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OncoTargets and Therapy Volume 6, 2013 - Issue
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Original Research

Arsenic trioxide inhibits viability of pancreatic cancer stem cells in culture and in a xenograft model via binding to SHH-Gli

Jin-bin Han1 Department of integrative Oncology, Fudan University Shanghai Cancer Center, Shanghai, People’s Republic of China;2 Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, People’s Republic of China
,
Feng Sang3 The Center for AIDS Research of the First Affiliated Hospital of Henan University of TCM, Zhengzhou, People’s Republic of China
,
Jin-jia Chang1 Department of integrative Oncology, Fudan University Shanghai Cancer Center, Shanghai, People’s Republic of China;4 Department of Medical Oncology, Fudan University Shanghai Cancer Center, Shanghai, People’s Republic of China
,
Yong-qiang Hua1 Department of integrative Oncology, Fudan University Shanghai Cancer Center, Shanghai, People’s Republic of China;2 Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, People’s Republic of China
,
Wei-dong Shi1 Department of integrative Oncology, Fudan University Shanghai Cancer Center, Shanghai, People’s Republic of China;2 Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, People’s Republic of China
,
Li-hua Tang1 Department of integrative Oncology, Fudan University Shanghai Cancer Center, Shanghai, People’s Republic of China;2 Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, People’s Republic of China
&
Lu-ming Liu1 Department of integrative Oncology, Fudan University Shanghai Cancer Center, Shanghai, People’s Republic of China;2 Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, People’s Republic of ChinaCorrespondence[email protected]
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Pages 1129-1138 | Published online: 19 Aug 2013

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Simin Yu, Ning Wu, Jianmin Zhu, Ying Liu & Jinbin Han. (2020) Pyrrolidine Dithiocarbamate Facilitates Arsenic Trioxide Against Pancreatic Cancer via Perturbing Ubiquitin-Proteasome Pathway. Cancer Management and Research 12, pages 13149-13159.
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Gregory N. Gan & Antonio Jimeno. (2016) Emerging from their burrow: Hedgehog pathway inhibitors for cancer. Expert Opinion on Investigational Drugs 25:10, pages 1153-1166.
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Wang Manni & Wu Min. (2022) Signaling pathways in the regulation of cancer stem cells and associated targeted therapy. MedComm 3:4.
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Kalyani Patil, Farheen B. Khan, Sabah Akhtar, Aamir Ahmad & Shahab Uddin. (2021) The plasticity of pancreatic cancer stem cells: implications in therapeutic resistance. Cancer and Metastasis Reviews 40:3, pages 691-720.
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Renyan Tang, Jianmin Zhu, Ying Liu, Ning Wu & Jinbin Han. (2021) Formulation Comprising Arsenic Trioxide and Dimercaprol Enhances Radiosensitivity of Pancreatic Cancer Xenografts. Technology in Cancer Research & Treatment 20, pages 153303382110363.
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Asunción Espinosa-Sánchez, Elisa Suárez-Martínez, Laura Sánchez-Díaz & Amancio Carnero. (2020) Therapeutic Targeting of Signaling Pathways Related to Cancer Stemness. Frontiers in Oncology 10.
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Qian Qian Wang, Yu Jiang & Hua Naranmandura. (2020) Therapeutic strategy of arsenic trioxide in the fight against cancers and other diseases. Metallomics 12:3, pages 326-336.
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Giuseppina D’Alessandro, Deborah Quaglio, Lucia Monaco, Clotilde Lauro, Francesca Ghirga, Cinzia Ingallina, Michela De Martino, Sergio Fucile, Alessandra Porzia, Maria Amalia Di Castro, Federica Bellato, Francesca Mastrotto, Mattia Mori, Paola Infante, Paola Turano, Stefano Salmaso, Paolo Caliceti, Lucia Di Marcotullio, Bruno Botta, Veronica Ghini & Cristina Limatola. (2019) 1H-NMR metabolomics reveals the Glabrescione B exacerbation of glycolytic metabolism beside the cell growth inhibitory effect in glioma. Cell Communication and Signaling 17:1.
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Cong‑Ya Zhou, Liu‑Yun Gong, Rong Liao, Ning‑Na Weng, Yao‑Yue Feng, Yi‑Ping Dong, Hong Zhu, Ya‑Qin Zhao, Yuan‑Yuan Zhang, Qing Zhu & Su‑Xia Han. (2019) Evaluation of the target genes of arsenic trioxide in pancreatic cancer by bioinformatics analysis. Oncology Letters.
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Hai-Yang Wang, Biao Zhang, Jun-Nian Zhou, Dong-Xing Wang, Ying-Chen Xu, Quan Zeng, Ya-Li Jia, Jia-Fei Xi, Xue Nan, Li-Juan He, Wen Yue & Xue-Tao Pei. (2019) Arsenic trioxide inhibits liver cancer stem cells and metastasis by targeting SRF/MCM7 complex. Cell Death & Disease 10:6.
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Jiankun Gao, Gu Wang, Jingrong Wu, Yu Zuo, Jing Zhang & Xintian Jin. (2019) Skp2 Expression Is Inhibited by Arsenic Trioxide through the Upregulation of miRNA-330-5p in Pancreatic Cancer Cells. Molecular Therapy - Oncolytics 12, pages 214-223.
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Richard L. Carpenter & Haimanti Ray. (2019) Safety and Tolerability of Sonic Hedgehog Pathway Inhibitors in Cancer. Drug Safety 42:2, pages 263-279.
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Aryung NAM, Taewon KIM, Qiang LI, Robert B. REBHUNHwa-Young YOUN & Kyoung-Won SEO. (2019) Melarsomine suppresses canine osteosarcoma cell survival via inhibition of Hedgehog-GLI signaling. Journal of Veterinary Medical Science 81:12, pages 1722-1729.
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Tadas Rimkus, Richard Carpenter, Shadi Qasem, Michael Chan & Hui-Wen Lo. (2016) Targeting the Sonic Hedgehog Signaling Pathway: Review of Smoothened and GLI Inhibitors. Cancers 8:2, pages 22.
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Bin Li, Camilla Giambelli, Bo Tang, Emily Winterbottom, Jun Long, Ke Jin, Zhiqiang Wang, Dennis Liang Fei, Dao M. Nguyen, Mohammad Athar, Baolin Wang, Pochi R. Subbarayan, Lily Wang, Priyamvada Rai, Bach Ardalan, Anthony J. Capobianco & David J. Robbins. (2016) Arsenic Attenuates GLI Signaling, Increasing or Decreasing its Transcriptional Program in a Context-Dependent Manner. Molecular Pharmacology 89:2, pages 226-232.
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