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OncoTargets and Therapy Volume 8, 2015 - Issue
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Original Research

Echinacoside induces apoptotic cancer cell death by inhibiting the nucleotide pool sanitizing enzyme MTH1

Liwei Dong1 Key Laboratory for Molecular Enzymology and Engineering of the Ministry of Education, National Engineering Laboratory for AIDS Vaccine, School of Life Sciences, Jilin University, Changchun, Jilin Province, People’s Republic of China
,
Hongge Wang1 Key Laboratory for Molecular Enzymology and Engineering of the Ministry of Education, National Engineering Laboratory for AIDS Vaccine, School of Life Sciences, Jilin University, Changchun, Jilin Province, People’s Republic of China
,
Jiajing Niu1 Key Laboratory for Molecular Enzymology and Engineering of the Ministry of Education, National Engineering Laboratory for AIDS Vaccine, School of Life Sciences, Jilin University, Changchun, Jilin Province, People’s Republic of China
,
Mingwei Zou2 Department of Psychology, College of Liberal Arts and Social Sciences, University of Houston, Houston, TX, USA
,
Nuoting Wu1 Key Laboratory for Molecular Enzymology and Engineering of the Ministry of Education, National Engineering Laboratory for AIDS Vaccine, School of Life Sciences, Jilin University, Changchun, Jilin Province, People’s Republic of China
,
Debin Yu1 Key Laboratory for Molecular Enzymology and Engineering of the Ministry of Education, National Engineering Laboratory for AIDS Vaccine, School of Life Sciences, Jilin University, Changchun, Jilin Province, People’s Republic of China
,
Ye Wang1 Key Laboratory for Molecular Enzymology and Engineering of the Ministry of Education, National Engineering Laboratory for AIDS Vaccine, School of Life Sciences, Jilin University, Changchun, Jilin Province, People’s Republic of China
&
Zhihua Zou1 Key Laboratory for Molecular Enzymology and Engineering of the Ministry of Education, National Engineering Laboratory for AIDS Vaccine, School of Life Sciences, Jilin University, Changchun, Jilin Province, People’s Republic of ChinaCorrespondence[email protected]
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Pages 3649-3664 | Published online: 08 Dec 2015

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Daniel Abraham Espinosa-Paredes, Jorge Cornejo-Garrido, Mario Adán Moreno-Eutimio, Oswaldo Pablo Martínez-Rodríguez, María Eugenia Jaramillo-Flores & Cynthia Ordaz-Pichardo. (2021) Echinacea Angustifolia DC Extract Induces Apoptosis and Cell Cycle Arrest and Synergizes with Paclitaxel in the MDA-MB-231 and MCF-7 Human Breast Cancer Cell Lines. Nutrition and Cancer 73:11-12, pages 2287-2305.
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Rayn Clarenc Aarland, Angel Ernesto Bañuelos-Hernández, Mabel Fragoso-Serrano, Edgar del Carmen Sierra-Palacios, Fernando Díaz de León-Sánchez, Laura Josefina Pérez-Flores, Fernando Rivera-Cabrera & José Alberto Mendoza-Espinoza. (2017) Studies on phytochemical, antioxidant, anti-inflammatory, hypoglycaemic and antiproliferative activities of Echinacea purpurea and Echinacea angustifolia extracts. Pharmaceutical Biology 55:1, pages 649-656.
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Articles from other publishers (8)

Ali Türeyen, Fahriye Zemheri Navruz, Sevilay Günay, Yavuz Erden & Sinan Ince. (2023) Tubuloside A Induces DNA Damage and Apoptosis in Human Ovarian Cancer A2780 Cells. European Journal of Therapeutics 29:4, pages 900-906.
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Yumei Sun, Chang Li, Zhongzhu Liu, Wei Zeng, Muhammad Jamil Ahmad, Mengjia Zhang, Lina Liu, Shujun Zhang, Wentao Li & Qigai He. (2023) Chinese herbal extracts with antiviral activity: evaluation, mechanisms, and potential for preventing PRV, PEDV and PRRSV infections. Animal Diseases 3:1.
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Mücahit SEÇME & Yavuz DODURGA. (2022) Ekinakozit PC3 androjen bağımsız prostat kanseri hücrelerinde hücre proliferasyonunu azaltır ve hücre invazyonunu inhibe eder. Pamukkale Medical Journal.
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Cristina Burlou-Nagy, Florin Bănică, Tünde Jurca, Laura Grațiela Vicaș, Eleonora Marian, Mariana Eugenia Muresan, Ildikó Bácskay, Rita Kiss, Pálma Fehér & Annamaria Pallag. (2022) Echinacea purpurea (L.) Moench: Biological and Pharmacological Properties. A Review. Plants 11:9, pages 1244.
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Cai-hua Xue, Shun-xian A, Meng-jie Wang, Qiang Wu, Jia-hua Liu, Long-fei Zhang, Yun Wu, Hua Wu & Sha-tuo Chai. (2021) Echinacea purpurea extract (cichoric acid) exerts an anti-inflammatory effect on yak PBMCs and regulates the TLR4 signalling pathway . Journal of Veterinary Research 65:1, pages 109-115.
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Axel Rudling, Robert Gustafsson, Ingrid Almlöf, Evert Homan, Martin Scobie, Ulrika Warpman Berglund, Thomas Helleday, Pål Stenmark & Jens Carlsson. (2017) Fragment-Based Discovery and Optimization of Enzyme Inhibitors by Docking of Commercial Chemical Space. Journal of Medicinal Chemistry 60:19, pages 8160-8169.
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Ningqun Wang, Shaozhen Ji, Hao Zhang, Shanshan Mei, Lumin Qiao & Xianglan Jin. (2017) Herba Cistanches: Anti-aging. Aging and disease 8:6, pages 740.
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Debin Ji, Andrew A. Beharry, James M. Ford & Eric T. Kool. (2016) A Chimeric ATP-Linked Nucleotide Enables Luminescence Signaling of Damage Surveillance by MTH1, a Cancer Target. Journal of the American Chemical Society 138:29, pages 9005-9008.
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