Advanced search
Publication Cover
OncoTargets and Therapy Volume 6, 2013 - Issue
Submit an article Journal homepage
194
Views
39
CrossRef citations to date
0
Altmetric
Review

Notch signaling: targeting cancer stem cells and epithelial-to-mesenchymal transition

Ingrid Espinoza1 Cancer Institute, University of Mississippi Medical Center, Jackson, MS, USA;2 Department of Biochemistry, University of Mississippi Medical Center, Jackson, MS, USA
,
Radhika Pochampally1 Cancer Institute, University of Mississippi Medical Center, Jackson, MS, USA;2 Department of Biochemistry, University of Mississippi Medical Center, Jackson, MS, USA
,
Fei Xing1 Cancer Institute, University of Mississippi Medical Center, Jackson, MS, USA
,
Kounosuke Watabe1 Cancer Institute, University of Mississippi Medical Center, Jackson, MS, USA;3 Department of Microbiology, University of Mississippi Medical Center, Jackson, MS, USA
&
Lucio Miele1 Cancer Institute, University of Mississippi Medical Center, Jackson, MS, USA;4 Department of Pharmacology and Toxicology, University of Mississippi Medical Center, Jackson, MS, USACorrespondence[email protected]
Pages 1249-1259 | Published online: 06 Sep 2013

Citations (39)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (4)

Michela Colombo, Leonardo Mirandola, Adair Reidy, Natallia Suvorava, Venu Konala, Raffaella Chiaramonte, Fabio Grizzi, Rakhshanda Layeequr Rahman, Marjorie R. Jenkins, Diane D. Nugyen, Scott Dalhbeck, Everardo Cobos, Jose A. Figueroa & Maurizio Chiriva-Internati. (2015) Targeting Tumor Initiating Cells through Inhibition of Cancer Testis Antigens and Notch Signaling: A Hypothesis. International Reviews of Immunology 34:2, pages 188-199.
Read now
Tommaso Susini, Barbara Berti, Carlo Carriero, Ketty Tavella, Jacopo Nori, Ermanno Vanzi, Cecilia Molino, Mariarosaria Di Tommaso, Marco Santini, Valeria Saladino & Simonetta Bianchi. (2014) Topoisomerase II alpha and TLE3 as predictive markers of response to anthracycline and taxane-containing regimens for neoadjuvant chemotherapy in breast cancer. OncoTargets and Therapy 7, pages 2111-2120.
Read now
Alessandro Allegra, Andrea Alonci, Giuseppa Penna, Vanessa Innao, Demetrio Gerace, Francesco Rotondo & Caterina Musolino. (2014) The Cancer Stem Cell Hypothesis: A Guide to Potential Molecular Targets. Cancer Investigation 32:9, pages 470-495.
Read now
Kevin R Ginnebaugh, Aamir Ahmad & Fazlul H Sarkar. (2014) The therapeutic potential of targeting the epithelial–mesenchymal transition in cancer. Expert Opinion on Therapeutic Targets 18:7, pages 731-745.
Read now

Articles from other publishers (35)

Serena Di Vincenzo, Dennis K. Ninaber, Chiara Cipollina, Maria Ferraro, Pieter S. Hiemstra & Elisabetta Pace. (2022) Cigarette Smoke Impairs Airway Epithelial Wound Repair: Role of Modulation of Epithelial-Mesenchymal Transition Processes and Notch-1 Signaling. Antioxidants 11:10, pages 2018.
Crossref
Weiwei Wang, Tetsuya Okajima & Hideyuki Takeuchi. (2022) Significant Roles of Notch O-Glycosylation in Cancer. Molecules 27:6, pages 1783.
Crossref
Nataša Kenda Šuster. 2022. Stem Cells in Reproductive Tissues and Organs. Stem Cells in Reproductive Tissues and Organs 109 123 .
Yidong Ge, Jie Wang, Hui Zhang, Jinyun Li, Meng Ye & Xiaofeng Jin. (2021) Fate of hematopoietic stem cells determined by Notch1 signaling (Review). Experimental and Therapeutic Medicine 23:2.
Crossref
Kathleen ZohorskyKibret Mequanint. (2021) Designing Biomaterials to Modulate Notch Signaling in Tissue Engineering and Regenerative Medicine. Tissue Engineering Part B: Reviews 27:5, pages 383-410.
Crossref
Thahomina Khan & Horacio Cabral. (2021) Abnormal Glycosylation of Cancer Stem Cells and Targeting Strategies. Frontiers in Oncology 11.
Crossref
Rashu Barua, Kazuyuki Mizuno, Yuko Tashima, Mitsutaka Ogawa, Hideyuki Takeuchi, Ayumu Taguchi & Tetsuya Okajima. (2021) Bioinformatics and Functional Analyses Implicate Potential Roles for EOGT and L-fringe in Pancreatic Cancers. Molecules 26:4, pages 882.
Crossref
Jörg Reichrath & Sandra Reichrath. 2021. Notch Signaling in Embryology and Cancer. Notch Signaling in Embryology and Cancer 123 154 .
McKenna BeLow & Clodia Osipo. (2020) Notch Signaling in Breast Cancer: A Role in Drug Resistance. Cells 9:10, pages 2204.
Crossref
Kevin Dzobo, Dimakatso Alice Senthebane, Chelene Ganz, Nicholas Ekow Thomford, Ambroise Wonkam & Collet Dandara. (2020) Advances in Therapeutic Targeting of Cancer Stem Cells within the Tumor Microenvironment: An Updated Review. Cells 9:8, pages 1896.
Crossref
Zhenzhen Liu, Yongchun Zhu, Fangfang Li & Yuge Xie. (2020) GATA1-regulated JAG1 promotes ovarian cancer progression by activating Notch signal pathway. Protoplasma 257:3, pages 901-910.
Crossref
Sitong Wang, Fanwu Wu, Bin Ye, Shiping Zhang, Xingjun Wang, Qian Xu, Guowang Li, Menglong Zhang, Shuai Wang, Yongsen Jia, Chunhua Jiang, Xiaojin La, Hong Chang, Zixue Zhao, Peng Li, Ji-an Li & Chenxi Wu. (2020) Effects of Xuefu Zhuyu Decoction on Cell Migration and Ocular Tumor Invasion in Drosophila . BioMed Research International 2020, pages 1-13.
Crossref
Ji-li Wang, Yan Wang & Guo-ping Ren. (2020) Identification of PTPRR and JAG1 as key genes in castration-resistant prostate cancer by integrated bioinformatics methods通过生物信息学方法鉴定PTPRR 和JAG1 为去 势抵抗性前列腺癌(CRPC)的关键基因. Journal of Zhejiang University-SCIENCE B 21:3, pages 246-255.
Crossref
Sara S. Oltra, Maria Peña-Chilet, Kirsty Flower, María Teresa Martinez, Elisa Alonso, Octavio Burgues, Ana Lluch, James M. Flanagan & Gloria Ribas. (2019) Acceleration in the DNA methylation age in breast cancer tumours from very young women. Scientific Reports 9:1.
Crossref
Valentin Platel, Sébastien Faure, Isabelle Corre & Nicolas Clere. (2019) Endothelial-to-Mesenchymal Transition (EndoMT): Roles in Tumorigenesis, Metastatic Extravasation and Therapy Resistance. Journal of Oncology 2019, pages 1-13.
Crossref
Liliana Mendonça, Alexandre Trindade, Catarina Carvalho, Jorge Correia, Marina Badenes, Joana Gigante & António Duarte. (2019) Metastasis is impaired by endothelial-specific Dll4 loss-of-function through inhibition of epithelial-to-mesenchymal transition and reduction of cancer stem cells and circulating tumor cells. Clinical & Experimental Metastasis 36:4, pages 365-380.
Crossref
Erik W. J. Mollen, Jonathan Ient, Vivianne C. G. Tjan-Heijnen, Liesbeth J. Boersma, Lucio Miele, Marjolein L. Smidt & Marc A. G. G. Vooijs. (2018) Moving Breast Cancer Therapy up a Notch. Frontiers in Oncology 8.
Crossref
Dominika Piasecka, Marcin Braun, Radzislaw Kordek, Rafal Sadej & Hanna Romanska. (2018) MicroRNAs in regulation of triple-negative breast cancer progression. Journal of Cancer Research and Clinical Oncology 144:8, pages 1401-1411.
Crossref
Yu Fan, Yu Hu, Cheng Yan, Radoslav Goldman, Yang Pan, Raja Mazumder & Hayley M. Dingerdissen. (2018) Loss and gain of N-linked glycosylation sequons due to single-nucleotide variation in cancer. Scientific Reports 8:1.
Crossref
Alice Faversani, Stefano Amatori, Claudia Augello, Federico Colombo, Laura Porretti, Mirco Fanelli, Stefano Ferrero, Alessandro Palleschi, Pier Giuseppe Pelicci, Elena Belloni, Giulia Ercoli, Anna Degrassi, Marco Baccarin, Dario C. Altieri, Valentina Vaira & Silvano Bosari. (2016) miR-494-3p is a novel tumor driver of lung carcinogenesis. Oncotarget 8:5, pages 7231-7247.
Crossref
Andrew J. Stacy, Michael P. Craig, Suraj Sakaram & Madhavi Kadakia. (2016) ΔNp63α and microRNAs: leveraging the epithelial-mesenchymal transition. Oncotarget 8:2, pages 2114-2129.
Crossref
Rajesh Kumar, Lucienne Juillerat-Jeanneret & Dela Golshayan. (2016) Notch Antagonists: Potential Modulators of Cancer and Inflammatory Diseases. Journal of Medicinal Chemistry 59:17, pages 7719-7737.
Crossref
Lakmali Atapattu, Nayanendu Saha, Chanly Chheang, Moritz F. Eissman, Kai Xu, Mary E. Vail, Linda Hii, Carmen Llerena, Zhanqi Liu, Katja Horvay, Helen E. Abud, Ulrike Kusebauch, Robert L. Moritz, Bi-Sen Ding, Zhongwei Cao, Shahin Rafii, Matthias Ernst, Andrew M. Scott, Dimitar B. Nikolov, Martin Lackmann & Peter W. Janes. (2016) An activated form of ADAM10 is tumor selective and regulates cancer stem-like cells and tumor growth. Journal of Experimental Medicine 213:9, pages 1741-1757.
Crossref
Ling Yu, Zhengfu Fan, Shuo Fang, Jian Yang, Tian Gao, Bruno M. Simões, Rachel Eyre, Weichun Guo & Robert B. Clarke. (2016) Cisplatin selects for stem-like cells in osteosarcoma by activating Notch signaling. Oncotarget 7:22, pages 33055-33068.
Crossref
Wei Huang, Emily E. Martin, Boris Burman, Maria E. Gonzalez & Celina G. Kleer. (2016) The matricellular protein CCN6 (WISP3) decreases Notch1 and suppresses breast cancer initiating cells. Oncotarget 7:18, pages 25180-25193.
Crossref
Judy S. Crabtree, Ciera S. Singleton & Lucio Miele. (2016) Notch Signaling in Neuroendocrine Tumors. Frontiers in Oncology 6.
Crossref
George D. Wilson, Bryan J. Thibodeau, Laura E. Fortier, Barbara L. Pruetz, Sandra Galoforo, Brian Marples, Andrew M. Baschnagel, Jan Akervall & Jiayi Huang. (2016) Cancer Stem Cell Signaling during Repopulation in Head and Neck Cancer. Stem Cells International 2016, pages 1-10.
Crossref
Federica Verginelli, Laura Adesso, Isabelle Limon, Anna Alisi, Marie Gueguen, Nadia Panera, Ezio Giorda, Lavinia Raimondi, Roberta Ciarapica, Antonio F. Campese, Isabella Screpanti, Stefano Stifani, Jan Kitajewski, Lucio Miele, Rossella Rota & Franco Locatelli. (2015) Activation of an endothelial Notch1-Jagged1 circuit induces VCAM1 expression, an effect amplified by interleukin-1β. Oncotarget 6:41, pages 43216-43229.
Crossref
Monica Faronato, Van T.M. Nguyen, Darren K. Patten, Ylenia Lombardo, Jennifer H. Steel, Naina Patel, Laura Woodley, Sami Shousha, Giancarlo Pruneri, R. Charles Coombes & Luca Magnani. (2015) DMXL2 drives epithelial to mesenchymal transition in hormonal therapy resistant breast cancer through notch hyper-activation. Oncotarget 6:26, pages 22467-22479.
Crossref
Silvia Esposito, Marco V. Russo, Irma Airoldi, Maria Grazia Tupone, Carlo Sorrentino, Giulia Barbarito, Serena Di Meo & Emma Di Carlo. (2015) SNAI2/Slug gene is silenced in prostate cancer and regulates neuroendocrine differentiation, metastasis-suppressor and pluripotency gene expression . Oncotarget 6:19, pages 17121-17134.
Crossref
Kah Jing Lim, William D. Brandt, Jason A. Heth, Karin M. Muraszko, Xing Fan, Eli E. Bar & Charles G. Eberhart. (2014) Lateral inhibition of Notch signaling in neoplastic cells. Oncotarget 6:3, pages 1666-1677.
Crossref
Bing Han. (2015) Notch1 downregulation combined with interleukin-24 inhibits invasion and migration of hepatocellular carcinoma cells. World Journal of Gastroenterology 21:33, pages 9727.
Crossref
Lixia Guo, Ting Zhang, Ying Xiong & Yanan Yang. (2015) Roles of NOTCH1 as a Therapeutic Target and a Biomarker for Lung Cancer: Controversies and Perspectives. Disease Markers 2015, pages 1-8.
Crossref
Riccardo Schweizer, Wakako Tsuji, Vijay S. Gorantla, Kacey G. Marra, J. Peter Rubin & Jan A. Plock. (2015) The Role of Adipose-Derived Stem Cells in Breast Cancer Progression and Metastasis. Stem Cells International 2015, pages 1-17.
Crossref
Maria Dominguez. (2014) Oncogenic programmes and Notch activity: An ‘organized crime’?. Seminars in Cell & Developmental Biology 28, pages 78-85.
Crossref

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.