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Original Research

Pomalidomide: a novel drug to treat relapsed and refractory multiple myeloma

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Pages 531-538 | Published online: 10 May 2013

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Rafael Ríos-Tamayo, Agustín Martín-García, Carolina Alarcón-Payer, Dolores Sánchez-Rodríguez, Ana María del Valle Díaz de la Guardia, Carlos Gustavo García Collado, Alberto Jiménez Morales, Manuel Jurado Chacón & José Cabeza Barrera. (2017) Pomalidomide in the treatment of multiple myeloma: design, development and place in therapy. Drug Design, Development and Therapy 11, pages 2399-2408.
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Anna Guidetti, Claudia Paba Prada, Jacob P Laubach, Cindy Varga, Michelle E Maglio, Mary McKenney, Deborah Doss, Robert L Schlossman, Constantine Mitsiades, Teru Hideshima, Güllü T Görgün, Irene M Ghobrial, Noopur Raje, Nikhil Munshi, Kenneth C Anderson & Paul G Richardson. (2014) Pomalidomide for the treatment of relapsed and refractory multiple myeloma. Expert Opinion on Orphan Drugs 2:10, pages 1089-1108.
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Articles from other publishers (24)

Abdallah E. Abdallah, Ibrahim H. Eissa, Ahmed B.M. Mehany, Helmy Sakr, Ahmed Atwa, Khaled El-Adl & Mohamed Ayman El-Zahabi. (2023) Immunomodulatory quinazoline-based thalidomide analogs: Design, synthesis, apoptosis and anticancer evaluations. Journal of Molecular Structure 1281, pages 135164.
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Anas Ramadan Kotb, Abdallah E. Abdallah, Hazem Elkady, Ibrahim H. Eissa, Mohammed S. Taghour, Dina Abed Bakhotmah, Tamer M. Abdelghany & Mohamed Ayman El-Zahabi. (2023) Design, synthesis, anticancer evaluation, and in silico ADMET analysis of novel thalidomide analogs as promising immunomodulatory agents . RSC Advances 13:16, pages 10488-10502.
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Surya K. De. 2023. Medicines for Cancer. Medicines for Cancer 205 411 .
Maria Cristina Cardia, Maria Francesca Palmas, Luca Casula, Augusta Pisanu, Salvatore Marceddu, Donatella Valenti, Chiara Sinico, Elena Pini, Michael T. Scerba, David Tweedie, Nigel H. Greig, Anna Rosa Carta & Francesco Lai. (2022) Nanocrystals as an effective strategy to improve Pomalidomide bioavailability in rodent. International Journal of Pharmaceutics 625, pages 122079.
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Burak Kuzu, Ceylan Hepokur, Mehmet Abdullah Alagoz, Serdar Burmaoglu & Oztekin Algul. (2022) Synthesis, Biological Evaluation and In Silico Studies of Some 2‐Substituted Benzoxazole Derivatives as Potential Anticancer Agents to Breast Cancer . ChemistrySelect 7:1.
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Maria Francesca Palmas, Anna Ena, Chiara Burgaletto, Maria Antonietta Casu, Giuseppina Cantarella, Ezio Carboni, Michela Etzi, Alfonso De Simone, Giuliana Fusco, Maria Cristina Cardia, Francesco Lai, Luca Picci, David Tweedie, Michael T. Scerba, Valentina Coroneo, Renato Bernardini, Nigel H. Greig, Augusta Pisanu & Anna R. Carta. (2022) Repurposing Pomalidomide as a Neuroprotective Drug: Efficacy in an Alpha-Synuclein-Based Model of Parkinson’s Disease. Neurotherapeutics 19:1, pages 305-324.
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Pen-Sen Huang, Ping-Yen Tsai, Ling-Yu Yang, Daniela Lecca, Weiming Luo, Dong Seok Kim, Barry J. Hoffer, Yung-Hsiao Chiang, Nigel H. Greig & Jia-Yi Wang. (2021) 3,6′-Dithiopomalidomide Ameliorates Hippocampal Neurodegeneration, Microgliosis and Astrogliosis and Improves Cognitive Behaviors in Rats with a Moderate Traumatic Brain Injury. International Journal of Molecular Sciences 22:15, pages 8276.
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Evangelos Terpos, Panagiotis Repousis, Chrysavgi Lalayanni, Evdoxia Hatjiharissi, Theodora Assimakopoulou, Georgios Vassilopoulos, Anastasia Pouli, Emmanouil Spanoudakis, Eurydiki Michalis, Gerassimos Pangalis, Ioannis Ntanasis-Stathopoulos, Christos Poziopoulos, Marie-Christine Kyrtsonis, Vasiliki Pappa, Argiris Symeonidis, Christos Georgopoulos, Panagiotis M. Zikos, Maria Gavriatopoulou, Helen A. Papadaki, Magdalini Dadakaridou, Kiki Karvounis-Marolachakis & Eirini Katodritou. (2021) Pomalidomide Plus Low-Dose Dexamethasone in Relapsed/Refractory Multiple Myeloma Patients: Results of the Real-World “POWERFUL” Study. Journal of Clinical Medicine 10:7, pages 1509.
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Mohamed Ayman El-Zahabi, Helmy Sakr, Khaled. El-Adl, Mohamed Zayed, Adel S. Abdelraheem, Sally I. Eissa, Hazem Elkady & Ibrahim H. Eissa. (2020) Design, synthesis, and biological evaluation of new challenging thalidomide analogs as potential anticancer immunomodulatory agents. Bioorganic Chemistry 104, pages 104218.
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Bo Li, Qiao Zhou, Chaofan Sun, Bifa Cao, You Li, Jianhui Han, Hang Yin & Ying Shi. (2020) Revised excited-state intramolecular proton transfer of the 3-Aminophthalimide molecule: A TDDFT study. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy 239, pages 118386.
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Chih-Tung Lin, Daniela Lecca, Ling-Yu Yang, Weiming Luo, Michael T Scerba, David Tweedie, Pen-Sen Huang, Yoo-Jin Jung, Dong Seok Kim, Chih-Hao Yang, Barry J Hoffer, Jia-Yi Wang & Nigel H Greig. (2020) 3,6’-dithiopomalidomide reduces neural loss, inflammation, behavioral deficits in brain injury and microglial activation. eLife 9.
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Maria Antonietta Casu, Ignazia Mocci, Raffaella Isola, Augusta Pisanu, Laura Boi, Giovanna Mulas, Nigel H. Greig, Maria Dolores Setzu & Anna R. Carta. (2020) Neuroprotection by the Immunomodulatory Drug Pomalidomide in the Drosophila LRRK2WD40 Genetic Model of Parkinson’s Disease. Frontiers in Aging Neuroscience 12.
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Stanislav Semenovich Bessmeltsev, E.V. Karyagina, E.Yu. Ilyushkina, Zh.L. Stolypina, R.R. Miftakhova, I.I. Kostroma & T.L. Shelkovskaya. (2020) Clinical Efficacy of Daratumumab in Monotherapy of Relapsed/Refractory Multiple Myeloma. Clinical oncohematology 13:1, pages 25-32.
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Yan-Rou Tsai, David Tweedie, Ignacio Navas-Enamorado, Michael T. Scerba, Cheng-Fu Chang, Jing-Huei Lai, John Chung-Che Wu, Yen-Hua Chen, Shuo-Jhen Kang, Barry J. Hoffer, Rafael de Cabo, Nigel H. Greig, Yung-Hsiao Chiang & Kai-Yun Chen. (2019) Pomalidomide Reduces Ischemic Brain Injury in Rodents. Cell Transplantation 28:4, pages 439-450.
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Yan-Rou Tsai, Cheng-Fu Chang, Jing-Huei Lai, John Wu, Yen-Hua Chen, Shuo-Jhen Kang, Barry Hoffer, David Tweedie, Weiming Luo, Nigel Greig, Yung-Hsiao Chiang & Kai-Yun Chen. (2018) Pomalidomide Ameliorates H2O2-Induced Oxidative Stress Injury and Cell Death in Rat Primary Cortical Neuronal Cultures by Inducing Anti-Oxidative and Anti-Apoptosis Effects. International Journal of Molecular Sciences 19:10, pages 3252.
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Bo Chen, Jing Huang, Huiqing Geng, Lingli Xuan, Tengfei Xu, Xin Li & Yifeng Han. (2017) A new ESIPT-based fluorescent probe for highly selective and sensitive detection of hydrogen sulfide and its application in live-cell imaging. New Journal of Chemistry 41:3, pages 1119-1123.
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Maiko Matsushita, Yoshie Ozaki, Yuka Hasegawa, Fukiko Terada, Noriko Tabata, Hirokazu Shiheido, Hiroshi Yanagawa, Tsukasa Oikawa, Koichi Matsuo, Wenlin Du, Taketo Yamada, Masashi Hozumi, Daiju Ichikawa & Yutaka Hattori. (2015) A Novel Phthalimide Derivative, TC11, Has Preclinical Effects on High-Risk Myeloma Cells and Osteoclasts. PLOS ONE 10:1, pages e0116135.
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Yinan Li, Sengwang Fu, Haiying Chen, Qian Feng, Yunjie Gao, Hanbing Xue, Zhizheng Ge, Jingyuan Fang & Shudong Xiao. (2014) Inhibition of Endothelial Slit2/Robo1 Signaling by Thalidomide Restrains Angiogenesis by Blocking the PI3K/Akt Pathway. Digestive Diseases and Sciences 59:12, pages 2958-2966.
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Sonja Genadieva-Stavric, Federica Cavallo & Antonio Palumbo. (2014) New Approaches to Management of Multiple Myeloma. Current Treatment Options in Oncology 15:2, pages 157-170.
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Nuozhou Wang, Patrick Bartlow, Qin Ouyang & Xiang-Qun Xie. (2014) Recent advances in antimultiple myeloma drug development. Pharmaceutical Patent Analyst 3:3, pages 261-277.
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Goutam Chowdhury, Norio Shibata, Hiroshi Yamazaki & F. Peter Guengerich. (2013) Human Cytochrome P450 Oxidation of 5-Hydroxythalidomide and Pomalidomide, an Amino Analogue of Thalidomide. Chemical Research in Toxicology 27:1, pages 147-156.
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Gang LuRichard E. MiddletonHuahang SunMarkVic NaniongChristopher J. OttConstantine S. MitsiadesKwok-Kin WongJames E. BradnerWilliam G. KaelinJr.Jr.. (2014) The Myeloma Drug Lenalidomide Promotes the Cereblon-Dependent Destruction of Ikaros Proteins. Science 343:6168, pages 305-309.
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Charles L. Sawyers, Cory Abate-Shen, Kenneth C. Anderson, Anna Barker, Jose Baselga, Nathan A. Berger, Margaret Foti, Ahmedin Jemal, Theodore S. Lawrence, Christopher I. Li, Elaine R. Mardis, Peter J. Neumann, Drew M. Pardoll, George C. Prendergast, John C. Reed & George J. Weiner. (2013) AACR Cancer Progress Report 2013. Clinical Cancer Research 19:20_Supplement, pages S1-S98.
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