Search in:

OncoTargets and Therapy Volume 13, 2020 - Issue

Submit an article Journal homepage

Open access

279

Views

CrossRef citations to date

Altmetric

Review

The Potential Role of N6-Methyladenosine (m6A) Demethylase Fat Mass and Obesity-Associated Gene (FTO) in Human Cancers

Jin-yan Wang1 Department of Obstetrics and Gynecology, Zhangjiagang First People’s Hospital, ZhangjiagangJiangsu215600, People’s Republic of China;2 Department of Oncology, The First Affiliated Hospital of Nanjing Medical University, Nanjing210029, People’s Republic of China

Li-juan Chen1 Department of Obstetrics and Gynecology, Zhangjiagang First People’s Hospital, ZhangjiagangJiangsu215600, People’s Republic of ChinaCorrespondence[email protected]

https://orcid.org/0000-0001-7331-4359

Ping Qiang3 Department of Gynecology, Zhangjiagang First People’s Hospital, Zhangjiagang Affiliated Hospital of Soochow University, Zhangjiagang, Jiangsu215600, People’s Republic of ChinaCorrespondence[email protected]

Pages 12845-12856 | Published online: 15 Dec 2020

Cite this article
CrossMark

Full Article
Figures & data
References
Citations
Metrics
Licensing
Reprints & Permissions
View PDF PDF

Citations (35)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Articles from other publishers (35)

Mehrdad Hashemi, Pouria Daneii, Mohammad Arad Zandieh, Rasoul Raesi, Neda Zahmatkesh, Mehrsa Bayat, Anwar Abuelrub, Zeinab Khazaei Koohpar, Amir Reza Aref, Ali Zarrabi, Mohsen Rashidi, Shokooh Salimimoghadam, Maliheh Entezari, Afshin Taheriazam & Ramin Khorrami. (2024) Non-coding RNA-Mediated N6-Methyladenosine (m6A) deposition: A pivotal regulator of cancer, impacting key signaling pathways in carcinogenesis and therapy response. Non-coding RNA Research 9:1, pages 84-104.
Crossref

Weiwei Xie, Yongqing Shao, Qingyun Bo, Zhen Li, Qihua Yu, Layi Wang & Guohai Wu. (2024) FTO promotes the progression of retinoblastoma through YTHDF2‐dependent N6‐methyladenosine modification in E2F3. Molecular Carcinogenesis.
Crossref

Xuming Zhou, Hezhen Zhu, Cong Luo, Zhaojie Yan, Guansong Zheng, Xiaofeng Zou, Junrong zou & Guoxi Zhang. (2023) The role of RNA modification in urological cancers: mechanisms and clinical potential. Discover Oncology 14:1.
Crossref

Yuran Chen, Wenjing Wang, Wuchao Zhang, Mei He, Yuming Li, Guosheng Qu & Jie Tong. (2023) Emerging roles of biological m6A proteins in regulating virus infection: A review. International Journal of Biological Macromolecules 253, pages 126934.
Crossref

Danyang Li, Chengqing Huang, Zhihua Liu, Shu Ai & Hui-Li Wang. (2023) Decreased expression of Chrna4 by METTL3-mediated m6A modification participates in BPA-induced spatial memory deficit. Environmental Research 236, pages 116717.
Crossref

Zeyu Han, Xianyanling Yi, Jin Li, Tianyi Zhang, Dazhou Liao, Jia You & Jianzhong Ai. (2023) RNA m6A modification in prostate cancer: A new weapon for its diagnosis and therapy. Biochimica et Biophysica Acta (BBA) - Reviews on Cancer 1878:5, pages 188961.
Crossref

Chao Li, Mengqi Zhu, Jiajia Wang, Hengshuang Wu, Yameng Liu & Di Huang. (2023) Role of m6A modification in immune microenvironment of digestive system tumors. Biomedicine & Pharmacotherapy 164, pages 114953.
Crossref

Baihetiya Azhati, Aerziguli Reheman, Diliyaer Dilixiati & Mulati Rexiati. (2023) FTO-stabilized miR-139–5p targets ZNF217 to suppress prostate cancer cell malignancies by inactivating the PI3K/Akt/mTOR signal pathway. Archives of Biochemistry and Biophysics 741, pages 109604.
Crossref

Matthew C. Pahl, Struan F. A. Grant, Rudolph L. Leibel & George Stratigopoulos. (2023) Technologies, strategies, and cautions when deconvoluting genome‐wide association signals: FTO in focus . Obesity Reviews 24:5.
Crossref

Yong Luo, Jin Chen, Ying Cui, Fang Fang, Ziyu Zhang, Lili Hu, Xiaoyong Chen, Zengming Li, Liping Li & Lina Chen. (2023) Transcriptome‐wide high‐throughput m 6 A sequencing of differential m 6 A methylation patterns in the decidual tissues from RSA patients . The FASEB Journal 37:3.
Crossref

Chatchaphan Udompatanakorn, Pichamon Sriviriyakul & Patrayu Taebunpakul. (2023) A study of RNA m6A demethylases in oral epithelial dysplasia and oral squamous cell carcinoma. Journal of Oral Biology and Craniofacial Research 13:2, pages 111-116.
Crossref

Bodo C. Melnik, Swen Malte John, Pedro Carrera-Bastos, Loren Cordain, Claus Leitzmann, Ralf Weiskirchen & Gerd Schmitz. (2023) The Role of Cow’s Milk Consumption in Breast Cancer Initiation and Progression. Current Nutrition Reports 12:1, pages 122-140.
Crossref

Linzhu Zhang, Yaguang Zhang, Su Zhang, Lei Qiu, Yang Zhang, Ying Zhou, Junhong Han & Jiang Xie. (2022) Translational Regulation by eIFs and RNA Modifications in Cancer. Genes 13:11, pages 2050.
Crossref

Sepideh Abdollahi, Naeemeh Hasanpour Ardekanizadeh, Seyed Mohammad Poorhosseini, Maryam Gholamalizadeh, Zahra Roumi, Mark O Goodarzi & Saeid Doaei. (2022) Unraveling the Complex Interactions between the Fat Mass and Obesity-Associated (FTO) Gene, Lifestyle, and Cancer. Advances in Nutrition 13:6, pages 2406-2419.
Crossref

Anke Hinney, Antje Körner & Pamela Fischer-Posovszky. (2022) The promise of new anti-obesity therapies arising from knowledge of genetic obesity traits. Nature Reviews Endocrinology 18:10, pages 623-637.
Crossref

Yiming Ma, Jun Yang, Tiantai Ji & Fengyun Wen. (2022) Identification of a novel m5C/m6A-related gene signature for predicting prognosis and immunotherapy efficacy in lung adenocarcinoma. Frontiers in Genetics 13.
Crossref

Lemei Zheng, Mengna Li, Jianxia Wei, Shipeng Chen, Changning Xue, Yuting Zhan, Yumei Duan, Hongyu Deng, Wei Xiong, Guiyuan Li & Ming Zhou. (2022) The emerging roles of the interaction between m6A modification and c‐Myc in driving tumorigenesis and development. Journal of Cellular Physiology 237:7, pages 2758-2769.
Crossref

Na Song, Kai Cui, Ke Zhang, Jie Yang, Jia Liu, Zhuang Miao, Feiyue Zhao, Hongjing Meng, Lu Chen, Chong Chen, Yushan Li, Minglong Shao, Jinghang Zhang & Haijun Wang. (2022) The Role of m6A RNA Methylation in Cancer: Implication for Nature Products Anti-Cancer Research. Frontiers in Pharmacology 13.
Crossref

Chen Xue, Qingfei Chu, Qiuxian Zheng, Shiman Jiang, Zhengyi Bao, Yuanshuai Su, Juan Lu & Lanjuan Li. (2022) Role of main RNA modifications in cancer: N6-methyladenosine, 5-methylcytosine, and pseudouridine. Signal Transduction and Targeted Therapy 7:1.
Crossref

Jiazhu Sun, Xueyou Ma, Yufan Ying, Weiyu Wang, Haixiang Shen, Song Wang, Haiyun Xie, Jiahe Yi, Weitao Zhan, Jiangfeng Li & Ben Liu. (2022) SMAD3 and FTO are involved in miR-5581-3p-mediated inhibition of cell migration and proliferation in bladder cancer. Cell Death Discovery 8:1.
Crossref

Zhaolin Chen, Ying Hu, Le Jin, Fan Yang, Haiwen Ding, Lei Zhang, Lili Li & Tingting Pan. (2022) The Emerging Role of N6-Methyladenosine RNA Methylation as Regulators in Cancer Therapy and Drug Resistance. Frontiers in Pharmacology 13.
Crossref

Yunlong Dang, Qiao Dong, Bowei Wu, Shuhua Yang, Jiaming Sun, Gengyuan Cui, Weixiang Xu, Meiling Zhao, Yunxuan Zhang, Peng Li & Lin Li. (2022) Global Landscape of m6A Methylation of Differently Expressed Genes in Muscle Tissue of Liaoyu White Cattle and Simmental Cattle. Frontiers in Cell and Developmental Biology 10.
Crossref

Yan-Bing Huo, Xiang Gao, Qi Peng, Qiang Nie & Wei Bi. (2022) Dihydroartemisinin alleviates AngII-induced vascular smooth muscle cell proliferation and inflammatory response by blocking the FTO/NR4A3 axis. Inflammation Research 71:2, pages 243-253.
Crossref

Li Liu, Hui Li, Dingyu Hu, Yanyan Wang, Wenjun Shao, Jing Zhong, Shudong Yang, Jing Liu & Ji Zhang. (2022) Insights into N6-methyladenosine and programmed cell death in cancer. Molecular Cancer 21:1.
Crossref

Xue-Ming Fu, Wen-Jie Wang & Zi-Fang Song. (2021) Role of RNA modification in gastrointestinal tumors. World Chinese Journal of Digestology 29:20, pages 1179-1185.
Crossref

Lin-Lin Zhou, Hongjiao Xu, Yue Huang & Cai-Guang Yang. (2021) Targeting the RNA demethylase FTO for cancer therapy. RSC Chemical Biology 2:5, pages 1352-1369.
Crossref

Maryam Gholamalizadeh, Zohreh Mokhtari, Saeid Doaei, Vahideh Jalili, Sayed Hossein Davoodi, Mona Jonoush, Mohammad Esmail Akbari, Azadeh Hajipour, Bojlul Bahar, Ghasem Azizi Tabesh, Saeed Omidi & Seyed Alireza Mosavi Jarrahi. (2021) The association between fat mass and obesity‐associated ( FTO ) genotype and serum vitamin D level in breast cancer patients . Journal of Cellular and Molecular Medicine 25:20, pages 9627-9633.
Crossref

Dongqin Wei, Qian Sun, Yizhou Li, Chaowei Li, Xinjian Li & Chao Sun. (2021) Leptin Reduces Plin5 m6A Methylation through FTO to Regulate Lipolysis in Piglets. International Journal of Molecular Sciences 22:19, pages 10610.
Crossref

Lei Zhan, Junhui Zhang, Suding Zhu, Xiaojing Liu, Jing Zhang, Wenyan Wang, Yijun Fan, Shiying Sun, Bing Wei & Yunxia Cao. (2021) N6-Methyladenosine RNA Modification: An Emerging Immunotherapeutic Approach to Turning Up Cold Tumors. Frontiers in Cell and Developmental Biology 9.
Crossref

Shenghua Dong, Yutong Wu, Yadi Liu, Hengyou Weng & Huilin Huang. (2021) N 6 ‐methyladenosine Steers RNA Metabolism and Regulation in Cancer . Cancer Communications 41:7, pages 538-559.
Crossref

Sunil Kumar, Ravinder Nagpal, Amit Kumar, Muhammad Umer Ashraf & Yong-Soo Bae. (2021) Immunotherapeutic Potential of m6A-Modifiers and MicroRNAs in Controlling Acute Myeloid Leukaemia. Biomedicines 9:6, pages 690.
Crossref

Wen-min Zhou, Bin Liu, Amin Shavandi, Lu Li, Hang Song & Jian-ye Zhang. (2021) Methylation Landscape: Targeting Writer or Eraser to Discover Anti-Cancer Drug. Frontiers in Pharmacology 12.
Crossref

Bodo C. Melnik. (2021) Lifetime Impact of Cow’s Milk on Overactivation of mTORC1: From Fetal to Childhood Overgrowth, Acne, Diabetes, Cancers, and Neurodegeneration. Biomolecules 11:3, pages 404.
Crossref

Anna Wardowska. (2021) m6A RNA Methylation in Systemic Autoimmune Diseases—A New Target for Epigenetic-Based Therapy?. Pharmaceuticals 14:3, pages 218.
Crossref

Manon Duforestel, Florestan Courant, Louis Paré, Aurélien A. Sérandour & Pierre-François Cartron. 2021. Epitranscriptomics. Epitranscriptomics 527 553 .

Share icon
Back to Top

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.

People also read
Recommended articles
Cited by

To cite this article:

Reference style: APA Chicago Harvard

Citation copied to clipboard

Reference styles above use APA (6th edition), Chicago (16th edition) & Harvard (10th edition)

Download citation

Download a citation file in RIS format that can be imported by citation management software including EndNote, ProCite, RefWorks and Reference Manager.

Choose format: RIS BibTex RefWorks Direct Export

Choose options: Citation Citation & abstract Citation & references

The Potential Role of N6-Methyladenosine (m6A) Demethylase Fat Mass and Obesity-Associated Gene (FTO) in Human Cancers

Articles from other publishers (35)

Information for

Open access

Opportunities

Help and information

Your download is now in progress and you may close this window

Login or register to access this feature

The Potential Role of N6-Methyladenosine (m6A) Demethylase Fat Mass and Obesity-Associated Gene (FTO) in Human Cancers

Citations (35)

Articles from other publishers (35)

Related research

To cite this article:

Download citation

Information for

Open access

Opportunities

Help and information

Keep up to date