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OncoTargets and Therapy Volume 10, 2017 - Issue
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Original Research

miRNA-221 of exosomes originating from bone marrow mesenchymal stem cells promotes oncogenic activity in gastric cancer

Min Ma1 Department of Gastroduodenal and Pancreatic Surgery, Laboratory of Digestive Oncology, Hunan Cancer Institute, Hunan Cancer Hospital, Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University
,
Shilin Chen1 Department of Gastroduodenal and Pancreatic Surgery, Laboratory of Digestive Oncology, Hunan Cancer Institute, Hunan Cancer Hospital, Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University
,
Zhuo Liu1 Department of Gastroduodenal and Pancreatic Surgery, Laboratory of Digestive Oncology, Hunan Cancer Institute, Hunan Cancer Hospital, Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University
,
Hailong Xie2 Institute of Cancer Research, South China University
,
Hongyu Deng3 Department of Laboratory Medicine, Hunan Cancer Hospital, Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University
,
Song Shang1 Department of Gastroduodenal and Pancreatic Surgery, Laboratory of Digestive Oncology, Hunan Cancer Institute, Hunan Cancer Hospital, Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University
,
Xiaohong Wang4 Department of Molecular Medicine, College of Biology, State Key Laboratory of Chemo/Biosensing and Chemometrics, Hunan University
,
Man Xia5 Department of Gynecological Oncology, Hunan Cancer Hospital, Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, Hunan, ChinaCorrespondence[email protected]
&
Chaohui Zuo1 Department of Gastroduodenal and Pancreatic Surgery, Laboratory of Digestive Oncology, Hunan Cancer Institute, Hunan Cancer Hospital, Affiliated Cancer Hospital of Xiangya School of Medicine, Central South UniversityCorrespondence[email protected]
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Pages 4161-4171 | Published online: 22 Aug 2017

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Hongwei Fu, Yinan Wu, Xiaobin Yang, Shiyi Huang, Fenglin Yu, Hong Deng, Shu Zhang & Qi Xiang. (2021) Stem cell and its derivatives as drug delivery vehicles: an effective new strategy of drug delivery system. All Life 14:1, pages 782-798.
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Zhao-li Wei, Ai-bin Gao, Qing Wang, Xiu-e Lou, Jing Zhao & Qing-jun Lu. (2019) MicroRNA-221 promotes papillary thyroid carcinoma cell migration and invasion via targeting RECK and regulating epithelial–mesenchymal transition. OncoTargets and Therapy 12, pages 2323-2333.
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Yinghui Zhao, Mei Tao, Meiling Wei, Shengye Du, Hongping Wang & Xiaohong Wang. (2019) Mesenchymal stem cells derived exosomal miR-323-3p promotes proliferation and inhibits apoptosis of cumulus cells in polycystic ovary syndrome (PCOS). Artificial Cells, Nanomedicine, and Biotechnology 47:1, pages 3804-3813.
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Xiaorong Zhou, Manli Xu, Yonghong Guo, Ling Ye, Limin Long, Haiqin Wang, Pan Tan & Meili Xu. (2018) MicroRNA-588 regulates invasion, migration and epithelial–mesenchymal transition via targeting EIF5A2 pathway in gastric cancer. Cancer Management and Research 10, pages 5187-5197.
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Hai-Liang Yuan, Ting Wang & Kun-He Zhang. (2018) MicroRNAs as potential biomarkers for diagnosis, therapy and prognosis of gastric cancer. OncoTargets and Therapy 11, pages 3891-3900.
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Yue Cao, Peng Xu, Yangling Shen, Wei Wu, Min Chen, Fei Wang, Yuandong Zhu, Feng Yan, Weiying Gu & Yan Lin. (2023) Exosomes and cancer immunotherapy: A review of recent cancer research. Frontiers in Oncology 12.
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Chuanyun Li, Tong Zhou, Jing Chen, Rong Li, Huan Chen, Shumin Luo, Dexi Chen, Cao Cai & Weihua Li. (2022) The role of Exosomal miRNAs in cancer. Journal of Translational Medicine 20:1.
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Pengcheng Sun, Samuel O. Antwi, Kurt Sartorius, Xiao Zheng & Xiaodong Li. (2022) Tumor Microenvironment, Clinical Features, and Advances in Therapy for Bone Metastasis in Gastric Cancer. Cancers 14:19, pages 4888.
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Lin-Xian Zhao, Kai Zhang, Bing-Bing Shen & Jian-Nan Li. (2021) Mesenchymal stem cell-derived exosomes for gastrointestinal cancer. World Journal of Gastrointestinal Oncology 13:12, pages 1981-1996.
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Yuyi Li, Xingwei Zhong, Yunzhu Zhang & Xinliang Lu. (2021) Mesenchymal Stem Cells in Gastric Cancer: Vicious but Hopeful. Frontiers in Oncology 11.
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Min Liu, Zaiguo Wang, Shaolei Ren & Hongli Zhao. (2021) Exosomes derived from mycobacterium tuberculosis-infected MSCs induce a pro-inflammatory response of macrophages. Aging 13:8, pages 11595-11609.
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Xiaoli Qian, Nan An, Yifan Ren, Chenxin Yang, Xiaoling Zhang & Lisha Li. (2020) Immunosuppressive Effects of Mesenchymal Stem Cells-derived Exosomes. Stem Cell Reviews and Reports 17:2, pages 411-427.
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Guiping Zhao, Anni Zhou, Xiao Li, Shengtao Zhu, Yongjun Wang, Shutian Zhang & Peng Li. (2021) The Significance of Exosomal RNAs in the Development, Diagnosis, and Treatment of Gastric Cancer. Genes 12:1, pages 73.
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Ran Li, Kunchi Zhao, Qing Ruan, Chunyang Meng & Fei Yin. (2020) Bone marrow mesenchymal stem cell-derived exosomal microRNA-124-3p attenuates neurological damage in spinal cord ischemia-reperfusion injury by downregulating Ern1 and promoting M2 macrophage polarization. Arthritis Research & Therapy 22:1.
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Ziyuan Guo, Zhuo Zhao, Chuang Yang & Chunli Song. (2020) Transfer of microRNA-221 from mesenchymal stem cell-derived extracellular vesicles inhibits atherosclerotic plaque formation. Translational Research 226, pages 83-95.
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Soudeh Ghafouri-Fard, Reza Vafaee, Hamed Shoorei & Mohammad Taheri. (2020) MicroRNAs in gastric cancer: Biomarkers and therapeutic targets. Gene 757, pages 144937.
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Qing Wang, Ti Li, Wei Wu & Gang Ding. (2020) Interplay between mesenchymal stem cell and tumor and potential application. Human Cell 33:3, pages 444-458.
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Vadims Parfejevs, Krizia Sagini, Arturs Buss, Kristine Sobolevska, Alicia Llorente, Una Riekstina & Arturs Abols. (2020) Adult Stem Cell-Derived Extracellular Vesicles in Cancer Treatment: Opportunities and Challenges. Cells 9:5, pages 1171.
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Xiaojing Shi, Qinqin Cheng & Yong Zhang. (2020) Reprogramming extracellular vesicles with engineered proteins. Methods 177, pages 95-102.
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Fa Qin, Haoyu Tang, Yong Zhang, Zhenhua Zhang, Pinge Huang & Jun Zhu. (2019) Bone marrow‐derived mesenchymal stem cell‐derived exosomal microRNA‐208a promotes osteosarcoma cell proliferation, migration, and invasion. Journal of Cellular Physiology 235:5, pages 4734-4745.
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Jian-Nan Li, Wei Li, Lan-Qing Cao, Ning Liu & Kai Zhang. (2020) Efficacy of mesenchymal stem cells in the treatment of gastrointestinal malignancies. World Journal of Gastrointestinal Oncology 12:4, pages 365-382.
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Zhiyong Deng, Jianhong Wu, Song Xu, Fang Chen, Zhiqing Zhang, Anqi Jin & Jianjun Wang. (2020) Exosomes-microRNAs interacted with gastric cancer and its microenvironment: a mini literature review. Biomarkers in Medicine 14:2, pages 141-150.
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Lisa Linck-Paulus, Claus Hellerbrand, Anja K. Bosserhoff & Peter Dietrich. (2020) Dissimilar Appearances Are Deceptive–Common microRNAs and Therapeutic Strategies in Liver Cancer and Melanoma. Cells 9:1, pages 114.
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Bárbara Adem, Patricia F. Vieira & Sonia A. Melo. (2020) Decoding the Biology of Exosomes in Metastasis. Trends in Cancer 6:1, pages 20-30.
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Kyong-Su Park, Elga Bandeira, Ganesh V. Shelke, Cecilia Lässer & Jan Lötvall. (2019) Enhancement of therapeutic potential of mesenchymal stem cell-derived extracellular vesicles. Stem Cell Research & Therapy 10:1.
Crossref
Min Fu, Jianmei Gu, Pengcheng Jiang, Hui Qian, Wenrong Xu & Xu Zhang. (2019) Exosomes in gastric cancer: roles, mechanisms, and applications. Molecular Cancer 18:1.
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Tingting Huang, Chunli Song, Lei Zheng, Ligang Xia, Yang Li & Yiwen Zhou. (2019) The roles of extracellular vesicles in gastric cancer development, microenvironment, anti-cancer drug resistance, and therapy. Molecular Cancer 18:1.
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Zhen-Hua Gong, Feng Zhou, Chao Shi, Tie Xiang, Chang-Kai Zhou, Qian-Qian Wang, Ya-Su Jiang & Sheng-Feng Gao. (2019) miRNA-221 promotes cutaneous squamous cell carcinoma progression by targeting PTEN. Cellular & Molecular Biology Letters 24:1.
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Xudong Yao, Wei Wei, Xiaozhao Wang, Li Chenglin, Mikael Björklund & Hongwei Ouyang. (2019) Stem cell derived exosomes: microRNA therapy for age-related musculoskeletal disorders. Biomaterials 224, pages 119492.
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Song Shang, Jinfeng Wang, Shilin Chen, Renyun Tian, Hui Zeng, Liang Wang, Man Xia, Haizhen Zhu & Chaohui Zuo. (2019) Exosomal miRNA‐1231 derived from bone marrow mesenchymal stem cells inhibits the activity of pancreatic cancer. Cancer Medicine 8:18, pages 7728-7740.
Crossref
Yi Qian, Yaoshu Teng, Yuandong Li, Xiaojiang Lin, Ming Guan, Yong Li, Xiaolin Cao & Yueqiu Gao. (2019) MiR-143-3p suppresses the progression of nasal squamous cell carcinoma by targeting Bcl-2 and IGF1R. Biochemical and Biophysical Research Communications 518:3, pages 492-499.
Crossref
Xudong Xie, Hongpei Wu, Mei Li, Xiaojun Chen, Xiaoyun Xu, Wenkai Ni, Cuihua Lu, Runzhou Ni, Baijun Bao & Mingbing Xiao. (2019) Progress in the application of exosomes as therapeutic vectors in tumor-targeted therapy. Cytotherapy 21:5, pages 509-524.
Crossref
Inbal Wortzel, Shani Dror, Candia M. Kenific & David Lyden. (2019) Exosome-Mediated Metastasis: Communication from a Distance. Developmental Cell 49:3, pages 347-360.
Crossref
Houman Kahroba, Mohammad Saeid Hejazi & Nasser Samadi. (2019) Exosomes: from carcinogenesis and metastasis to diagnosis and treatment of gastric cancer. Cellular and Molecular Life Sciences 76:9, pages 1747-1758.
Crossref
Amer F. Saleh, Elisa Lázaro-Ibáñez, Malin A.-M. Forsgard, Olga Shatnyeva, Xabier Osteikoetxea, Fredrik Karlsson, Nikki Heath, Madeleine Ingelsten, Jonathan Rose, Jayne Harris, Maelle Mairesse, Stephanie M. Bates, Maryam Clausen, Damla Etal, Emilyanne Leonard, Mick D. Fellows, Niek Dekker & Nicholas Edmunds. (2019) Extracellular vesicles induce minimal hepatotoxicity and immunogenicity. Nanoscale 11:14, pages 6990-7001.
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Bingyan Liu, Shaoqiu Wu, Jun Ma, Shuo Yan, Zhengguang Xiao, Linhuang Wan, Feng Zhang, Mingyi Shang & Aiwu Mao. (2018) lncRNA GAS5 Reverses EMT and Tumor Stem Cell-Mediated Gemcitabine Resistance and Metastasis by Targeting miR-221/SOCS3 in Pancreatic Cancer. Molecular Therapy - Nucleic Acids 13, pages 472-482.
Crossref
Lei Tian, Zhifeng Zhao, Ling Xie & JinPeng Zhu. (2018) RETRACTED: MiR-361-5p inhibits the mobility of gastric cancer cells through suppressing epithelial-mesenchymal transition via the Wnt/β-catenin pathway. Gene 675, pages 102-109.
Crossref
Saikat Dewanjee & Niloy Bhattacharjee. (2018) MicroRNA: A new generation therapeutic target in diabetic nephropathy. Biochemical Pharmacology 155, pages 32-47.
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Lin Liu, Tao Meng, Xin-Hui Yang, Parhat Sayim, Cheng Lei, Bo Jin, Lei Ge & Hai-Jiang Wang. (2018) Prognostic and predictive value of long non-coding RNA GAS5 and mircoRNA-221 in colorectal cancer and their effects on colorectal cancer cell proliferation, migration and invasion. Cancer Biomarkers 22:2, pages 283-299.
Crossref
Joana Maia, Sergio Caja, Maria Carolina Strano Moraes, Nuno Couto & Bruno Costa-Silva. (2018) Exosome-Based Cell-Cell Communication in the Tumor Microenvironment. Frontiers in Cell and Developmental Biology 6.
Crossref
Xinyan Wang, Yifei Jin, Hui Zhang, Xinyu Huang, Yuanhui Zhang & Jianwei Zhu. (2018) MicroRNA-599 inhibits metastasis and epithelial-mesenchymal transition via targeting EIF5A2 in gastric cancer. Biomedicine & Pharmacotherapy 97, pages 473-480.
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