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OncoTargets and Therapy Volume 12, 2019 - Issue
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Original Research

Rhein sensitizes human colorectal cancer cells to EGFR inhibitors by inhibiting STAT3 pathway

Yan Zhuang1 The Institute of Life Sciences, Wenzhou University, Wenzhou, Zhejiang 325035, People’s Republic of China;2 School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang 325035, People’s Republic of China
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Ying Bai1 The Institute of Life Sciences, Wenzhou University, Wenzhou, Zhejiang 325035, People’s Republic of China;2 School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang 325035, People’s Republic of China
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Yan Hu3 Department of Pharmacy, Taizhou Enze Medical Center (Group), Taizhou Hospital of Zhejiang Province, Taizhou, Zhejiang 317000, People’s Republic of China
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Yueqin Guo1 The Institute of Life Sciences, Wenzhou University, Wenzhou, Zhejiang 325035, People’s Republic of China;2 School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang 325035, People’s Republic of China
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Lingyuan Xu1 The Institute of Life Sciences, Wenzhou University, Wenzhou, Zhejiang 325035, People’s Republic of China;2 School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang 325035, People’s Republic of China
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Wanle Hu4 Department of Coloproctology, The Second Affiliated Hospital and Yuying Children’s Hospital, Wenzhou Medical University, Wenzhou, Zhejiang 325000, People’s Republic of China
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Lehe Yang1 The Institute of Life Sciences, Wenzhou University, Wenzhou, Zhejiang 325035, People’s Republic of China;2 School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang 325035, People’s Republic of China
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Chengguang Zhao1 The Institute of Life Sciences, Wenzhou University, Wenzhou, Zhejiang 325035, People’s Republic of China;2 School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang 325035, People’s Republic of China
,
Xiaokun Li1 The Institute of Life Sciences, Wenzhou University, Wenzhou, Zhejiang 325035, People’s Republic of China;2 School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang 325035, People’s Republic of ChinaCorrespondence[email protected]
&
Haiyang Zhao1 The Institute of Life Sciences, Wenzhou University, Wenzhou, Zhejiang 325035, People’s Republic of China;2 School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang 325035, People’s Republic of ChinaCorrespondence[email protected]
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Pages 5281-5291 | Published online: 03 Jul 2019

Citations (18)

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Feng Gao, Rui Li, Pei-Feng Wei, Li Ou, Min Li, Yang Bai, Wen-Jia Luo & Zhen Fan. (2022) Synergistic anticancer effects of everolimus (RAD001) and Rhein on gastric cancer cells via phosphoinositide-3-kinase (PI3K)/protein kinase B (AKT)/mammalian target of rapamycin (mTOR) pathway. Bioengineered 13:3, pages 6332-6342.
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Articles from other publishers (17)

Mehrdad Hashemi, Sahar Abbaszadeh, Mohsen Rashidi, Nafisesadat Amini, Kasra Talebi Anaraki, Motahhar Motahhary, Ensi Khalilipouya, Abdorrahman Harif Nashtifani, Sasan Shafiei, Marzieh Ramezani Farani, Noushin Nabavi, Shokooh Salimimoghadam, Amir Reza Aref, Rasoul Raesi, Afshin Taheriazam, Maliheh Entezari & Wenliang Zha. (2023) STAT3 as a newly emerging target in colorectal cancer therapy: Tumorigenesis, therapy response, and pharmacological/nanoplatform strategies. Environmental Research 233, pages 116458.
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Haibo Zhang, Lei Ma, Eungyung Kim, Junkoo Yi, Hai Huang, Hyeonjin Kim, Muhammad Atif Raza, Sijun Park, Soyoung Jang, Kirim Kim, Sung-Hyun Kim, Youngkyun Lee, Eunkyong Kim, Zae Young Ryoo & Myoung Ok Kim. (2023) Rhein Induces Oral Cancer Cell Apoptosis and ROS via Suppresse AKT/mTOR Signaling Pathway In Vitro and In Vivo. International Journal of Molecular Sciences 24:10, pages 8507.
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Rongbing Xiong, Xiaodi Hu, Shuangyan Hu, Minqi Yao & Xiaojun Fu. (2022) Rhein Inhibits Proliferation, Extracellular Matrix Deposition, and Inflammation in Mesangial Cells via ROS/Akt Signaling Pathway. Natural Product Communications 17:10, pages 1934578X2211316.
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Tian-hao Guo, Yuan-yuan Li, Sheng-wei Hong, Qian-yu Cao, Heng Chen, Yuan Xu, Guo-liang Dai & Gang Shao. (2022) Evidence for Anticancer Effects of Chinese Medicine Monomers on Colorectal Cancer. Chinese Journal of Integrative Medicine 28:10, pages 939-952.
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Wojciech Trybus, Teodora Król & Ewa Trybus. (2022) Rhein induces changes in the lysosomal compartment of HeLa cells. Journal of Cellular Biochemistry 123:9, pages 1506-1524.
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Batoul Al-Khatib, Akram Hijazi, Nafez Hareb, Mona Diab-Assaf & Racha Karaky. (2022) Anticancer effect of different rhizome extracts of the Lebanese Rheum ribes L. species on colorectal cancer cell lines. Phytomedicine Plus 2:3, pages 100321.
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Yemeng Tang, Yanmao Wang, Xian Wang, Zhucheng Zhao, Haijian Cai, Mengyao Xie, Xintong Jiang, Luyao Zhang, Jiayun Cheng, Lehe Yang, Liangxing Wang, Chengguang Zhao & Xiaoying Huang. (2022) Acetylshikonin exerts anti-tumor effects on non-small cell lung cancer through dual inhibition of STAT3 and EGFR. Phytomedicine 101, pages 154109.
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Yili Shen, Haijian Cai, Shenjie Ma, Wenjing Zhu, Haiyang Zhao, Jifa Li, Hua Ye, Lehe Yang, Chengguang Zhao, Xiaoying Huang & Zhongxiao Xiao. (2022) Telocinobufagin Has Antitumor Effects in Non-Small-Cell Lung Cancer by Inhibiting STAT3 Signaling. Journal of Natural Products 85:4, pages 765-775.
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Jinxin Liu, Dapeng Ding, Feiye Liu & Yizhi Chen. (2022) Rhein Inhibits the Progression of Chemoresistant Lung Cancer Cell Lines via the Stat3/Snail/MMP2/MMP9 Pathway. BioMed Research International 2022, pages 1-8.
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Raghda T. Abdel-Latif, Walaa Wadie, Yousra Abdel-mottaleb, Dalaal M. Abdallah, Nabila N. El-Maraghy & Hanan S. El-Abhar. (2022) Reposition of the anti-inflammatory drug diacerein in an in-vivo colorectal cancer model. Saudi Pharmaceutical Journal 30:1, pages 72-90.
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Gayathri Chalikonda, Hoomin Lee, Aliya Sheik & Yun Suk Huh. (2021) Targeting key transcriptional factor STAT3 in colorectal cancer. Molecular and Cellular Biochemistry 476:9, pages 3219-3228.
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Antonios N. Gargalionis, Kostas A. Papavassiliou & Athanasios G. Papavassiliou. (2021) Targeting STAT3 Signaling Pathway in Colorectal Cancer. Biomedicines 9:8, pages 1016.
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Xianbin Kong, Chuanxin Liu, Peng Lu, Yuzhu Guo, Chenchen Zhao, Yuying Yang, Zhichao Bo, Fangyuan Wang, Yingying Peng & Jingyan Meng. (2021) Combination of UPLC–Q-TOF/MS and Network Pharmacology to Reveal the Mechanism of Qizhen Decoction in the Treatment of Colon Cancer. ACS Omega 6:22, pages 14341-14360.
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Zoleykha Asadi, Mojtaba Fathi, Elham Rismani, Zahra Bigdelou & Behrooz Johari. (2021) Application of decoy oligodeoxynucleotides strategy for inhibition of cell growth and reduction of metastatic properties in nonresistant and erlotinib‐resistant SW480 cell line. Cell Biology International 45:5, pages 1001-1014.
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Haibo Zhang, Jun-Koo Yi, Hai Huang, Song Park, Sijun Park, Wookbong Kwon, Eungyung Kim, Soyoung Jang, Si-Yong Kim, Seong-Kyoon Choi, Sung-Hyun Kim, Kangdong Liu, Zigang Dong, Zae Young Ryoo & Myoung Ok Kim. (2021) Rhein Suppresses Colorectal Cancer Cell Growth by Inhibiting the mTOR Pathway In Vitro and In Vivo. Cancers 13:9, pages 2176.
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Huiqi Huang, Ji Hao, Kejian Pang, Yibing Lv, Dingrong Wan, Chaoqun Wu, Yuanren Ma, Xinzhou Yang & Wei K. Zhang. (2020) A biflavonoid‐rich extract from Selaginella moellendorffii Hieron. induces apoptosis via STAT3 and Akt/NF‐κB signalling pathways in laryngeal carcinoma . Journal of Cellular and Molecular Medicine 24:20, pages 11922-11935.
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Sahu Henamayee, Kishore Banik, Bethsebie Lalduhsaki Sailo, Bano Shabnam, Choudhary Harsha, Satti Srilakshmi, Naidu VGM, Seung Ho Baek, Kwang Seok Ahn & Ajaikumar B Kunnumakkara. (2020) Therapeutic Emergence of Rhein as a Potential Anticancer Drug: A Review of Its Molecular Targets and Anticancer Properties. Molecules 25:10, pages 2278.
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