comisi, Chiara Polichetti, Silvio Caravelli, Massimiliano Mosca, Nicola Mondanelli, Elisa Troiano, Giulio Maccauro & Carlo Perisano. (2023) RANKL-RANK-OPG Pathway in Charcot Diabetic Foot: Pathophysiology and Clinical-Therapeutic Implications. International Journal of Molecular Sciences 24:3, pages 3014.
Crossref
Faiza Hayat, Najeeb Ullah Khan, Aakif Ullah Khan, Iftikhar Ahmad, Ahmad M. Alamri & Bushra Iftikhar. (2022) Risk association of RANKL and OPG gene polymorphism with breast cancer to bone metastasis in Pashtun population of Khyber Pakhtunkhwa, Pakistan. PLOS ONE 17:11, pages e0276813.
Crossref
Ianny Brum Reis, Luiz Henrique Soares Tibo, Bianca Ribeiro de Souza, Nelson Durán & Wagner José Fávaro. (2022) OncoTherad® is an immunomodulator of biological response that downregulate RANK/RANKL signaling pathway and PD-1/PD-L1 immune checkpoint in non-muscle invasive bladder cancer. Journal of Cancer Research and Clinical Oncology.
Crossref
Jakub Litak, Wojciech Czyżewski, Michał Szymoniuk, Leon Sakwa, Barbara Pasierb, Joanna Litak, Zofia Hoffman, Piotr Kamieniak & Jacek Roliński. (2022) Biological and Clinical Aspects of Metastatic Spinal Tumors. Cancers 14:19, pages 4599.
Crossref
Sabah Akhtar, Shireen Hourani, Lubna Therachiyil, Abdullah Al-Dhfyan, Abdelali Agouni, Asad Zeidan, Shahab Uddin & Hesham M. Korashy. (2022) Epigenetic Regulation of Cancer Stem Cells by the Aryl Hydrocarbon Receptor Pathway. Seminars in Cancer Biology 83, pages 177-196.
Crossref
E. M. Spevak, D. Yu. Christophorando, V. A. Shutov & A. V. Ermakova. (2022) Prevention Of Drug-Induced Osteonecrosis Of The Jaw In Cancer Patients. Creative surgery and oncology 12:2, pages 151-158.
Crossref
Joaquim Soares do Brito, Raquel Lopes-Brás, André Abrunhosa-Branquinho, Isabel Fernandes, Inês Gomes, Sandra Casimiro & Luís Costa. (2022) A Tailored Approach for Appendicular Impending and Pathologic Fractures in Solid Cancer Metastases. Cancers 14:4, pages 893.
Crossref
Minghai Shao, Caiping Jiang, Changhui Yu, Haijian Jia, Yanli Wang & Xinli Mao. (2022) Capecitabine inhibits epithelial‑to‑mesenchymal transition and proliferation of colorectal cancer cells by mediating the RANK/RANKL pathway. Oncology Letters 23:3.
Crossref
Bartosz Kamil Sobocki, Charbel A. Basset, Bożena Bruhn-Olszewska, Paweł Olszewski, Olga Szot, Karolina Kaźmierczak-Siedlecka, Mateusz Guziak, Luigi Nibali & Angelo Leone. (2022) Molecular Mechanisms Leading from Periodontal Disease to Cancer. International Journal of Molecular Sciences 23:2, pages 970.
Crossref
Jingnan zhang, Feng Wang, Gengbao Qu & Baokai Wang. (2021) Murrayanine suppresses the proliferation and metastasis of human breast cancer cells via induction of apoptosis and inhibition of RANK/RANKL signaling pathway. Applied Biological Chemistry 64:1.
Crossref
Emanuela Palmerini, Leanne L. Seeger, Marco Gambarotti, Alberto Righi, Peter Reichardt, Susan Bukata, Jean-Yves Blay, Tian Dai, Danielle Jandial & Piero Picci. (2021) Malignancy in giant cell tumor of bone: analysis of an open-label phase 2 study of denosumab. BMC Cancer 21:1.
Crossref
Sujeetha A. Rajakumar, Ildiko Grandal, Mark D. Minden, Johann K. Hitzler, Cynthia J. Guidos & Jayne S. Danska. (2021) Targeted blockade of immune mechanisms inhibit B precursor acute lymphoblastic leukemia cell invasion of the central nervous system. Cell Reports Medicine 2:12, pages 100470.
Crossref
Maura Argenziano, Chiara Tortora, Elvira Pota, Alessandra Di Paola, Martina Di Martino, Caterina Di Leva, Daniela Di Pinto & Francesca Rossi. (2021) Osteosarcoma in Children: Not Only Chemotherapy. Pharmaceuticals 14:9, pages 923.
Crossref
Sonny Hermanus Johannes Sliepen. 2021. Recent Advances in Bone Tumours and Osteoarthritis. Recent Advances in Bone Tumours and Osteoarthritis.
Ke Wan, Ziwei Tu, Zhentian Liu, Yun Cai, Yinglan Chen & Chunhua Ling. (2021) Upregulated osteoprotegerin expression promotes lung cancer cell invasion by increasing miR‑20a expression. Experimental and Therapeutic Medicine 22:2.
Crossref
Qian Liang, Yun Wang, Yingsi Lu, Qingqing Zhu, Wenlin Xie, Nannan Tang, Lifen Huang, Tailai An, Di Zhang, Anqi Yan, Shaoyu Liu, Liping Ye & Chengming Zhu. (2021) RANK promotes colorectal cancer migration and invasion by activating the Ca2+-calcineurin/NFATC1-ACP5 axis. Cell Death & Disease 12:4.
Crossref
Yulian Erwin D. (2021) CXCR4 and RANK Combination as a Predictor of Breast Cancer Bone Metastasis in Indonesia. Journal of Surgery and Surgical Research, pages 020-025.
Crossref
Shreya Medhi, Simran Narvekar & Amrita Srivastav. (2021) Repurposing of a muscle relaxant drug thiocolchicoside as an anticancer agent. MGM Journal of Medical Sciences 8:1, pages 33.
Crossref
David I. Suster, Pawel Kurzawa, Azfar Neyaz, Jason A. Jarzembowski, Santiago Lozano-Calderon, Kevin Raskin, Joseph Schwab, Edwin Choy, Ivan Chebib & Vikram Deshpande. (2020) Chondroblastoma Expresses RANKL by RNA In Situ Hybridization and May Respond to Denosumab Therapy. American Journal of Surgical Pathology 44:12, pages 1581-1590.
Crossref
Muhammad A.B. Ashraf, Ayesha Zahid, Shazia Ashraf, Sulayman Waquar, Saima Iqbal & Arif Malik. (2020) Implication of Prophetic Variables and their Impulsive Interplay in CA Prostate Patients Experiencing Osteo-Metastasis. Anti-Cancer Agents in Medicinal Chemistry 20:17, pages 2106-2113.
Crossref
Robert Coleman. (2020) Bisphosphonates and breast cancer – From cautious palliation to saving lives. Bone 140, pages 115570.
Crossref
Vagelis Rinotas, Athanasios Papakyriakou, Foteini Violitzi, Christos Papaneophytou, Maria-Dimitra Ouzouni, Polyxeni Alexiou, Alexandros Strongilos, Elias Couladouros, George Kontopidis, Elias Eliopoulos & Eleni Douni. (2020) Discovery of Small-Molecule Inhibitors of Receptor Activator of Nuclear Factor-κB Ligand with a Superior Therapeutic Index. Journal of Medicinal Chemistry 63:20, pages 12043-12059.
Crossref
Ji-Yoon Noh, Young Yang & Haiyoung Jung. (2020) Molecular Mechanisms and Emerging Therapeutics for Osteoporosis. International Journal of Molecular Sciences 21:20, pages 7623.
Crossref
Quincy S.C. Chu. (2020) How Is Receptor Activator of Nuclear Factor-κβ/Receptor Activator of Nuclear Factor-κβ Ligand Targeting Ranked as an Immuno-Oncology Target for NSCLC: a Pathway Unclear as yet?. Journal of Thoracic Oncology 15:10, pages 1561-1564.
Crossref
Emma Risson, Ana Rita Nobre, Veronique Maguer-Satta & Julio A. Aguirre-Ghiso. (2020) The current paradigm and challenges ahead for the dormancy of disseminated tumor cells. Nature Cancer 1:7, pages 672-680.
Crossref
Timothy O. Adekoya & Ricardo M. Richardson. (2020) Cytokines and Chemokines as Mediators of Prostate Cancer Metastasis. International Journal of Molecular Sciences 21:12, pages 4449.
Crossref
Yu Fan, Xuyu Gu, Huiwen Pan, Zhe Dai, Chen Zou, Zhenjun Gao & Heng Zhang. (2020) Association of Genetic Polymorphisms in TNFRSF11 with the Progression of Genetic Susceptibility to Gastric Cancer . Journal of Oncology 2020, pages 1-9.
Crossref
Jun-Xiao Yang, Peng Xie, Yu-Sheng Li, Ting Wen & Xu-Cheng Yang. (2020) Osteoclast-derived miR-23a-5p-containing exosomes inhibit osteogenic differentiation by regulating Runx2. Cellular Signalling 70, pages 109504.
Crossref
Ning Zhang, Zong-Kang Zhang, Yuanyuan Yu, Zhenjian Zhuo, Ge Zhang & Bao-Ting Zhang. (2020) Pros and Cons of Denosumab Treatment for Osteoporosis and Implication for RANKL Aptamer Therapy. Frontiers in Cell and Developmental Biology 8.
Crossref
Stella D’Oronzo, Erica Silvestris, Angelo Paradiso, Mauro Cives & Marco Tucci. (2020) Role of Bone Targeting Agents in the Prevention of Bone Metastases from Breast Cancer. International Journal of Molecular Sciences 21:8, pages 3022.
Crossref
Bo Yan, Yan Li, Shaoju Min, Peng Zhang, Bin Xu, Zhen Wang, Wei Zhang, Jiasheng Chen, Guangheng Luo & Chunxiao Liu. (2020) Effects of the Bone/Bone Marrow Microenvironments on Prostate Cancer Cells and CD59 Expression. BioMed Research International 2020, pages 1-13.
Crossref
Britton Trabert, Mark E Sherman, Nagarajan Kannan & Frank Z Stanczyk. (2020) Progesterone and Breast Cancer. Endocrine Reviews 41:2, pages 320-344.
Crossref
Xiaoqiu Wu, Fangfei Li, Lei Dang, Chao Liang, Aiping Lu & Ge Zhang. (2020) RANKL/RANK System-Based Mechanism for Breast Cancer Bone Metastasis and Related Therapeutic Strategies. Frontiers in Cell and Developmental Biology 8.
Crossref
Negin Amin, Cain C.T. Clark, Mohsen Taghizadeh & Sadegh Djafarnejad. (2020) Zinc supplements and bone health: The role of the RANKL-RANK axis as a therapeutic target. Journal of Trace Elements in Medicine and Biology 57, pages 126417.
Crossref
Gabriel M. Pagnotti, Silvia Marino, Daniela N. Petrusca, Teresita Bellido, G. David Roodman & Jesus Delgado-Calle. 2020. Encyclopedia of Bone Biology. Encyclopedia of Bone Biology 201 218 .
Lan Hai, Maria M. Szwarc, David M. Lonard, Kimal Rajapakshe, Dimuthu Perera, Cristian Coarfa, Michael Ittmann, Rodrigo Fernandez-Valdivia & John P. Lydon. (2019) Short-term RANKL exposure initiates a neoplastic transcriptional program in the basal epithelium of the murine salivary gland. Cytokine 123, pages 154745.
Crossref
Tomalika Rahmat Ullah. (2019) The role of CXCR4 in multiple myeloma: Cells’ journey from bone marrow to beyond. Journal of Bone Oncology 17, pages 100253.
Crossref
S. Peters, P. Clézardin, I. Márquez-Rodas, D. Niepel & C. Gedye. (2019) The RANK–RANKL axis: an opportunity for drug repurposing in cancer?. Clinical and Translational Oncology 21:8, pages 977-991.
Crossref
Chiara Spadazzi, Federica Recine, Laura Mercatali, Giacomo Miserocchi, Chiara Liverani, Alessandro De Vita, Alberto Bongiovanni, Valentina Fausti & Toni Ibrahim. (2019) mTOR inhibitor and bone-targeted drugs break the vicious cycle between clear-cell renal carcinoma and osteoclasts in an in vitro co-culture model. Journal of Bone Oncology 16, pages 100227.
Crossref
Foteinos-Ioannis D. Dimitrakopoulos, Anastasia E. Kottorou, Anna G. Antonacopoulou, Nikolaos Panagopoulos, Chrisoula Scopa, Melpomeni Kalofonou, Dimitrios Dougenis, Angelos Koutras, Thomas Makatsoris, Vassiliki Tzelepi & Haralabos P. Kalofonos. (2019) Expression of Immune System-Related Membrane Receptors CD40, RANK, BAFFR and LTβR is Associated with Clinical Outcome of Operated Non-Small-Cell Lung Cancer Patients. Journal of Clinical Medicine 8:5, pages 741.
Crossref
Xin Liu, Zhifeng Chen, Tianjun Lan, Peisheng Liang & Qian Tao. (2019) Upregulation of interleukin-8 and activin A induces osteoclastogenesis in ameloblastoma. International Journal of Molecular Medicine.
Crossref
Giuseppe Carota, Giuseppe Sferrazzo, Mariarita Spampinato, Valeria Sorrenti & Luca Vanella. (2019) Antiproliferative Effects of Ellagic Acid on DU145 Cells. The Open Biochemistry Journal 13:1, pages 23-31.
Crossref
Peter A. van Dam, Yannick Verhoeven, Xuan B. Trinh, An Wouters, Filip Lardon, Hans Prenen, Evelien Smits, Marcella Baldewijns & Martin Lammens. (2019) RANK/RANKL signaling inhibition may improve the effectiveness of checkpoint blockade in cancer treatment. Critical Reviews in Oncology/Hematology 133, pages 85-91.
Crossref
Francesca Punzo, Chiara Tortora, Daniela Di Pinto, Elvira Pota, Maura Argenziano, Alessandra Di Paola, Fiorina Casale & Francesca Rossi. (2018) Bortezomib and endocannabinoid/endovanilloid system: a synergism in osteosarcoma. Pharmacological Research 137, pages 25-33.
Crossref
Benjamin Navet, Kosei Ando, Jorge Vargas-Franco, Régis Brion, Jérome Amiaud, Kanji Mori, Hideo Yagita, Christopher Mueller, Franck Verrecchia, Clotilde Dumars, Marie-Françoise Heymann, Dominique Heymann & Frédéric Lézot. (2018) The Intrinsic and Extrinsic Implications of RANKL/RANK Signaling in Osteosarcoma: From Tumor Initiation to Lung Metastases. Cancers 10:11, pages 398.
Crossref
Vahedeh Hosseini, Samira Mohammadi‐Yeganeh, Hossein Ghanbarian, Seyed Mahmoud Hashemi & Arash Khojasteh. (2018) The power of precise bioinformatics prediction of miRNA:mRNA interactions:miR‐4699 as a potential inducer of Wnt signaling pathway. Journal of Cellular Biochemistry 119:7, pages 5960-5969.
Crossref