108
Views
18
CrossRef citations to date
0
Altmetric
Original Research

Rhein sensitizes human colorectal cancer cells to EGFR inhibitors by inhibiting STAT3 pathway

, , , , , , , , & show all
Pages 5281-5291 | Published online: 03 Jul 2019

References

  • Misale S, Yaeger R, Hobor S, et al. Emergence of KRAS mutations and acquired resistance to anti-EGFR therapy in colorectal cancer. Nature. 2012;486:532–536. doi:10.1038/nature1115622722830
  • Siegel RL, Miller KD, Jemal A. Cancer statistics, 2019. CA Cancer J Clin. 2019;69:7–34.30620402
  • Wolf AMD, Fontham ETH, Church TR, et al. Colorectal cancer screening for average-risk adults: 2018 guideline update from the American Cancer Society. CA Cancer J Clin. 2018;68:250–281.29846947
  • Okada Y, Kimura T, Nakagawa T, et al. EGFR downregulation after Anti-EGFR therapy predicts the antitumor effect in colorectal cancer. Mol Cancer Re. 2017;15:1445–1454. doi:10.1158/1541-7786.MCR-17-0157
  • Wu P, Nielsen TE, Clausen MH. FDA-approved small-molecule kinase inhibitors. Trends Pharmacol Sci. 2015;36:422–439. doi:10.1016/j.tips.2015.04.00525975227
  • Bertotti A, Papp E, Jones S, et al. The genomic landscape of response to EGFR blockade in colorectal cancer. Nature. 2015;526:263–267. doi:10.1038/nature1496926416732
  • Misale S, Di Nicolantonio F, Sartore-Bianchi A, Siena S, Bardelli A. Resistance to anti-EGFR therapy in colorectal cancer: from heterogeneity to convergent evolution. Cancer Discov. 2014;4:1269–1280. doi:10.1158/2159-8290.CD-13-064625293556
  • Troiani T, Martinelli E, Napolitano S, et al. Increased TGF-alpha as a mechanism of acquired resistance to the Anti-EGFR inhibitor cetuximab through EGFR-MET interaction and activation of MET signaling in colon cancer cells. Clin Cancer Res. 2013;19:6751–6765. doi:10.1158/1078-0432.CCR-13-042324122793
  • Miroddi M, Sterrantino C, Simmonds M, et al. Systematic review and meta-analysis of the risk of severe and life-threatening thromboembolism in cancer patients receiving anti-EGFR monoclonal antibodies (cetuximab or panitumumab). Int J Cancer. 2016;139:2370–2380. doi:10.1002/ijc.v139.1027450994
  • Johnson DE, O’Keefe RA, Grandis JR. Targeting the IL-6/JAK/STAT3 signalling axis in cancer. NAt Rev Clin Oncol. 2018;15:234–248. doi:10.1038/nrclinonc.2018.829405201
  • Huynh J, Chand A, Gough D, Ernst M. Therapeutically exploiting STAT3 activity in cancer - using tissue repair as a road map. Nat Rev Cancer. 2019;19:82–96. doi:10.1038/s41568-018-0090-8.
  • Yang L, Lin S, Kang Y, et al. Rhein sensitizes human pancreatic cancer cells to EGFR inhibitors by inhibiting STAT3 pathway. J Exp Clin Cancer Res. 2019;38:31. doi:10.1186/s13046-018-1015-930674340
  • Zhao CG, Li HM, Lin HJ, Yang SL, Lin JY, Liang G. Feedback activation of STAT3 as a cancer drug-resistance mechanism. Trends Pharmacol Sci. 2016;37:47–61. doi:10.1016/j.tips.2015.10.00126576830
  • Shi LY, Zheng HL, Hu WL, et al. Niclosamide inhibition of STAT3 synergizes with erlotinib in human colon cancer. Oncotargets Ther. 2017;10:1767–1776. doi:10.2147/OTT.S129449
  • Zhao CG, Xiao H, Wu XJ, et al. Rational combination of MEK inhibitor and the STAT3 pathway modulator for the therapy in K-Ras mutated pancreatic and colon cancer cells. Oncotarget. 2015;6:14472–14487.25961376
  • Beebe JD, Liu JY, Zhang JT. Two decades of research in discovery of anticancer drugs targeting STAT3, how close are we? Pharmacol Ther. 2018;191:74–91. doi:10.1016/j.pharmthera.2018.06.00629933035
  • Zheng H, Yang L, Kang Y, et al. Alantolactone sensitizes human pancreatic cancer cells to EGFR inhibitors through the inhibition of STAT3 signaling. Mol Carcinog. 2019;58:565–576. doi:10.1002/mc.22951.
  • Yang LH, Li JF, Xu LY, et al. Rhein shows potent efficacy against non-small-cell lung cancer through inhibiting the STAT3 pathway. Cancer Manag Res. 2019;11:1167–1176. doi:10.2147/CMAR.S17151730774444
  • Zheng HL, Hong H, Zhang LL, et al. Nifuratel, a novel STAT3 inhibitor with potent activity against human gastric cancer cells. Cancer Manag Res. 2017;9:565–571. doi:10.2147/CMAR.S14617329138596
  • Wei J, Ma L, Lai YH, et al. Bazedoxifene as a novel GP130 inhibitor for Colon Cancer therapy. J Exp Clin Cancer Res. 2019;38:63. doi:10.1186/s13046-019-1072-830736824
  • Bai EC, Yang LH, Xiang YQ, et al. L61H46 shows potent efficacy against human pancreatic cancer through inhibiting STAT3 pathway. Cancer Manag Res. 2018;10:565–581. doi:10.2147/CMAR.S15909029606890
  • Bin Z, Hong Z, Zheng HL, et al. Pectolinarigenin suppresses pancreatic cancer cell growth by inhibiting STAT3 signaling. Nat Prod Commun. 2017;12:1861–1864.