104
Views
10
CrossRef citations to date
0
Altmetric
Original Research

Echinacoside induces apoptotic cancer cell death by inhibiting the nucleotide pool sanitizing enzyme MTH1

, , , , , , & show all
Pages 3649-3664 | Published online: 08 Dec 2015

References

  • TopalMDBakerMSDNA precursor pool: a significant target for N-methyl-N-nitrosourea in C3H/10T1/2 clone 8 cellsProc Natl Acad Sci U S A1982797221122156954535
  • IchikawaJTsuchimotoDOkaSOxidation of mitochondrial deoxynucleotide pools by exposure to sodium nitroprusside induces cell deathDNA Repair (Amst)20087341843018155646
  • RaiPOnderTTYoungJJContinuous elimination of oxidized nucleotides is necessary to prevent rapid onset of cellular senescenceProc Natl Acad Sci U S A2009106116917419118192
  • KatafuchiANohmiTDNA polymerases involved in the incorporation of oxidized nucleotides into DNA: their efficiency and template base preferenceMutat Res20107031243120542140
  • FreudenthalBDBeardWAPereraLUncovering the polymerase-induced cytotoxicity of an oxidized nucleotideNature2015517753663563925409153
  • DizdarogluMOxidatively induced DNA damage and its repair in cancerMutat Res Rev Mutat Res201576321224525795122
  • NakabeppuYCellular levels of 8-oxoguanine in either DNA or the nucleotide pool play pivotal roles in carcinogenesis and survival of cancer cellsInt J Mol Sci2014157125431255725029543
  • van LoonBMarkkanenEHubscherUOxygen as a friend and enemy: how to combat the mutational potential of 8-oxo-guanineDNA Repair (Amst)20109660461620399712
  • PfeiferGPBesaratiniaAMutational spectra of human cancerHum Genet20091255–649350619308457
  • RussoMTBlasiMFChieraFThe oxidized deoxynucleoside triphosphate pool is a significant contributor to genetic instability in mismatch repair-deficient cellsMol Cell Biol200424146547414673178
  • KamiyaHMutagenicity of oxidized DNA precursors in living cells: roles of nucleotide pool sanitization and DNA repair enzymes, and translesion synthesis DNA polymerasesMutat Res20107031323620542139
  • NagyGNLevelesIVértessyBGPreventive DNA repair by sanitizing the cellular (deoxy)nucleoside triphosphate poolFEBS J2014281184207422325052017
  • McLennanAGThe Nudix hydrolase superfamilyCell Mol Life Sci200663212314316378245
  • FujikawaKKamiyaHYakushijiHNakabeppuYKasaiHHuman MTH1 protein hydrolyzes the oxidized ribonucleotide, 2-hydroxy-ATPNucleic Acids Res200129244945411139615
  • NakabeppuYOkaSShengZTsuchimotoDSakumiKProgrammed cell death triggered by nucleotide pool damage and its prevention by MutT homolog-1 (MTH1) with oxidized purine nucleoside triphosphataseMutat Res20107031515820542142
  • DizdarogluMOxidatively induced DNA damage: mechanisms, repair and diseaseCancer Lett20123271–2264722293091
  • BridgeGRashidSMartinSADNA mismatch repair and oxidative DNA damage: implications for cancer biology and treatmentCancers (Basel)2014631597161425099886
  • CaldecottKWSingle-strand break repair and genetic diseaseNat Rev Genet20089861963118626472
  • KlementKGoodarziAADNA double strand break responses and chromatin alterations within the aging cellExp Cell Res20143291425225218945
  • SchulzeAHarrisALHow cancer metabolism is tuned for proliferation and vulnerable to disruptionNature2012491742436437323151579
  • CairnsRAHarrisISMakTWRegulation of cancer cell metabolismNat Rev Cancer2011112859521258394
  • RaiPHuman Mut T homolog 1 (MTH1): a roadblock for the tumor-suppressive effects of oncogenic RAS-induced ROSSmall GTPases20123212012522790201
  • KennedyCHCuetoRBelinskySALechnerJFPryorWAOverexpression of hMTH1 mRNA: a molecular marker of oxidative stress in lung cancer cellsFEBS Lett199842917209657375
  • LidaTFurutaAKawashimaMNishidaJNakabeppuYIwakiTAccumulation of 8-oxo-2′-deoxyguanosine and increased expression of hMTH1 protein in brain tumorsNeuro Oncol20013738111296483
  • CoskunEJarugaPJemthASAddiction to MTH1 protein results in intense expression in human breast cancer tissue as measured by liquid chromatography-isotope-dilution tandem mass spectrometryDNA Repair (Amst)20153310111026202347
  • TudekBWinczuraAJanikJSiomekAFoksinskiMOlinskiRInvolvement of oxidatively damaged DNA and repair in cancer development and agingAm J Transl Res20102325428420589166
  • SpeinaEArczewskaKDGackowskiDContribution of hMTH1 to the maintenance of 8-oxoguanine levels in lung DNA of non-small-cell lung cancer patientsJ Natl Cancer Inst200597538439515741575
  • KennedyCHPassHIMitchellJBExpression of human MutT homologue (hMTH1) protein in primary non-small-cell lung carcinomas and histologically normal surrounding tissueFree Radic Biol Med200334111447145712757855
  • RaiPYoungJJBurtonDGGiribaldiMGOnderTTWeinbergRAEnhanced elimination of oxidized guanine nucleotides inhibits oncogenic RAS-induced DNA damage and premature senescenceOncogene201130121489149621076467
  • SakumiKTominagaYFuruichiMOgg1 knockout-associated lung tumorigenesis and its suppression by Mth1 gene disruptionCancer Res20036390290512615700
  • PatelABurtonDGHalvorsenKMutT homolog 1 (MTH1) maintains multiple KRAS-driven pro-malignant pathwaysOncogene201534202586259625023700
  • GadHKoolmeisterTJemthASMTH1 inhibition eradicates cancer by preventing sanitation of the dNTP poolNature2014508749521522124695224
  • HuberKVSalahERadicBStereospecific targeting of MTH1 by (S)-crizotinib as an anticancer strategyNature2014508749522222724695225
  • GiribaldiMGMunozAHalvorsenKPatelARaiPMTH1 expression is required for effective transformation by oncogenic HRASOncotarget2015613115191152925893378
  • BauerABronstrupMIndustrial natural product chemistry for drug discovery and developmentNat Prod Rep2014311356024142193
  • OrlikovaBLegrandNPanningJDicatoMDiederichMAnti-inflammatory and anticancer drugs from natureCancer Treat Res201415912314324114478
  • LiJWVederasJCDrug discovery and natural products: end of an era or an endless frontier?Science2009325593716116519589993
  • LiuEHQiLWWuQPengYBLiPAnticancer agents derived from natural productsMini Rev Med Chem20099131547155520205636
  • NobiliSLippiDWitortENatural compounds for cancer treatment and preventionPharmacol Res200959636537819429468
  • HsiaoWLLiuLThe role of traditional Chinese herbal medicines in cancer therapy – from TCM theory to mechanistic insightsPlanta Med201076111118113120635308
  • BaykovAAEvtushenkoOAAvaevaSMA malachite green procedure for orthophosphate determination and its use in alkaline phosphatase-based enzyme immunoassayAnal Biochem198817122662703044186
  • StruthersLPatelRClarkJThomasSDirect detection of 8-oxodeoxyguanosine and 8-oxoguanine by avidin and its analoguesAnal Biochem1998255120319448838
  • ShengZOkaSTsuchimotoD8-Oxoguanine causes neurodegeneration during MUTYH-mediated DNA base excision repairJ Clin Invest2012122124344436123143307
  • XiongQKadotaSTaniTNambaTAntioxidative effects of phenylethanoids from Cistanche deserticolaBiol Pharm Bull19961912158015858996643
  • HuCKittsDDStudies on the antioxidant activity of Echinacea root extractJ Agric Food Chem20004851466147210820044
  • WallaceSSMurphyDLSweasyJBBase excision repair and cancerCancer Lett20123271–2738922252118
  • CaldecottKWDNA single-strand break repairExp Cell Res201432912825176342
  • SchultzLBChehabNHMalikzayAHalazonetisTDp53 binding protein 1 (53BP1) is an early participant in the cellular response to DNA double-strand breaksJ Cell Biol200015171381139011134068
  • LiYYWangLLuCDAn E2F site in the 5′-promoter region contributes to serum-dependent up-regulation of the human proliferating cell nuclear antigen geneFEBS Lett20035441–311211812782299
  • González BesteiroMAGottifrediVThe fork and the kinase: a DNA replication tale from a CHK1 perspectiveMutat Res Rev Mutat Res201576316818025795119
  • WangYHaoHWangGAn approach to identifying sequential metabolites of a typical phenylethanoid glycoside, echinacoside, based on liquid chromatography-ion trap-time of flight mass spectrometry analysisTalanta200980257258019836522
  • HudsonJBApplications of the phytomedicine Echinacea purpurea (purple coneflower) in infectious diseasesJ Biomed Biotechnol2012201276989622131823
  • MulaniSKGuhJHMongKKA general synthetic strategy and the anti-proliferation properties on prostate cancer cell lines for natural phenylethanoid glycosidesOrg Biomol Chem201412182926293724691797
  • KuoYYJimWTSuLCCaffeic acid phenethyl ester is a potential therapeutic agent for oral cancerInt J Mol Sci2015165107481076625984601
  • LiXGouCYangHQiuJGuTWenTEchinacoside ameliorates D-galactosamine plus lipopolysaccharide-induced acute liver injury in mice via inhibition of apoptosis and inflammationScand J Gastroenterol2014498993100024797709
  • GaiXYTangFMaJAntiproliferative effect of echinacoside on rat pulmonary artery smooth muscle cells under hypoxiaJ Pharmacol Sci2014126215516325341567
  • ZhuMLuCLiWTransient exposure to echinacoside is sufficient to activate Trk signaling and protect neuronal cells from rotenoneJ Neurochem2013124457158023189969
  • DongLYuDWuNEchinacoside induces apoptosis in human SW480 colorectal cancer cells by induction of oxidative DNA damagesInt J Mol Sci2015167146551466826132569
  • BesterACRonigerMOrenYSNucleotide deficiency promotes genomic instability in early stages of cancer developmentCell2011145343544621529715
  • XieMYenYOwonikokoTKBcl2 induces DNA replication stress by inhibiting ribonucleotide reductaseCancer Res201474121222324197132
  • VenturaIRussoMTDe LucaGBignamiMOxidized purine nucleotides, genome instability and neurodegenerationMutat Res20107031596520601098
  • DeNicolaGMKarrethFAHumptonTJOncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesisNature2011475735410610921734707
  • SantosMAFaryabiRBErgenAVDNA-damage-induced differentiation of leukaemic cells as an anti-cancer barrierNature2014514752010711125079327
  • SayinVIIbrahimMXLarssonENilssonJALindahlPBergoMOAntioxidants accelerate lung cancer progression in miceSci Transl Med20146221221ra215
  • EgashiraAYamauchiKYoshiyamaKMutational specificity of mice defective in the MTH1 and/or the MSH2 genesDNA Repair (Amst)200211188189312531017
  • VaillantFMerinoDLeeLTargeting BCL-2 with the BH3 mimetic ABT-199 in estrogen receptor-positive breast cancerCancer Cell201324112012923845444
  • HanBParkDLiRSmall-molecule Bcl2 BH4 antagonist for lung cancer therapyCancer Cell201527685286326004684
  • XinMLiRXieMSmall-molecule Bax agonists for cancer therapyNat Commun20145493525230299
  • StreibMKralingKRichterKXieXSteuberHMeggersEAn organometallic inhibitor for the human repair enzyme 7,8-dihydro-8-oxoguanosine triphosphataseAngew Chem Int Ed Engl201453130530924258965
  • SzychowskiJTruchonJFBennaniYLNatural products in medicine: transformational outcome of synthetic chemistryJ Med Chem201457229292930825144261